Circulating microvesicles and exosomes in small cell lung cancer by quantitative proteomics

Table 2 Significantly differentially expressed proteins for 20 K and 100 K comparing SCLC to the control group

SCLC\|control: common proteins in microvesicle (20 K) and exosome (100 K) samples
Uniprot ID	Gene name	Protein name	Log₂ FC		p-value
Uniprot ID	Gene name	Protein name	20 K	100 K	20 K	100 K
P02741	CRP	C-reactive protein	3.5	1.2	0.0001	0.0016
P15144	ANPEP	Aminopeptidase N	3.2	2.4	0.0004	0.0006
P0DJI8	SAA1	Serum amyloid A-1 protein	2.4	2.9	< 0.0001	< 0.0001
P02763	ORM1	Alpha-1-acid glycoprotein 1	1.0	0.4	0.0011	0.0474
P02750	LRG1	Leucine-rich alpha-2-glycoprotein	0.9	1.2	0.0140	< 0.0001
P00738	HP	Haptoglobin	0.9	1.2	0.0004	< 0.0001
P06396	GSN	Gelsolin	− 1.0	− 0.7	< 0.0001	0.0001
P69905	HBA1	Hemoglobin subunit alpha	− 1.2	− 1.4	0.0002	< 0.0001
P06727	APOA4	Apolipoprotein A-IV	− 1.1	− 0.6	0.0001	0.0109
P68871	HBB	Hemoglobin subunit beta	− 1.6	− 0.9	< 0.0001	0.0003

SCLC\|control: proteins detected only in the microvesicle samples (20 K)
Uniprot ID	Gene name	Protein name	Log₂ FC	p-value
P02786	TFRC	Transferrin receptor protein 1	2.2	0.0003
Q08380	LGALS3BP	Galectin-3-binding protein	2.2	0.0008
P05164	MPO	Myeloperoxidase	1.2	0.0424
Q13418	ILK	Integrin-linked protein kinase	1.0	0.0140
P23229	ITGA6	Integrin alpha-6	1.0	0.0193
Q96PD5	PGLYRP2	N-acetylmuramoyl-l-alanine amidase	− 1.0	< 0.0001
O00391	QSOX1	Sulfhydryl oxidase 1	− 1.1	0.0052
P02724	GYPA	Glycophorin-A	− 1.1	0.0046
P00915	CA1	Carbonic anhydrase 1	− 1.2	0.0028
P32119	PRDX2	Peroxiredoxin-2	− 1.2	0.0351
Q15582	TGFBI	Transforming growth factor-beta-induced protein ig-h3	− 1.2	< 0.0001
P02730	SLC4A1	Band 3 anion transport protein	− 1.6	0.0001
P02042	HBD	Hemoglobin subunit delta	− 1.7	< 0.0001
P16157	ANK1	Ankyrin-1	− 2.6	0.0233
P11277	SPTB	Spectrin beta chain erythrocytic	− 2.7	0.0502
P02549	SPTA1	Spectrin alpha chain erythrocytic 1	− 3.2	0.0106

SCLC\|control: proteins detected only in the exosome samples (100 K)
Uniprot ID	Gene name	Protein name	Log₂ FC	p-value
P0DJI8	SAA2	Serum amyloid A-1 protein	3.3	0.0016
P02655	APOC2	Apolipoprotein C-II	2.8	0.0062
P08519	LPA	Apolipoprotein(a)	1.4	0.0346
Q92496	CFHR4	Complement factor H-related protein 4	1.2	0.0005
P04114	APOB	Apolipoprotein B	1.1	< 0.0001
P00736	C1R	Complement C1r subcomponent	− 1.0	0.0077
Q06830	PRDX1	Peroxiredoxin-1	− 1.0	0.0203
P05160	F13B	Coagulation factor XIII B chain	− 1.0	0.0060
P48740	MASP1	Mannan-binding lectin serine protease 1	− 1.1	0.0067
P02745	C1QA	Complement C1q subcomponent subunit A	− 1.1	0.0005
P00488	F13A1	Coagulation factor XIII A chain	− 1.1	0.0003
P00739	HPR	Haptoglobin-related protein	− 1.1	0.0002
Q8WWZ8	OIT3	Oncoprotein-induced transcript 3 protein	– 1.2	0.0052
P03951	F11	Coagulation factor XI	−1.3	0.0001
Q9Y6R7	FCGBP	IgGFc-binding protein	−1.4	0.0333
Q15485	FCN2	Ficolin-2	−1.5	< 0.0001
P06312	IGKV4-1	Ig kappa chain V–IV region	– 3.0	< 0.0001

A Log₂ FC ± 1 indicates a twofold increase (+) or decrease (−) in SCLC compared to controls.
SCLC small cell lung cancer, FC fold change

ISSN: 1559-0275