Accuracy
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Level of agreement between biomarker and standard measure of disease presence/outcome
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Bias
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Repeated biomarker measurements do not result in under/overestimation of disease activity
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Repeatability
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Precision of biomarker under standard "unchanged" conditions e.g. between batches
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Intermediate precision
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Precision of biomarker test in spite of laboratory variations e.g. time analysed, operator, equipment, calibration
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Reproducibility
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Precision of biomarker test between laboratories with potential variability in operators and measuring systems
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LoD
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The smallest amount of analyte that can be detected with a specified probability
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LoQ
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The smallest amount of analyte that can be quantitatively determined with acceptable precision
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Linearity
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Measured quantity values are directly proportional to the amount of biomarker in the experimental matrix
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