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Clinical Proteomics


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  1. Content type: Research

    Hepatocellular carcinoma is an aggressive malignancy with poor prognosis and easy to recur even the tumor is totally removed by surgery. Portal vascular invasion is one of the major factors contributing to tum...

    Authors: Wei-Chen Lee, Hong-Shiue Chou, Ting-Jung Wu, Chen-Fang Lee, Pao-Yueh Hsu, Hsiu-Ying Hsu, Tsung-Han Wu and Kun-Ming Chan

    Citation: Clinical Proteomics 2017 14:29

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  2. Content type: Research

    The aim was to improve upon an existing blood-based colorectal cancer (CRC) test directed to high-risk symptomatic patients, by developing a new CRC classifier to be used with a new test embodiment. The new te...

    Authors: Lisa J. Croner, Roslyn Dillon, Athit Kao, Stefanie N. Kairs, Ryan Benz, Ib J. Christensen, Hans J. Nielsen, John E. Blume and Bruce Wilcox

    Citation: Clinical Proteomics 2017 14:28

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  3. Content type: Research

    Post-stroke infections occur in 20–36% of stroke patients and are associated with high morbidity and mortality rates. Early identification of patients at risk of developing an infection could improve care via ...

    Authors: L. Azurmendi, V. Lapierre-Fetaud, J. Schneider, J. Montaner, M. Katan and Jean-Charles Sanchez

    Citation: Clinical Proteomics 2017 14:27

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  4. Content type: Research

    Mesenchymal stem/stromal cells (MSC) display a range of immunoregulatory properties which can be enhanced by the exposure to cytokines such interferon γ (IFN-γ). However the compositional changes associated wi...

    Authors: Qingdong Guan, Peyman Ezzati, Victor Spicer, Oleg Krokhin, Donna Wall and John A. Wilkins

    Citation: Clinical Proteomics 2017 14:26

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  5. Content type: Research

    The number of pulmonary nodules detected in the US is expected to increase substantially following recent recommendations for nationwide CT-based lung cancer screening. Given the low specificity of CT screenin...

    Authors: Charles E. Birse, Jennifer L. Tomic, Harvey I. Pass, William N. Rom and Robert J. Lagier

    Citation: Clinical Proteomics 2017 14:25

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  6. Content type: Research

    The pathogenesis of systemic lupus erythematosus (SLE) is poorly understood but has been linked to defective clearance of subcellular particulate material from the circulation. This study investigates the orig...

    Authors: Ole Østergaard, Christoffer Tandrup Nielsen, Julia T. Tanassi, Line V. Iversen, Søren Jacobsen and Niels H. H. Heegaard

    Citation: Clinical Proteomics 2017 14:23

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  7. Content type: Research

    Atherosclerotic plaque rupture is the culprit event which underpins most acute vascular syndromes such as acute myocardial infarction. Novel biomarkers of plaque rupture could improve biological understanding...

    Authors: Regent Lee, Roman Fischer, Philip D. Charles, David Adlam, Alessandro Valli, Katalin Di Gleria, Rajesh K. Kharbanda, Robin P. Choudhury, Charalambos Antoniades, Benedikt M. Kessler and Keith M. Channon

    Citation: Clinical Proteomics 2017 14:22

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  8. Content type: Research

    Mycobacterium tuberculosis (Mtb) is the causative agent of Tuberculosis (TB), the number one cause of death due to an infectious disease. TB diagnosis is performed by microscopy, cultu...

    Authors: Carolina Mehaffy, Karen M. Dobos, Payam Nahid and Nicole A. Kruh-Garcia

    Citation: Clinical Proteomics 2017 14:21

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  9. Content type: Research

    Ovarian cancer is one of the most lethal gynecological malignancies, in which platinum resistance is a common cause of its relapse and death. Glycosylation has been reported to be involved in drug resistance, ...

    Authors: Ran Zhao, Wenjun Qin, Ruihuan Qin, Jing Han, Can Li, Yisheng Wang and Congjian Xu

    Citation: Clinical Proteomics 2017 14:20

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  10. Content type: Research

    The Xiaoke Pill containing Chinese herb extracts and Glibenclamide, is used in therapy for type 2 diabetes mellitus (T2DM), and is effective in reducing the risk of hypoglycemia and improving diabetes symptoms...

    Authors: Xiuying Zhang, Haidan Sun, Sanjoy K. Paul, Quanhui Wang, Xiaomin Lou, Guixue Hou, Bo Wen, Linong Ji and Siqi Liu

    Citation: Clinical Proteomics 2017 14:19

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  11. Content type: Research

    To develop a new molecular targeted treatment for brain (AVMs), identification of membrane proteins that are localised on the AVM endothelium is crucial. Current treatment methods are surgery and radiosurgery....

    Authors: Margaret Simonian, Rachel R. Ogorzalek Loo, Nalaka Rannulu, Joseph A. Loo, Mark P. Molloy and Marcus A. Stoodley

    Citation: Clinical Proteomics 2017 14:17

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  12. Content type: Research

    Nephrotic syndrome (NS) is a nonspecific kidney disorder, commonly caused by minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN). Here we analyzed urinary p...

    Authors: Young Wook Choi, Yang Gyun Kim, Min-Young Song, Ju-Young Moon, Kyung-Hwan Jeong, Tae-Won Lee, Chun-Gyoo Ihm, Kang-Sik Park and Sang-Ho Lee

    Citation: Clinical Proteomics 2017 14:18

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  13. Content type: Research

    Epithelial ovarian carcinomas encompass a heterogeneous group of diseases with a poor 5-year survival rate. Serous carcinoma is the most common type. Most FDA-approved serum tumor markers are glycoproteins. Th...

