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Fig. 2 | Clinical Proteomics

Fig. 2

From: Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model

Fig. 2

Transcriptome and proteome changes by RIC. A The top left-hand corner displays Box plots of log2 normalized transcriptomics data. The heat map displays the regularized log-transformed data for the top differentially expressed transcripts. The PCA plot visualizes the regularized log-transformed data which minimizes differences between samples for rows with small counts, and which normalizes with respect to library size. Finally, the MA plot shows the log2 fold changes attributable to a given variable over the mean of normalized counts. Red points have adjusted p-value less than 0.05. B Volcano plot displaying differential transcriptome expression. The x-axis measures expression difference by log2(fold change), and the y-axis indicates statistical significance by -log10(p-value). Down-regulated species are coloured blue, while their up-regulated counterparts are coloured red. Enriched biological processes (Gene Ontology) determined from differentially regulated transcripts (displayed by their gene symbol) are listed underneath the plot. C Hierarchical clustering analysis of RIC and non-RIC proteomes. D Volcano plot displaying differential proteome expression. Down-regulated immunoglobulins of interest are circled in green

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