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Table 4 Mitochondrial proteins identified from SEQUEST was compared by Chi-Square between COVID vs ICU and COVID vs NHP from the non-redundant sum of tryptic (TRYP) and optional phosphotryptic (STYP) peptides

From: Mitochondria and cytochrome components released into the plasma of severe COVID-19 and ICU acute respiratory distress syndrome patients

Gene Symbol

COVID vs ICU Delta

COVID vs ICU χ2

Gene Symbol

COVID vs NHP Delta

COVID vs NHP χ2

Gene Symbol

ICU vs COVID Delta

ICU vs COVID χ2

Gene Symbol

ICU vs NHP Delta

ICU vs NHP χ2

MRPL58

931

643*

MRPL37

389

922*

CHCHD6

269

333*

NDUFC1

81

418*

MRPL37

273

240*

CARS2

226

341*

SLC25A13

906

299*

CYB561D1

106

379*

MRPL4

153

164*

COX7B2

49

313*

LIPT1

149

147*

PTCD3

67

207*

ALDH1L2

175

105*

MRPS16

145

256*

NDUFC1

62

108*

SLC25A13

725

197*

NUDT9

121

103*

GCSH

60

252*

SLIRP

97

62*

CARS2

149

175*

ALDH2

63

100*

CYB561D1

84

206*

SARDH

53

56*

MRPS16

115

162*

MRPL40

49

99*

IDH2

38

195*

ABCB8

17

30*

MRPS18A

166

160*

MIEF1

58

92*

LOC101060817

85

189*

PTCD3

21

24*

HTRA2

74

158*

DHODH

60

89*

MRPL58

563

186*

NDUFS8

14

21*

RSAD1

86

137*

COX6B2

24

89*

HTRA2

88

180*

   

MTG2

73

106*

DHTKD1

68

88*

RSAD1

100

171*

   

COQ8A

162

102*

GATB

51

69*

NLN

107

155*

   

COX7B2

26

98*

cytb

49

69*

CHCHD10

37

145*

   

MRPL37

102

90*

ATPAF1

56

68*

HSPA9

76

137*

   

HSCB

72

89*

NDUFV1

118

67*

SQOR

44

116*

   

TCAIM

9

81*

SIRT3

62

67*

CYP3A4

66

104*

   

DARS2

65

80*

SLC25A42

89

65*

CYP3A43/CYP3A4

71

102*

   

PCCB

65

78*

MALSU1

131

64*

DHTKD1

70

99*

   

TOMM7

55

76*

TRNT1

79

62*

ACAD9

110

99*

   

PRDX5

57

75*

XRCC6BP1

28

62*

ALDH2

60

89*

   

NDUFAF1

91

74*

LOC102724023

105

61*

L2HGDH

173

88*

   

HSPA9

43

72*

CYTB

18

60*

CYP3A43

72

81*

   

ATP5O

18

71*

44621

27

58*

GATB

52

76*

   

ACSS3

156

71*

CYP3A5

33

49*

COA6

78

73*

   

CYP3A4

57

67*

CYP2C9

47

48*

CYBRD1

28

71*

   

MTFMT

48

67*

AUH

60

47*

MRPL19

48

70*

   

CYP3A43/CYP3A4

61

64*

CYP2E1

26

44*

COX6B2

23

70*

   

AASS

113

63*

COQ2

33

43*

TRAP1

29

67*

   

IDH2

23

61*

TARS2

45

43*

C14orf159

26

66*

   

IMMT

73

60*

MRPL32

31

41*

DARS2

62

66*

   

CHCHD6

139

57*

TFAM

68

40*

SLC25A30

8

64*

   

GCSH

23

54*

MRPL57

35

40*

TCAIM

8

64*

   

CHCHD10

20

54*

TDH

20

39*

CYP27B1

44

64*

   

SLIRP

105

53*

ATP5B

40

37*

CYB5B

28

61*

   

MRPL49

19

52*

ATP5H

15

37*

ETFA

14

60*

   

ERAL1

10

52*

COI

6

36*

MRPL52

14

58*

   

METTL17

33

51*

ATP23

36

35*

BDH1

71

57*

   

SQOR

34

49*

TOMM5

13

35*

MRPS18A

105

56*

   

CLPX

34

47*

CHDH

57

34*

TOMM7

33

53*

   

MRPS22

11

44*

ACAD9

64

34*

GLRX5

44

52*

   

LOC101060817

38

43*

NDUFV3

38

33*

MRPL1

67

50*

   

NLN

53

43*

GOT2

46

33*

COQ9

77

49*

   

SLC25A21

38

43*

PMPCB

57

33*

MRPS25

7

49*

   

TOP1MT

48

40*

ME3

20

32*

SLC25A21

38

47*

   

NDUFS8

17

40*

GFM1

53

32*

C2orf47

55

46*

   

TIMM50

18

38*

SDHB

39

32*

BCS1L

15

46*

   

COX5B

38

38*

PDF

21

31*

MTFMT

41

43*

   

CYP2W1

40

37*

RHOT1

18

31*

RHOT2

23

42*

   

MCCC1

60

36*

CYP11B1

12

31*

AUH

57

42*

   

PGAM5

19

36*

HIBCH

27

29*

LOC102724023

89

42*

   

TRAP1

20

35*

  1. The observation frequency was computed after correcting for the number of MS/MS spectra in each treatment with precursor intensity ≥ E3 detector counts. The difference (Delta) and Chi Square value χ2 with respect to NHP are shown. The Chi Square values of observation frequency computed from fully tryptic or phosphotryptic peptides between COVID-19 plasma and ICU-ARDS versus NHP are shown sorted for each comparison. The SQL SERVER accession descriptions were queried by “*mitochondria*” or “*cytochrome*”. The asterisk * indicates a significant increase in observation frequency by the Chi Square test in the COVID-19 or ICU-ARDS plasma compared to the Normal Human Plasma (NHP) with χ2 ≥ 21, p ≤ 0.001