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  1. Early diagnosis of Oral Squamous Cell Carcinoma (OSCC) increases the survival rate of oral cancer. For early diagnosis, molecular biomarkers contained in samples collected non-invasively and directly from at-r...

    Authors: Joel A Kooren, Nelson L Rhodus, Chuanning Tang, Pratik D Jagtap, Bryan J Horrigan and Timothy J Griffin

    Citation: Clinical Proteomics 2011 8:13

    Content type: Research

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  2. To determine whether functional proteomics improves breast cancer classification and prognostication and can predict pathological complete response (pCR) in patients receiving neoadjuvant taxane and anthracycl...

    Authors: Ana M Gonzalez-Angulo, Bryan T Hennessy, Funda Meric-Bernstam, Aysegul Sahin, Wenbin Liu, Zhenlin Ju, Mark S Carey, Simen Myhre, Corey Speers, Lei Deng, Russell Broaddus, Ana Lluch, Sam Aparicio, Powel Brown, Lajos Pusztai, W Fraser Symmans…

    Citation: Clinical Proteomics 2011 8:11

    Content type: Research

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  3. The vast difference in the abundance of different proteins in biological samples limits the determination of the complete proteome of a cell type, requiring fractionation of proteins and peptides before MS ana...

    Authors: Beerelli Seshi, Kumaraguru Raja and KH Chandramouli

    Citation: Clinical Proteomics 2011 8:10

    Content type: Research

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  4. The ADAMs are transmembrane proteins implicated in proteolysis and cell adhesion. Forty gene members of the family have been identified, of which 21 are believed to be functional in humans. As proteases, their...

    Authors: Michael J Duffy, Maeve Mullooly, Norma O'Donovan, Sumainizah Sukor, John Crown, Aisling Pierce and Patricia M McGowan

    Citation: Clinical Proteomics 2011 8:9

    Content type: Review

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  5. Predicting the response to medical therapy and subsequently individualizing the treatment to increase efficacy or reduce toxicity has been a longstanding clinical goal. Not least within oncology, where many pa...

    Authors: Jacob Nersting, Louise Borst and Kjeld Schmiegelow

    Citation: Clinical Proteomics 2011 8:8

    Content type: Review

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  6. In cerebrospinal fluid (CSF), which is a rich source of biomarkers for neurological diseases, identification of biomarkers requires methods that allow reproducible detection of low abundance proteins. It is th...

    Authors: Jacques Borg, Alex Campos, Claudio Diema, Núria Omeñaca, Eliandre de Oliveira, Joan Guinovart and Marta Vilaseca

    Citation: Clinical Proteomics 2011 8:6

    Content type: Research

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  7. Kallikrein-related peptidase 5 (KLK5) is a secreted trypsin-like protease of the KLK family, encoded by the KLK5 gene. KLK5 has been found to cleave various extracellular matrix components, as well as to activate...

    Authors: Margaritis Avgeris, Georgia Papachristopoulou, Athanasios Polychronis and Andreas Scorilas

    Citation: Clinical Proteomics 2011 8:5

    Content type: Research

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  8. Visceral leishmaniasis is a parasitic infection caused by Lesihmania donovani complex and transmitted by the bite of the phlebotomine sand fly. It is an endemic disease in many developing countries with more than...

    Authors: Lokesh A Rukmangadachar, Jitender Kataria, Gururao Hariprasad, Jyotish C Samantaray and Alagiri Srinivasan

    Citation: Clinical Proteomics 2011 8:4

    Content type: Research

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  9. Sulfur mustard "bis (2-chlroethyl) sulphide" (SM) is a chemical warfare agent that remains a threat to human health. The aim of this study was to identify protein expression signature or biomarkers that reflec...

    Authors: Hossein Mehrani, Mostafa Ghanei, Jafar Aslani and Zahra Tabatabaei

    Citation: Clinical Proteomics 2011 8:2

    Content type: Research

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  10. Experiments show that upon traumatic injury the composition of mesenteric lymph changes such that it initiates an immune response that can ultimately result in multiple organ dysfunction syndrome (MODS). To id...

