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Table 1 Differentially expressed acetylation sites obtained in 9 GIST samples

From: Quantitative proteomic analysis of aberrant expressed lysine acetylation in gastrointestinal stromal tumors

Protein accession

Protein description

Position

G_MH/G_L Ratio

Regulated Type

G_MH/G_L P value

A0A024RBG1

Diphosphoinositol polyphosphate phosphohydrolase NUDT4B OS=Homo sapiens OX=9606 GN=NUDT4B PE=3 SV=1

134

0.672

Down

0.044143

O00193

Small acidic protein OS=Homo sapiens OX=9606 GN=SMAP PE=1 SV=1

13

2.136

Up

0.00072261

O60563

Cyclin-T1 OS=Homo sapiens OX=9606 GN=CCNT1 PE=1 SV=1

638

1.707

Up

0.047559

O60934

Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1

544

1.308

Up

0.027417

O75874

Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens OX=9606 GN=IDH1 PE=1 SV=2

87

1.319

Up

0.0058635

O94868

F-BAR and double SH3 domains protein 2 OS=Homo sapiens OX=9606 GN=FCHSD2 PE=1 SV=3

24

0.266

Down

0.0096962

P00450

Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=1

712

0.571

Down

0.046757

P00738

Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1

291

0.448

Down

0.00135938

P00738

Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1

321

0.653

Down

0.0165435

P00966

Argininosuccinate synthase OS=Homo sapiens OX=9606 GN=ASS1 PE=1 SV=2

340

0.612

Down

0.025202

P01024

Complement C3 OS=Homo sapiens OX=9606 GN=C3 PE=1 SV=2

1360

0.687

Down

0.048143

P02647

Apolipoprotein A-I OS=Homo sapiens OX=9606 GN=APOA1 PE=1 SV=1

219

0.557

Down

0.023881

P02787

Serotransferrin OS=Homo sapiens OX=9606 GN=TF PE=1 SV=3

618

0.662

Down

0.0162807

P04406

Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3

117

2.461

Up

0.040164

P06753

Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2

153

1.538

Up

0.006816

P07585

Decorin OS=Homo sapiens OX=9606 GN=DCN PE=1 SV=1

164

0.678

Down

0.0138641

P08133

Annexin A6 OS=Homo sapiens OX=9606 GN=ANXA6 PE=1 SV=3

306

1.351

Up

0.043101

P08133

Annexin A6 OS=Homo sapiens OX=9606 GN=ANXA6 PE=1 SV=3

9

1.62

Up

0.042521

P08237

ATP-dependent 6-phosphofructokinase, muscle type OS=Homo sapiens OX=9606 GN=PFKM PE=1 SV=2

476

1.469

Up

0.043421

P08571

Monocyte differentiation antigen CD14 OS=Homo sapiens OX=9606 GN=CD14 PE=1 SV=2

119

0.553

Down

0.030401

P08670

Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4

373

0.708

Down

0.00153584

P08708

40S ribosomal protein S17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2

44

1.373

Up

0.042363

P10412

Histone H1.4 OS=Homo sapiens OX=9606 GN=HIST1H1E PE=1 SV=2

75

0.784

Down

0.033478

P11021

Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2

213

0.8

Down

0.0138592

P12429

Annexin A3 OS=Homo sapiens OX=9606 GN=ANXA3 PE=1 SV=3

58

1.505

Up

0.0192233

P13010

X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3

565

1.942

Up

0.023699

P13987

CD59 glycoprotein OS=Homo sapiens OX=9606 GN=CD59 PE=1 SV=1

63

0.612

Down

0.042604

P17844

Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1

197

1.222

Up

0.038495

P17844

Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1

33

1.361

Up

0.034019

P17858

ATP-dependent 6-phosphofructokinase, liver type OS=Homo sapiens OX=9606 GN=PFKL PE=1 SV=6

469

1.335

Up

0.030163

P19338

Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3

96

1.722

Up

0.026438

P19827

Inter-alpha-trypsin inhibitor heavy chain H1 OS=Homo sapiens OX=9606 GN=ITIH1 PE=1 SV=3

