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Fig. 4 | Clinical Proteomics

Fig. 4

From: Time dependent effect of cold ischemia on the phosphoproteome and protein kinase activity in fresh-frozen colorectal cancer tissue obtained from patients

Fig. 4

Correlation of signal intensity with CIT. Statistical analysis of the correlation of signal intensity with time till freezing analyzed per tumor (a PTK and c STK) and for all tumors combined (b PTK and d STK) represented in Volcano plots. The -log p-values (Y-axis) are plotted as function of effect size (X-axis). Peptides are colored according to p-values. Peptides with a p-value < 0.01 and effect size > 2 are boxed. In total 33 (35.5%) peptides (box in a, patient 1) and 3 (3%) peptides (box in b) of the peptides were phosphorylated with a significant (p < 0.01) and ≥ twofold increased signal after 180 min of CIT. For STK 62 (53%, box in c, patient 1) and 1 (0.9%, box in d) peptides showed a significant (p < 0.01) and ≥ twofold decreased signal intensities with 180 min of CIT

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Clinical Proteomics

ISSN: 1559-0275