Fig. 3

Volcano plot of quantitative placenta proteomic analysis of FT and TP. 513 matched protein dots in first and third- trimester placentas are shown in a Volcano plot. Statistical analysis was performed by student t-test, and statistical significance was considered when p < 0.05. Red dots represent identified proteins exhibiting significant fold changes (FC) in the normal FT compared to TP. Despite no significant fold change for ECHM, this spot was carefully selected in visual inspection of the stained gels. MYDGF and MESD were only expressed in first-trimester placentas and located at infinitive region of the plot. FT: First trimester placenta; TP: Term placenta