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  1. Owing to its noninvasive collection, saliva is considered as a potent diagnostic fluid. The goal of this study was to investigate the modification of the salivary proteome occurring in type 1 diabetes to highl...

    Authors: Christophe Hirtz, François Chevalier, Nicolas Sommerer, Isabelle Raingeard, Jacques Bringer, Michel Rossignol and Dominique Deville de Périere

    Citation: Clinical Proteomics 2006 2:201117

    Content type: Original Article

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  2. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) serves as a rapid and accurate means to determine masses of proteins independent of their shapes or interactions with...

    Authors: Glen L. Hortin and Alan T. Remaley

    Citation: Clinical Proteomics 2006 2:201103

    Content type: Original Article

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  3. Despite many years of research efforts and continued progress in the identification of urine markers for detection of bladder cancer, none of the markers described to date has been able to replace cystoscopy a...

    Authors: Pavel Gromov, Josè M. A. Moreira, Irina Gromova and Julio E. Celis

    Citation: Clinical Proteomics 2006 2:20145

    Content type: Original Article

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  4. Data mining application to proteomic data from mass spectrometry has gained much interest in recent years. Advances made in proteomics and mass spectrometry have resulted in considerable amount of data that ca...

    Authors: Asha Thomas, Georgia D. Tourassi, Adel S. Elmaghraby, Roland Valdes Jr. and Saeed A. Jortani

    Citation: Clinical Proteomics 2006 2:20113

    Content type: Original Article

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  5. Although most patients with early-stage nasopharyngeal carcinoma (NPC) can be cured by radiotherapy, there is a high recurrence rate in patients with advanced NPC. We attempted to identify proteomic patterns i...

    Authors: Terence C. W. Poon, Shuk Man Chow, Brigette B. Y. Ma, Edwin P. Hui and Anthony T. C. Chan

    Citation: Clinical Proteomics 2004 1:13104365

    Content type: Original Article

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  6. The identification of disease markers in human body fluids requires an extensive and thorough analysis of its protein constituents. In the present study, we have extended our analysis of the human cerebrospina...

    Authors: Giuseppina Maccarrone, Isabel Birg, Eva Malisch, Marcus C. Rosenhagen, Claudia Ditzen, John A. Chakel, Friedrich Mandel, Andreas Reimann, Can-Carlo Doertbudak, Katrin Haegler, Florian Holsboer and Christoph W. Turck

    Citation: Clinical Proteomics 2004 1:13104333

    Content type: Original Article

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  7. Hepatocellular carcinoma (HCC) and hepatoblastoma (HB) are malignancies of the liver with different etiologies, but the HB cell line HepG2 has been frequently used in various studies of HCC. In this study, we ...

    Authors: Ronald T. K. Pang, Terence C. W. Poon, Nathalie Wong, Paul B. S. Lai, Navy L. Y. Wong, Charles M. L. Chan, Jasmine W. S. Yu, Anthony T. C. Chan and Joseph J. Y. Sung

    Citation: Clinical Proteomics 2004 1:13104313

    Content type: Original Article

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  8. The evaluation of clinical tumor tissues is a valuable approach to discovering novel drug targets because of the direct relevance of human samples. We used activity-based proteomic profiling (ABPP) to study th...

    Authors: Melissa C. Zhang, Jiangyue Wu, Kristin G. Ardlie and Emme C. K. Lin

    Citation: Clinical Proteomics 2004 1:13104301

    Content type: Original Article

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  9. Here, we show a strategy for high-throughput antibody-based tissue profiling with the aim to create an atlas of protein expression patterns in normal human tissues and cancer tissues representing the 20 most p...

    Authors: Caroline Kampf, Ann-Catrin Andersson, Kenneth Wester, Erik Björling, Mathias Uhlen and Fredrik Ponten

    Citation: Clinical Proteomics 2004 1:13104285

    Content type: Original Article

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  10. The objective of this study was to examine the effects of heparan sulfate (HS) on factors involved in the remodeling of connective tissue observed in patients with fibrotic respiratory disorders such as asthma...

    Authors: Kristoffer Larsen, Johan Malmström, Ellen Tufvesson, György Marko-Varga and Gunilla Westergren-Thorsson

    Citation: Clinical Proteomics 2004 1:13104271

    Content type: Original Article

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  11. Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) has been recently used to identify disease markers by directly profiling and quantifying the peptide/proteins in bi...

    Authors: Ronald T. K. Pang, Philip J. Johnson, Charles M. L. Chan, Ebenezer K. C. Kong, Anthony T. C. Chan, Joseph J. Y. Sung and Terence C. W. Poon

    Citation: Clinical Proteomics 2004 1:13104259

    Content type: Original Article

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  12. The use of proteomic analysis to discover proteins (previously identified or unknown) in a tissue sample is a valuable tool. However, there is a limit to the extent one can validate a discovery with any single...

    Authors: Stanley M. Belkowski, Raymond W. Colburn, Dennis J. Stone, Christopher R. Van Besien, Deborah Polkovitch, Patricia Andrade-Gordon and Michael R. D'Andrea

    Citation: Clinical Proteomics 2004 1:13104249

    Content type: Original Article

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  13. Methotrexate has been a clinical agent used in cancer, immunosuppression, rheumatoid arthritis, and other highly proliferative diseases for many years, yet its underlying molecular mechanism of action in these...