    Authors: Qing Kay Li, Punit Shah, Yuan Tian, Yingwei Hu, Richard B. S. Roden, Hui Zhang and Daniel W. Chan

    Citation: Clinical Proteomics 2017 14:16

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  14. Content type: Research

    Aberrant expression of Na+/K+-ATPase α1 subunit (ATP1A1) is widely observed in multiple types of tumors, and its tissue-specific expression relates to cancer development. However, the functions and molecular mech...

    Authors: Dan Zhang, Peng Zhang, Pengbo Yang, Yu He, Xixi Wang, Yanfang Yang, Hongxia Zhu, Ningzhi Xu and Shufang Liang

    Citation: Clinical Proteomics 2017 14:15

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  15. Content type: Research

    The systematic mechanisms of acute intracerebral hemorrhage are still unknown and unverified, although many recent researches have indicated the secondary insults. This study was aimed to disclose the patholog...

    Authors: Guo-chun Li, Lina Zhang, Ming Yu, Haiyu Jia, Ting Tian, Junqin Wang, Fuqiang Wang and Ling Zhou

    Citation: Clinical Proteomics 2017 14:14

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  16. Content type: Research

    X-linked retinoschisis (XLRS) is a vitreoretinal degenerative disorder causing vision deterioration, due to structural defects in retina. The hallmark of this disease includes radial streaks arising from the f...

    Authors: Dhandayuthapani Sudha, Mahdokht Kohansal-Nodehi, Purnima Kovuri, Srikanth Srinivas Manda, Srividya Neriyanuri, Lingam Gopal, Pramod Bhende, Subbulakshmi Chidambaram and Jayamuruga Pandian Arunachalam

    Citation: Clinical Proteomics 2017 14:13

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  17. Content type: Research

    Calcific aortic stenosis (CAS) is the most common heart valve disease in the elderly, representing an important economic and social burden in developed countries. Currently, there is no way to predict either t...

    Authors: Tatiana Martin-Rojas, Laura Mourino-Alvarez, Felix Gil-Dones, Fernando de la Cuesta, Esther Rosello-Lleti, Carlos M. Laborde, Miguel Rivera, Luis Fernando Lopez-Almodovar, Juan Antonio Lopez, Finn Akerstrom, Luis R. Padial and Maria G. Barderas

    Citation: Clinical Proteomics 2017 14:12

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  18. Content type: Review

    Subcellular microvesicles (MVs) have attracted increasing interest during the past decades. While initially considered as inert cellular debris, several important roles for MVs in physiological homeostasis, ca...

    Authors: Christoffer T. Nielsen, Ole Østergaard, Niclas S. Rasmussen, Søren Jacobsen and Niels H. H. Heegaard

    Citation: Clinical Proteomics 2017 14:11

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  19. Content type: Research

    Recent epidemiological studies indicate that only 30–50% of undiagnosed type 2 diabetes mellitus (T2DM) patients are identified using glycated hemoglobin (HbA1c) and elevated fasting plasma glucose (FPG) levels. ...

    Authors: Sandro Spiller, Yichao Li, Matthias Blüher, Lonnie Welch and Ralf Hoffmann

    Citation: Clinical Proteomics 2017 14:10

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  20. Content type: Research

    Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages remains challenging and is imp...

    Authors: Florence Quesada-Calvo, Charlotte Massot, Virginie Bertrand, Rémi Longuespée, Noëlla Blétard, Joan Somja, Gabriel Mazzucchelli, Nicolas Smargiasso, Dominique Baiwir, Marie-Claire De Pauw-Gillet, Philippe Delvenne, Michel Malaise, Carla Coimbra Marques, Marc Polus, Edwin De Pauw, Marie-Alice Meuwis…

    Citation: Clinical Proteomics 2017 14:9

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  21. Content type: Research

    Tubulointerstitial nephritis antigen-like 1 protein (TINAGL1), is a matricellular protein, known to play role in cell adhesion and cell receptor interaction. Research related to TINAGL1 is limited to cell cult...

    Authors: Sheon Mary, Mahesh J. Kulkarni, Savita S. Mehendale, Sadhana R. Joshi and Ashok P. Giri

    Citation: Clinical Proteomics 2017 14:8

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  22. Content type: Research

    Endometriosis is a chronic gynecological inflammatory disease characterized by the presence of functional endometrial glands and stroma outside of the uterine cavity. It affects 7–10% of women of reproductive ...

    Authors: Giuseppe Grande, Federica Vincenzoni, Domenico Milardi, Giuseppina Pompa, Domenico Ricciardi, Erika Fruscella, Francesca Mancini, Alfredo Pontecorvi, Massimo Castagnola and Riccardo Marana

    Citation: Clinical Proteomics 2017 14:7

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  23. Content type: Research

    Nasopharyngeal carcinoma (NPC) is a major head and neck cancer with high occurrence in Southeast Asia and southern China. We aimed to identify autoantibodies that may contribute to early detection of NPC.

    Authors: Lie-Hao Lin, Yi-Wei Xu, Li-Sheng Huang, Chao-Qun Hong, Tian-Tian Zhai, Lian-Di Liao, Wen-Jie Lin, Li-Yan Xu, Kai Zhang, En-Min Li and Yu-Hui Peng

    Citation: Clinical Proteomics 2017 14:6

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