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Fig. 3 | Clinical Proteomics

Fig. 3

From: Proteomic and phosphoproteomic measurements enhance ability to predict ex vivo drug response in AML

Fig. 3

Interpretation of top-performing signatures by heatmap and protein network integration. A Heatmap of proteins and phosphosites selected by the logistic regression depicts clustering of patients by sensitivity to quizartinib. B Interaction network links proteins (ovals) and phosphosites (diamonds) selected by signature (yellow) to other proteins (blue) to illustrate how they relate to one another. C Heatmap of proteins and transcripts by the LASSO regression shows how they cluster patients by trametinib AUC. D Interaction network showing how those proteins (ovals) and transcripts (triangles) selected by the signature (yellow) are closely related via protein interactions with related proteins (blue)

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