    Authors: Jacek J. Slon-Usakiewicz, Andrew Pasternak, Neil Reid and Leticia M. Toledo-Sherman

    Citation: Clinical Proteomics 2004 1:13104227

    Content type: Molecular Targets

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  14. In this study, proteomics was used to explore the antigenic proteins that are involved in cross-reactivity during serodiagnosis between Neospora caninum (N. caninum) and Toxoplasma gondii (T. gondii). Competitive...

    Authors: Yong-seung Shin, Eung-goo Lee, Gee-wook Shin, Young-rim Kim, Eun-young Lee, Jae-hoon Kim, Hwan Jang, Dae-yong Kim, Yong-hwan Kim, Gon-sup Kim, Myung-deuk Suh and Tae-sung Jung

    Citation: Clinical Proteomics 2004 1:235

    Content type: Original Article

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  15. Changes in serum proteins that signal histopathological states, such as cancer, are useful diagnostic and prognostic biomarkers. Unfortunately, the large dynamic concentration range of proteins in serum makes ...

    Authors: King C. Chan, David A. Lucas, Denise Hise, Carl F. Schaefer, Zhen Xiao, George M. Janini, Kenneth H. Buetow, Haleem J. Issaq, Timothy D. Veenstra and Thomas P. Conrads

    Citation: Clinical Proteomics 2004 1:12101

    Content type: Serum/Plasma Proteome

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  16. In order to evaluate the critical components of the process necessary to preserve clinical plasma samples collected at research sites for proteomic analysis, various collection and preservation protocols with ...

    Authors: Jeffrey D. Hulmes, Deidra Bethea, Keith Ho, Shu-Pang Huang, Deborah L. Ricci, Gregory J. Opiteck and Stanley A. Hefta

    Citation: Clinical Proteomics 2004 1:21117

    Content type: Serum/Plasma Proteome

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  17. Many protein functions are conferred by posttranslational modifications, which allow proteins to perform specific cellular tasks. Protein microarrays enable specific detection of posttranslational modification...

    Authors: Virginia Espina, Emanuel F. Petricoin III, Lance A. Liotta and David Geho

    Citation: Clinical Proteomics 2004 1:11091

    Content type: Brief Technical Report

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  18. Protein microarrays have been recently employed for signal pathway profiling and high-throughput protein expression analysis. Reversephase arrays, where the array consists of immobilized analytes and lysates h...

    Authors: Valerie S. Calvert, Yihui Tang, Vince Boveia, Julie Wulfkuhle, Amy Schutz-Geschwender, D. Michael Olive, Lance A. Liotta and Emanuel F. Petricoin III

    Citation: Clinical Proteomics 2004 1:11081

    Content type: Brief Technical Report

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  19. The purpose of this phospho-proteomics study was to demonstrate the broad analysis of cellular protein phosphorylation in cells and tissue as a means to monitor changes in cellular states. As a cancer model, h...

    Authors: David R. Stover, Jennifer Caldwell, Jarrod Marto, Karen Root, Juergan Mestan, Michael Stumm, Olga Ornatsky, Chris Orsi, Nina Radosevic, Linda Liao, Doriano Fabbro and Michael F. Moran

    Citation: Clinical Proteomics 2004 1:11069

    Content type: Molecular Targets

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  20. Methotrexate has been a clinical agent used in cancer, immunosuppression, rheumatoid arthritis and other highly proliferative diseases for many years, yet its underlying molecular mechanism of action in these ...

    Authors: Leticia M. Toledo-Sherman, Leroi Desouza, Christopher M. Hosfield, Linda Liao, Kelly Boutillier, Paul Taylor, Shane Climie, Linda McBroom-Cerajewski and Michael F. Moran

    Citation: Clinical Proteomics 2004 1:11045

    Content type: Molecular Targets

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  21. Monitoring increased plasma unbound free fatty acid (FFAu) concentrations has been proposed as a biomarker for myocardial ischemia. In the current study, 30 acute coronary syndrome (ACS) patients presenting in th...

    Authors: Fred S. Apple, Alan M. Kleinfeld and Jesse Adams III

    Citation: Clinical Proteomics 2004 1:11041

    Content type: Biomarker Discovery and Profiling

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  22. The tissue specificity of creatine kinase (CK-MB) has been shown not to be absolute for the myocardium. Unexplained increases of plasma creatine kinase (CK-MB) occur in patients with skeletal muscle disease, c...

    Authors: Vincent Ricchiuti, Ellen M. Voss, Arthur Ney, Mark Odland and Fred S. Apple

    Citation: Clinical Proteomics 2004 1:11033

    Content type: Biomarker Discovery and Profiling

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  23. With increased interest in clinical proteomics—the comparative investigation of differential protein expression patterns for use in the diagnostic and prognostic assessment of disease states—the demand for tec...

    Authors: Urban A. Kiernan, Dobrin Nedelkov, Kemmons A. Tubbs, Eric E. Niederkofler and Randall W. Nelson

    Citation: Clinical Proteomics 2004 1:11007

    Content type: Serum/Plasma Proteome

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