From: Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets
Accession number (Uniprot DB) | Gene | Protein | Coverage sequence | #Unique peptides | Mascot Score | All PV versus HC | T-PV versus HC* | Molecular function | ||
---|---|---|---|---|---|---|---|---|---|---|
Fold change | p- Valuea | Fold change | p- Valuea | |||||||
P02776 | CXCL4 | Platelet factor 4/CXCL4 | 35.64 | 2 | 375.00 | − 2.28 | 0.003 | − 1.92 | 0.0084 | Inhibits endothelial cell proliferation (E) |
P60660 | MYL6 | Myosin light polypeptide 6 | 68.21 | 8 | 638.00 | − 2.16 | 0.001 | − 2.17 | 0.001 | Regulatory light chain of myosin |
O14950 | MYL12B | Myosin regulatory light chain 12B | 21.51 | 3 | 163.00 | − 1.96 | 0.0002 | − 1.92 | 0.0025 | Regulate the cell contractile activity via its phosphorylation |
O95810 | CAVIN2 | Caveolae-associated protein 2 | 17.88 | 7 | 597.00 | − 1.73 | 0.004 | − 1.50 | 0.0171 | Plays a role in caveola formation |
Q01518 | CAP1 | Adenylyl cyclase-assoc. protein 1 | 15.16 | 6 | 275.00 | − 1.54 | 0.0007 | − 1.41 | 0.0044 | High specific activity and sensitivity to prostaglandins |
P09493 | TPM1 | Tropomyosin alpha-1 chain | 28.17 | 2 | 601.00 | − 1.50 | 0.016 | − 1.38 | 0.1335 | Calcium-dependent regulation of cell contraction |
P35579 | MYH9 | Myosin-9 | 44.85 | 74 | 4772.00 | − 1.50 | 0.007 | − 1.77 | 0.0029 | Play a role in cytokinesis, cell shape, among others |
P04406 | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | 49.25 | 12 | 972.00 | − 1.47 | 0.002 | − 1.44 | 0.0069 | Delivery of nitric oxide to PLTs activated by thrombin |
O75083 | WDR1 | WD repeat-containing protein 1 | 12.21 | 7 | 202.00 | − 1.41 | 0.0006 | − 1.26 | < 0.0001 | Decreased in PLTs activated by thrombin |
P68032 | ACTC1 | Actin, alpha cardiac muscle 1 | 36.60 | 3 | 2649.00 | − 1.41 | 0.007 | − 1.06 | 0.009 | Found in muscle tissues |
P40197 | GPV | Platelet glycoprotein 5 | 7.74 | 2.14 | 195.00 | − 1.40 | 0.025 | − 2.08 | 0.0094 | Mediate PLTs adhesion to blood vessels through VWf |
Q86UX7 | FERMT3 | Fermitin family homolog 3 | 21.44 | 10 | 1167.00 | − 1.36 | 0.0009 | − 1.20 | 0.006 | Activate the integrin β [1,2,3] for adhesion to endothelial cells |
P00338 | LDHA | L-lactate dehydrogenase A chain | 6.63 | 1 | 195.00 | − 1.34 | 0.003 | − 1.37 | 0.0023 | Involved in cadherin and kinase binding |
P61224 | RAP1B | Ras-related protein Rap-1b | 48.91 | 6 | 627.00 | − 1.31 | 0.015 | − 1.55 | 0.0007 | Maintenance of endothelial polarity |
P08567 | PLEK | Pleckstrin | 48.57 | 17 | 1688.00 | − 1.30 | 0.005 | − 1.29 | 0.0123 | Regulates the fusion of granules to the membrane |
A0A0A0MRZ8 | IGKV3D-11 | Immunoglobulin kappa variable 3D-11 | 7.83 | 1 | 114.00 | − 1.30 | 0.534 | − 2.54 | 0.0097 | Region that participates in the antigen recognition |
Q9H4B7 | TUBB1 | Tubulin beta-1 chain | 20.40 | 6 | 602.00 | − 1.24 | 0.002 | − 1.05 | 0.0025 | Main protein in microtubules. It binds GTP molecules |
P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 17.18 | 9 | 488.00 | − 1.24 | 0.002 | − 1.18 | 0.0867 | Protects the proteome from stress, folding and transport of newly synthesized polypeptides |
P26038 | MSN | Moesin | 8.49 | 5 | 131.00 | − 1.21 | 0.014 | − 0.99 | 0.075 | Involved in connections of cytoskeletal structures to the plasma membrane |
P07737 | PFN1 | Profilin-1 | 79.29 | 14 | 2112.00 | − 1.15 | 0.003 | − 1.19 | 0.0516 | Binds to actin affecting the structure of the cytoskeleton |
Q92686 | NRGN | Neurogranin | 19.23 | 1 | 352.00 | − 1.02 | 0.019 | − 0.75 | 0.0583 | Third messenger substrate during synaptic development and remodeling |
P01009 | SERPINA 1 | alpha-1antitrypsin | 35.89 | 16 | 136.00 | 1.33 | 0.001 | 1.22 | 0.0136 | Thrombin formation and clotting by inhibition of APC system |
P0DOX8 | IGL1LC | Immunoglobulin lambda-1 light chain | 40.74 | 3 | 753.00 | 1.49 | 0.002 | − 1.60 | 0.0051 | Antigen binding |
P01011 | SERPINA3 | Alpha-1-antichymotrypsin | 11.11 | 5 | 136.00 | 1.65 | 0.048 | 1.00 | 0.2071 | PLTs degranulation |
P01859 | IGHG2 | Immunoglobulin heavy constant gamma 2 | 52.45 | 8 | 1310.00 | 1.92 | 0.001 | 1.22 | 0.3589 | Complement activation and phagocytosis |
P0DJI8 | SAA1 | Serum amyloid A-1 protein | 64.75 | 3 | 357.00 | 2.73 | 0.065 | 2.81 | 0.0314 | Adhesion to PLTs modulating vascular endothelial adhesion |