Table 1 Top 10 GO terms (biological process and molecular function) and involved proteins by DAVID
GO ID | Term | P value | Involved proteins | Fold Enrichment |
|---|---|---|---|---|
Biological process | ||||
 GO:0060333 | Interferon-gamma-mediated signaling pathway | 1.45 × 10–4 | HLA-DRB1, HLA-C, HLA-B, HLA-DRA, GBP1 | 18.48 |
 GO:0098532 | Histone H3-K27 trimethylation | 2.06 × 10−4 | HIST1H1E, HIST1H1D, HIST1H1C | 131.19 |
 GO:0016584 | Nucleosome positioning | 3.82 × 10−4 | HIST1H1E, HIST1H1D, HIST1H1C | 98.39 |
 GO:0006334 | Nucleosome assembly | 1.03 × 10−3 | H1F0, HIST1H1E, HMGB2, HIST1H1D, IST1H1C | 11.02 |
 GO:0019882 | Antigen processing and presentation | 1.14 × 10−3 | HLA-DRB1, HLA-C, HLA-B, HLA-DRA | 19.09 |
 GO:0080182 | Histone H3-K4 trimethylation | 1.41 × 10−3 | HIST1H1E, HIST1H1D, HIST1H1C | 52.48 |
 GO:0002437 | Inflammatory response to antigenic stimulus | 1.41 × 10−3 | HMGB1, HMGB2, HLA-DRB1 | 52.48 |
 GO:0006309 | Apoptotic DNA fragmentation | 1.41 × 10−3 | H1F0, HMGB1, HMGB2 | 52.48 |
 GO:0060337 | Type I interferon signaling pathway | 1.78 × 10−3 | IFIT1, HLA-C, HLA-B, ISG20 | 16.40 |
 GO:0051607 | Defense response to virus | 3.41 × 10−3 | AZU1, IFIT1, DEFA3, ISG20, GBP1 | 7.96 |
Molecular function | ||||
 GO:0032395 | MHC class II receptor activity | 1.98 × 10−5 | KRT17, HLA-DRB1, HLA-C, HLA-DRA | 72.61 |
 GO:0042605 | Peptide antigen binding | 1.38 × 10−4 | HLA-DRB1, HLA-C, HLA-B, HLA-DRA | 38.90 |
 GO:0005198 | Structural molecule activity | 2.62 × 10−3 | KRT6C, PGM5, KRT17, FLG, SPRR1B, KRT1, SPRR3 | 7.72 |
 GO:0000400 | Four-way junction DNA binding | 1.14 × 10−3 | HMGB1, MSH6, HMGB2 | 58.34 |
 GO:0031490 | Chromatin DNA binding | 1.20 × 10−3 | H1F0, HIST1H1E, HIST1H1D, HIST1H1C | 18.78 |
 GO:0003684 | Damaged DNA binding | 1.53 × 10−3 | HMGB1, MSH6, HMGB2, MSH5 | 17.29 |
 GO:0046977 | TAP binding | 1.08 × 10−2 | HLA-C, HLA-B | 181.52 |
 GO:097100 | Supercoiled DNA binding | 1.44 × 10−2 | HMGB1, HMGB2 | 136.14 |
 GO:0044822 | Poly(A) RNA binding | 1.94 × 10−2 | H1F0, HMGB1, HIST1H1E, HMGB2, HIST1H1D, HIST1H1C, TRA2B, RPL26, TMSB4X, MANF | 2.41 |
 GO:0003725 | Double-stranded RNA binding | 2.05 × 10−2 | HMGB1, YRDC, TUBB4B | 13.39 |