Fig. 4

Mitochondria associated DEPs and their functional analysis. A Venn diagram of DEPs of maternal vs fetal, maternal vs middle, middle vs fetal, and proteins and genes associated with mitochondrial functions and processes from the databases MitoXplorer, human protein atlas (HPA)—mitochondria specific, and MitoCarta V3.0. The section of proteins used for further analysis is within the red border. B GO biological processes included and figure legend to C. GOCircle plots of the 10 most significantly overrepresented mitochondria associated with GO biological process terms, including DEPs falling into each term. Regulation direction is colour coded: upregulated (red), downregulated (blue). Size of the inner segments is indicative of the number of proteins falling into each term. The colour of each inner segment indicates the z-score—general up or downregulation of the GO term considering the number up- and downregulated proteins. D Clustered heatmap of average normalized LFQ intensities of mitochondria associated DEPs. Proteins are grouped into samples from maternal, middle, fetal sub-anatomical regions