Fig. 2
From: Urine proteomics identifies biomarkers for diabetic kidney disease at different stages
A classifier for distinguishing DKD from Diabetes. a A bioinformatic analysis workflow to find candidate biomarkers between the Diabetes and the DKD group. n: number of samples used in the analyses. b Volcano plot displaying the differentially expressed proteins between Diabetes and DKD. Red and Blue indicated proteins that were significantly enriched in DKD and Diabetes, respectively (p values < 0.05, more than threefold change). Other proteins were colored in grey. c ROC curve of distinguishing the Diabetes and DKD samples predicted by the 2-protein classifier. d Boxplots showing the ALB and AFM abundance in Diabetes and DKD in the two datasets (center line: median, bounds of box: 25th and 75th percentiles, and whiskers: from Q1-1.5*IQR to Q3 + 1.5*IQR, p-value calculated by Mann–Whitney U test). e Reactome pathway analysis of the up-regulated (red) and down-regulated (blue) DEPs in DKD samples