Fig. 9

Distinct patterns of allergen-induced BALF proteins by resting FEV₁. A PCA analysis of post BALF samples, labeled by volunteer number. Volunteers with low FEV₁ (< 87%) are tightly grouped by differences in the first principal component. B, C Box plots of the significant proteins differentiating low vs normal FEV₁. B Levels of MUC1 were 15.8 ± 0.2 in Low FEV₁ group vs 14.0 ± 0.2 in the normal FEV₁ group (p = 0.05). C Levels of CAPG were 15.6 ± 0.7 in the Low FEV₁ group vs 14.7 ± 2.3 in the normal FEV₁ group (p = 0.03). D Levels of SLC9A3R1 were 14.5 ± 1.1 vs 13.1 ± 1.1 (p = 0.04). Levels of HSPB1 were 15.1 ± 0.2 vs 13.8 ± 0.5 (p = 0.005). Levels of TTP3 were 14.8 ± 0.8 vs 14 ± 1.8 (p = 0.04). Levels of APRT were 14.3 ± 1.5 vs 13.1 ± 1.2 (p = 0.05). Levels of CDH1 were 14.6 ± 0.2 vs 12.5 ± 1.3 (p = 0.01). Levels of CD55 were 16.0 ± 0.5 vs 14.8 ± 1 (p = 0.04). Abbreviations: MUC1, mucin 1; CD55, CD55 molecule/decay accelerating factor; TPPP3, Tubulin Polymerization Promoting Protein Family Member 3; CAPG, Capping Actin Protein, Gelsolin Like; HSPB1, Heat Shock Protein Family B (Small) Member 1; SLC9A3R1, solute carrier SLC9A3 Regulator 1; APRT, Adenine Phosphoribosyltransferase; CDH1, Cadherin 1