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Table 2 Proteins selected from PPI analysis

From: Label-free proteomic analysis of serum exosomes from paroxysmal atrial fibrillation patients

Protein group Protein name Function
A8K2T4 C7, Complement component 7 Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor
G3XAM2 CFI, Complement factor I Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively
B7Z550 C8B, Complement component 8, beta polypeptide Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells
P07357 C8A, Complement component 8, alpha polypeptide Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself
P07360 C8G, Complement component 8, gamma polypeptide C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol
P08603 CFH, Complement factor H Factor H functions as a cofactor in the inactivation of C3b by factor I and increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b) NBB complex (C5 convertase) in the alternative complement pathway
Q6IPT9 EEF1A1 Eukaryotic translation elongation factor 1 alpha 1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production
Q15084 PDIA6, Protein disulfide isomerase family A, member 6 May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin
F8WE65 PPIA, Peptidylprolyl isomerase A (cyclophilin A) PPIases accelerate the folding of proteins. It catalyzes the cistrans isomerization of proline imidic peptide bonds in oligopeptides