Skip to main content

Table 2 Univariate analysis of the top proteins and genes differentially expressed in HCC explants and key clinical characteristics, as predictors of HCC recurrence post-transplant

From: Combined proteomic/transcriptomic signature of recurrence post-liver transplantation for hepatocellular carcinoma beyond Milan

Variable

HR (95% CI)

p-value

DTWD2 (protein)

0.15 (0.032–0.69)

0.014

LGALS3 (protein)

2.6 (1.2–5.5)

0.015

ALDH1A1 (gene)

0.084 (0.01–0.68)

0.02

NSDHL (protein)

0.63 (0.42–0.94)

0.026

BLMH (protein)

1.6 (1–2.5)

0.03

ALDH1A1 (protein)

0.39 (0.16–0.91)

0.03

Age

0.85 (0.74–0.98)

0.03

LGALS3BP (gene)

7.1 (1.2–43)

0.032

LGALS3BP (protein)

2.6 (1.1–6.1)

0.036

LGALS3 (gene)

2.9 (1–8.3)

0.05

HAL (protein)

1.4 (1–2.1)

0.05

RETREAT score

2 (0.94–4.3)

0.074

THBS1 (protein)

1.5 (0.96–2.4)

0.077

DTWD2 (gene)

0.17 (0.023–1.2)

0.08

GSTA2 (gene)

0.72 (0.49–1)

0.081

MGST1 (protein)

0.67 (0.42–1.1)

0.094

HAL (gene)

1.9 (0.88–4.2)

0.1

BLMH (gene)

2.3 (0.85–6)

0.1

NQO2 (protein)

0.57 (0.29–1.1)

0.11

NQO2 (gene)

0.44 (0.15–1.3)

0.14

NSDHL (gene)

0.045 (0.00051–3.9)

0.17

THBS1 (gene)

1.7 (0.79–3.5)

0.18

GSTA2 (protein)

0.83 (0.62–1.1)

0.19

AFP

1 (1–1)

0.23

MGST1 (gene)

0.55 (0.2–1.5)

0.24

microvascular invasion

2.2 (0.45–10)

0.33

No. of tumors

1.1 (0.93–1.2)

0.42

  1. The significant molecular and clinical variables are listed in bold
  2. HR hazard ratio, CI confidence interval