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Table 2 Comparison of the mean percentage intensity of the differentially expressed spots between first trimester (First) and third trimester (Third) human placentas and their main biological process

From: Proteome profiling of human placenta reveals developmental stage-dependent alterations in protein signature

No

Uniprot ID

Protein name

First

Third

Changea

Fold changeb

Biological process

P value

1

P11021

GRP78

1.6276

0.6599

â–²

2.466

Protein folding

1.515E-05

2

P02787

TRFE

0.1619

0.3618

â–¼

0.447

Hemostatic process

6.275E-04

3

P02768

ALBU

0.3066

0.7733

â–¼

0.396

Hemostatic process

7.095E-03

4

P30101

PDIA3

1.240

0.7803

â–²

1.589

Protein folding

2.545E-03

5

P04264

K2C1

0.0988

0.3107

â–¼

0.317

Blood coagulation

9.41E-05

6

P06733

ENOA

0.4726

0.2174

â–²

2.173

Cellular catabolic process

4.259E-04

7

P63261

ACTG

0.372

0.7053

â–¼

0.527

Blood coagulation

5.944E-03

8

Q13011

ECH1

0.169

0.0976

â–²

1.731

Metabolic pathways

2.595E-03

9

Q13162

PRDX4

0.2158

0.0788

â–²

2.738

Response to stress

6.958E-04

10

P30040

ERP29

0.1616

0.042

â–²

3.847

Protein folding

7.616E-05

11

P30084

ECHM

0.1258

0.104

â–²

1.210

Metabolic pathways

8.5655E-01

12

P0DML3

CSH2

0.207

0.376

â–¼

0.550

Metabolic pathways

1.192E-02

13

P32119

PRDX2

0.276

0.551

â–¼

0.500

Cellular response to external stimuli

5.214E-04

14

Q969H8

MYDGF

0.223

0.000

â–²

####

Cellular response to external stimuli

7.942E-05

15

Q01469

FABP5

0.128

0.346

â–¼

0.369

Metabolic pathways

3.527E-02

16

P69891

HBG1

2.030

9.27

â–¼

0.218

Blood coagulation

2.182E-03

17

P15090

FABP4

0.040

0.32

â–¼

0.129

Metabolic pathways

1.275E-03

18

P05787

K2C8

0.273

0.760

â–¼

0.359

Programing cell death

8.455E-05

19

Q14696

MESD

0.120

0.000

â–²

####

Protein folding

1.395E-02

20

P35527

K1C9

0.135

0.473

â–¼

0.285

Programing cell death

1.841E-05

  1. aUp-regulation or down-regulation of the spots in the normal FT compared to TP indicated by â–² and â–¼, respectively
  2. bFold change in the normal FT compared to the TPs calculated based on exact P values by Mann–Whitney T test