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  1. Transthyretin (TTR), an abundant protein in cerebrospinal fluid (CSF), contains a free, oxidation-prone cysteine residue that gives rise to TTR isoforms. These isoforms may reflect conditions in vivo. Since incre...

    Authors: Keld Poulsen, Justyna MC Bahl, Anja H Simonsen, Steen G Hasselbalch and Niels HH Heegaard

    Citation: Clinical Proteomics 2014 11:12

    Content type: Research

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  2. It is well known that cell surface glycans or glycocalyx play important roles in sperm motility, maturation and fertilization. A comprehensive profile of the sperm surface glycans will greatly facilitate both ...

    Authors: Ai-Jie Xin, Li Cheng, Hua Diao, Peng Wang, Yi-Hua Gu, Bin Wu, Yan-Cheng Wu, Guo-Wu Chen, Shu-Min Zhou, Shu-Juan Guo, Hui-Juan Shi and Sheng-Ce Tao

    Citation: Clinical Proteomics 2014 11:10

    Content type: Research

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  3. Glycoproteins secreted into plasma from T cells infected with human immunodeficiency virus (HIV) latent infection may provide insight into understanding the host response to HIV infection in vivo. Glycoproteomics...

    Authors: Weiming Yang, Jian-Ying Zhou, Li Chen, Minghui Ao, Shisheng Sun, Paul Aiyetan, Antoine Simmons, Hui Zhang and Jay Brooks Jackson

    Citation: Clinical Proteomics 2014 11:9

    Content type: Research

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  4. O-linked β-D-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) onto serine and threonine residues of proteins is an important post-translational modification (PTM), which is involved in many crucial b...

    Authors: Junfeng Ma and Gerald W Hart

    Citation: Clinical Proteomics 2014 11:8

    Content type: Review

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  5. Analysis of native or endogenous peptides in biofluids can provide valuable insights into disease mechanisms. Furthermore, the detected peptides may also have utility as potential biomarkers for non-invasive m...

    Authors: Tara K Sigdel, Carrie D Nicora, Szu-Chuan Hsieh, Hong Dai, Wei-Jun Qian, David G Camp II and Minnie M Sarwal

    Citation: Clinical Proteomics 2014 11:7

    Content type: Research

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  6. Osteoarthritis is a chronic musculoskeletal disorder characterized mainly by progressive degradation of the hyaline cartilage. Patients with osteoarthritis often postpone seeking medical help, which results in...

    Authors: Lavanya Balakrishnan, Raja Sekhar Nirujogi, Sartaj Ahmad, Mitali Bhattacharjee, Srikanth S Manda, Santosh Renuse, Dhanashree S Kelkar, Yashwanth Subbannayya, Rajesh Raju, Renu Goel, Joji Kurian Thomas, Navjyot Kaur, Mukesh Dhillon, Shantal Gupta Tankala, Ramesh Jois, Vivek Vasdev…

    Citation: Clinical Proteomics 2014 11:6

    Content type: Research

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  7. Cryptococcus neoformans, a basidiomycetous fungus of universal occurrence, is a significant opportunistic human pathogen causing meningitis. Owing to an increase in the number of immunosuppressed individuals alon...

    Authors: Lakshmi Dhevi Nagarajha Selvan, Jyothi Embekkat Kaviyil, Raja Sekhar Nirujogi, Babylakshmi Muthusamy, Vinuth N Puttamallesh, Tejaswini Subbannayya, Nazia Syed, Aneesha Radhakrishnan, Dhanashree S Kelkar, Sartaj Ahmad, Sneha M Pinto, Praveen Kumar, Anil K Madugundu, Bipin Nair, Aditi Chatterjee, Akhilesh Pandey…

    Citation: Clinical Proteomics 2014 11:5

    Content type: Research

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  8. Numerous formaldehyde-fixed and paraffin-embedded clinical tissues have been created in the past decades and stored in pathological depositories at hospitals as well as in clinical laboratories worldwide. In a...

