Fig. 2

Differentially expressed proteins between pre- and postoperative visits’ tear samples. a, b The volcano plots display the results of differential expression analyses for a Vpre-Vpost (55 sample pairs available) and b Vpost-V1m (35 sample pairs available) comparisons. The adjusted p-values (y-axis) are shown in –log₁₀ scale and the dashed horizontal line represents the adjusted p-value threshold of 0.05 and the points above this horizontal line are statistically significant. The median fold changes are in the x-axis and are in log₂ scale. The two dashed lines here are showing the 1.5 and 0.67-fold change thresholds. The values on the left side of the thresholds represent proteins, which were downregulated and the points on the far right were upregulated. Some of the proteins of interest are named (red) and the purple dots represent immunoglobulin subunits. c There were altogether 158 significantly differentiated proteins in Vpre-Vpost and 110 in Vpost-V1m comparisons. The results from Vpre-Vpost and Vpost-V1m comparisons share altogether 104 proteins, which are differentially expressed in both comparisons