Fig. 12

NTA was performed to compare average vesicle concentrations and sizes for each phenotype. Bright lines represent average EV concentration, while error bars are shown in lighter lines above and below this line. Total vesicle abundance was greater in PDR vitreous than that of controls and increased in parallel with increasing ranges of hemoglobin concentration. Across all subphenotype groups, an EV population at an approximate diameter of 90 nm predominates. A second EV population at ~130 nm increases in abundance with increasing hemoglobin concentration