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Fig. 6 | Clinical Proteomics

Fig. 6

From: Transcriptome profiling and proteomic validation reveals targets of the androgen receptor signaling in the BT-474 breast cancer cell line

Fig. 6

Proposed action of AR in the AR+ER+BCa cell line, BT474. Treatment of BT474 cells with the androgen DHT caused upregulation of known and unknown A-regulated genes, including genes related to fatty acid metabolism and tumor-suppressor genes, such as ZBTB16 and CLDN8. At the same time, AR suppressed directly or indirectly the expression of genes related to various pathways, such as WNT signaling, and ER-responsive pathways, resulting in decreased cell proliferation and tumor growth. Boxes in red and blue color represent upregulated and downregulated pathways, respectively

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Clinical Proteomics

ISSN: 1559-0275