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  1. Alzheimer’s disease (AD) poses specific challenges for drug development. It has a slow and variable clinical course, an insidious onset, and symptom expression is only observed when a significant proportion of...

    Authors: N. Guerreiro, B. Gomez-Mancilla, B. Williamson, M. Minkoff and S. Guertin

    Citation: Clinical Proteomics 2009 5:9030

    Content type: Article

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  2. Annexin A11 was previously identified as an autoantigen in 4.1–10.1% of patients with various systemic autoimmune diseases. In this study, an enzyme-linked immunosorbent assay (ELISA) was developed to investig...

    Authors: Jin Song, Xiaer Sun, Lori J. Sokoll, Masatoshi Maki, Yuan Tian, Daniel W. Chan and Zhen Zhang

    Citation: Clinical Proteomics 2009 5:9031

    Content type: Article

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  3. Human urine is a complex matrix of proteins, endogenous peptides, lipids, and metabolites. The level of any or all of these components can reflect the pathophysiological status of an individual especially of t...

    Authors: Tara K. Sigdel, Xuefeng B. Ling, Ken H. Lau, Li Li, James Schilling and Minnie M. Sarwal

    Citation: Clinical Proteomics 2009 5:9029

    Content type: Article

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  4. Tandem mass spectrometry (MS/MS) has emerged as a cornerstone of proteomic screens aimed at discovering putative protein biomarkers of disease with potential clinical applications. Systematic validation of lea...

    Authors: Jian Liu, Johannes A. Hewel, Vincent Fong, Michelle Chan-Shen-Yue and Andrew Emili

    Citation: Clinical Proteomics 2009 5:9023

    Content type: Article

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  5. Variability in response to acetaminophen (APAP)-induced aseptic inflammation and tolerance to the impending hepatic damage has been described. To understand the mechanism of adaptive tolerance, we investigated...

    Authors: Pamela S. Steele, Mark W. Linder, Roland Valdes Jr., Deanna D. H. Franke and Saeed A. Jortani

    Citation: Clinical Proteomics 2009 5:9022

    Content type: Article

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  6. Glycosylation is an important component for a number of biological processes and is perhaps the most abundant and complicated of the known post-translational modifications found on proteins.

    Authors: Melissa Sondej, Patricia A. Denny, Yongming Xie, Prasanna Ramachandran, Yan Si, Jona Takashima, Wenyuan Shi, David T. Wong, Joseph A. Loo and Paul C. Denny

    Citation: Clinical Proteomics 2008 5:9021

    Content type: Article

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  7. A proof-of-concept demonstration of the use of label-free quantitative glycoproteomics for biomarker discovery workflow is presented in this paper, using a mouse model for skin cancer as an example.

    Authors: Simon Letarte, Mi-Youn Brusniak, David Campbell, James Eddes, Christopher J. Kemp, Hollis Lau, Lukas Mueller, Alexander Schmidt, Paul Shannon, Karen S. Kelly-Spratt, Olga Vitek, Hui Zhang, Ruedi Aebersold and Julian D. Watts

    Citation: Clinical Proteomics 2008 4:9018

    Content type: Article

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  8. Glycans have unique characteristics that are significantly different from nucleic acids and proteins in terms of biosynthesis, structures, and functions. Moreover, their isomeric nature and the complex linkage...

    Authors: Richard K. T. Kam and Terence C. W. Poon

    Citation: Clinical Proteomics 2008 4:9017

    Content type: Article

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  9. All neoplastic cells express one or more members of a unique family of tumor-associated cell surface ubiquinone (NADH) oxidase proteins with protein disulfide-thiol interchange activity (ENOX2 or tNOX proteins...

    Authors: Brandon Hostetler, Nicole Weston, Chinpal Kim, Dorothy M. Morré and D. James Morré

    Citation: Clinical Proteomics 2008 5:9016

    Content type: Article

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  10. Plasma has been the focus of testing different proteomic technologies for the identification of biomarkers due to its ready accessibility. However, it is not clear if direct proteomic analysis of plasma can be...

