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Clinical Proteomics

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  1. Content type: Research

    Normal human EDTA plasma samples were collected on ice, processed ice cold, and stored in a freezer at – 80 °C prior to experiments. Plasma test samples from the – 80 °C freezer were thawed on ice or intention...

    Authors: Jaimie Dufresne, Angelique Florentinus-Mefailoski, Juliet Ajambo, Ammara Ferwa, Peter Bowden and John Marshall

    Citation: Clinical Proteomics 2017 14:41

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  2. Content type: Research

    Vulvar squamous cell carcinoma (vSCC) is a rare but debilitating disease. One vSCC variant comprises tumor cells that grow and expand as a cohesive sheet of cells that “pushes” and compresses the associated ly...

    Authors: Emily R. Holthoff, Stephanie D. Byrum, Samuel G. Mackintosh, Thomas Kelly, Alan J. Tackett, Charles M. Quick and Steven R. Post

    Citation: Clinical Proteomics 2017 14:40

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  3. Content type: Research

    The tryptic peptides from ice cold versus room temperature plasma were identified by C18 liquid chromatography and micro electrospray ionization tandem mass spectrometry (LC–ESI–MS/MS). Samples collected on ic...

    Authors: Jaimie Dufresne, Angelique Florentinus-Mefailoski, Juliet Ajambo, Ammara Ferwa, Peter Bowden and John Marshall

    Citation: Clinical Proteomics 2017 14:39

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  4. Content type: Research

    It is well known that fibrin network binds a large variety of proteins, including inhibitors and activators of fibrinolysis, which may affect clot properties, such as stability and susceptibility to fibrinolys...

    Authors: Aneta Stachowicz, Jakub Siudut, Maciej Suski, Rafał Olszanecki, Ryszard Korbut, Anetta Undas and Jacek R. Wiśniewski

    Citation: Clinical Proteomics 2017 14:38

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  5. Content type: Research

    Idiopathic macular holes (IMH) are full-thickness defects of retinal tissue that cause severe vision loss due to disruption of the anatomic fovea. Abnormal vitreous traction is involved in the formation of mac...

    Authors: Pingbo Zhang, Min Zhu, Yuming Zhao, Jiang Qian, Craig Dufresne, Randi Turner, Richard D. Semba and Sharon D. Solomon

    Citation: Clinical Proteomics 2017 14:37

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  6. Content type: Research

    Bovine purified protein derivative (bPPD) and avian purified protein derivative (aPPD) are widely used for bovine tuberculosis diagnosis. However, little is known about their qualitative and quantitative chara...

    Authors: José Antonio Infantes-Lorenzo, Inmaculada Moreno, María de los Ángeles Risalde, Álvaro Roy, Margarita Villar, Beatriz Romero, Nieves Ibarrola, José de la Fuente, Eugenia Puentes, Lucía de Juan, Christian Gortázar, Javier Bezos, Lucas Domínguez and Mercedes Domínguez

    Citation: Clinical Proteomics 2017 14:36

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  7. Content type: Research

    Thirty human EDTA plasma samples from male and female subjects ranging in age from 24 to 74 years were collected on ice, processed ice cold and stored frozen at −80 °C, in liquid nitrogen (LN2), or freeze dri...

    Authors: Jaimie Dufresne, Trung Hoang, Juliet Ajambo, Angelique Florentinus-Mefailoski, Peter Bowden and John Marshall

    Citation: Clinical Proteomics 2017 14:35

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  8. Content type: Research

    Currently, there are no FDA approved screening tools for detecting early stage ovarian cancer in the general population. Development of a biomarker-based assay for early detection would significantly improve t...

    Authors: Kristin L. M. Boylan, Kate Geschwind, Joseph S. Koopmeiners, Melissa A. Geller, Timothy K. Starr and Amy P. N. Skubitz

    Citation: Clinical Proteomics 2017 14:34

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  9. Content type: Research

    Cancer associated fibroblasts are activated in the tumor microenvironment and contribute to tumor progression, angiogenesis, extracellular matrix remodeling, and inflammation.

    Authors: Daniel Drev, Andrea Bileck, Zeynep N. Erdem, Thomas Mohr, Gerald Timelthaler, Andrea Beer, Christopher Gerner and Brigitte Marian

    Citation: Clinical Proteomics 2017 14:33

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  10. Content type: Research

    Systemic lupus erythematosus (SLE) is a remarkably heterogeneous autoimmune disease. Despite tremendous efforts, our knowledge of serum protein patterns in severe SLE phenotypes is still limited. We investigat...

    Authors: Anna Petrackova, Andrea Smrzova, Petr Gajdos, Marketa Schubertova, Petra Schneiderova, Pavel Kromer, Vaclav Snasel, Martina Skacelova, Frantisek Mrazek, Josef Zadrazil, Pavel Horak and Eva Kriegova

    Citation: Clinical Proteomics 2017 14:32

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  11. Content type: Research

    Non-small cell lung carcinoma (NSCLC) remains the leading cause of cancer deaths in the United States. More than half of NSCLC patients have clinical presentations with locally advanced or metastatic disease a...

    Authors: Shuang Yang, Lijun Chen, Daniel W. Chan, Qing Kay Li and Hui Zhang

    Citation: Clinical Proteomics 2017 14:31

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  12. Content type: Research

    The clinical course of IgA nephropathy (IgAN) is variable and complement activation may predict prognosis. The present study investigated whether glomerular abundance of complement proteins associates with pro...

