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  1. It is widely believed that discovery of specific, sensitive, and reliable tumor biomarkers can improve the treatment of cancer. Currently, there are no obvious targets that can be used in treating triple-negat...

    Authors: Ming Lu, Stephen A. Whelan, Jianbo He, Romaine E. Saxton, Kym F. Faull, Julian P. Whitelegge and Helena R. Chang
    Citation: Clinical Proteomics 2010 6:9052
  2. The rational design of targeted therapies for acute myeloid leukemia (AML) requires the discovery of novel protein pathways in the systems biology of a specific AML subtype. We have shown that in the AML subty...

    Authors: Sheo Mohan Singh, Arun Kumar Trivedi, Savita Lochab, Maximilian Christopeit, Wolfgang Hiddemann and Gerhard Behre
    Citation: Clinical Proteomics 2010 6:9051
  3. Tumors lack normal drainage of secreted fluids and consequently build up tumor interstitial fluid (TIF). Unlike other bodily fluids, TIF likely contains a high proportion of tumor-specific proteins with potent...

    Authors: Matthew D. Stone, Rick M. Odland, Thomas McGowan, Getiria Onsongo, Chaunning Tang, Nelson L. Rhodus, Pratik Jagtap, Sricharan Bandhakavi and Timothy J. Griffin
    Citation: Clinical Proteomics 2010 6:9050
  4. Radiographic contrast media (RCM) have numerous effects on the hemostatic system, inflammatory pathways, and vascular endothelium. Given the increasing number of high-risk patients undergoing radiographic proc...

    Authors: Juan Martinez, Warren K. Laskey, Cheri Wells, Armin Foghi, Sarah Rohde, Mark Ricciardi and Charlotte Mobarak
    Citation: Clinical Proteomics 2010 6:9048
  5. The objective of this study was to identify cancer-associated protein expression patterns in bilateral matched nipple aspiration fluids using nanoscale reciprocal Cy3/Cy5 labeling and high-content antibody mic...

    Authors: Jinong Li, Junma Zhou, Bruce Trock, Theodore N. Tsangaris, Neil B. Friedman, Deanna Shapiro, Michelle Brotzman and Daniel W. Chan
    Citation: Clinical Proteomics 2010 6:9046
  6. HIV-associated neurocognitive disorders (HAND) has been associated with the up-regulation of various oxidative stress pathways. Previous studies have linked the neuronal damage observed in individuals diagnose...

    Authors: Ashley S. Beasley, Caroline Anderson, Justin McArthur, Ned Sacktor, Avindra Nath and Robert J. Cotter
    Citation: Clinical Proteomics 2010 6:9041

    The Erratum to this article has been published in Clinical Proteomics 2010 6:s12014-010-9043-2

  7. Cervical cancer is among the most common cancers in women worldwide. Discovery of biomarkers for the early detection of cervical cancer would improve current screening practices and reduce the burden of disease.

    Authors: Gitika Panicker, Yiming Ye, Dongxia Wang and Elizabeth R. Unger
    Citation: Clinical Proteomics 2010 6:9042
  8. Early detection, assessment of disease progression, and application of an appropriate therapeutic intervention are all important for the care of patients with type 2 diabetes. Currently, however, there is no s...

    Authors: Shigeru Okada, Edward O. List, Sudha Sankaran and John J. Kopchick
    Citation: Clinical Proteomics 2010 6:9040
  9. The use of mass spectrometry to investigate disease-associated proteins among thousands of candidates simultaneously creates challenges with the evaluation of operational and biological variation. Traditional ...

    Authors: Irene S. L. Zeng, Sharon R. Browning, Patrick Gladding, Mia Jüllig, Martin Middleditch and Ralph A. H. Stewart
    Citation: Clinical Proteomics 2009 5:9039
  10. Polypeptide fragments from cell surface receptors when found in plasma may be indicators of receptor regulation in disease conditions. It is known that subjects with diabetes have significantly lower plasma co...

    Authors: Michael J. Pugia, Deanna D. H. Franke, Sean L. Barnes, Amy Zercher, David Brock, Mary Foltz, Roland Valdes Jr. and Saeed A. Jortani
    Citation: Clinical Proteomics 2009 5:9036
  11. Lung cancer is the leading cause of cancer-related death worldwide. The discovery of new biomarkers could aid early diagnosis and monitoring of recurrence following tumor resection.

    Authors: Sridhar Rathinam, Aiman Alzetani, Jane Starczynski, Pala B. Rajesh, Stephen Nyangoma, Michael J. O. Wakelam, Nicholas D. James, Wenbin Wei, Lucinda J. Billingham, Philip J. Johnson, Ashley Martin and Douglas G. Ward
    Citation: Clinical Proteomics 2009 5:9033
  12. Proteomic profiling is a rapidly developing technology that may enable early disease screening and diagnosis. Surface-enhanced laser desorption ionization–time of flight mass spectrometry (SELDI-TOF MS) has de...