    Authors: Yusuke Kawashima, Yoshio Kodera, Anil Singh, Masaomi Matsumoto and Hiroyuki Matsumoto

    Citation: Clinical Proteomics 2014 11:4

    Content type: Research

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  9. Protein biomarkers offer major benefits for diagnosis and monitoring of disease processes. Recent advances in protein mass spectrometry make it feasible to use this very sensitive technology to detect and quan...

    Authors: John Marshall, Peter Bowden, Jean Claude Schmit and Fay Betsou

    Citation: Clinical Proteomics 2014 11:3

    Content type: Research

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  10. Experts agree that one of the more promising strategies in cancer management is early detection coupled with early intervention. In this study, we evaluated an early cancer detection strategy of cancer presenc...

    Authors: Claudia Hanau, D James Morré and Dorothy M Morré

    Citation: Clinical Proteomics 2014 11:2

    Content type: Research

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  11. Rheumatoid arthritis and osteoarthritis are two common musculoskeletal disorders that affect the joints. Despite high prevalence rates, etiological factors involved in these disorders remain largely unknown. D...

    Authors: Lavanya Balakrishnan, Mitali Bhattacharjee, Sartaj Ahmad, Raja Sekhar Nirujogi, Santosh Renuse, Yashwanth Subbannayya, Arivusudar Marimuthu, Srinivas M Srikanth, Rajesh Raju, Mukesh Dhillon, Navjyot Kaur, Ramesh Jois, Vivek Vasudev, YL Ramachandra, Nandini A Sahasrabuddhe, TS Keshava Prasad…

    Citation: Clinical Proteomics 2014 11:1

    Content type: Research

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  12. Plasma renin activity (PRA) is an essential analytical tool for screening and diagnosis of secondary forms of hypertension. Typically, PRA is measured by competitive radioimmunoassay, but there are significant...

    Authors: Alexander G Camenzind, Jessica Grace van der Gugten, Robert Popp, Daniel T Holmes and Christoph H Borchers

    Citation: Clinical Proteomics 2013 10:20

    Content type: Research

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  13. Potential biomarkers to aid diagnosis and therapy need to be identified for Amyotrophic Lateral Sclerosis, a progressive motor neuronal degenerative disorder. The present study was designed to identify the fac...

    Authors: Anu Mary Varghese, Aparna Sharma, Poojashree Mishra, Kalyan Vijayalakshmi, Hindalahalli Chandregowda Harsha, Talakad N Sathyaprabha, Srinivas MM Bharath, Atchayaram Nalini, Phalguni Anand Alladi and Trichur R Raju

    Citation: Clinical Proteomics 2013 10:19

    Content type: Research

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  14. The rapid advancement of high-throughput tools for quantitative measurement of proteins has demonstrated the potential for the identification of proteins associated with cancer. However, the quantitative resul...

    Authors: Jing Chen, Shadi Toghi Eshghi, George Steven Bova, Qing Kay Li, Xingde Li and Hui Zhang

    Citation: Clinical Proteomics 2013 10:18

    Content type: Research

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  15. Serine hydrolases constitute a large enzyme family involved in a diversity of proteolytic and metabolic processes which are essential for many aspects of normal physiology. The roles of serine hydrolases in re...

    Authors: Mario Navarrete, Julie Ho, Oleg Krokhin, Peyman Ezzati, Claudio Rigatto, Martina Reslerova, David N Rush, Peter Nickerson and John A Wilkins

    Citation: Clinical Proteomics 2013 10:17

    Content type: Research

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  16. Serum biomarkers can improve diagnosis and treatment of malignant pleural mesothelioma (MPM). However, the evaluation of potential new serum biomarker candidates is hampered by a lack of assay technologies for...

