Proteomic characteristics and diagnostic potential of exhaled breath particles in patients with COVID-19

Table 2 Significantly differentially expressed proteins

Gene names	Protein names	ANOVA	q-value	Mean difference		Andromeda score
Gene names	Protein names	ANOVA	q-value	COV-POS	COV-NEG	HCO
IGHG1	Ig gamma-1 chain C region	0.004	4.4	-3.0	-4.4	323
IGKC	Ig kappa chain C region	0.011	3.1	-3.1	2.2	323
ORM1	Alpha-1-acid glycoprotein 1	0.012	2.8	− 2.8	− 2.6	165
SFTPB	Pulmonary surfactant-associated protein B	0.016	− 2.7	− 2.2	2.7	69
TF	Serotransferrin	0.021	2.9	− 2.9	0.0	323
IGHA1	Ig alpha-1 chain C region	0.022	1.3	− 2.9	2.9	323
CASP14	Caspase-14	0.027	− 2.6	2.6	1.5	323
EPPK1	Epiplakin	0.029	2.6	− 1.4	− 2.6	292
CAPN1	Calpain-1 catalytic subunit	0.033	− 2.3	2.3	1.4	61
IGLC6	Ig lambda-6 chain C region	0.034	2.5	− 2.5	1.4	229
APOA1	Apolipoprotein A-I	0.036	2.4	− 2.4	0.0	308
CAT	Catalase	0.036	− 1.4	2.2	− 2.2	323
DSC3	Desmocollin-3	0.037	− 2.2	2.2	− 1.7	270
VCL	Vinculin	0.040	− 1.8	− 1.8	1.8	52
PKP1	Plakophilin-1	0.041	− 2.1	2.1	0.0	323
TGM1	Protein-glutamine gamma-glutamyltransferase K	0.043	− 1.8	1.8	− 1.5	261
PSMA3	Proteasome subunit alpha type-3	0.043	− 2.1	2.1	1.7	88
ZG16B	Zymogen granule protein 16 homolog B	0.043	0.0	− 2.2	2.2	323
ARG1	Arginase-1	0.044	− 2.1	2.1	0.0	323
SERPINA1	Alpha-1-antitrypsin	0.044	2.2	− 2.2	0.0	323
ACTN4	Alpha-actinin-4	0.046	2.0	− 1.3	− 2.0	65
S100A14	Protein S100-A14	0.047	− 1.9	1.9	0.0	227
TXN	Thioredoxin	0.048	− 1.3	− 1.8	1.8	84
PIGR	Polymeric immunoglobulin receptor	0.048	− 1.6	− 1.6	1.6	109
HP	Haptoglobin	0.049	2.0	0.0	− 2.0	188
PLBD1	Phospholipase B-like 1	0.049	− 1.9	1.9	0.0	76

Summary of significantly differentially expressed proteins between PCR-verified COVID-19 infection (COV-POS), COVID-19 PCR-negative patients with respiratory symptoms (COV-NEG) and healthy controls (HCO) and their adjusted p-value (ANOVA q-value) and Andromeda score from the MaxQuant search engine

ISSN: 1559-0275