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Clinical Proteomics

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  1. Content type: Research

    Epithelial ovarian carcinomas encompass a heterogeneous group of diseases with a poor 5-year survival rate. Serous carcinoma is the most common type. Most FDA-approved serum tumor markers are glycoproteins. Th...

    Authors: Qing Kay Li, Punit Shah, Yuan Tian, Yingwei Hu, Richard B. S. Roden, Hui Zhang and Daniel W. Chan

    Citation: Clinical Proteomics 2017 14:16

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  2. Content type: Research

    Aberrant expression of Na+/K+-ATPase α1 subunit (ATP1A1) is widely observed in multiple types of tumors, and its tissue-specific expression relates to cancer development. However, the functions and molecular mech...

    Authors: Dan Zhang, Peng Zhang, Pengbo Yang, Yu He, Xixi Wang, Yanfang Yang, Hongxia Zhu, Ningzhi Xu and Shufang Liang

    Citation: Clinical Proteomics 2017 14:15

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  3. Content type: Research

    The systematic mechanisms of acute intracerebral hemorrhage are still unknown and unverified, although many recent researches have indicated the secondary insults. This study was aimed to disclose the patholog...

    Authors: Guo-chun Li, Lina Zhang, Ming Yu, Haiyu Jia, Ting Tian, Junqin Wang, Fuqiang Wang and Ling Zhou

    Citation: Clinical Proteomics 2017 14:14

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  4. Content type: Research

    X-linked retinoschisis (XLRS) is a vitreoretinal degenerative disorder causing vision deterioration, due to structural defects in retina. The hallmark of this disease includes radial streaks arising from the f...

    Authors: Dhandayuthapani Sudha, Mahdokht Kohansal-Nodehi, Purnima Kovuri, Srikanth Srinivas Manda, Srividya Neriyanuri, Lingam Gopal, Pramod Bhende, Subbulakshmi Chidambaram and Jayamuruga Pandian Arunachalam

    Citation: Clinical Proteomics 2017 14:13

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  5. Content type: Research

    Calcific aortic stenosis (CAS) is the most common heart valve disease in the elderly, representing an important economic and social burden in developed countries. Currently, there is no way to predict either t...

    Authors: Tatiana Martin-Rojas, Laura Mourino-Alvarez, Felix Gil-Dones, Fernando de la Cuesta, Esther Rosello-Lleti, Carlos M. Laborde, Miguel Rivera, Luis Fernando Lopez-Almodovar, Juan Antonio Lopez, Finn Akerstrom, Luis R. Padial and Maria G. Barderas

    Citation: Clinical Proteomics 2017 14:12

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  6. Content type: Review

    Subcellular microvesicles (MVs) have attracted increasing interest during the past decades. While initially considered as inert cellular debris, several important roles for MVs in physiological homeostasis, ca...

    Authors: Christoffer T. Nielsen, Ole Østergaard, Niclas S. Rasmussen, Søren Jacobsen and Niels H. H. Heegaard

    Citation: Clinical Proteomics 2017 14:11

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  7. Content type: Research

    Recent epidemiological studies indicate that only 30–50% of undiagnosed type 2 diabetes mellitus (T2DM) patients are identified using glycated hemoglobin (HbA1c) and elevated fasting plasma glucose (FPG) levels. ...

    Authors: Sandro Spiller, Yichao Li, Matthias Blüher, Lonnie Welch and Ralf Hoffmann

    Citation: Clinical Proteomics 2017 14:10

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  8. Content type: Research

    Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages remains challenging and is imp...

    Authors: Florence Quesada-Calvo, Charlotte Massot, Virginie Bertrand, Rémi Longuespée, Noëlla Blétard, Joan Somja, Gabriel Mazzucchelli, Nicolas Smargiasso, Dominique Baiwir, Marie-Claire De Pauw-Gillet, Philippe Delvenne, Michel Malaise, Carla Coimbra Marques, Marc Polus, Edwin De Pauw, Marie-Alice Meuwis…

    Citation: Clinical Proteomics 2017 14:9

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  9. Content type: Research

    Tubulointerstitial nephritis antigen-like 1 protein (TINAGL1), is a matricellular protein, known to play role in cell adhesion and cell receptor interaction. Research related to TINAGL1 is limited to cell cult...