    Authors: Yuan Tian, Karen S. Kelly-Spratt, Christopher J. Kemp and Hui Zhang

    Citation: Clinical Proteomics 2008 4:9014

    Content type: Article

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  11. With the rapid development of mass spectrometry-based technologies such as multiple reaction monitoring and heavy-isotope-labeled-peptide standards, quantitative analysis of biomarker proteins using mass spect...

    Authors: Yan Li, Lori J. Sokoll, Peter E. Barker, Hui Zhang and Daniel W. Chan

    Citation: Clinical Proteomics 2008 4:9011

    Content type: Article

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  12. A novel approach of ion mobility tandem mass spectrometry (IMS-MS/MS) is applied to analysis of human glycourinome to obtain carbohydrate pattern data of congenital disorders of glycosylation patient. Overlapp...

    Authors: Sergey Y. Vakhrushev, James Langridge, Iain Campuzano, Chris Hughes and Jasna Peter-Katalinić

    Citation: Clinical Proteomics 2008 4:9010

    Content type: Articles

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  13. Quantitative proteomics using tandem mass spectrometry is an attractive approach for identification of potential cancer biomarkers. Fractionation of complex tissue samples into subproteomes prior to mass spect...

    Authors: Raghothama Chaerkady, Paul J. Thuluvath, Min-Sik Kim, Anuradha Nalli, Perumal Vivekanandan, Jessica Simmers, Michael Torbenson and Akhilesh Pandey

    Citation: Clinical Proteomics 2008 4:9013

    Content type: Article

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  14. Glycoproteomics is undergoing rapid development, largely as a result of advances in technologies for isolating glycoproteins and analyzing glycan structures. However, given the number and diversity of glycans,...

    Authors: David W. Ralin, Shane C. Dultz, Judd E. Silver, Jeffrey C. Travis, Majlinda Kullolli, William S. Hancock and Marina Hincapie

    Citation: Clinical Proteomics 2008 4:9007

    Content type: Articles

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  15. Biomarkers for early detection of renal cell carcinoma (RCC) may help diagnose minimal residual disease in patients at risk for RCC, can guide anti-angiogenic therapy, or may help identify candidates for adjuv...

    Authors: Peter Hulick, Michael Zimmer, Vitaly Margulis, Steven Skates, Maureen Hamel, Douglas M. Dahl, Dror M. Michaelson, Towia Liebermann, Sabina Signoretti, Walter Carney, Christopher Wood and Othon Iliopoulos

    Citation: Clinical Proteomics 2008 5:9012

    Content type: Article

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  16. Glycosylations range among the most common posttranslational modifications with an estimated 50% of all proteins supposed to be glycosylated. These modifications are required for essential cellular processes i...

    Authors: Urs Lewandrowski, Katharina Lohrig, René P. Zahedi, Dirk Wolters and Albert Sickmann

    Citation: Clinical Proteomics 2008 4:9006

    Content type: Article

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  17. This study established two-dimensional gel electrophoresis (2-DE) profiles for human well-differentiated laryngeal squamous cell carcinoma tissue and paired normal mucosa epithelia tissue and identified protei...

    Authors: Jian-rong Zhou, Zhong-xue Fu, Jie Li, Lian-zhi Wei and Jun-cai Li

    Citation: Clinical Proteomics 2008 3:9009

    Content type: Article

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  18. Saliva is a body fluid that holds promise for use as a diagnostic fluid for detecting diseases. Salivary proteins are known to be heavily glycosylated and are known to play functional roles in the oral cavity....

    Authors: Prasanna Ramachandran, Pinmanee Boontheung, Eric Pang, Weihong Yan, David T. Wong and Joseph A. Loo

    Citation: Clinical Proteomics 2008 4:9005

    Content type: Article

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  19. The collection of lung fluid using a suction catheter (s-Cath) and non-bronchoscopic bronchoalveolar lavage (mini-BAL) are two minimally invasive methods of sampling the distal airspaces in patients with the a...

