The use of proteomics for blood biomarker research in premature infants: a scoping review

Letunica, Natasha; Cai, Tengyi; Cheong, Jeanie L. Y.; Doyle, Lex W.; Monagle, Paul; Ignjatovic, Vera

doi:10.1186/s12014-021-09316-y

Clinical Proteomics

Table 2 Proteins identified in the studies included in this scoping review

From: The use of proteomics for blood biomarker research in premature infants: a scoping review

Protein	Gene	UniProt accession number	Molecular function	Biological process	Study
Natriuretic peptides B	NPPB	P16860	Diuretic hormone activity/ hormone receptor binding	Cell surface receptor signalling pathway/ body fluid secretion	[23]
Apolipoprotein C-II	APOC2	P02655	Lipoprotein lipase activator activity/ lipid binding	High-density lipoprotein particle remodelling/ retinoid metabolic process	[16]
Serum Amyloid A	SAA	P0DJI8	G protein-coupled receptor/heparin binding	Activation of MAPK activity/ acute-phase response	[12, 16]
C-reactive protein (1–205)	CRP	P02741	Calcium ion/ choline binding	Complement activation/ innate immune response	[12]
Macrophage migration inhibitory factor	MIF	P14174	Cytokine activity/ receptor binding	Innate immune response/inflammatory response	[12]
Serum amyloid A-2	SAA-2	P0DJI9	G protein-coupled receptor/heparin binding	Acute-phase response	[12]
Transthyretin	TTR	P02766	Hormone activity	Cellular protein metabolic process/ extracellular matrix organization	[12]
Haptoglobin	HP	P00738	Antioxidant activity/ haemoglobin binding	Acute inflammatory response	[12]
U5 small nuclear ribonucleoprotein	SNRNP40	Q96DI7	RNA binding	RNA splicing and processing	[12]
Lysophospholipid acyltransferase 7	MBOAT7	Q96N66	Lysophospholipid acyltransferase activity	Lipid modification/regulation of triglyceride metabolic process	[17]
Apolipoprotein L1	APOL1	O14791	Chloride channel activity/ lipid binding	Cellular Protein Metabolic Process/ cholesterol metabolic process	[15, 17]
Small ubiquitin-related modifier 3	SUMO3	P55854	Protein tag/ ubiquitin-like protein ligase binding	Negative regulation of DNA binding	[17]
Ficolin-2	FCN2	Q15485	Antigen/Calcium-dependant protein binding	Complement activation	[17]
Serotransferrin	TF	P02787	ferric iron binding	Cellular iron ion homeostasis	[15, 17]
Mitochondrial superoxide2	SOD2	P04179	DNA/enzyme binding	Cellular response to oxidative stress	[18]
Chordin-like protein 1	CHRDL1	Q9BU40	Developmental protein	BMP signalling pathway/ post-translational protein modification	[18]
Proprotein convertase subtilisin/kexin type 9	PCSK9	Q8NBP7	Apolipoprotein binding	Apoptotic process	[18]
Fibroblast growth factor 19	FGF-19	O95750	Fibroblast Growth Factor Receptor Binding	MAPK cascade/ positive regulation of protein phosphorylation	[18, 19]
Macrophage-stimulating protein receptor	MST1R	Q04912	ATP/ enzyme binding	Cell migration/ hepatocyte growth factor receptor signalling pathway	[18, 21]
Glycoprotein hormones alpha chain	CGA	P01215	Follicle-stimulating hormone activity	Peptide hormone processing	[25]
Cystatin-M	CST6	Q15828	Cysteine-Type Endopeptidase Inhibitor Activity	Anatomical structure morphogenesis	[18]
Plasminogen	PLG	P00747	Apolipoprotein Binding/ protein domain specific binding	Blood coagulation/ cellular protein metabolic process	[18]
Insulin-like growth factor-binding protein 7	IGFBP-7	Q16270	Insulin-Like Growth Factor Binding	Cell Adhesion/ cellular protein metabolic process	[18]
Plasma protease C1 inhibitor	SERPING1	P05155	Serine-Type Endopeptidase Inhibitor Activity	Blood coagulation, intrinsic pathway/ complement activation, classical pathway	[13]
Complement C3	C3	P01024	C5L2 anaphylatoxin chemotactic receptor binding	Cellular protein metabolic process	[10, 13]
Coagulation factor V	F5	P12259	Copper ion binding	Cellular protein metabolic process/ platelet degranulation	[13]