    Authors: Ashley Zurawel, Ernest E Moore, Erik D Peltz, Janeen R Jordan, Sagar Damle, Monika Dzieciatkowska, Anirban Banerjee and Kirk C Hansen

    Citation: Clinical Proteomics 2010 8:1

    Content type: Research

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  11. The lack of large panels of validated antibodies, tissue handling variability, and intratumoral heterogeneity potentially hamper comprehensive study of the functional proteome in non-microdissected solid tumor...

    Authors: Bryan T. Hennessy, Yiling Lu, Ana Maria Gonzalez-Angulo, Mark S. Carey, Simen Myhre, Zhenlin Ju, Michael A. Davies, Wenbin Liu, Kevin Coombes, Funda Meric-Bernstam, Isabelle Bedrosian, Mollianne McGahren, Roshan Agarwal, Fan Zhang, Jens Overgaard, Jan Alsner…

    Citation: Clinical Proteomics 2010 6:9055

    Content type: Article

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  12. Proteomic characterization of the human pancreatic islets, containing the insulin producing beta-cells, is likely to be of great importance for improved treatment and understanding of the pathophysiology of di...

    Authors: Sara F. Hansson, Åsa Henriksson, Lars Johansson, Olle Korsgren, Jan W. Eriksson, Hans Tornqvist and Pia Davidsson

    Citation: Clinical Proteomics 2010 6:9060

    Content type: Article

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  13. Candida albicans and Candida glabrata are the two most common opportunistic pathogens which are part of the normal flora in humans. Clinical diagnosis of infection by these organisms is still largely based on cul...

    Authors: Thottethodi Subrahmanya Keshava Prasad, Shivakumar Keerthikumar, Raghothama Chaerkady, Kumaran Kandasamy, Santosh Renuse, Arivusudar Marimuthu, Abhilash Karavattu Venugopal, Joji Kurian Thomas, Harrys K. C. Jacob, Renu Goel, Harsh Pawar, Nandini A. Sahasrabuddhe, Venkatarangaiah Krishna, Bipin G. Nair, Marjan Gucek, Robert N. Cole…

    Citation: Clinical Proteomics 2010 6:9057

    Content type: Article

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  14. Systemic juvenile idiopathic arthritis is a chronic pediatric disease. The initial clinical presentation can mimic other pediatric inflammatory conditions, which often leads to significant delays in diagnosis ...

    Authors: Xuefeng B. Ling, Kenneth Lau, Chetan Deshpande, Jane L. Park, Diana Milojevic, Claudia Macaubas, Chris Xiao, Viorica Lopez-Avila, John Kanegaye, Jane C. Burns, Harvey Cohen, James Schilling and Elizabeth D. Mellins

    Citation: Clinical Proteomics 2010 6:9058

    Content type: Article

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  15. In the search for novel cancer biomarkers, various proteolytically derived peptides have been proposed to exhibit cancer or cancer-type specificity. As these peptides are presumably also generated after sample...

    Authors: Irene van den Broek, Rolf W. Sparidans, Jan H. M. Schellens and Jos H. Beijnen

    Citation: Clinical Proteomics 2010 6:9054

    Content type: Article

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  16. High glucose concentrations induce the production of IL-1β in human pancreatic beta cells leading to impaired insulin secretion, decreased cell proliferation and apoptosis. Blockade of IL-1 signalling with the...

    Authors: Mette Koefoed, Claus M. Larsen, Mirjam V. Faulenbach, Allan Vaag, Jan A. Ehses, Marc Y. Donath, James Norton McGuire, Flemming Pociot and Thomas Mandrup-Poulsen

    Citation: Clinical Proteomics 2010 6:9056

    Content type: Article

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  17. As part of a clinical proteomics programme focused on diabetes and its complications, it was our goal to investigate the proteome of plasma in order to find improved candidate biomarkers to predict diabetic ne...

    Authors: Anne Julie Overgaard, Tine E. Thingholm, Martin R. Larsen, Lise Tarnow, Peter Rossing, James N. McGuire and Flemming Pociot

    Citation: Clinical Proteomics 2010 6:9053

    Content type: Article

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  18. It is widely believed that discovery of specific, sensitive, and reliable tumor biomarkers can improve the treatment of cancer. Currently, there are no obvious targets that can be used in treating triple-negat...