    Authors: Teodora Ioana Flavia Paunas, Kenneth Finne, Sabine Leh, Hans-Peter Marti, Tom Eirik Mollnes, Frode Berven and Bjørn Egil Vikse

    Citation: Clinical Proteomics 2017 14:30

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  13. Content type: Research

    Hepatocellular carcinoma is an aggressive malignancy with poor prognosis and easy to recur even the tumor is totally removed by surgery. Portal vascular invasion is one of the major factors contributing to tum...

    Authors: Wei-Chen Lee, Hong-Shiue Chou, Ting-Jung Wu, Chen-Fang Lee, Pao-Yueh Hsu, Hsiu-Ying Hsu, Tsung-Han Wu and Kun-Ming Chan

    Citation: Clinical Proteomics 2017 14:29

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  14. Content type: Research

    The aim was to improve upon an existing blood-based colorectal cancer (CRC) test directed to high-risk symptomatic patients, by developing a new CRC classifier to be used with a new test embodiment. The new te...

    Authors: Lisa J. Croner, Roslyn Dillon, Athit Kao, Stefanie N. Kairs, Ryan Benz, Ib J. Christensen, Hans J. Nielsen, John E. Blume and Bruce Wilcox

    Citation: Clinical Proteomics 2017 14:28

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  15. Content type: Research

    Post-stroke infections occur in 20–36% of stroke patients and are associated with high morbidity and mortality rates. Early identification of patients at risk of developing an infection could improve care via ...

    Authors: L. Azurmendi, V. Lapierre-Fetaud, J. Schneider, J. Montaner, M. Katan and Jean-Charles Sanchez

    Citation: Clinical Proteomics 2017 14:27

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  16. Content type: Research

    Mesenchymal stem/stromal cells (MSC) display a range of immunoregulatory properties which can be enhanced by the exposure to cytokines such interferon γ (IFN-γ). However the compositional changes associated wi...

    Authors: Qingdong Guan, Peyman Ezzati, Victor Spicer, Oleg Krokhin, Donna Wall and John A. Wilkins

    Citation: Clinical Proteomics 2017 14:26

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  17. Content type: Research

    The number of pulmonary nodules detected in the US is expected to increase substantially following recent recommendations for nationwide CT-based lung cancer screening. Given the low specificity of CT screenin...

    Authors: Charles E. Birse, Jennifer L. Tomic, Harvey I. Pass, William N. Rom and Robert J. Lagier

    Citation: Clinical Proteomics 2017 14:25

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  18. Content type: Research

    The pathogenesis of systemic lupus erythematosus (SLE) is poorly understood but has been linked to defective clearance of subcellular particulate material from the circulation. This study investigates the orig...

    Authors: Ole Østergaard, Christoffer Tandrup Nielsen, Julia T. Tanassi, Line V. Iversen, Søren Jacobsen and Niels H. H. Heegaard

    Citation: Clinical Proteomics 2017 14:23

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  19. Content type: Research

    Atherosclerotic plaque rupture is the culprit event which underpins most acute vascular syndromes such as acute myocardial infarction. Novel biomarkers of plaque rupture could improve biological understanding...

    Authors: Regent Lee, Roman Fischer, Philip D. Charles, David Adlam, Alessandro Valli, Katalin Di Gleria, Rajesh K. Kharbanda, Robin P. Choudhury, Charalambos Antoniades, Benedikt M. Kessler and Keith M. Channon

    Citation: Clinical Proteomics 2017 14:22

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  20. Content type: Research

    Mycobacterium tuberculosis (Mtb) is the causative agent of Tuberculosis (TB), the number one cause of death due to an infectious disease. TB diagnosis is performed by microscopy, cultu...

    Authors: Carolina Mehaffy, Karen M. Dobos, Payam Nahid and Nicole A. Kruh-Garcia

    Citation: Clinical Proteomics 2017 14:21

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  21. Content type: Research

    Ovarian cancer is one of the most lethal gynecological malignancies, in which platinum resistance is a common cause of its relapse and death. Glycosylation has been reported to be involved in drug resistance, ...

    Authors: Ran Zhao, Wenjun Qin, Ruihuan Qin, Jing Han, Can Li, Yisheng Wang and Congjian Xu

    Citation: Clinical Proteomics 2017 14:20

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  22. Content type: Research

    The Xiaoke Pill containing Chinese herb extracts and Glibenclamide, is used in therapy for type 2 diabetes mellitus (T2DM), and is effective in reducing the risk of hypoglycemia and improving diabetes symptoms...

    Authors: Xiuying Zhang, Haidan Sun, Sanjoy K. Paul, Quanhui Wang, Xiaomin Lou, Guixue Hou, Bo Wen, Linong Ji and Siqi Liu

    Citation: Clinical Proteomics 2017 14:19

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  23. Content type: Research

    To develop a new molecular targeted treatment for brain (AVMs), identification of membrane proteins that are localised on the AVM endothelium is crucial. Current treatment methods are surgery and radiosurgery....

    Authors: Margaret Simonian, Rachel R. Ogorzalek Loo, Nalaka Rannulu, Joseph A. Loo, Mark P. Molloy and Marcus A. Stoodley

    Citation: Clinical Proteomics 2017 14:17

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  24. Content type: Research

    Nephrotic syndrome (NS) is a nonspecific kidney disorder, commonly caused by minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN). Here we analyzed urinary p...

    Authors: Young Wook Choi, Yang Gyun Kim, Min-Young Song, Ju-Young Moon, Kyung-Hwan Jeong, Tae-Won Lee, Chun-Gyoo Ihm, Kang-Sik Park and Sang-Ho Lee

    Citation: Clinical Proteomics 2017 14:18

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