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Fig. 2 | Clinical Proteomics

Fig. 2

From: Use of MS-GUIDE for identification of protein biomarkers for risk stratification of patients with prostate cancer

Fig. 2

Hypothesis-driven protein marker selection. A Most protein biomarker candidates were selected from a previous study of a PTEN-knockout mouse model successfully used to identify diagnostic markers of prostate cancer (9) supplemented with potentially glycosylated and secreted proteins derived from literature. The abundance of these potentially glycosylated and secreted proteins was monitored in serum samples from a prostatectomy cohort. B In total, 52 proteins related to various hallmarks of cancer [56] were analyzed in human serum using protein glycocapture. Of these, 48 were proteins with a potential prognostic value in prostate cancer (bold), whereas four additional secreted proteins used in routine diagnostics were monitored as negative controls

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