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Table 2 PLT proteins differentially expressed in uncomplicated P. vivax malaria patients with thrombocytopenia

From: Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets

Accession number

(Uniprot DB)

Gene

Protein

Coverage sequence

#Unique peptides

Mascot Score

All PV versus HC

T-PV versus HC*

Molecular function

Fold change

p- Valuea

Fold change

p- Valuea

P02776

CXCL4

Platelet factor 4/CXCL4

35.64

2

375.00

− 2.28

0.003

− 1.92

0.0084

Inhibits endothelial cell proliferation (E)

P60660

MYL6

Myosin light polypeptide 6

68.21

8

638.00

− 2.16

0.001

− 2.17

0.001

Regulatory light chain of myosin

O14950

MYL12B

Myosin regulatory light chain 12B

21.51

3

163.00

− 1.96

0.0002

− 1.92

0.0025

Regulate the cell contractile activity via its phosphorylation

O95810

CAVIN2

Caveolae-associated protein 2

17.88

7

597.00

− 1.73

0.004

− 1.50

0.0171

Plays a role in caveola formation

Q01518

CAP1

Adenylyl cyclase-assoc. protein 1

15.16

6

275.00

− 1.54

0.0007

− 1.41

0.0044

High specific activity and sensitivity to prostaglandins

P09493

TPM1

Tropomyosin alpha-1 chain

28.17

2

601.00

− 1.50

0.016

− 1.38

0.1335

Calcium-dependent regulation of cell contraction

P35579

MYH9

Myosin-9

44.85

74

4772.00

− 1.50

0.007

− 1.77

0.0029

Play a role in cytokinesis, cell shape, among others

P04406

GAPDH

Glyceraldehyde-3-phosphate dehydrogenase

49.25

12

972.00

− 1.47

0.002

− 1.44

0.0069

Delivery of nitric oxide to PLTs activated by thrombin

O75083

WDR1

WD repeat-containing protein 1

12.21

7

202.00

− 1.41

0.0006

− 1.26

 < 0.0001

Decreased in PLTs activated by thrombin

P68032

ACTC1

Actin, alpha cardiac muscle 1

36.60

3

2649.00

− 1.41

0.007

− 1.06

0.009

Found in muscle tissues

P40197

GPV

Platelet glycoprotein 5

7.74

2.14

195.00

− 1.40

0.025

− 2.08

0.0094

Mediate PLTs adhesion to blood vessels through VWf

Q86UX7

FERMT3

Fermitin family homolog 3

21.44

10

1167.00

− 1.36

0.0009

− 1.20

0.006

Activate the integrin β [1,2,3] for adhesion to endothelial cells

P00338

LDHA

L-lactate dehydrogenase A chain

6.63

1

195.00

− 1.34

0.003

− 1.37

0.0023

Involved in cadherin and kinase binding

P61224

RAP1B

Ras-related protein Rap-1b

48.91

6

627.00

− 1.31

0.015

− 1.55

0.0007

Maintenance of endothelial polarity

P08567

PLEK

Pleckstrin

48.57

17

1688.00

− 1.30

0.005

− 1.29

0.0123

Regulates the fusion of granules to the membrane

A0A0A0MRZ8

IGKV3D-11

Immunoglobulin kappa variable 3D-11

7.83

1

114.00

− 1.30

0.534

− 2.54

0.0097

Region that participates in the antigen recognition

Q9H4B7

TUBB1

Tubulin beta-1 chain

20.40

6

602.00

− 1.24

0.002

− 1.05

0.0025

Main protein in microtubules. It binds GTP molecules

P11142

HSPA8

Heat shock cognate 71 kDa protein

17.18

9

488.00

− 1.24

0.002

− 1.18

0.0867

Protects the proteome from stress, folding and transport of newly synthesized polypeptides

P26038

MSN

Moesin

8.49

5

131.00

− 1.21

0.014

− 0.99

0.075

Involved in connections of cytoskeletal structures to the plasma membrane

P07737

PFN1

Profilin-1

79.29

14

2112.00

− 1.15

0.003

− 1.19

0.0516

Binds to actin affecting the structure of the cytoskeleton

Q92686

NRGN

Neurogranin

19.23

1

352.00

− 1.02

0.019

− 0.75

0.0583

Third messenger substrate during synaptic development and remodeling

P01009

SERPINA 1

alpha-1antitrypsin

35.89

16

136.00

1.33

0.001

1.22

0.0136

Thrombin formation and clotting by inhibition of APC system

P0DOX8

IGL1LC

Immunoglobulin lambda-1 light chain

40.74

3

753.00

1.49

0.002

− 1.60

0.0051

Antigen binding

P01011

SERPINA3

Alpha-1-antichymotrypsin

11.11

5

136.00

1.65

0.048

1.00

0.2071

PLTs degranulation

P01859

IGHG2

Immunoglobulin heavy constant gamma 2

52.45

8

1310.00

1.92

0.001

1.22

0.3589

Complement activation and phagocytosis

P0DJI8

SAA1

Serum amyloid A-1 protein

64.75

3

357.00

2.73

0.065

2.81

0.0314

Adhesion to PLTs modulating vascular endothelial adhesion

  1. *T-Pv patients (Thrombocytopenic Pv patients) from the entire cohort of Pv patients
  2. aStatistical significance was defined by p-value < 0.05 shown in bold. The table only depicts 26 proteins significantly different between patients and healthy controls. Also, those proteins were classified from lower to higher fold change