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Fig. 1 | Clinical Proteomics

Fig. 1

From: Neoplastic cell enrichment of tumor tissues using coring and laser microdissection for proteomic and genomic analyses of pancreatic ductal adenocarcinoma

Fig. 1

Schematic diagram of the workflow. A Three cases of treatment naïve PDAC and tumor-matched NATs were prospectively collected. The tumor area and tumor-matched NAT were marked and matched to corresponding tissue blocks. All tissue blocks were sampled using three techniques, including bulk sampling the tumor (entire section of the block), laser microdissection (LMD) of selected area, and coring of the selected area. B Morphological features of study cases. C3L-01032 demonstrated over 80% of tumor cellularity with a minimal amount of desmoplastic stroma. The case C3L-01158 revealed less than 10% of tumor cellularity. In the case C3L-01160, the tumor demonstrated an approximate 40% of tumor cellularity. In addition, the NAT samples also represented a wide range of pancreatic tissue, including predominately acinar cells, benign ductal structures (i.e. C3L-01032) and a low-grade pancreatic intraepithelial neoplasia (i.e. C3L-01160)

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Clinical Proteomics

ISSN: 1559-0275