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Table 3 Proteins selected in immune system and protein folding monitored by PRM/MS

From: Label-free proteomic analysis of serum exosomes from paroxysmal atrial fibrillation patients

Protein group Pathway Signature peptide(s) Normalized peak area Relative abundance of protein Ratio TTEST
Patient 1 Patient 2 Patient 3 Control 1 Control 2 Control 3 Patient average Control average Patient/Control
A8K2T4 Prion diseases LIDQYGTHYLQSGSLGGEYR
QNDFNSVEEK
SSGWHFVVK
0.2679 0.3582 0.3529 0.1314 0.0987 0.0911 0.3263 0.1071 3.05 0.00231
G3XAM2 Staphylococcus aureus infection Complement and coagulation cascades HGNTDSEGIVEVK, IVIEYVDR 1.6821 1.4129 1.3069 0.7351 0.6307 0.7247 1.4673 0.6968 2.11 0.0027
B4E1Z4 Complement and coagulation cascades, Staphylococcus aureus infection EELLPAQDIK, QLNEINYEDHK 16.2201 12.5770 9.5189 7.9080 2.6827 5.3475 12.7720 5.3127 2.40 0.0385
B7Z550 Prion diseases Complement and coagulation cascades, Systemic lupus erythematosus, Amoebiasis EYESYSDFER, LPLEYSYGEYR, QALEEFQK, SGFSFGFK 1.6165 1.6726 1.1954 0.8485 0.3616 0.5914 1.4949 0.6005 2.49 0.0122
P08603 Complement and coagulation cascades, Staphylococcus aureus infection GEWVALNPLR, IVSSAMEPDR, NGFYPATR 30.7818 20.2144 22.8060 16.6629 12.3889 13.2042 24.6007 14.0853 1.75 0.0377
P01031 Systemic lupus erythematosus, Pertussis, Herpes simplex infection, Prion diseases, Complement and coagulation cascades, Staphylococcus aureus infection DSEITFIK, IDTQDIEASHYR 3.2947 2.6653 2.4174 1.2760 0.6331 0.8486 2.7925 0.9192 3.04 0.0044
Q6IPT9 RNA transport, Legionellosis IGGIGTVPVGR 0.4415 0.1840 0.2476 0.6172 0.3933 0.4184 0.2910 0.4763 0.61 0.1522
A0A024R8S5 Protein processing in endoplasmic reticulum EADDIVNWLK 0.0297 0.0277 0.0265 0.0220 0.0348 0.0441 0.0280 0.0336 0.83 0.4315
F8WE65 Necroptosis VSFELFADK 0.0246 0.0350 0.0421 0.0387 0.0383 0.0469 0.0339 0.0413 0.82 0.2716