312

0.588

Down

0.0089201

P19827

Inter-alpha-trypsin inhibitor heavy chain H1 OS=Homo sapiens OX=9606 GN=ITIH1 PE=1 SV=3

222

0.507

Down

0.00162407

P20700

Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2

156

0.78

Down

0.049082

P24821

Tenascin OS=Homo sapiens OX=9606 GN=TNC PE=1 SV=3

1011

0.354

Down

0.039499

P27816

Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3

769

0.617

Down

0.027344

P32119

Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5

26

1.502

Up

0.022156

P35241

Radixin OS=Homo sapiens OX=9606 GN=RDX PE=1 SV=1

400

0.519

Down

0.043557

P35579

Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4

972

1.236

Up

0.0171213

P35579

Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4

1775

2.07

Up

0.0140371

P35579

Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4

1459

1.309

Up

0.0028802

P36578

60S ribosomal protein L4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5

239

1.423

Up

0.0178187

P41218

Myeloid cell nuclear differentiation antigen OS=Homo sapiens OX=9606 GN=MNDA PE=1 SV=1

55

0.663

Down

0.0091989

P45974

Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens OX=9606 GN=USP5 PE=1 SV=2

357

1.384

Up

0.025318

P46013

Proliferation marker protein Ki-67 OS=Homo sapiens OX=9606 GN=MKI67 PE=1 SV=2

1063

5.681

Up

0.027464

P47756

F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=4

235

1.399

Up

0.022458

P47895

Aldehyde dehydrogenase family 1 member A3 OS=Homo sapiens OX=9606 GN=ALDH1A3 PE=1 SV=2

373

2.773

Up

0.0454

P48163

NADP-dependent malic enzyme OS=Homo sapiens OX=9606 GN=ME1 PE=1 SV=1

60

0.731

Down

0.02706

P51659

Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3

139

1.529

Up

0.025245

P53396

ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3

978

1.791

Up

0.026841

P57740

Nuclear pore complex protein Nup107 OS=Homo sapiens OX=9606 GN=NUP107 PE=1 SV=1

85

1.363

Up

0.048177

P61086

Ubiquitin-conjugating enzyme E2 K OS=Homo sapiens OX=9606 GN=UBE2K PE=1 SV=3

14

1.529

Up

0.037338

P63010

AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1

318

0.76

Down

0.023057

P80511

Protein S100-A12 OS=Homo sapiens OX=9606 GN=S100A12 PE=1 SV=2

91

1.881

Up

0.0102004

Q01082

Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2

2344

0.722

Down

0.0020834

Q03252

Lamin-B2 OS=Homo sapiens OX=9606 GN=LMNB2 PE=1 SV=4

298

0.651

Down

0.042461

Q05682

Caldesmon OS=Homo sapiens OX=9606 GN=CALD1 PE=1 SV=3

618

1.986

Up

0.0157559

Q07065

Cytoskeleton-associated protein 4 OS=Homo sapiens OX=9606 GN=CKAP4 PE=1 SV=2

388

0.612

Down

0.045483

Q07666

KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1

152

1.442

Up

0.022284

Q13813

Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1 PE=1 SV=3

1486

0.684

Down

0.0195798

Q15075

Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2

791

0.695

Down

0.020596

Q15582

Transforming growth factor-beta-induced protein ig-h3 OS=Homo sapiens OX=9606 GN=TGFBI PE=1 SV=1

60

0.428

Down

0.03408

Q15582

Transforming growth factor-beta-induced protein ig-h3 OS=Homo sapiens OX=9606 GN=TGFBI PE=1 SV=1

53

0.799

Down

0.049475

Q16563

Synaptophysin-like protein 1 OS=Homo sapiens OX=9606 GN=SYPL1 PE=1 SV=1

194

0.561

Down

0.0034449

Q5QNW6

Histone H2B type 2-F OS=Homo sapiens OX=9606 GN=HIST2H2BF PE=1 SV=3

24

1.536

Up

0.0174835

Q5VTE0

Putative elongation factor 1-alpha-like 3 OS=Homo sapiens OX=9606 GN=EEF1A1P5 PE=5 SV=1

