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Table 1 Top 10 GO terms (biological process and molecular function) and involved proteins by DAVID

From: Identification of differentially expressed proteins and clinicopathological significance of HMGB2 in cervical cancer

GO ID Term P value Involved proteins Fold Enrichment
Biological process
 GO:0060333 Interferon-gamma-mediated signaling pathway 1.45 × 10–4 HLA-DRB1, HLA-C, HLA-B, HLA-DRA, GBP1 18.48
 GO:0098532 Histone H3-K27 trimethylation 2.06 × 10−4 HIST1H1E, HIST1H1D, HIST1H1C 131.19
 GO:0016584 Nucleosome positioning 3.82 × 10−4 HIST1H1E, HIST1H1D, HIST1H1C 98.39
 GO:0006334 Nucleosome assembly 1.03 × 10−3 H1F0, HIST1H1E, HMGB2, HIST1H1D, IST1H1C 11.02
 GO:0019882 Antigen processing and presentation 1.14 × 10−3 HLA-DRB1, HLA-C, HLA-B, HLA-DRA 19.09
 GO:0080182 Histone H3-K4 trimethylation 1.41 × 10−3 HIST1H1E, HIST1H1D, HIST1H1C 52.48
 GO:0002437 Inflammatory response to antigenic stimulus 1.41 × 10−3 HMGB1, HMGB2, HLA-DRB1 52.48
 GO:0006309 Apoptotic DNA fragmentation 1.41 × 10−3 H1F0, HMGB1, HMGB2 52.48
 GO:0060337 Type I interferon signaling pathway 1.78 × 10−3 IFIT1, HLA-C, HLA-B, ISG20 16.40
 GO:0051607 Defense response to virus 3.41 × 10−3 AZU1, IFIT1, DEFA3, ISG20, GBP1 7.96
Molecular function
 GO:0032395 MHC class II receptor activity 1.98 × 10−5 KRT17, HLA-DRB1, HLA-C, HLA-DRA 72.61
 GO:0042605 Peptide antigen binding 1.38 × 10−4 HLA-DRB1, HLA-C, HLA-B, HLA-DRA 38.90
 GO:0005198 Structural molecule activity 2.62 × 10−3 KRT6C, PGM5, KRT17, FLG, SPRR1B, KRT1, SPRR3 7.72
 GO:0000400 Four-way junction DNA binding 1.14 × 10−3 HMGB1, MSH6, HMGB2 58.34
 GO:0031490 Chromatin DNA binding 1.20 × 10−3 H1F0, HIST1H1E, HIST1H1D, HIST1H1C 18.78
 GO:0003684 Damaged DNA binding 1.53 × 10−3 HMGB1, MSH6, HMGB2, MSH5 17.29
 GO:0046977 TAP binding 1.08 × 10−2 HLA-C, HLA-B 181.52
 GO:097100 Supercoiled DNA binding 1.44 × 10−2 HMGB1, HMGB2 136.14
 GO:0044822 Poly(A) RNA binding 1.94 × 10−2 H1F0, HMGB1, HIST1H1E, HMGB2, HIST1H1D, HIST1H1C, TRA2B, RPL26, TMSB4X, MANF 2.41
 GO:0003725 Double-stranded RNA binding 2.05 × 10−2 HMGB1, YRDC, TUBB4B 13.39
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