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  1. Lymph node metastasis (LNM) and lymphatic vasculature space infiltration (LVSI) in cervical cancer patients indicate a poor prognosis, but satisfactory methods for diagnosing these phenotypes are lacking. This...

    Authors: Sai Han, Xiaoli Liu, Shuang Ju, Wendi Mu, Gulijinaiti Abulikemu, Qianwei Zhen, Jiaqi Yang, Jingjing Zhang, Yi Li, Hongli Liu, Qian Chen, Baoxia Cui, Shuxia Wu and Youzhong Zhang
    Citation: Clinical Proteomics 2023 20:35
    Content type: Research Published on:

  3. Multiple sclerosis (MS) remains a highly unpredictable disease. Many hope that fluid biomarkers may contribute to better stratification of disease, aiding the personalisation of treatment decisions, ultimately...

    Authors: Dorsa Sohaei, Simon Thebault, Lisa M. Avery, Ihor Batruch, Brian Lam, Wei Xu, Rubah S. Saadeh, Isobel A. Scarisbrick, Eleftherios P. Diamandis, Ioannis Prassas and Mark S. Freedman
    Citation: Clinical Proteomics 2023 20:33
    Content type: Research Published on:

  5. Human plasma contains a wide variety of circulating proteins. These proteins can be important clinical biomarkers in disease and also possible drug targets. Large scale genomics studies of circulating proteins...

    Authors: Corinne Carland, Grace Png, Anders Malarstig, Pik Fang Kho, Stefan Gustafsson, Karl Michaelsson, Lars Lind, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Anna Ramisch, Erin Macdonald-Dunlop, Lucija Klaric, Peter K. Joshi, Yan Chen, Hanna M. Björck…
    Citation: Clinical Proteomics 2023 20:31
    Content type: Research Published on:

  6. The detection of SARS-CoV-2 biomarkers by real time PCR (rRT-PCR) has shown that the sensitivity of the test is negatively affected by low viral loads and the severity of the disease. This limitation can be ov...

    Authors: Lina M. Marin, George S. Katselis, Paulos Chumala, Stephen Sanche, Lucas Julseth, Erika Penz, Robert Skomro and Walter L. Siqueira
    Citation: Clinical Proteomics 2023 20:30
    Content type: Research Published on:

  7. Systemic lupus erythematosus (SLE) is a clinically and biologically heterogenous autoimmune disease. We aimed to investigate the plasma proteome of patients with active SLE to identify novel subgroups, or endo...

    Authors: Kevin Y. C. Su, John A. Reynolds, Rachel Reed, Rachael Da Silva, Janet Kelsall, Ivona Baricevic-Jones, David Lee, Anthony D. Whetton, Nophar Geifman, Neil McHugh and Ian N. Bruce
    Citation: Clinical Proteomics 2023 20:29
    Content type: Research Published on:

  8. Non-muscle-invasive bladder cancer (NMIBC) has a high recurrence rate and muscle-invasive bladder cancer (MIBC) has unfavorable outcomes in urothelial bladder cancer (UBC) patients. Complex UBC-related protein...

    Authors: Samira Tabaei, Mohammad Reza Haghshenas, Ali Ariafar, Kambiz Gilany, Allan Stensballe, Shirin Farjadian and Abbas Ghaderi
    Citation: Clinical Proteomics 2023 20:28
    Content type: Research Published on:

  9. Within healthy dietary patterns, manipulation of the proportion of macronutrient can reduce CVD risk. However, the biological pathways underlying healthy diet-disease associations are poorly understood. Using ...

    Authors: Hyunju Kim, Alice H. Lichtenstein, Peter Ganz, Edgar R. Miller III, Josef Coresh, Lawrence J. Appel and Casey M. Rebholz
    Citation: Clinical Proteomics 2023 20:27
    Content type: Research Published on:

  10. We have developed a rapid and highly specific assay for detecting and monitoring SARS-CoV-2 infections by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). As MALDI-T...