41

0.793

Down

0.0117988

Q6NZI2

Caveolae-associated protein 1 OS=Homo sapiens OX=9606 GN=CAVIN1 PE=1 SV=1

326

0.376

Down

0.0038804

Q86T29

Zinc finger protein 605 OS=Homo sapiens OX=9606 GN=ZNF605 PE=2 SV=1

118

0.719

Down

0.0197837

Q96EV2

RNA-binding protein 33 OS=Homo sapiens OX=9606 GN=RBM33 PE=1 SV=3

756

1.775

Up

0.022658

Q96G03

Phosphoglucomutase-2 OS=Homo sapiens OX=9606 GN=PGM2 PE=1 SV=4

36

1.255

Up

0.029339

Q96IX5

ATP synthase membrane subunit DAPIT, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MD PE=1 SV=1

16

0.622

Down

0.046917

Q96JC9

ELL-associated factor 1 OS=Homo sapiens OX=9606 GN=EAF1 PE=1 SV=1

150

1.501

Up

0.0129383

Q96L91

E1A-binding protein p400 OS=Homo sapiens OX=9606 GN=EP400 PE=1 SV=4

1160

0.609

Down

0.043665

Q96TA1

Niban-like protein 1 OS=Homo sapiens OX=9606 GN=FAM129B PE=1 SV=3

479

0.344

Down

0.0158443

Q99612

Krueppel-like factor 6 OS=Homo sapiens OX=9606 GN=KLF6 PE=1 SV=3

228

1.553

Up

0.045342

Q9BR76

Coronin-1B OS=Homo sapiens OX=9606 GN=CORO1B PE=1 SV=1

21

0.279

Down

0.043319

Q9BUL5

PHD finger protein 23 OS=Homo sapiens OX=9606 GN=PHF23 PE=1 SV=1

211

1.85

Up

0.0127642

Q9BWH2

FUN14 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FUNDC2 PE=1 SV=2

161

0.601

Down

0.0180819

Q9BWH2

FUN14 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FUNDC2 PE=1 SV=2

150

0.572

Down

0.0109557

Q9H147

Deoxynucleotidyltransferase terminal-interacting protein 1 OS=Homo sapiens OX=9606 GN=DNTTIP1 PE=1 SV=2

147

1.557

Up

0.0122376

Q9H223

EH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=EHD4 PE=1 SV=1

378

0.795

Down

0.0054175

Q9P0V9

Septin-10 OS=Homo sapiens OX=9606 GN=SEPT10 PE=1 SV=2

377

0.531

Down

0.0059765

Q9UJZ1

Stomatin-like protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=STOML2 PE=1 SV=1

140

0.551

Down

0.045145

Q9ULV4

Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1

19

0.742

Down

0.0141771

Q9UQ35

Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2

2602

2.555

Up

0.012981

Q9Y2W1

Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2

420

0.503

Down

0.0188206

Q9Y2W2

WW domain-binding protein 11 OS=Homo sapiens OX=9606 GN=WBP11 PE=1 SV=1

13

1.594

Up

0.0122

Q9Y4G6

Talin-2 OS=Homo sapiens OX=9606 GN=TLN2 PE=1 SV=4

287

0.714

Down

0.023017

Q9Y5B6

PAX3- and PAX7-binding protein 1 OS=Homo sapiens OX=9606 GN=PAXBP1 PE=1 SV=2

278

1.802

Up

0.0107447

Q9Y6N5

Sulfide:quinone oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=SQOR PE=1 SV=1

372

0.651

Down

0.0026847

Q9Y6X0

SET-binding protein OS=Homo sapiens OX=9606 GN=SETBP1 PE=1 SV=3

747

2.17

Up

0.0064602

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Clinical Proteomics

ISSN: 1559-0275