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Table 1 Relative ubiquitin occupancy and total protein abundance ratios for the seven partially ubiquitinated sites in HER2

From: Proteomic analysis of degradation ubiquitin signaling by ubiquitin occupancy changes responding to 26S proteasome inhibition

Lysine residue position in HER2

Peptide sequence

Ubiquitinated ratio (Rub)

Protein ratio (Rprotein)

724

VKVLGSGAFGTVYK

13.2

2.18

736

VLGSGAFGTVYKGIWIPDGENVK

3.96

2.02

747

GIWIPDGENVKIPVAIK

1.65

1.76

765

ANKEILDEAYVMAGVGSPYVSR

4.96

1.75

860

SPNHVKITDFGLAR

19.89

3.17

883

LLDIDETEYHADGGKVPIK

11.75

3.85

937

EIPDLLEKGER

4.56

2.78

716

ILKETELR

Only ubiquitin occupied state

854

NVLVKSPNHVK

Only ubiquitin occupied state

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Clinical Proteomics

ISSN: 1559-0275