    Authors: Lydia Kollhoff, Marc Kipping, Manfred Rauh, Uta Ceglarek, Günes Barka, Frederik Barka and Andrea Sinz
    Citation: Clinical Proteomics 2023 20:26
    Content type: Research Published on:

  11. Close to three-quarters of ovarian cancer cases are frequently diagnosed at an advanced stage, with more than 70% of them failing to respond to primary therapy and relapsing within 5 years. There is an urgent ...

    Authors: Jin Song, Lori J. Sokoll, Zhen Zhang and Daniel W. Chan
    Citation: Clinical Proteomics 2023 20:25
    Content type: Research Published on:

  12. Immune thrombocytopenia (ITP) is a common autoimmune disease characterized by loss of immune tolerance to platelet autoantigens leading to excessive destruction and insufficient production of platelets.

    Authors: Dong-mei Yin, Dai Yuan, Rui-jie Sun, Hong-zhi Xu, Shou-yong Hun, Xiao-hui Sui and Ning-ning Shan
    Citation: Clinical Proteomics 2023 20:24
    Content type: Research Published on:

  13. Molecular components in blood, such as proteins, are used as biomarkers to detect or predict disease states, guide clinical interventions and aid in the development of therapies. While multiplexing proteomics ...

    Authors: Camilla Johansson, Helian Hunt, Mirko Signorelli, Fredrik Edfors, Andreas Hober, Anne-Sophie Svensson, Hanna Tegel, Björn Forstström, Annemieke Aartsma-Rus, Erik Niks, Pietro Spitali, Mathias Uhlén and Cristina Al-Khalili Szigyarto
    Citation: Clinical Proteomics 2023 20:23
    Content type: Research Published on:

  14. Unpredictable treatment responses have been an obstacle for the successful management of rheumatoid arthritis. Although numerous serum proteins have been proposed, there is a lack of integrative survey to comp...

    Authors: Shuo-Fu Chen, Fu-Chiang Yeh, Ching-Yun Chen and Hui-Yin Chang
    Citation: Clinical Proteomics 2023 20:22
    Content type: Review Published on:

  15. IgA nephropathy (IgAN) and IgA vasculitis with nephritis (IgAVN) are related glomerular diseases characterized by marked similarities in immunological and histological findings. We herein performed a comparati...

    Authors: Hajime Kaga, Hirotoshi Matsumura, Ayano Saito, Masaya Saito, Fumito Abe, Takehiro Suzuki, Naoshi Dohmae, Masafumi Odaka, Atsushi Komatsuda, Hideki Wakui and Naoto Takahashi
    Citation: Clinical Proteomics 2023 20:21
    Content type: Research Published on:

  16. Sepsis is a common worldwide health condition with high mortality. It is caused by a dysregulated immune response to the pathogen. Severe infections resulting in sepsis can be also determined by monitoring sev...

    Authors: Josef Dvorak, Jana Novakova, Lucie Kraftova, Vendula Studentova, Martin Matejovic, Jaroslav Radej, Thomas Karvunidis, Jan Horak, Marcela Kralovcova, Jaroslav Hrabak, Zuzana Kalaninova, Michael Volny, Petr Novak and Petr Pompach
    Citation: Clinical Proteomics 2023 20:20
    Content type: Research Published on:

  17. Halting progression of chronic kidney disease (CKD) to established end stage kidney disease is a major goal of global health research. The mechanism of CKD progression involves pro-inflammatory, pro-fibrotic, ...

    Authors: Carlos R. Ramírez Medina, Ibrahim Ali, Ivona Baricevic-Jones, Aghogho Odudu, Moin A. Saleem, Anthony D. Whetton, Philip A. Kalra and Nophar Geifman
    Citation: Clinical Proteomics 2023 20:19
    Content type: Research Published on:

    The Correction to this article has been published in Clinical Proteomics 2024 21:25

  19. Proteomic analysis of human plasma by LC–ESI–MS/MS has discovered a limited number of new cellular protein biomarkers that may be confirmed by independent biochemical methods. Analysis of COVID-19 plasma has i...

