Table 3 List of Transcription factors responsible for different biological processes, and the proteins that are identified in the Secretomes of HNSCC cells
From: Secreted protein markers in oral squamous cell carcinoma (OSCC)
Serial. No | Most connected biological network Clusters | Target genes/Proteins | Transcription factors by iRegulon | Proteins secreted in cell line HNSCC secretomes |
|---|---|---|---|---|
1 | Secretory Pathway | KLC1, LMAN2, SEC24C, SEC23A, SEC23B, SEC16A, SEC13, TFG, SEC24D, EML4, COPB1, COPB2, GOLGB1, COPA, LMAN1, SEC23IP, SURF4, COPG1 | Creb3L1 | LMAN2, SEC24C, SEC23A, SEC23B, SEC13, TFG, SEC24D, EML4, COPB1, COPB2, GOLGB1, COPA, LMAN1, COPG1 |
2 | Spliceosomal complex assembly | [SF3B1, SNRNP200, SRSF1, SRSF9] | ESSRA | [SF3B1, SNRNP200, SRSF1, SRSF9] |
3 | Protein localization to Endosome | [PACSIN2, RAB35, VPS35] | YY | [PACSIN2, VPS35] |
4 | tRNA aminoacylation for protein translation | [AARS1, CARS1, EPRS1, LARS1] | ELF2 | [AARS1, CARS1, LARS1] |
5 | Type I interferon pathway/viral process | [ADAR, EIF2AK2, IFI16, MX1, OAS2, PLSCR1, STAT1] | STAT1 | [ADAR, EIF2AK2, STAT1] |
6 | IRE1-mediate unfolded protein response | [DNAJB11, DNAJC3, PDIA5] | XBP1 | [DNAJB11, DNAJC3] |