    Authors: Sheon Mary, Mahesh J. Kulkarni, Savita S. Mehendale, Sadhana R. Joshi and Ashok P. Giri

    Citation: Clinical Proteomics 2017 14:8

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  10. Content type: Research

    Endometriosis is a chronic gynecological inflammatory disease characterized by the presence of functional endometrial glands and stroma outside of the uterine cavity. It affects 7–10% of women of reproductive ...

    Authors: Giuseppe Grande, Federica Vincenzoni, Domenico Milardi, Giuseppina Pompa, Domenico Ricciardi, Erika Fruscella, Francesca Mancini, Alfredo Pontecorvi, Massimo Castagnola and Riccardo Marana

    Citation: Clinical Proteomics 2017 14:7

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  11. Content type: Research

    Nasopharyngeal carcinoma (NPC) is a major head and neck cancer with high occurrence in Southeast Asia and southern China. We aimed to identify autoantibodies that may contribute to early detection of NPC.

    Authors: Lie-Hao Lin, Yi-Wei Xu, Li-Sheng Huang, Chao-Qun Hong, Tian-Tian Zhai, Lian-Di Liao, Wen-Jie Lin, Li-Yan Xu, Kai Zhang, En-Min Li and Yu-Hui Peng

    Citation: Clinical Proteomics 2017 14:6

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  12. Content type: Research

    Kallikrein 9 (KLK9) is a member of the human kallikrein-related peptidases family, whose physiological role and implications in disease processes remain unclear. The active form of the enzyme is predicted to h...

    Authors: Panagiota Filippou, Dimitrios Korbakis, Sofia Farkona, Antoninus Soosaipillai, Theano Karakosta and Eleftherios P. Diamandis

    Citation: Clinical Proteomics 2017 14:4

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  13. Content type: Research

    Glycans play critical roles in a number of biological activities. Two common types of glycans, N-linked and O-linked, have been extensively analyzed in the last decades. N-glycans are typically released from g...

    Authors: Shuang Yang, Naseruddin Höti, Weiming Yang, Yang Liu, Lijun Chen, Shuwei Li and Hui Zhang

    Citation: Clinical Proteomics 2017 14:3

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  14. Content type: Research

    sIgE and sIgG4 detection is necessary for more accurate and effective type I hypersensitivity diagnostics and the estimation of disease development. Typically, the analyses of these antibodies are performed se...

    Authors: Guzel Feyzkhanova, Sergei Voloshin, Olga Smoldovskaya, Alla Arefieva, Marina Filippova, Viktor Barsky, Ludmila Pavlushkina, Veronika Butvilovskaya, Alexei Tikhonov, Yuri Reznikov and Alla Rubina

    Citation: Clinical Proteomics 2017 14:1

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  15. Content type: Research

    Autism is a severe childhood neurological disorder with poorly understood etiology and pathology. Currently, there is no authentic laboratory test to confirm the diagnosis of autism. Oxidative damage may play ...

    Authors: Chengyun Feng, Youjiao Chen, Jintao Pan, Aochu Yang, Li Niu, Jie Min, Xianling Meng, Liping Liao, Kaoyuan Zhang and Liming Shen

    Citation: Clinical Proteomics 2017 14:2

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  16. Content type: Review

    Proteomics plays an increasingly important role in our quest to understand cardiovascular biology. Fueled by analytical and computational advances in the past decade, proteomics applications can now go beyond ...

    Authors: Maggie P. Y. Lam, Edward Lau, Dominic C. M. Ng, Ding Wang and Peipei Ping

    Citation: Clinical Proteomics 2016 13:23

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  17. Content type: Research

    Excretory-secretory (ES) proteins of E. histolytica are thought to play important roles in the host invasion, metabolism, and defence. Elucidation of the types and functions of E. histolytica ES proteins can furt...

