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Table 2 Full list of the 29 proteins whose expression patterns change consistently when comparing pre-eclamptic versus control serum/plasma samples

From: Quantitative proteomics-based analyses performed on pre-eclampsia samples in the 2004–2020 period: a systematic review

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Gene namea

Protein namea

PE > Cb,d

PE < Cc,d

P00740

F9

Coagulation factor IX

[68]

[69, 70]

P00751

CFB

Complement factor B

[71]

[48, 70, 72]

P01009

SERPINA1

Alpha-1-antitrypsin

[48, 73,74,75]

[71]

P01023

A2M

Alpha-2-macroglobulin

 

[68, 71, 74, 76, 77]

P02649

APOE

Apolipoprotein E

[74, 75, 78]

[76]

P02679

FGG

Fibrinogen gamma chain

[68, 74, 78, 79]

 

P02741

CRP

C-reactive protein

[68, 69, 75, 76]

[80]

P02746

C1QB

Complement C1q subcomponent subunit B

[76]

[68, 69, 72]

P02751

FN1

Fibronectin

[69,70,71, 74, 75, 79, 81]

[77]

P02760

AMBP

Protein AMBP

[73,74,75,76]

[75]

P02766

TTR

Transthyretin

 

[14, 74, 81, 82]

P02787

TF

Serotransferrin

[48, 69, 78, 79]

 

P04114

APOB

Apolipoprotein B-100

[77]

[69, 74, 81]

P04196

HRG

Histidine-rich glycoprotein

[68, 69, 75, 82]

[72]

P05155

SERPING1

Plasma protease C1 inhibitor

[71]

[69, 70, 77]

P08514

ITGA2B

Integrin alpha-IIb

[70, 83]

 

P08697

SERPINF2

Alpha-2-antiplasmin

[84]

[69, 70, 76]

P09237

MMP7

Matrilysin

[70, 83]

 

P0C0L5

C4B

Complement C4-B

 

[68, 77, 81, 83]

P10909

CLU

Clusterin

[68, 73,74,75, 77,78,79, 81, 85, 86]

[76]

P11464

PSG1

Pregnancy-specific B-1 glycoprotein 1

[77]

[69, 75, 76, 84]

P17813

ENG

Endoglin

[69, 77, 80, 87, 88]

 

P20742

PZP

Pregnancy zone protein

[68, 69]

[69, 74, 75]

P22352

GPX3

Glutathione peroxidase 3

[89]

[74,75,76]

P36955

SERPINF1

Pigment epithelium-derived factor

[71, 72, 74, 81]

[76]

P49763

PGF

Placenta growth factor

 

[70, 83, 87]

Q14624

ITIH4

Inter-alpha-trypsin inhibitor heavy chain H4

[68, 75, 76]

[72]

Q15485

FCN2

Ficolin-2

 

[70, 80, 90]

Q16610

ECM1

Extracellular matrix protein 1

[87]

[69, 76, 77]

  1. Reference 69 reports two independent data for F9, C1QB, FN1, TF, APOB, HRG, SERPING1, SERPINF2, PSG1, ENG, PZP and ECM1 and four independent data for CRP; reference 70 reports two independent data for FCN2, CFB, MMP7 and PGF and three independent data for ITGA2B; reference 83 reports two independent data for MMP7.
  2. aAccording to UniprotKB
  3. bPE > C: expression levels have been described to be higher in pre-eclampsia versus control samples
  4. cPE < C: expression levels have been described to be lower in pre-eclampsia versus control samples
  5. dNumbers correspond to bibliographic references