TY - BOOK AU - Arlington, S. A. PY - 2001 DA - 2001// TI - Industrialization of R&D in the 21st Century PB - Pricewaters Coopers, ECPI CY - Barcelona, Spain ID - Arlington2001 ER - TY - STD TI - Banik, G.M. (2004, May). In silico ADME-Tox prediction: The more the merrier. Current Drug Discovery, pp. 31–34. ID - ref2 ER - TY - STD TI - CHI. (2002, May). CHI's Third Annual Conference on Pharmacogenomics/Pharmacoproteomics Europe. Munich, Germany. ID - ref3 ER - TY - JOUR AU - Leung, D. AU - Hardouin, C. AU - Boger, D. L. AU - Cravatt, B. F. PY - 2003 DA - 2003// TI - Discovering potent and selective reversible inhibitors of enzymes in complex proteomes JO - Nat. Biotechnol. VL - 21 UR - https://doi.org/10.1038/nbt826 DO - 10.1038/nbt826 ID - Leung2003 ER - TY - JOUR AU - Kim, E. AU - Park, J. M. PY - 2003 DA - 2003// TI - Identification of novel target proteins of cyclic GMP signaling pathways using chemical proteomics JO - J. Biochem. Mol. Biol. VL - 36 ID - Kim2003 ER - TY - JOUR AU - Graves, P. R. AU - Kwiek, J. J. AU - Fadden, P. AU - Ray, R. AU - Hardeman, K. AU - Coley, A. M. PY - 2002 DA - 2002// TI - Discovery of novel targets of quinoline drugs in the human purine binding proteome JO - Mol. Pharmacol. VL - 62 UR - https://doi.org/10.1124/mol.62.6.1364 DO - 10.1124/mol.62.6.1364 ID - Graves2002 ER - TY - JOUR AU - Weber, G. AU - Prajda, N. PY - 1994 DA - 1994// TI - Targeted and non-targeted actions of anti-cancer drugs JO - Adv. Enzyme Regul. VL - 34 UR - https://doi.org/10.1016/0065-2571(94)90009-4 DO - 10.1016/0065-2571(94)90009-4 ID - Weber1994 ER - TY - JOUR AU - Allison, A. C. PY - 2000 DA - 2000// TI - Immunosuppressive drugs: the first 50 years and a glance forward JO - Immunopharmacology VL - 47 UR - https://doi.org/10.1016/S0162-3109(00)00186-7 DO - 10.1016/S0162-3109(00)00186-7 ID - Allison2000 ER - TY - JOUR AU - Saravanan, V. AU - Hamilton, J. PY - 2002 DA - 2002// TI - Advances in the treatment of rheumatoid arthritis: old versus new therapies JO - Expert Opin. Pharmacother. VL - 3 UR - https://doi.org/10.1517/14656566.3.7.845 DO - 10.1517/14656566.3.7.845 ID - Saravanan2002 ER - TY - JOUR AU - Fairbanks, L. D. AU - Ruckemann, K. AU - Qiu, Y. AU - Hawrylowicz, C. M. AU - Richards, D. F. AU - Swaminathan, R. PY - 1999 DA - 1999// TI - Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis? JO - Biochem. J. VL - 342 UR - https://doi.org/10.1042/0264-6021:3420143 DO - 10.1042/0264-6021:3420143 ID - Fairbanks1999 ER - TY - JOUR AU - Cronstein, B. N. PY - 1997 DA - 1997// TI - The mechanism of action of methotrexate JO - Rheum. Dis. Clin. North Am. VL - 23 UR - https://doi.org/10.1016/S0889-857X(05)70358-6 DO - 10.1016/S0889-857X(05)70358-6 ID - Cronstein1997 ER - TY - JOUR AU - Costi, M. P. AU - Ferrari, S. PY - 2001 DA - 2001// TI - Update on antifolate drugs targets JO - Curr. Drug Targets VL - 2 UR - https://doi.org/10.2174/1389450013348669 DO - 10.2174/1389450013348669 ID - Costi2001 ER - TY - JOUR AU - Allegra, C. J. AU - Drake, J. C. AU - Jolivet, J. AU - Chabner, B. A. PY - 1985 DA - 1985// TI - Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates JO - Proc. Natl. Acad. Sci. USA VL - 82 UR - https://doi.org/10.1073/pnas.82.15.4881 DO - 10.1073/pnas.82.15.4881 ID - Allegra1985 ER - TY - JOUR AU - Mauritz, R. AU - Peters, G. J. AU - Priest, D. G. AU - Assaraf, Y. G. AU - Drori, S. AU - Kathmann, I. PY - 2002 DA - 2002// TI - Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis JO - Biochem. Pharmacol. VL - 63 UR - https://doi.org/10.1016/S0006-2952(01)00824-3 DO - 10.1016/S0006-2952(01)00824-3 ID - Mauritz2002 ER - TY - JOUR AU - Toledo-Sherman, L. M. AU - Desouza, L. AU - Hosfield, C. AU - Liao, L. AU - Boutellier, K. AU - Taylor, P. PY - 2004 DA - 2004// TI - New targets for an old drug: a chemical proteomics approach to unraveling the molecular mechanism of action of methotrexate JO - Clin. Proteomics VL - 1 UR - https://doi.org/10.1385/CP:1:1:045 