    Authors: Ferdinando Cerciello, Meena Choi, Annalisa Nicastri, Damaris Bausch-Fluck, Annemarie Ziegler, Olga Vitek, Emanuela Felley-Bosco, Rolf Stahel, Ruedi Aebersold and Bernd Wollscheid

    Citation: Clinical Proteomics 2013 10:16

    Content type: Research

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  17. Lung cancer is the number one cause of cancer-related deaths in the United States and worldwide. The complex protein changes and/or signature of protein expression in lung cancer, particularly in non-small cel...

    Authors: Yan Li, Xiangchun Wang, MingHui Ao, Edward Gabrielson, Frederic Askin, Hui Zhang and Qing Kay Li

    Citation: Clinical Proteomics 2013 10:15

    Content type: Research

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  18. Chikungunya is a highly debilitating febrile illness caused by Chikungunya virus, a single-stranded RNA virus, which is transmitted by Aedes aegypti or Aedes albopictus mosquito species. The pathogenesis and host...

    Authors: Vinuth N Puttamallesh, Sreelakshmi K Sreenivasamurthy, Pradeep Kumar Singh, H C Harsha, Anjali Ganjiwale, Shobha Broor, Akhilesh Pandey, Jayasuryan Narayana and T S Keshava Prasad

    Citation: Clinical Proteomics 2013 10:14

    Content type: Research

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  19. Arthritis refers to inflammation of joints and includes common disorders such as rheumatoid arthritis (RA) and spondyloarthropathies (SpAs). These diseases differ mainly in terms of their clinical manifestatio...

    Authors: Mitali Bhattacharjee, Rakesh Sharma, Renu Goel, Lavanya Balakrishnan, Santosh Renuse, Jayshree Advani, Shantal Tankala Gupta, Renu Verma, Sneha M Pinto, Nirujogi Raja Sekhar, Bipin Nair, T S Keshava Prasad, H C Harsha, Ramesh Jois, Subramanian Shankar and Akhilesh Pandey

    Citation: Clinical Proteomics 2013 10:11

    Content type: Research

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  20. To characterize changes in global protein expression in kidneys of transgenic rats overexpressing human selenoprotein M (SelM) in response to increased bioabivility of selenium (Sel), total proteins extracted ...

    Authors: Jun Seo Goo, Yo Na Kim, Kyung Mi Choi, In Sik Hwang, Ji Eun Kim, Young Ju Lee, Moon Hwa Kwak, Sun Bo Shim, Seung Wan Jee, Chul Joo Lim, Je Kyung Seong and Dae Youn Hwang

    Citation: Clinical Proteomics 2013 10:10

    Content type: Research

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  21. The ciliary body is the circumferential muscular tissue located just behind the iris in the anterior chamber of the eye. It plays a pivotal role in the production of aqueous humor, maintenance of the lens zonu...

    Authors: Renu Goel, Krishna R Murthy, Srinivas M Srikanth, Sneha M Pinto, Mitali Bhattacharjee, Dhanashree S Kelkar, Anil K Madugundu, Gourav Dey, Sujatha S Mohan, Venkatarangaiah Krishna, TS Keshava Prasad, Shukti Chakravarti, HC Harsha and Akhilesh Pandey

    Citation: Clinical Proteomics 2013 10:9

    Content type: Research

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  22. Purified protein derivative (PPD) has been used for more than half a century as an antigen for the diagnosis of tuberculosis infection based on delayed type hypersensitivity. Although designated as “purified,”...

    Authors: Thottethodi Subrahmanya Keshava Prasad, Renu Verma, Satish Kumar, Raja Sekhar Nirujogi, Gajanan J Sathe, Anil K Madugundu, Jyoti Sharma, Vinuth N Puttamallesh, Anjali Ganjiwale, Vithal P Myneedu, Aditi Chatterjee, Akhilesh Pandey, HC Harsha and Jayasuryan Narayana

    Citation: Clinical Proteomics 2013 10:8

    Content type: Research

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  23. Heart failure is a multifactorial disease associated with staggeringly high morbidity and motility. Recently, alterations of multiple metabolites have been implicated in heart failure; however, the lack of an ...

