Table 6 Student’s t-test analysis of tear proteome from patients diagnosed with ocular GVHD versus control

TKT

Transketolase

2.75E−05

Y

Y

Y

DEFA1; DEFA3

Neutrophil defensin 1; HP 1–56; Neutrophil defensin 2; Neutrophil defensin 3; HP 3–56; Neutrophil defensin 2

3.90E−05

Y

Y

Y

KRT13§

Keratin, type I cytoskeletal 13

5.89E−05

Y

Y

Y

KRT4

Keratin, type II cytoskeletal 4

6.68E−04

Y

N

N

KRT5

Keratin, type II cytoskeletal 5

7.04E−04

Y

N

N

SAA4

Serum amyloid A-4 protein

1.49E−03

Y

N

N

CASP14

Caspase-14; Caspase-14 subunit p19; Caspase-14 subunit p10

2.43E−03

Y

N

N

ANXA1

Annexin A1; Annexin

2.47E−03

Y

N

N

KRT19

Keratin, type I cytoskeletal 19

2.48E−03

Y

N

N

A2M

Alpha-2-macroglobulin

2.89E−03

Y

N

N

CFB

Complement factor B; Complement factor B Ba fragment; Complement factor B Bb fragment

3.20E−03

Y

N

N

KRT6A; KRT6C

Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 6C

3.74E−03

Y

N

N

SPRR3

Small proline-rich protein 3

4.04E−03

Y

N

N

PLG

Plasminogen

4.67E−03

Y

N

N

IGHM

Ig mu chain C region; Ig mu heavy chain disease protein

4.86E−03

Y

N

N

ANXA2; ANXA2P2

Annexin A2; Annexin; Putative annexin A2-like protein

5.22E−03

Y

N

N

HRG

Histidine-rich glycoprotein

5.85E−03

Y

N

N

H2AFX#

Histone H2AX

6.76E−03

N

N

N

FLG

Filaggrin

6.93E−03

N

N

N

MYL6

Myosin light polypeptide 6

8.11E−03

N

N

N

IGHG3

Ig gamma-3 chain C region

9.38E−03

N

N

N

CTSG

Cathepsin G

9.40E−03

N

N

N

HIST1H4A

Histone H4

1.00E−02

N

N

N

CFH

Complement factor H

1.22E−02

N

N

N

YWHAZ

14–3-3 protein zeta/delta

1.25E−02

N

N

N

EZR

Ezrin

1.80E−02

N

N

N

HSPA8

Heat shock cognate 71 kDa protein

1.94E−02

N

N

N

ACTN4

Alpha-actinin-4

1.98E−02

N

N

N

LRG1

Leucine-rich alpha-2-glycoprotein

2.05E−02

N

N

N

S100A14

Protein S100-A14

2.09E−02

N

N

N

KRT14

Keratin, type I cytoskeletal 14

2.30E−02

N

N

N

C4BPA

C4b-binding protein alpha chain

2.41E−02

N

N

N

TF

Serotransferrin

2.41E−02

N

N

N

YWHAB

14–3-3 protein beta/alpha; 14–3-3 protein beta/alpha, N-terminally processed

2.51E−02

N

N

N

ITIH1

Inter-alpha-trypsin inhibitor heavy chain H1

2.58E−02

N

N

N

C3Φ

Complement C3

2.61E−02

N

N

N

TFF1

Trefoil factor 1

2.65E−02

N

N

N

ALB

Serum albumin

2.82E−02

N

N

N

ACTB

Actin, cytoplasmic 1; Actin, cytoplasmic 1, N-terminally processed

3.14E−02

N

N

N

CFL1

Cofilin-1

3.62E−02

N

N

N

KNG1

Kininogen-1

4.37E−02

N

N

N

S100A9

Protein S100-A9

4.40E−02

N

N

N

UPK3BL; POLR2J3

Uroplakin-3b-like protein

4.44E−02

N

N

N

TXN

Thioredoxin

4.96E−02

N

N

N