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Table 6 List of glomerular basement membrane proteins

From: Comparative proteomic analysis of glomerular proteins in IgA nephropathy and IgA vasculitis with nephritis

Accession ID

NCBInr DB

Accession ID

GenBank DB

Protein name

Sequence

coverage

(%)

Peptide

match

(n)

IgAN-I (n = 6) /

Control (n = 5) ratio

(Ratio variability [%])

IgAN-II (n = 6) /

Control (n = 5) ratio

(Ratio variability [%])

IgAVN-I (n = 6) /

Control (n = 5) ratio

(Ratio variability [%])

IgAVN-II (n = 6) /

Control (n = 5) ratio

(Ratio variability [%])

125987809

 

COL4 α1

 6

 5

0.27 (87.87)

0.28 (109.92)

0.12 ** (53.43)

0.60 (129.11)

116256354

 

COL4 α2

7

9

2.14 (55.82)

2.13 (77.60)

1.40 (71.10)

1.55 (49.45)

119591260

 

COL4 α3

 7

 6

 2.20 (108.21)

0.82 (112.25)

1.57 (113.08)

1.71 (114.47)

116256356

 

COL4 α4

 4

 4

1.50 (57.26)

1.41 (76.00)

1.14 (77.27)

1.62 (58.07)

1034673478

 

COL4 α5

 4

 4

2.02 (76.80)

1.35 (72.18)

1.48 (92.65)

2.16 (80.63)

20147503

 

Laminin α5

19

58

1.72 (111.36)

2.25 (100.34)

1.40 (108.82)

1.85 (93.85)

1103585

 

Laminin β2

28

44

1.27 (84.02)

0.91 (83.36)

1.06 (85.04)

1.09 (85.79)

145309326

 

Laminin γ1

24

32

1.32 (72.95)

1.02 (78.48)

1.07 (86.85)

1.11 (81.63)

115298674

 

Nidogen-1

19

24

2.10 (45.61)

1.57 (81.36)

1.87 (60.30)

2.15 (46.04)

530360311

 

Agrin

27

40

0.99 (78.54)

0.64 (82.89)

0.60 (93.13)

0.72 (82.41)

11602963

 

HSPG perlecan

17

54

1.31 (76.31)

1.19 (81.45)

1.08 (84.44)

1.15 (73.35)

34364820

 

Fibronectin

22

38

2.42 (94.55)

2.95 (100.41)

2.59 (94.34)

2.47 (97.14)

  1. COL4: type IV collagen; DB: database; HSPG: heparan sulfate proteoglycan; IgAN: IgA nephropathy; IgAVN: IgA vasculitis with nephritis; NCBInr: National Center for Biotechnology information non-redundant
  2. **P < 0.01