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Table 2 Proteins selected from PPI analysis

From: Label-free proteomic analysis of serum exosomes from paroxysmal atrial fibrillation patients

Protein group

Protein name

Function

A8K2T4

C7, Complement component 7

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor

G3XAM2

CFI, Complement factor I

Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively

B7Z550

C8B, Complement component 8, beta polypeptide

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells

P07357

C8A, Complement component 8, alpha polypeptide

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself

P07360

C8G, Complement component 8, gamma polypeptide

C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol

P08603

CFH, Complement factor H

Factor H functions as a cofactor in the inactivation of C3b by factor I and increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b) NBB complex (C5 convertase) in the alternative complement pathway

Q6IPT9 EEF1A1

Eukaryotic translation elongation factor 1 alpha 1

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production

Q15084

PDIA6, Protein disulfide isomerase family A, member 6

May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin

F8WE65

PPIA, Peptidylprolyl isomerase A (cyclophilin A)

PPIases accelerate the folding of proteins. It catalyzes the cis–trans isomerization of proline imidic peptide bonds in oligopeptides