    Authors: Bashar A. Zeidan, Ramsey I. Cutress, Claire Hastie, Alex H. Mirnezami, Graham Packham and Paul A. Townsend
    Citation: Clinical Proteomics 2009 5:9032
  13. Alzheimer’s disease (AD) poses specific challenges for drug development. It has a slow and variable clinical course, an insidious onset, and symptom expression is only observed when a significant proportion of...

    Authors: N. Guerreiro, B. Gomez-Mancilla, B. Williamson, M. Minkoff and S. Guertin
    Citation: Clinical Proteomics 2009 5:9030
  14. Annexin A11 was previously identified as an autoantigen in 4.1–10.1% of patients with various systemic autoimmune diseases. In this study, an enzyme-linked immunosorbent assay (ELISA) was developed to investig...

    Authors: Jin Song, Xiaer Sun, Lori J. Sokoll, Masatoshi Maki, Yuan Tian, Daniel W. Chan and Zhen Zhang
    Citation: Clinical Proteomics 2009 5:9031
  15. Human urine is a complex matrix of proteins, endogenous peptides, lipids, and metabolites. The level of any or all of these components can reflect the pathophysiological status of an individual especially of t...

    Authors: Tara K. Sigdel, Xuefeng B. Ling, Ken H. Lau, Li Li, James Schilling and Minnie M. Sarwal
    Citation: Clinical Proteomics 2009 5:9029
  16. Tandem mass spectrometry (MS/MS) has emerged as a cornerstone of proteomic screens aimed at discovering putative protein biomarkers of disease with potential clinical applications. Systematic validation of lea...

    Authors: Jian Liu, Johannes A. Hewel, Vincent Fong, Michelle Chan-Shen-Yue and Andrew Emili
    Citation: Clinical Proteomics 2009 5:9023
  17. Variability in response to acetaminophen (APAP)-induced aseptic inflammation and tolerance to the impending hepatic damage has been described. To understand the mechanism of adaptive tolerance, we investigated...

    Authors: Pamela S. Steele, Mark W. Linder, Roland Valdes Jr., Deanna D. H. Franke and Saeed A. Jortani
    Citation: Clinical Proteomics 2009 5:9022
  18. Glycosylation is an important component for a number of biological processes and is perhaps the most abundant and complicated of the known post-translational modifications found on proteins.

    Authors: Melissa Sondej, Patricia A. Denny, Yongming Xie, Prasanna Ramachandran, Yan Si, Jona Takashima, Wenyuan Shi, David T. Wong, Joseph A. Loo and Paul C. Denny
    Citation: Clinical Proteomics 2008 5:9021
  19. A proof-of-concept demonstration of the use of label-free quantitative glycoproteomics for biomarker discovery workflow is presented in this paper, using a mouse model for skin cancer as an example.

    Authors: Simon Letarte, Mi-Youn Brusniak, David Campbell, James Eddes, Christopher J. Kemp, Hollis Lau, Lukas Mueller, Alexander Schmidt, Paul Shannon, Karen S. Kelly-Spratt, Olga Vitek, Hui Zhang, Ruedi Aebersold and Julian D. Watts
    Citation: Clinical Proteomics 2008 4:9018
  20. Glycans have unique characteristics that are significantly different from nucleic acids and proteins in terms of biosynthesis, structures, and functions. Moreover, their isomeric nature and the complex linkage...

    Authors: Richard K. T. Kam and Terence C. W. Poon
    Citation: Clinical Proteomics 2008 4:9017
  21. All neoplastic cells express one or more members of a unique family of tumor-associated cell surface ubiquinone (NADH) oxidase proteins with protein disulfide-thiol interchange activity (ENOX2 or tNOX proteins...

    Authors: Brandon Hostetler, Nicole Weston, Chinpal Kim, Dorothy M. Morré and D. James Morré
    Citation: Clinical Proteomics 2008 5:9016
  22. Plasma has been the focus of testing different proteomic technologies for the identification of biomarkers due to its ready accessibility. However, it is not clear if direct proteomic analysis of plasma can be...

    Authors: Yuan Tian, Karen S. Kelly-Spratt, Christopher J. Kemp and Hui Zhang
    Citation: Clinical Proteomics 2008 4:9014
  23. With the rapid development of mass spectrometry-based technologies such as multiple reaction monitoring and heavy-isotope-labeled-peptide standards, quantitative analysis of biomarker proteins using mass spect...

    Authors: Yan Li, Lori J. Sokoll, Peter E. Barker, Hui Zhang and Daniel W. Chan
    Citation: Clinical Proteomics 2008 4:9011
  24. A novel approach of ion mobility tandem mass spectrometry (IMS-MS/MS) is applied to analysis of human glycourinome to obtain carbohydrate pattern data of congenital disorders of glycosylation patient. Overlapp...