Complement C4-A	C4A	P0C0L4	Endopeptidase inhibitor activity	Cellular protein metabolic process/ regulation of complement activation	[13]
Leucine-rich alpha-2-glycoprotein	LRG1	P02750	Transforming growth factor beta receptor binding	Neutrophil degranulation	[13, 14]
Serum amyloid P-component	APCS	P02743	Calcium ion/ carbohydrate binding	cellular protein metabolic process/ complement activation	[13]
Apolipoprotein D	APOD	P05090	Cholesterol binding/ lipid transporter activity	Angiogenesis/ lipid metabolic process	[13]
Alpha-1-acid glycoprotein 1	ORM 1	P02763	Inflammatory response	Platelet/ neutrophil degranulation	[14]
Zinc-alpha-2-glycoprotein	AZGP1	P25311	Protein transmembrane transporter activity	Transmembrane transport/ retina homeostasis	[14]
Platelet factor 4	PF4	P02776	Chemokine activity/ heparin binding	G protein-coupled receptor signalling pathway	[19, 21]
Amyloid-beta precursor protein	APP	P05067	Acetylcholine receptor binding	Cellular protein metabolic process	[21]
Serine/threonine-protein kinase 16	STK16	O75716	ATP binding/ protein serine/threonine kinase activity	Protein autophosphorylation	[21]
Afamin	AFM	P43652	Fatty acid/ vitamin E binding	Vitamin transport/ protein stabilisation	[14, 15]
Gelsolin	GSN	P06396	Actin/ calcium ion binding	Cellular protein metabolic process	[15]
Galectin-3	LGALS3	P17931	Oligosaccharide/ RNA binding	Neutrophil degranulation/ innate immune response	[15]
Vascular endothelial growth factor A	VEGFA	P15692	Vascular endothelial growth factor receptor binding	Activation of protein kinase activity/ angiogenesis	[19]
Angiopoietin-2	ANGPT2	O15123	Metal ion binding/ receptor tyrosine kinase binding	Angiogenesis/ leukocyte migration	[19]
Angiopoietin-1	ANGPT1	Q15389	Receptor tyrosine kinase binding	Angiogenesis/ leukocyte migration	[19]
Bone morphogenetic protein 10	BMP10	O95393	Growth factor/ cytokine activity	Cell adhesion/ BMP signalling	[19]
Hepatocyte growth factor receptor	MET	P08581	ATP binding/ protein tyrosine kinase activity	cell surface receptor signalling pathway/ cell migration	[19]
Protein S100-A12	S100A12	P80511	Calcium/ion binding	Cytokine secretion/ inflammatory response	[24]
Interleukin-6	IL6	P05231	Cytokine/ growth factor activity	Cellular protein metabolic process/ acute-phase response	[24]
Interleukin-10	IL10	P22301	Cytokine/ growth factor activity	B cell differentiation/ cytokine-mediated signalling pathway	[24]
Complement receptor type 2	CR2	P20023	Complement binding/ DNA binding	B cell differentiation/ immune response	[25]
Coagulation factor VII	F7	P08709	Calcium ion binding/ signalling receptor binding	Blood coagulation-extrinsic pathway	[25]
Coagulation factor XI	F11	P03951	Heparin binding	Blood coagulation-intrinsic pathway/ plasminogen activation	[25]
L-selectin	SELL	P14151	Calcium ion binding	Leukocyte migration/ regulation of immune response	[25]
Interleukin-2 receptor subunit alpha	IL2RA	P01589	Interleukin-2 binding/ receptor activity	cytokine-mediated signalling pathway	[25]
Platelet glycoprotein VI	GP6	Q9HCN6	Collagen binding/ signalling receptor activity	Blood coagulation/ platelet activation/ leukocyte migration	[25]
Collectin-12	COLEC12	Q5KU26	Galactose binding/ low-density lipoprotein particle binding	Receptor-mediated endocytosis/ regulation of immune response	[25]
Follistatin-related protein 3	FSTL3	O95633	Activin/ fibronectin binding	Cellular protein metabolic process/ cell differentiation	[25]
Growth/differentiation factor 15	GDF15	Q99988	BMP receptor binding/ growth factor activity	Activation of MAPK activity/ BMP signalling	[25]
Insulin-like growth factor-binding protein 1	IGFBP1	P08833	Insulin-like growth factor binding	Cellular protein metabolic process	[25]

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