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Fig. 4 | Clinical Proteomics

Fig. 4

From: Optimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer’s disease biomarkers

Fig. 4

Influence of co-isolation on pepmix TMT ratios and peptide abundance distribution in both individual and pool CSF TMT sets. Mean pepmix TMT ratios were evaluated based on the extent of co-isolation in the corresponding peptide spectrum match. The data was plotted in a cumulative fashion displaying the mean TMT ratio of the fraction of pepmix data below the respective co-isolation threshold (A). Median-centered peptide abundance distribution for each TMT channel (sample) in (B) the TMT set comprised of individual samples and (C) the TMT set consisting of pool CSF samples

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Clinical Proteomics

ISSN: 1559-0275