Table 3 Proteins selected in immune system and protein folding monitored by PRM/MS
From: Label-free proteomic analysis of serum exosomes from paroxysmal atrial fibrillation patients
Protein group | Pathway | Signature peptide(s) | Normalized peak area | Relative abundance of protein | Ratio | TTEST | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patient 1 | Patient 2 | Patient 3 | Control 1 | Control 2 | Control 3 | Patient average | Control average | Patient/Control | ||||
A8K2T4 | Prion diseases | LIDQYGTHYLQSGSLGGEYR QNDFNSVEEK SSGWHFVVK | 0.2679 | 0.3582 | 0.3529 | 0.1314 | 0.0987 | 0.0911 | 0.3263 | 0.1071 | 3.05 | 0.00231 |
G3XAM2 | Staphylococcus aureus infection Complement and coagulation cascades | HGNTDSEGIVEVK, IVIEYVDR | 1.6821 | 1.4129 | 1.3069 | 0.7351 | 0.6307 | 0.7247 | 1.4673 | 0.6968 | 2.11 | 0.0027 |
B4E1Z4 | Complement and coagulation cascades, Staphylococcus aureus infection | EELLPAQDIK, QLNEINYEDHK | 16.2201 | 12.5770 | 9.5189 | 7.9080 | 2.6827 | 5.3475 | 12.7720 | 5.3127 | 2.40 | 0.0385 |
B7Z550 | Prion diseases Complement and coagulation cascades, Systemic lupus erythematosus, Amoebiasis | EYESYSDFER, LPLEYSYGEYR, QALEEFQK, SGFSFGFK | 1.6165 | 1.6726 | 1.1954 | 0.8485 | 0.3616 | 0.5914 | 1.4949 | 0.6005 | 2.49 | 0.0122 |
P08603 | Complement and coagulation cascades, Staphylococcus aureus infection | GEWVALNPLR, IVSSAMEPDR, NGFYPATR | 30.7818 | 20.2144 | 22.8060 | 16.6629 | 12.3889 | 13.2042 | 24.6007 | 14.0853 | 1.75 | 0.0377 |
P01031 | Systemic lupus erythematosus, Pertussis, Herpes simplex infection, Prion diseases, Complement and coagulation cascades, Staphylococcus aureus infection | DSEITFIK, IDTQDIEASHYR | 3.2947 | 2.6653 | 2.4174 | 1.2760 | 0.6331 | 0.8486 | 2.7925 | 0.9192 | 3.04 | 0.0044 |
Q6IPT9 | RNA transport, Legionellosis | IGGIGTVPVGR | 0.4415 | 0.1840 | 0.2476 | 0.6172 | 0.3933 | 0.4184 | 0.2910 | 0.4763 | 0.61 | 0.1522 |
A0A024R8S5 | Protein processing in endoplasmic reticulum | EADDIVNWLK | 0.0297 | 0.0277 | 0.0265 | 0.0220 | 0.0348 | 0.0441 | 0.0280 | 0.0336 | 0.83 | 0.4315 |
F8WE65 | Necroptosis | VSFELFADK | 0.0246 | 0.0350 | 0.0421 | 0.0387 | 0.0383 | 0.0469 | 0.0339 | 0.0413 | 0.82 | 0.2716 |