    Authors: Dong W. Chang, Giuseppe Colucci, Tomas Vaisar, Trevor King, Shinichi Hayashi, Gustavo Matute-Bello, Roger Bumgarner, Jay Heinecke, Thomas R. Martin and Guido M. Domenighetti

    Citation: Clinical Proteomics 2008 3:9002

    Content type: Article

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  20. The aim of this study was to evaluate a multiple immunoaffinity protein depletion (multiple affinity removal system, MARS) pre-treatment strategy with subsequent two-dimensional polyacrylamide gel electrophore...

    Authors: Karen T. Oliva, Mustafa Ayhan, Gillian Barker, Nicole L. Dellios, Michael A. Quinn and Gregory E. Rice

    Citation: Clinical Proteomics 2007 3:9001

    Content type: Article

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  21. In recent years, differential analysis of proteins from human saliva, i.e., proteomic analysis, has received much attention mainly due to its unstressful sampling and its great potential for biomarker research...

    Authors: François Chevalier, Christophe Hirtz, Sandrine Chay, Frédéric Cuisinier, Nicolas Sommerer, Michel Rossignol and Dominique Deville de Périère

    Citation: Clinical Proteomics 2007 3:9000

    Content type: Article

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  22. The aim of this study was to examine the protein expression profiles of persistentChlamydia pneumoniae by two-dimensional polyacrylamide gel electrophoresis (2D PAGE) and surface-enhanced laser desorption ionizat...

    Authors: Sanghamitra Mukhopadhyay, Saeed A. Jortani, Roland Valdes, Christine Q. Simmons, Erin D. Sullivan, Richard D. Miller and James T. Summersgill

    Citation: Clinical Proteomics 2006 2:BF02752501

    Content type: Original Article

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  23. The proteins in blood were all first expressed as mRNAs from genes within cells. There are databases of human proteins that are known to be expressed as mRNA in human cells and tissues. Proteins identified fro...

    Authors: Peihong Zhu, Peter Bowden, Voitek Pendrak, Herbert Thiele, Du Zhang, Michael Siu, Eleftherios P. Diamandis and John Marshall

    Citation: Clinical Proteomics 2006 2:BF02752500

    Content type: Original Article

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  24. Fetal growth restriction (FGR) affects 3–5% of pregnancies and is associated with increased perinatal morbidity and mortality. Currently, there is no reliable biochemical test to differentiate a pathological F...

    Authors: Madhulika B. Gupta, Maxim D. Seferovic, Suya Liu, Robert J. Gratton, Amanda Doherty-Kirby, Gilles A. Lajoie and Victor K. M. Han

    Citation: Clinical Proteomics 2006 2:BF02752499

    Content type: Original Article

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  25. Epidemiological studies have shown that Asian populations display a lower incidence of hormone-dependant cancers, cardiovascular disease, osteoporosis, and menopausal ailments compared to Western societies. Av...

    Authors: Nicki Konstantakopoulos, Martin R. Larsen, Ian G. Campbell, Michael A. Quinn, Mark S. Baker, Harry M. Georgiou and Gregory E. Rice

    Citation: Clinical Proteomics 2006 2:BF02752498

    Content type: Original Article

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  26. In this manuscript, we compared serum profiles obtained with two related technologies, SELDI-TOF and Clinprot, using a single bioinformatic algorithm. These two approaches rely on mass spectrometry to detect p...

    Authors: Christelle Reynès, Stéphane Roche, Laurent Tiers, Robert Sabatier, Patrick Jouin, Nicolas Molinari and Sylvain Lehmann

    Citation: Clinical Proteomics 2006 2:BF02752497

    Content type: Original Article

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  27. Reversible phosphorylation is one of the most important posttranslational modifications of cellular proteins. Mass spectrometry is a widely used technique in the characterization of phosphorylated proteins and...

    Authors: Dongxia Wang, Philip A. Cole and Robert J. Cotter

    Citation: Clinical Proteomics 2006 2:BF02752496

    Content type: Original Article

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  28. The future of cancer diagnostics will be based on a panel of proteomic biomarkers. They could be used to detect cancer at an early stage, to predict and to direct therapies. Enzymes and related proteins are im...