    Authors: Zhuo Zhen Chen, Lloyd Johnson, Uriel Trahtemberg, Andrew Baker, Saaimatul Huq, Jaimie Dufresne, Peter Bowden, Ming Miao, Ja-An Ho, Cheng-Chih Hsu, Claudia C. dos Santos and John G. Marshall
    Citation: Clinical Proteomics 2023 20:17
    Content type: Research Published on:

  20. Authors: Dilana E. Staudt, Heather C. Murray, David A. Skerrett-Byrne, Nathan D. Smith, M. Fairuz B. Jamaluddin, Richard G. S. Kahl, Ryan J. Duchatel, Zacary P. Germon, Tabitha McLachlan, Evangeline R. Jackson, Izac J. Findlay, Padraic S. Kearney, Abdul Mannan, Holly P. McEwen, Alicia M. Douglas, Brett Nixon…
    Citation: Clinical Proteomics 2023 20:16
    Content type: Correction Published on:

    The original article was published in Clinical Proteomics 2022 19:48

  21. Colorectal cancer (CRC) is one of the major causes of cancer-related death worldwide. Although commercial biomarkers of CRC are currently available, they are still lacking in terms of sensitivity and specifici...

    Authors: Chris Verathamjamras, Juthamard Chantaraamporn, Thiwaree Sornprachum, Photsathorn Mutapat, Daranee Chokchaichamnankit, Kanokwan Mingkwan, Virat Luevisadpibul, Chantragan Srisomsap, Somchai Chutipongtanate, Jisnuson Svasti and Voraratt Champattanachai
    Citation: Clinical Proteomics 2023 20:15
    Content type: Research Published on:

  22. Clinical bronchoalveolar lavage fluid (BALF) samples are rich in biomolecules, including proteins, and useful for molecular studies of lung health and disease. However, mass spectrometry (MS)-based proteomic a...

    Authors: Danielle O. Weise, Monica E. Kruk, LeeAnn Higgins, Todd W. Markowski, Pratik D. Jagtap, Subina Mehta, Alan Mickelson, Laurie L. Parker, Christine H. Wendt and Timothy J. Griffin
    Citation: Clinical Proteomics 2023 20:14
    Content type: Methodology Published on:

  23. SARS-CoV-2 has been shown to predominantly infect the airways and the respiratory tract and too often have an unpredictable and different pathologic pattern compared to other respiratory diseases. Current clin...

    Authors: Gabriel Hirdman, Embla Bodén, Sven Kjellström, Carl-Johan Fraenkel, Franziska Olm, Oskar Hallgren and Sandra Lindstedt
    Citation: Clinical Proteomics 2023 20:13
    Content type: Research Published on:

  24. Gliomas are among the most malignant tumors, with a very poor prognosis. Early diagnosis is highly desirable since it can help implement more effective treatments for smaller tumors, which have not yet extensi...

    Authors: Atefeh Ghorbani, Lisa M. Avery, Dorsa Sohaei, Andrea Soosaipillai, Maxime Richer, Craig Horbinski, Katy McCortney, Wei Xu, Eleftherios P. Diamandis and Ioannis Prassas
    Citation: Clinical Proteomics 2023 20:12
    Content type: Research Published on:

  25. Salivary stones, also known as sialoliths, are formed in a pathological situation in the salivary glands. So far, neither the mechanism of their formation nor the factors predisposing to their formation are kn...

    Authors: Natalia Musiał, Aleksandra Bogucka, Dmitry Tretiakow, Andrzej Skorek, Jacek Ryl and Paulina Czaplewska
    Citation: Clinical Proteomics 2023 20:11
    Content type: Research Published on:

  26. Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma with poor prognosis in children. The 5-year survival rate for early RMS has improved, whereas it remains unsatisfactory for advanced patients. Urin...