    Authors: Sergey Y. Vakhrushev, James Langridge, Iain Campuzano, Chris Hughes and Jasna Peter-Katalinić
    Citation: Clinical Proteomics 2008 4:9010
  25. Quantitative proteomics using tandem mass spectrometry is an attractive approach for identification of potential cancer biomarkers. Fractionation of complex tissue samples into subproteomes prior to mass spect...

    Authors: Raghothama Chaerkady, Paul J. Thuluvath, Min-Sik Kim, Anuradha Nalli, Perumal Vivekanandan, Jessica Simmers, Michael Torbenson and Akhilesh Pandey
    Citation: Clinical Proteomics 2008 4:9013
  26. Glycoproteomics is undergoing rapid development, largely as a result of advances in technologies for isolating glycoproteins and analyzing glycan structures. However, given the number and diversity of glycans,...

    Authors: David W. Ralin, Shane C. Dultz, Judd E. Silver, Jeffrey C. Travis, Majlinda Kullolli, William S. Hancock and Marina Hincapie
    Citation: Clinical Proteomics 2008 4:9007
  27. Biomarkers for early detection of renal cell carcinoma (RCC) may help diagnose minimal residual disease in patients at risk for RCC, can guide anti-angiogenic therapy, or may help identify candidates for adjuv...

    Authors: Peter Hulick, Michael Zimmer, Vitaly Margulis, Steven Skates, Maureen Hamel, Douglas M. Dahl, Dror M. Michaelson, Towia Liebermann, Sabina Signoretti, Walter Carney, Christopher Wood and Othon Iliopoulos
    Citation: Clinical Proteomics 2008 5:9012
  28. Glycosylations range among the most common posttranslational modifications with an estimated 50% of all proteins supposed to be glycosylated. These modifications are required for essential cellular processes i...

    Authors: Urs Lewandrowski, Katharina Lohrig, René P. Zahedi, Dirk Wolters and Albert Sickmann
    Citation: Clinical Proteomics 2008 4:9006
  29. This study established two-dimensional gel electrophoresis (2-DE) profiles for human well-differentiated laryngeal squamous cell carcinoma tissue and paired normal mucosa epithelia tissue and identified protei...

    Authors: Jian-rong Zhou, Zhong-xue Fu, Jie Li, Lian-zhi Wei and Jun-cai Li
    Citation: Clinical Proteomics 2008 3:9009
  30. Saliva is a body fluid that holds promise for use as a diagnostic fluid for detecting diseases. Salivary proteins are known to be heavily glycosylated and are known to play functional roles in the oral cavity....

    Authors: Prasanna Ramachandran, Pinmanee Boontheung, Eric Pang, Weihong Yan, David T. Wong and Joseph A. Loo
    Citation: Clinical Proteomics 2008 4:9005
  31. The collection of lung fluid using a suction catheter (s-Cath) and non-bronchoscopic bronchoalveolar lavage (mini-BAL) are two minimally invasive methods of sampling the distal airspaces in patients with the a...

    Authors: Dong W. Chang, Giuseppe Colucci, Tomas Vaisar, Trevor King, Shinichi Hayashi, Gustavo Matute-Bello, Roger Bumgarner, Jay Heinecke, Thomas R. Martin and Guido M. Domenighetti
    Citation: Clinical Proteomics 2008 3:9002
  32. The aim of this study was to evaluate a multiple immunoaffinity protein depletion (multiple affinity removal system, MARS) pre-treatment strategy with subsequent two-dimensional polyacrylamide gel electrophore...

    Authors: Karen T. Oliva, Mustafa Ayhan, Gillian Barker, Nicole L. Dellios, Michael A. Quinn and Gregory E. Rice
    Citation: Clinical Proteomics 2007 3:9001
  33. In recent years, differential analysis of proteins from human saliva, i.e., proteomic analysis, has received much attention mainly due to its unstressful sampling and its great potential for biomarker research...

    Authors: François Chevalier, Christophe Hirtz, Sandrine Chay, Frédéric Cuisinier, Nicolas Sommerer, Michel Rossignol and Dominique Deville de Périère
    Citation: Clinical Proteomics 2007 3:9000
  34. In this manuscript, we compared serum profiles obtained with two related technologies, SELDI-TOF and Clinprot, using a single bioinformatic algorithm. These two approaches rely on mass spectrometry to detect p...

    Authors: Christelle Reynès, Stéphane Roche, Laurent Tiers, Robert Sabatier, Patrick Jouin, Nicolas Molinari and Sylvain Lehmann
    Citation: Clinical Proteomics 2006 2:BF02752497
  35. The future of cancer diagnostics will be based on a panel of proteomic biomarkers. They could be used to detect cancer at an early stage, to predict and to direct therapies. Enzymes and related proteins are im...

    Authors: Daniel W. Chan and Shu-Ling Liang
    Citation: Clinical Proteomics 2006 2:BF02752495

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