Proteome profiling of human placenta reveals developmental stage-dependent alterations in protein signature

Table 2 Comparison of the mean percentage intensity of the differentially expressed spots between first trimester (First) and third trimester (Third) human placentas and their main biological process

No	Uniprot ID	Protein name	First	Third	Change^a	Fold change^b	Biological process	P value
1	P11021	GRP78	1.6276	0.6599	▲	2.466	Protein folding	1.515E-05
2	P02787	TRFE	0.1619	0.3618	▼	0.447	Hemostatic process	6.275E-04
3	P02768	ALBU	0.3066	0.7733	▼	0.396	Hemostatic process	7.095E-03
4	P30101	PDIA3	1.240	0.7803	▲	1.589	Protein folding	2.545E-03
5	P04264	K2C1	0.0988	0.3107	▼	0.317	Blood coagulation	9.41E-05
6	P06733	ENOA	0.4726	0.2174	▲	2.173	Cellular catabolic process	4.259E-04
7	P63261	ACTG	0.372	0.7053	▼	0.527	Blood coagulation	5.944E-03
8	Q13011	ECH1	0.169	0.0976	▲	1.731	Metabolic pathways	2.595E-03
9	Q13162	PRDX4	0.2158	0.0788	▲	2.738	Response to stress	6.958E-04
10	P30040	ERP29	0.1616	0.042	▲	3.847	Protein folding	7.616E-05
11	P30084	ECHM	0.1258	0.104	▲	1.210	Metabolic pathways	8.5655E-01
12	P0DML3	CSH2	0.207	0.376	▼	0.550	Metabolic pathways	1.192E-02
13	P32119	PRDX2	0.276	0.551	▼	0.500	Cellular response to external stimuli	5.214E-04
14	Q969H8	MYDGF	0.223	0.000	▲	####	Cellular response to external stimuli	7.942E-05
15	Q01469	FABP5	0.128	0.346	▼	0.369	Metabolic pathways	3.527E-02
16	P69891	HBG1	2.030	9.27	▼	0.218	Blood coagulation	2.182E-03
17	P15090	FABP4	0.040	0.32	▼	0.129	Metabolic pathways	1.275E-03
18	P05787	K2C8	0.273	0.760	▼	0.359	Programing cell death	8.455E-05
19	Q14696	MESD	0.120	0.000	▲	####	Protein folding	1.395E-02
20	P35527	K1C9	0.135	0.473	▼	0.285	Programing cell death	1.841E-05

^aUp-regulation or down-regulation of the spots in the normal FT compared to TP indicated by ▲ and ▼, respectively
^bFold change in the normal FT compared to the TPs calculated based on exact P values by Mann–Whitney T test

ISSN: 1559-0275