DO - 10.1385/CP:1:1:045 ID - Toledo-Sherman2004 ER - TY - JOUR AU - Jones, G. AU - Willett, P. AU - Glen, R. C. AU - Leach, A. R. AU - Taylor, R. PY - 1997 DA - 1997// TI - Development and validation of a genetic algorithm for flexible docking JO - J. Mol. Biol. VL - 267 UR - https://doi.org/10.1006/jmbi.1996.0897 DO - 10.1006/jmbi.1996.0897 ID - Jones1997 ER - TY - JOUR AU - Chen, Y. Z. AU - Zhi, D. G. PY - 2001 DA - 2001// TI - Ligand-protein inverse docking and its potential use in the computer search of protein targets of a small molecule JO - Proteins VL - 43 UR - https://doi.org/3.0.CO;2-G DO - 3.0.CO;2-G ID - Chen2001 ER - TY - JOUR AU - Chan, N. W. C. AU - Lewis, D. F. AU - Hewko, S. AU - Hindsgaul, O. AU - Schriemer, D. C. PY - 2002 DA - 2002// TI - Frontal affinity chromatography for the screening of mixtures JO - Comb. Chem. High Throughput Screen. VL - 5 ID - Chan2002 ER - TY - JOUR AU - Weber, G. AU - Nagai, M. AU - Natsumeda, Y. AU - Ichikawa, S. AU - Nakamura, H. AU - Eble, J. N. PY - 1991 DA - 1991// TI - Regulation of de novo and salvage pathways in chemotherapy JO - Adv. Enzyme Regul. VL - 31 ID - Weber1991 ER - TY - JOUR AU - Balendiran, G. K. AU - Molina, J. A. AU - Xu, Y. AU - Torres-Martinez, J. AU - Stevens, R. AU - Focia, P. J. PY - 1999 DA - 1999// TI - Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding JO - Protein Sci. VL - 8 UR - https://doi.org/10.1110/ps.8.5.1023 DO - 10.1110/ps.8.5.1023 ID - Balendiran1999 ER - TY - JOUR AU - Schoettle, S. L. AU - Christopherson, R. I. PY - 1994 DA - 1994// TI - Inhibition of murine amido phosphoribosyl-transferase by folate derivatives JO - Adv. Exp. Med. Biol. VL - 370 ID - Schoettle1994 ER - TY - JOUR AU - Jones, R. J. AU - Twelves, C. J. PY - 2002 DA - 2002// TI - Pemetrexed: a multitargeted antifolate (ALIMTA, LY-231514) JO - Expert Rev. Anticancer Ther. VL - 2 UR - https://doi.org/10.1586/14737140.2.1.13 DO - 10.1586/14737140.2.1.13 ID - Jones2002 ER - TY - JOUR AU - Aherne, G. W. AU - Hardcastle, A. AU - Ward, E. AU - Dobinson, D. AU - Crompton, T. AU - Valenti, M. PY - 2001 DA - 2001// TI - Pharmacokinetic/pharmacodynamic study of ZD9331, a nonpolyglutamatable inhibitor of thymidylate synthase, in a murine model following two curative administration schedules JO - Clin. Cancer Res. VL - 7 ID - Aherne2001 ER - TY - JOUR AU - Romain, S. AU - Martin, P. M. AU - Klijn, J. G. AU - Putten, W. L. AU - Look, M. P. AU - Guirou, O. PY - 1997 DA - 1997// TI - DNA-synthesis enzyme activity: a biological tool useful for predicting antimetabolic drug sensitivity in breast cancer? JO - Int. J. Cancer VL - 74 UR - https://doi.org/3.0.CO;2-Y DO - 3.0.CO;2-Y ID - Romain1997 ER - TY - JOUR AU - Weber, G. AU - Prajda, N. PY - 1994 DA - 1994// TI - Targeted and non-targeted actions of anti-cancer drugs JO - Adv. Enzyme Regul. VL - 34 UR - https://doi.org/10.1016/0065-2571(94)90009-4 DO - 10.1016/0065-2571(94)90009-4 ID - Weber1994 ER - TY - JOUR AU - Gordon, R. B. AU - Keough, D. T. AU - Emmerson, B. T. PY - 1987 DA - 1987// TI - HPRT-deficiency associated with normal PRPP concentration and APRT activity JO - J. Inherit. Metab. Dis. VL - 10 UR - https://doi.org/10.1007/BF01799493 DO - 10.1007/BF01799493 ID - Gordon1987 ER - TY - JOUR AU - Fung, K. P. AU - Lam, W. P. AU - Choy, Y. M. AU - Lee, C. Y. PY - 1996 DA - 1996// TI - Effect of methotrexate on the intracellular phosphoribosyl pyrophosphate level and glucose transport of Ehrlich ascites tumor cells in vitro JO - Oncology VL - 53 UR - https://doi.org/10.1159/000227530 DO - 10.1159/000227530 ID - Fung1996 ER - TY - JOUR AU - Slon-Usakiewicz, J. J. AU - Ng, W. AU - Foster, J. E. AU - Dai, J. -. R. AU - Deretey, E. AU - Toledo-Sherman, L. PY - 2004 DA - 2004// TI - Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 1. Comparison with conventional ELISA JO - J. Med. Chem. VL - 47 UR - https://doi.org/10.1021/jm049733a DO - 10.1021/jm049733a ID - Slon-Usakiewicz2004 ER -