    Authors: Na Xu, Yuncui Yu, Chao Duan, Jing Wei, Wei Sun, Chiyi Jiang, Binglin Jian, Wang Cao, Lulu Jia and Xiaoli Ma
    Citation: Clinical Proteomics 2023 20:10
    Content type: Research Published on:

  27. Aspiration pneumonia (AP), which is a major cause of death in the elderly, does present with typical symptoms in the early stages of onset, thus it is difficult to detect and treat at an early stage. In this s...

    Authors: Kohei Ogura, Maho Endo, Takashi Hase, Hitomi Negami, Kohsuke Tsuchiya, Takumi Nishiuchi, Takeshi Suzuki, Kazuhiro Ogai, Hiromi Sanada, Shigefumi Okamoto and Junko Sugama
    Citation: Clinical Proteomics 2023 20:9
    Content type: Research Published on:

  28. Gallbladder cancer (GBC) is a lethal cancer with a poor prognosis. The lack of specific and sensitive biomarkers results in delayed diagnosis with most patients presenting at late stages of the disease. Furth...

    Authors: Pavan Baichan, Previn Naicker, Tanya Nadine Augustine, Martin Smith, Geoffrey Candy, John Devar and Ekene Emmanuel Nweke
    Citation: Clinical Proteomics 2023 20:8
    Content type: Research Published on:

  29. RA is a common chronic and systemic autoimmune disease, and the diagnosis is based significantly on autoantibody detection. This study aims to investigate the glycosylation profile of serum IgG in RA patients ...

    Authors: Xiaoyue Deng, Xiaomin Liu, Yan Zhang, Dan Ke, Rui Yan, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng and Chaojun Hu
    Citation: Clinical Proteomics 2023 20:7
    Content type: Research Published on:

  30. Inflammatory bowel disease (IBD) encompasses a group of chronic relapsing disorders which include ulcerative colitis (UC) and Crohn’s disease (CD). The incidences of IBD and overweight/obesity are increasing i...

    Authors: Ping Yan, Yang Sun, Juan Luo, Xiaolin Liu, Jing Wu and Yinglei Miao
    Citation: Clinical Proteomics 2023 20:6
    Content type: Research Published on:

  31. We aimed to compare absolute plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) and growth differentiation factor 15 (GDF-15) obtained by a conventional immunoassay with the correspo...

    Authors: Emma Skau, Philippe Wagner, Jerzy Leppert, Johan Ärnlöv and Pär Hedberg
    Citation: Clinical Proteomics 2023 20:5
    Content type: Research Published on:

  32. Continuous renal replacement therapy (CRRT) has been considered as an adjuvant therapy for sepsis. However, the novel biomarker to evaluate the benefits of CRRT is limited. The aim of this study was to explore...

    Authors: Yun Cui, Shuyun Feng, Huijie Miao, Tiantian Liu, Jingyi Shi, Jiaying Dou, Chunxia Wang and Yucai Zhang
    Citation: Clinical Proteomics 2023 20:4
    Content type: Research Published on:

  33. Non-invasive detection of blood-based markers is a critical clinical need. Plasma has become the main sample type for clinical proteomics research because it is easy to obtain and contains measurable protein b...

    Authors: Xueting Ye, Xiaozhen Cui, Luobin Zhang, Qiong Wu, Xintong Sui, An He, Xinyou Zhang, Ruilian Xu and Ruijun Tian
    Citation: Clinical Proteomics 2023 20:3
    Content type: Research Published on:

  34. Spermatozoa have the task of delivering an intact paternal genome to the oocyte and supporting successful embryo development. The detection of sperm DNA fragmentation (SDF) has been emerging as a complementary...

    Authors: Chun-Hui Zhu, Ye Wei, Fang Chen, Feng Li, Sheng-Min Zhang, Nai-Jun Dong, Tong-Min Xue, Kai-Feng Liu, Heng-Mi Cui and Jin-Chun Lu
    Citation: Clinical Proteomics 2023 20:2
    Content type: Research Published on:

  35. The placenta remains one of the least studied organs within the human body. Yet, placental dysfunction has been associated with various pregnancy complications leading to both maternal and fetal death and long...

