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Table 2 Unadjusted Cox regression analysis showing the hazard ratios per one standard deviation increase for NT-proBNP and GDF-15 in predicting CV events measured by Proximity extension assay (PEA) and conventional immunoassay (CIA) in two cohorts

From: Are the results from a multiplex proteomic assay and a conventional immunoassay for NT-proBNP and GDF-15 comparable?

 

HR (95% CI)

P-value

PADVa cohort

 NT-proBNP (PEA)

1.67 (1.33–2.13)

 < 0.001

 NT-proBNP (CIA)

1.74 (1.44–2.10)

 < 0.001

 GDF-15 (PEA)

1.59 (1.32–1.91)

 < 0.001

 GDF-15 (CIA)

1.56 (1.30–1.87)

 < 0.001

Population-based cohort

 NT-proBNP (PEA)

2.52 (1.74–3.65)

 < 0.001

 NT-proBNP (CIA)

2.62 (1.96–3.51)

 < 0.001

 GDF-15 (PEA)

2.32 (1.70–3.17)

 < 0.001

 GDF-15 (CIA)

2.26 (1.64–3.12)

 < 0.001

  1. NT-proBNP N-terminal pro-brain natriuretic peptide, GDF-15 Growth differentiation factor 15, CV cardiovascular, HR Hazard ratio per unit change, CI Confidence interval, NPX Normalized Protein Expression