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Fig. 4 | Clinical Proteomics

Fig. 4

From: Mass spectrometry-based proteomics in basic and translational research of SARS-CoV-2 coronavirus and its emerging mutants

Fig. 4

Correlation between the abundance of SARS-CoV-2 proteins and IgG/IgM binding epitopes. A Re-analysis of Davidson et al. dataset [20] using the label-free intensity-based absolute quantification (iBAQ) approach revealed the relative abundance of SARS-CoV-2 proteins. Interestingly, the relative abundance of SARS-CoV-2 proteins correlated with the number of IgG and IgM binding epitopes identified by Wang et al.[81]. B Emerging mutations within the “binding” and confirmed “neutralizing” epitopes of SARS-CoV-2 structural and accessory proteins, according to the GISAID hCoV-19 database [153]. Fourteen mutations within the confirmed “neutralizing” epitopes of S protein (red, underlined, bold) and 35 mutations within the antibody “binding” epitopes (bold, underlined) are presented

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