Fig. 3

Gene Ontology (GO) analyses of the proteins in AF serum exosome and controls. GO function included three categories: biological processes (BP), cell components (CCs), and molecular function (MF) The abscissa in the graph represents the enriched GO functional classification, the ordinate represents the number of differentiated proteins under each functional classification; and the bar color represents the significance of enriched GO functional classification, i.e. based on Fisher exact test. (Fisher’s Exact Test) calculates p value. The color gradient represents the size of p value. The color gradient changes from orange to red, and the closer the red represents p value, the higher the significance level of GO functional category enrichment. The upper label on bar chart shows richFator <= 1, and the enrichment factor represents the number of differentially expressed proteins annotated to a GO functional category, proportion of all identified proteins released into the GO functional category