Fig. 5

Senescence associated DEPs and their functional analysis. A Venn diagram of DEPs of maternal vs fetal, maternal vs middle, middle vs fetal, and proteins and genes associated with mitochondrial functions and processes from the databases CellAge, CSGene, and NCBI database results for the keyword senescence. The section of proteins used for further analysis is within the red border. B GOCircle plots of the 10 most significantly overrepresented GO biological process terms, including senescence associated DEPs falling into each term. Regulation direction is colour coded: upregulated (red), downregulated (blue). Size of the inner segments is indicative of the number of proteins falling into each term. The colour of each inner segment indicates the z-score—general up or downregulation of the GO term considering the number up- and downregulated proteins