    Authors: CY X’avia Chan, Anjum A Khan, JH Howard Choi, CM Dominic Ng, Martin Cadeiras, Mario Deng and Peipei Ping

    Citation: Clinical Proteomics 2013 10:7

    Content type: Research

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  24. Complex molecular events lead to development and progression of liver cirrhosis to HCC. Differentially expressed nuclear membrane associated proteins are responsible for the functional and structural alteratio...

    Authors: Rizma Khan, Saadia Zahid, Yu-Jui Yvonne Wan, Jameson Forster, A-Bashar Abdul Karim, Atta M Nawabi, Abid Azhar, M Ataur Rahman and Nikhat Ahmed

    Citation: Clinical Proteomics 2013 10:6

    Content type: Research

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  25. Alzheimer’s disease (AD) is the most common type of dementia affecting people over 65 years of age. The hallmarks of AD are the extracellular deposits known as amyloid β plaques and the intracellular neurofibr...

    Authors: Ilijana Begcevic, Hari Kosanam, Eduardo Martínez-Morillo, Apostolos Dimitromanolakis, Phedias Diamandis, Uros Kuzmanov, Lili-Naz Hazrati and Eleftherios P Diamandis

    Citation: Clinical Proteomics 2013 10:5

    Content type: Research

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  26. Epithelial-derived ovarian adenocarcinoma (EOC) is the most deadly gynecologic tumor, and the principle cause of the poor survival rate is diagnosis at a late stage. Screening and diagnostic biomarkers with ac...

    Authors: Björg Kristjansdottir, Kristina Levan, Karolina Partheen, Elisabet Carlsohn and Karin Sundfeldt

    Citation: Clinical Proteomics 2013 10:4

    Content type: Research

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  27. Rabies is a fatal acute viral disease of the central nervous system, which is a serious public health problem in Asian and African countries. Based on the clinical presentation, rabies can be classified into e...

    Authors: Abhilash K Venugopal, S Sameer Kumar Ghantasala, Lakshmi Dhevi N Selvan, Anita Mahadevan, Santosh Renuse, Praveen Kumar, Harsh Pawar, Nandini A Sahasrabhuddhe, Mooriyath S Suja, Yarappa L Ramachandra, Thottethodi S Keshava Prasad, Shampur N Madhusudhana, Harsha HC, Raghothama Chaerkady, Parthasarathy Satishchandra, Akhilesh Pandey…

    Citation: Clinical Proteomics 2013 10:3

    Content type: Research

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  28. Down syndrome (DS), caused by an extra copy of chromosome 21, affects 1 in 750 live births and is characterized by cognitive impairment and a constellation of congenital defects. Currently, little is known abo...

    Authors: Chan-Kyung J Cho, Andrei P Drabovich, George S Karagiannis, Eduardo Martínez-Morillo, Shawn Dason, Apostolos Dimitromanolakis and Eleftherios P Diamandis

    Citation: Clinical Proteomics 2013 10:2

    Content type: Research

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  29. In sickle cell disease (SCD), the mitogen-activated protein kinase (MAPK) ERK1/2 is constitutively active and can be inducible by agonist-stimulation only in sickle but not in normal human red blood cells (RBC...

    Authors: Erik J Soderblom, J Will Thompson, Evan A Schwartz, Edward Chiou, Laura G Dubois, M Arthur Moseley and Rahima Zennadi

    Citation: Clinical Proteomics 2013 10:1

    Content type: Research

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  30. We aimed to investigate the use of ovarian cyst fluid as a source for biomarker discovery and to find novel biomarkers for use in the diagnosis of epithelial ovarian tumors.

    Authors: Björg Kristjansdottir, Karolina Partheen, Eric T Fung, Janusz Marcickiewicz, Christine Yip, Mats Brännström and Karin Sundfeldt

    Citation: Clinical Proteomics 2012 9:14

    Content type: Research

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  31. Autosomal dominant polycystic kidney disease (ADPKD) is responsible for 10% of cases of the end stage renal disease. Early diagnosis, especially of potential fast progressors would be of benefit for efficient ...