    Authors: Samprikta Manna, Julia Scheel, Aisling Noone, Colm J. McElwain, Caitriona Scaife, Shailendra Gupta, Jane English, Cathal McCarthy and Fergus P. McCarthy
    Citation: Clinical Proteomics 2023 20:1
    Content type: Research Published on:

  36. Immunoglobulin A nephropathy (IgAN), a globally common primary chronic glomerulopathy, is one of the leading causes of end-stage renal disease. However, the underlying mechanisms of IgAN have yet to be demonst...

    Authors: Di Zhang, Yaohan Li, Mingzhu Liang, Yan Liang, Jingkui Tian, Qiang He, Bingxian Yang, Juan Jin and Wei Zhu
    Citation: Clinical Proteomics 2022 19:51
    Content type: Research Published on:

  37. Despite the high morbidity and mortality associated with sepsis, the relationship between the plasma proteome and clinical outcome is poorly understood. In this study, we used targeted plasma proteomics to ide...

    Authors: Logan R. Van Nynatten, Marat Slessarev, Claudio M. Martin, Aleks Leligdowicz, Michael R. Miller, Maitray A. Patel, Mark Daley, Eric K. Patterson, Gediminas Cepinskas and Douglas D. Fraser
    Citation: Clinical Proteomics 2022 19:50
    Content type: Research Published on:

  38. The progression of chronic pancreatitis (CP), an inflammatory disease of the pancreas, causes pancreatic stones to form within the pancreatic ductal lumen/parenchyma, which occurs via protein plug formation. P...

    Authors: Renuka Goudshelwar, Bala Manikanta Adimoolam, Sundeep Lakhtakia, Jagadeshwar Reddy Thota, Prabhakar Sripadi, Karuna Rupula, D Nageshwar Reddy and Mitnala Sasikala
    Citation: Clinical Proteomics 2022 19:49
    Content type: Research Published on:

  39. Global high-throughput phosphoproteomic profiling is increasingly being applied to cancer specimens to identify the oncogenic signaling cascades responsible for promoting disease initiation and disease progres...

    Authors: Dilana E. Staudt, Heather C. Murray, David A. Skerrett-Byrne, Nathan D. Smith, M. Fairuz B. Jamaluddin, Richard G. S. Kahl, Ryan J. Duchatel, Zacary P. Germon, Tabitha McLachlan, Evangeline R. Jackson, Izac J. Findlay, Padraic S. Kearney, Abdul Mannan, Holly P. McEwen, Alicia M. Douglas, Brett Nixon…
    Citation: Clinical Proteomics 2022 19:48
    Content type: Research Published on:

    The Correction to this article has been published in Clinical Proteomics 2023 20:16

  40. Recurrent spontaneous abortion (RSA) is a common and complicated pregnancy-related disease that lacks a suitable biomarker to predict its recrudescence.

    Authors: Xiaohe Sun, Jiamin Jin, Yin-Li Zhang, Yerong Ma, Songying Zhang and Xiaomei Tong
    Citation: Clinical Proteomics 2022 19:47
    Content type: Research Published on:

  41. The outbreak of a novel coronavirus (SARS-CoV-2) in 2019 led to a worldwide pandemic, which remains an integral part of our lives to this day. Coronavirus disease (COVID-19) is a flu like condition, often acco...

    Authors: Juergen Gindlhuber, Tamara Tomin, Florian Wiesenhofer, Martin Zacharias, Laura Liesinger, Vadim Demichev, Klaus Kratochwill, Gregor Gorkiewicz, Matthias Schittmayer and Ruth Birner-Gruenberger
    Citation: Clinical Proteomics 2022 19:46
    Content type: Research Published on:

  42. High blood glucose level is one of the main characteristics of diabetes mellitus. Based on previous studies, it is speculated longevity families may have certain advantages in blood glucose regulation. However...