    Authors: Jorim Anak Ujang, Soon Hong Kwan, Mohd Nazri Ismail, Boon Huat Lim, Rahmah Noordin and Nurulhasanah Othman

    Citation: Clinical Proteomics 2016 13:33

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  18. Content type: Research

    High quality clinical samples are critical for meaningful interpretation of data obtained in both basic and translational medicine. More specifically, optimized pre-analysis handling to bio-sample is crucial ...

    Authors: Kai Liang, Hongmei Wu, Tony Y. Hu and Yan Li

    Citation: Clinical Proteomics 2016 13:34

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  19. Content type: Research

    Ovarian cancer is the most lethal gynecological malignancy due to its frequent recurrence and drug resistance even after successful initial treatment. Accumulating scientific evidence indicates that subpopulat...

    Authors: Ran Zhao, Xiaoxia Liu, Yisheng Wang, Xiaoxiang Jie, Ruihuan Qin, Wenjun Qin, Mengyu Zhang, Haiyan Tai, Caiting Yang, Lili Li, Peike Peng, Miaomiao Shao, Xingwang Zhang, Hao Wu, Yuanyuan Ruan, Congjian Xu…

    Citation: Clinical Proteomics 2016 13:32

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  20. Content type: Review

    Proteomics has emerged as a highly promising bioanalytical technique in various aspects of applied biological research. In Indian academia, proteomics research has grown remarkably over the last decade. It is ...

    Authors: Somaditya Mukherjee and Arun Bandyopadhyay

    Citation: Clinical Proteomics 2016 13:21

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  21. Content type: Research

    Lung cancer is the leading cause of cancer mortality in the United States. Non-small cell lung cancer accounts for 85% of all lung cancers for which adenocarcinoma is the most common histological type. Managem...

    Authors: Johannes F. Fahrmann, Dmitry Grapov, Brett S. Phinney, Carol Stroble, Brian C. DeFelice, William Rom, David R. Gandara, Yanhong Zhang, Oliver Fiehn, Harvey Pass and Suzanne Miyamoto

    Citation: Clinical Proteomics 2016 13:31

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  22. Content type: Research

    Correct identification of the amyloidosis-causing protein is crucial for clinical management. Recently the Mayo Clinic reported laser-capture microdissection (LCM) with liquid chromatography-coupled tandem mas...

    Authors: Peter Mollee, Samuel Boros, Dorothy Loo, Jayde E. Ruelcke, Vanessa A. Lakis, Kim-Anh Lê Cao, Patricia Renaut and Michelle M. Hill

    Citation: Clinical Proteomics 2016 13:30

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  23. Content type: Research

    Retinoblastoma is an ocular neoplastic cancer caused primarily due to the mutation/deletion of RB1 gene. Due to the rarity of the disease very limited information is available on molecular changes in primary r...

    Authors: Ravikanth Danda, Kalaivani Ganapathy, Gajanan Sathe, Anil K. Madugundu, Sharavan Ramachandran, Uma Maheswari Krishnan, Vikas Khetan, Pukhraj Rishi, T. S. Keshava Prasad, Akhilesh Pandey, Subramanian Krishnakumar, Harsha Gowda and Sailaja V. Elchuri

    Citation: Clinical Proteomics 2016 13:29

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  24. Content type: Research

    Early recurrence after surgical resection is a hallmark of poor prognosis in hepatocellular carcinoma (HCC). To determine the proteomic background of early recurrence of HCC, we focused on apoptosis-related pr...

    Authors: Noriaki Morofuji, Hidenori Ojima, Nobuyoshi Hiraoka, Takuji Okusaka, Minoru Esaki, Satoshi Nara, Kazuaki Shimada, Yoshiro Kishi and Tadashi Kondo

    Citation: Clinical Proteomics 2016 13:28

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