    Authors: Daniel W. Chan and Shu-Ling Liang

    Citation: Clinical Proteomics 2006 2:BF02752495

    Content type: Editorial

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  29. Owing to its noninvasive collection, saliva is considered as a potent diagnostic fluid. The goal of this study was to investigate the modification of the salivary proteome occurring in type 1 diabetes to highl...

    Authors: Christophe Hirtz, François Chevalier, Nicolas Sommerer, Isabelle Raingeard, Jacques Bringer, Michel Rossignol and Dominique Deville de Périere

    Citation: Clinical Proteomics 2006 2:201117

    Content type: Original Article

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  30. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) serves as a rapid and accurate means to determine masses of proteins independent of their shapes or interactions with...

    Authors: Glen L. Hortin and Alan T. Remaley

    Citation: Clinical Proteomics 2006 2:201103

    Content type: Original Article

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  31. Recent studies have evaluated proper acquisition and storage procedures for the use of serum or plasma for mass spectrometry (MS)-based proteomics. The present study examines the proteome stability of human ce...

    Authors: Srikanth Ranganathan, Anna Polshyna, Georgina Nicholl, James Lyons-Weiler and Robert Bowser

    Citation: Clinical Proteomics 2006 2:20191

    Content type: Original Article

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  32. There is a great desire to relate the patterns of endogenous peptides in blood to human disease and drug response. The best practices for the preparation of blood fluids for analysis are not clear and also rel...

    Authors: Declan Williams, Peihong Zhu, Peter Bowden, Catherine Stacey, Mike McDonell, Paul Kowalski, Jane Marie Kowalski, Ken Evans, Eleftherios P. Diamandis, K. W. Michael Siu and John Marshall

    Citation: Clinical Proteomics 2006 2:20167

    Content type: Original Article

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  33. Despite many years of research efforts and continued progress in the identification of urine markers for detection of bladder cancer, none of the markers described to date has been able to replace cystoscopy a...

    Authors: Pavel Gromov, Josè M. A. Moreira, Irina Gromova and Julio E. Celis

    Citation: Clinical Proteomics 2006 2:20145

    Content type: Original Article

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  34. Data mining application to proteomic data from mass spectrometry has gained much interest in recent years. Advances made in proteomics and mass spectrometry have resulted in considerable amount of data that ca...

    Authors: Asha Thomas, Georgia D. Tourassi, Adel S. Elmaghraby, Roland Valdes Jr. and Saeed A. Jortani

    Citation: Clinical Proteomics 2006 2:20113

    Content type: Original Article

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  35. Although most patients with early-stage nasopharyngeal carcinoma (NPC) can be cured by radiotherapy, there is a high recurrence rate in patients with advanced NPC. We attempted to identify proteomic patterns i...

    Authors: Terence C. W. Poon, Shuk Man Chow, Brigette B. Y. Ma, Edwin P. Hui and Anthony T. C. Chan

    Citation: Clinical Proteomics 2004 1:13104365

    Content type: Original Article

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  36. The use of proteomic analysis to discover proteins (previously identified or unknown) in a tissue sample is a valuable tool. However, there is a limit to the extent one can validate a discovery with any single...

    Authors: Stanley M. Belkowski, Raymond W. Colburn, Dennis J. Stone, Christopher R. Van Besien, Deborah Polkovitch, Patricia Andrade-Gordon and Michael R. D'Andrea

    Citation: Clinical Proteomics 2004 1:13104249

    Content type: Original Article

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  37. Methotrexate has been a clinical agent used in cancer, immunosuppression, rheumatoid arthritis, and other highly proliferative diseases for many years, yet its underlying molecular mechanism of action in these...

    Authors: Jacek J. Slon-Usakiewicz, Andrew Pasternak, Neil Reid and Leticia M. Toledo-Sherman

    Citation: Clinical Proteomics 2004 1:13104227

    Content type: Molecular Targets

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