    Authors: Rong Zhang, Fengjuan Liu, Shengliang Ye, Xi Du, Li Ma, Haijun Cao, Zongkui Wang and Changqing Li
    Citation: Clinical Proteomics 2022 19:45
    Content type: Research Published on:

  43. Lung cancer (LC) is a common malignant tumor with a high incidence and poor prognosis. Early LC could be cured, but the 5-year-survival rate for patients advanced is extremely low. Early screening of tumor bio...

    Authors: Hongyu Chen, Xiaoqin Lai, Yihan Zhu, Hong Huang, Lingyan Zeng and Li Zhang
    Citation: Clinical Proteomics 2022 19:44
    Content type: Research Published on:

  44. Circulating biomarkers play important roles in diagnosis of malignant tumors. N-glycosylation is an important post-translation patter and obviously affect biological behaviors of malignant tumor cells. However...

    Authors: Kai Fang, Qin Long, Zhonghua Liao, Chaoyu Zhang and Zhiqiang Jiang
    Citation: Clinical Proteomics 2022 19:43
    Content type: Correspondence Published on:

  45. Apolipoprotein E (ApoE) genotyping has been shown to have diagnostic value in the evaluation of cardiovascular diseases and neurodegenerative disorders such as Alzheimer’s disease. Although genetic testing is ...

    Authors: Anthony Maus, Dan Figdore, Dragana Milosevic, Alicia Algeciras-Schimnich and Joshua Bornhorst
    Citation: Clinical Proteomics 2022 19:42
    Content type: Research Published on:

  46. Regulatory degradation of intracellular proteins plays an essential role in most biological processes, particularly in the control of cell proliferation and differentiation.

    Authors: Hassan Filali, Ouadie Mohamed El Yaagoubi, Ayoub Lahmadi, Asmaa Quessar, Said El Antri, Hamid Samaki and Souad Aboudkhil
    Citation: Clinical Proteomics 2022 19:41
    Content type: Research Published on:

  47. Authors: Guillaume Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Sirui Zhou, Tomoko Nakanishi, Elsa Brunet-Ratnasingham, David Morrison, Laetitia Laurent, Jonathan Aflalo, Marc Aflalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi…
    Citation: Clinical Proteomics 2022 19:40
    Content type: Correction Published on:

    The original article was published in Clinical Proteomics 2022 19:34

  48. Proximity extension assay (PEA) is a novel antibody-based proteomic technology. Sparse data have been published concerning the matrix effect of serum vs. ethylenediamine tetraacetic acid (EDTA) plasma and the ...

    Authors: Troels D. Christensen, Emil Maag, Kasper Madsen, Sidsel Christy Lindgaard, Dorte L. Nielsen and Julia S. Johansen
    Citation: Clinical Proteomics 2022 19:39
    Content type: Research Published on:

  49. Most patients infected with SARS-CoV-2 display mild symptoms with good prognosis, while 20% of patients suffer from severe viral pneumonia and up to 5% may require intensive care unit (ICU) admission due to se...

    Authors: Fabiola Ciccosanti, Manuela Antonioli, Alessandra Sacchi, Stefania Notari, Anna Farina, Alessia Beccacece, Marisa Fusto, Alessandra Vergori, Gianpiero D’Offizi, Fabrizio Taglietti, Andrea Antinori, Emanuele Nicastri, Luisa Marchioni, Fabrizio Palmieri, Giuseppe Ippolito, Mauro Piacentini…
    Citation: Clinical Proteomics 2022 19:38
    Content type: Research Published on:

  50. BTBD7_hsa_circ_0000563 is a novel circRNA and contains conserved binding sites with RNA-binding proteins. However, BTBD7_hsa_circ_0000563 has not been fully studied in coronary artery disease (CAD). We aimed t...

    Authors: Hanxiao Zhou, Xiongkang Gan, Shu He, Yanjun Wang, Sheng Zhang, Jiaxin Chen, Yaqing Zhou, Can Hou, Lei Hua, Qian Zhang and Enzhi Jia
    Citation: Clinical Proteomics 2022 19:37
    Content type: Research Published on:
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Clinical Proteomics

ISSN: 1559-0275