    Authors: Ming Lu, Stephen A. Whelan, Jianbo He, Romaine E. Saxton, Kym F. Faull, Julian P. Whitelegge and Helena R. Chang

    Citation: Clinical Proteomics 2010 6:9052

    Content type: Article

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  19. The rational design of targeted therapies for acute myeloid leukemia (AML) requires the discovery of novel protein pathways in the systems biology of a specific AML subtype. We have shown that in the AML subty...

    Authors: Sheo Mohan Singh, Arun Kumar Trivedi, Savita Lochab, Maximilian Christopeit, Wolfgang Hiddemann and Gerhard Behre

    Citation: Clinical Proteomics 2010 6:9051

    Content type: Article

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  20. Tumors lack normal drainage of secreted fluids and consequently build up tumor interstitial fluid (TIF). Unlike other bodily fluids, TIF likely contains a high proportion of tumor-specific proteins with potent...

    Authors: Matthew D. Stone, Rick M. Odland, Thomas McGowan, Getiria Onsongo, Chaunning Tang, Nelson L. Rhodus, Pratik Jagtap, Sricharan Bandhakavi and Timothy J. Griffin

    Citation: Clinical Proteomics 2010 6:9050

    Content type: Article

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  21. Radiographic contrast media (RCM) have numerous effects on the hemostatic system, inflammatory pathways, and vascular endothelium. Given the increasing number of high-risk patients undergoing radiographic proc...

    Authors: Juan Martinez, Warren K. Laskey, Cheri Wells, Armin Foghi, Sarah Rohde, Mark Ricciardi and Charlotte Mobarak

    Citation: Clinical Proteomics 2010 6:9048

    Content type: Article

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  22. The objective of this study was to identify cancer-associated protein expression patterns in bilateral matched nipple aspiration fluids using nanoscale reciprocal Cy3/Cy5 labeling and high-content antibody mic...

    Authors: Jinong Li, Junma Zhou, Bruce Trock, Theodore N. Tsangaris, Neil B. Friedman, Deanna Shapiro, Michelle Brotzman and Daniel W. Chan

    Citation: Clinical Proteomics 2010 6:9046

    Content type: Article

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  23. HIV-associated neurocognitive disorders (HAND) has been associated with the up-regulation of various oxidative stress pathways. Previous studies have linked the neuronal damage observed in individuals diagnose...

    Authors: Ashley S. Beasley, Caroline Anderson, Justin McArthur, Ned Sacktor, Avindra Nath and Robert J. Cotter

    Citation: Clinical Proteomics 2010 6:9041

    Content type: Article

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    The Erratum to this article has been published in Clinical Proteomics 2010 6:9043

  24. Cervical cancer is among the most common cancers in women worldwide. Discovery of biomarkers for the early detection of cervical cancer would improve current screening practices and reduce the burden of disease.

    Authors: Gitika Panicker, Yiming Ye, Dongxia Wang and Elizabeth R. Unger

    Citation: Clinical Proteomics 2010 6:9042

    Content type: Article

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  25. Early detection, assessment of disease progression, and application of an appropriate therapeutic intervention are all important for the care of patients with type 2 diabetes. Currently, however, there is no s...

    Authors: Shigeru Okada, Edward O. List, Sudha Sankaran and John J. Kopchick

    Citation: Clinical Proteomics 2010 6:9040

    Content type: Article

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  26. The use of mass spectrometry to investigate disease-associated proteins among thousands of candidates simultaneously creates challenges with the evaluation of operational and biological variation. Traditional ...

    Authors: Irene S. L. Zeng, Sharon R. Browning, Patrick Gladding, Mia Jüllig, Martin Middleditch and Ralph A. H. Stewart

    Citation: Clinical Proteomics 2009 5:9039

    Content type: Article

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  27. Polypeptide fragments from cell surface receptors when found in plasma may be indicators of receptor regulation in disease conditions. It is known that subjects with diabetes have significantly lower plasma co...

    Authors: Michael J. Pugia, Deanna D. H. Franke, Sean L. Barnes, Amy Zercher, David Brock, Mary Foltz, Roland Valdes Jr. and Saeed A. Jortani

    Citation: Clinical Proteomics 2009 5:9036

    Content type: Article

    Published on:

  28. Lung cancer is the leading cause of cancer-related death worldwide. The discovery of new biomarkers could aid early diagnosis and monitoring of recurrence following tumor resection.