    Authors: Magda Bakun, Mariusz Niemczyk, Dominik Domanski, Radek Jazwiec, Anna Perzanowska, Stanislaw Niemczyk, Michal Kistowski, Agnieszka Fabijanska, Agnieszka Borowiec, Leszek Paczek and Michal Dadlez

    Citation: Clinical Proteomics 2012 9:13

    Content type: Research

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  32. Tuberculous meningitis is a frequent extrapulmonary disease caused by Mycobacterium tuberculosis and is associated with high mortality rates and severe neurological sequelae. In an earlier study employing DNA mic...

    Authors: Ghantasala S Sameer Kumar, Abhilash K Venugopal, Anita Mahadevan, Santosh Renuse, H C Harsha, Nandini A Sahasrabuddhe, Harsh Pawar, Rakesh Sharma, Praveen Kumar, Sudha Rajagopalan, Keith Waddell, Yarappa L Ramachandra, Parthasarathy Satishchandra, Raghothama Chaerkady, T S Keshava Prasad, K Shankar…

    Citation: Clinical Proteomics 2012 9:12

    Content type: Research

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  33. Pathogenesis of liver damage in patients with HIV and HCV co-infection is complex and multifactorial. Although global awareness regarding HIV-1/HCV co-infection is increasing little is known about the pathophy...

    Authors: Nawal M Boukli, Vivekananda Shetty, Luis Cubano, Martha Ricaurte, Jordana Coelho-dos-Reis, Zacharie Nickens, Punit Shah, Andrew H Talal, Ramila Philip and Pooja Jain

    Citation: Clinical Proteomics 2012 9:11

    Content type: Research

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  34. In approximately 80% of patients, ovarian cancer is diagnosed when the patient is already in the advanced stages of the disease. CA125 is currently used as the marker for ovarian cancer; however, it lacks spec...

    Authors: Vivekananda Shetty, Julie Hafner, Punit Shah, Zacharie Nickens and Ramila Philip

    Citation: Clinical Proteomics 2012 9:10

    Content type: Research

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  35. Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS). It involves damage to the myelin sheath surrounding axons and to the axons themselves. MS most often presents with a...

    Authors: Yan Jia, Tianxia Wu, Christine A Jelinek, Bibiana Bielekova, Linda Chang, Scott Newsome, Sharmilee Gnanapavan, Gavin Giovannoni, Dawn Chen, Peter A Calabresi, Avindra Nath and Robert J Cotter

    Citation: Clinical Proteomics 2012 9:9

    Content type: Research

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  36. A National Institutes of Health (NIH) workshop was convened in Bethesda, MD on September 26–27, 2011, with representative scientific leaders in the field of proteomics and its applications to clinical settings...

    Authors: Marc Vidal, Daniel W Chan, Mark Gerstein, Matthias Mann, Gilbert S Omenn, Danilo Tagle and Salvatore Sechi

    Citation: Clinical Proteomics 2012 9:6

    Content type: Meeting report

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  37. Pancreatic cancer is among the most lethal malignancies worldwide. This study aimed to identify a novel prognostic biomarker, facilitating treatment selection, using mass spectrometry (MS)-based proteomic anal...

    Authors: Tatsuyuki Takadate, Tohru Onogawa, Kiyonaga Fujii, Fuyuhiko Motoi, Sayaka Mikami, Tetsuya Fukuda, Makoto Kihara, Takashi Suzuki, Taro Takemura, Takashi Minowa, Nobutaka Hanagata, Kengo Kinoshita, Takanori Morikawa, Keiichi Shirasaki, Toshiki Rikiyama, Yu Katayose…

    Citation: Clinical Proteomics 2012 9:8

    Content type: Research

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  38. The molecular events that lead to malignant transformation and subsequent metastasis of breast carcinoma include alterations in the cells at genome, transcriptome and proteome levels. In this study, we used pu...

