Fig. 3a
From: Circulating microvesicles and exosomes in small cell lung cancer by quantitative proteomics
Receiver operating characteristic curves and boxplots of protein candidates for the 20 K samples. Proteins with diagnostic potential found to be upregulated in the SCLC patients were Serum amyloid A-1 protein (SAA1), C-reactive protein (CRP), Transferrin receptor protein 1 (TFRC), Aminopeptidase N (ANPEP), and Galectin-3-binding protein (LGALS3BP), while the proteins upregulated in the control group were Gelsolin (GSN), Transforming growth factor-beta-induced protein ig-h3 (TGFBI), Hemoglobin subunit beta and delta (HBB and HBD), and N-acetylmuramoyl-l-alanine amidase (PGLYRP2). Boxplots show non-logarithmic label-free quantification (LFQ) intensities excluding NaN (missing) values. AUC area under the curve, CI confidence interval, SCLC small cell lung cancer, LFQ label-free quantification. b Receiver operating characteristic curves and boxplots of protein candidates for the 100 K samples. Proteins with diagnostic potential found to be upregulated in the SCLC patients were Serum amyloid A-1 and A-2 protein (SAA1 and SAA2), Aminopeptidase N (ANPEP), Haptoglobin (HP), and Complement factor H-related protein 4 (CFHR4), and the proteins upregulated in the control group were Ig kappa chain V–IV region (IGKV4-1), Ficolin-2 (FCN2), Coagulation factor XI (F11), Coagulation factor XIII A chain (F13A1), and Hemoglobin subunit alpha (HBA1). Boxplots show non-logarithmic label-free quantification (LFQ) intensities and exclude NaN (missing) values. AUC area under the curve, CI confidence interval, SCLC small cell lung cancer, LFQ label-free quantification