    Authors: Sridhar Rathinam, Aiman Alzetani, Jane Starczynski, Pala B. Rajesh, Stephen Nyangoma, Michael J. O. Wakelam, Nicholas D. James, Wenbin Wei, Lucinda J. Billingham, Philip J. Johnson, Ashley Martin and Douglas G. Ward

    Citation: Clinical Proteomics 2009 5:9033

    Content type: Article

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  29. Proteomic profiling is a rapidly developing technology that may enable early disease screening and diagnosis. Surface-enhanced laser desorption ionization–time of flight mass spectrometry (SELDI-TOF MS) has de...

    Authors: Bashar A. Zeidan, Ramsey I. Cutress, Claire Hastie, Alex H. Mirnezami, Graham Packham and Paul A. Townsend

    Citation: Clinical Proteomics 2009 5:9032

    Content type: Article

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  30. Alzheimer’s disease (AD) poses specific challenges for drug development. It has a slow and variable clinical course, an insidious onset, and symptom expression is only observed when a significant proportion of...

    Authors: N. Guerreiro, B. Gomez-Mancilla, B. Williamson, M. Minkoff and S. Guertin

    Citation: Clinical Proteomics 2009 5:9030

    Content type: Article

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  31. Annexin A11 was previously identified as an autoantigen in 4.1–10.1% of patients with various systemic autoimmune diseases. In this study, an enzyme-linked immunosorbent assay (ELISA) was developed to investig...

    Authors: Jin Song, Xiaer Sun, Lori J. Sokoll, Masatoshi Maki, Yuan Tian, Daniel W. Chan and Zhen Zhang

    Citation: Clinical Proteomics 2009 5:9031

    Content type: Article

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  32. Human urine is a complex matrix of proteins, endogenous peptides, lipids, and metabolites. The level of any or all of these components can reflect the pathophysiological status of an individual especially of t...

    Authors: Tara K. Sigdel, Xuefeng B. Ling, Ken H. Lau, Li Li, James Schilling and Minnie M. Sarwal

    Citation: Clinical Proteomics 2009 5:9029

    Content type: Article

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  33. Tandem mass spectrometry (MS/MS) has emerged as a cornerstone of proteomic screens aimed at discovering putative protein biomarkers of disease with potential clinical applications. Systematic validation of lea...

    Authors: Jian Liu, Johannes A. Hewel, Vincent Fong, Michelle Chan-Shen-Yue and Andrew Emili

    Citation: Clinical Proteomics 2009 5:9023

    Content type: Article

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  34. Variability in response to acetaminophen (APAP)-induced aseptic inflammation and tolerance to the impending hepatic damage has been described. To understand the mechanism of adaptive tolerance, we investigated...

    Authors: Pamela S. Steele, Mark W. Linder, Roland Valdes Jr., Deanna D. H. Franke and Saeed A. Jortani

    Citation: Clinical Proteomics 2009 5:9022

    Content type: Article

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  35. Glycosylation is an important component for a number of biological processes and is perhaps the most abundant and complicated of the known post-translational modifications found on proteins.

    Authors: Melissa Sondej, Patricia A. Denny, Yongming Xie, Prasanna Ramachandran, Yan Si, Jona Takashima, Wenyuan Shi, David T. Wong, Joseph A. Loo and Paul C. Denny

    Citation: Clinical Proteomics 2008 5:9021

    Content type: Article

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  36. All neoplastic cells express one or more members of a unique family of tumor-associated cell surface ubiquinone (NADH) oxidase proteins with protein disulfide-thiol interchange activity (ENOX2 or tNOX proteins...

    Authors: Brandon Hostetler, Nicole Weston, Chinpal Kim, Dorothy M. Morré and D. James Morré

    Citation: Clinical Proteomics 2008 5:9016

    Content type: Article

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  37. Biomarkers for early detection of renal cell carcinoma (RCC) may help diagnose minimal residual disease in patients at risk for RCC, can guide anti-angiogenic therapy, or may help identify candidates for adjuv...

    Authors: Peter Hulick, Michael Zimmer, Vitaly Margulis, Steven Skates, Maureen Hamel, Douglas M. Dahl, Dror M. Michaelson, Towia Liebermann, Sabina Signoretti, Walter Carney, Christopher Wood and Othon Iliopoulos

    Citation: Clinical Proteomics 2008 5:9012

    Content type: Article

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