    Authors: Deepthi Telikicherla, Arivusudar Marimuthu, Manoj Kumar Kashyap, Y L Ramachandra, Sujatha Mohan, Juan Carlos Roa, Jagadeesha Maharudraiah and Akhilesh Pandey

    Citation: Clinical Proteomics 2012 9:7

    Content type: Research

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  39. Analysis of key therapeutic targets such as epidermal growth factor receptor (EGFR) in clinical tissue samples is typically done by immunohistochemistry (IHC) and is only subjectively quantitative through a na...

    Authors: Todd Hembrough, Sheeno Thyparambil, Wei-Li Liao, Marlene M Darfler, Joseph Abdo, Kathleen M Bengali, Paul Taylor, Jiefei Tong, Humberto Lara-Guerra, Thomas K Waddell, Michael F Moran, Ming-Sound Tsao, David B Krizman and Jon Burrows

    Citation: Clinical Proteomics 2012 9:5

    Content type: Research

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  40. The diagnosis and management of BK virus (BKV) reactivation following renal transplantation continues to be a significant clinical problem. Following reactivation of latent virus, impaired cellular immunity en...

    Authors: Rebecca Konietzny, Roman Fischer, Nicola Ternette, Cynthia A Wright, Ben W Turney, Aron Chakera, David Hughes, Benedikt M Kessler and Chris W Pugh

    Citation: Clinical Proteomics 2012 9:4

    Content type: Research

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  41. Central nervous system (CNS) infection is a nearly universal feature of untreated systemic HIV infection with a clinical spectrum that ranges from chronic asymptomatic infection to severe cognitive and motor d...

    Authors: Thomas E Angel, Jon M Jacobs, Serena S Spudich, Marina A Gritsenko, Dietmar Fuchs, Teri Liegler, Henrik Zetterberg, David G Camp II, Richard W Price and Richard D Smith

    Citation: Clinical Proteomics 2012 9:3

    Content type: Research

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  42. Prostatitis is an inflammation of the prostate gland which affects approximately 10% of men. Despite its frequency, diagnosing prostatitis and monitoring patient response to treatment remains frustrating. As t...

    Authors: Daniel Kagedan, Irene Lecker, Ihor Batruch, Christopher Smith, Ilia Kaploun, Kirk Lo, Ethan Grober, Eleftherios P Diamandis and Keith A Jarvi

    Citation: Clinical Proteomics 2012 9:2

    Content type: Research

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  43. Biomarkers that improve stratification of colorectal cancer patients for adjuvant therapy versus resection alone, or that are predictive of response to therapeutic agents, have the potential to greatly improve...

    Authors: Georgia Arentz, Tim Chataway, Timothy J Price, Zaipul Izwan, Gemma Hardi, Adrian G Cummins and Jennifer E Hardingham

    Citation: Clinical Proteomics 2011 8:16

    Content type: Research

    Published on:

  44. The objective of the present study is to identify proteins that change in the extent of the modification with O-linked N-acetylglucosamine (O-GlcNAcylation) in the kidney from diabetic model Goto-Kakizaki (GK) ra...

    Authors: Yoshihiro Akimoto, Yuri Miura, Tosifusa Toda, Margreet A Wolfert, Lance Wells, Geert-Jan Boons, Gerald W Hart, Tamao Endo and Hayato Kawakami

    Citation: Clinical Proteomics 2011 8:15

    Content type: Research

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  45. Raw spectral data from matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) with MS profiling techniques usually contains complex information not readily providing biological insight into dis...

    Authors: Dong L Tong, David J Boocock, Clare Coveney, Jaimy Saif, Susana G Gomez, Sergio Querol, Robert Rees and Graham R Ball

    Citation: Clinical Proteomics 2011 8:14

    Content type: Research

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