Table 2 Partial list of proteins overexpressed in HCC
From: 18O Labeling for a Quantitative Proteomic Analysis of Glycoproteins in Hepatocellular Carcinoma
RefSeq accession number | Gene symbol | Protein name | Lectin affinity (HCC:normal) | Whole tissue analysis (HCC:normal) |
|---|---|---|---|---|
NP_005498.1 | CFL1 | Cofilin 1 (non-muscle) | 13* | 3.2 |
NP_000604.1 | HPX | Hemopexin | 12* | 3.7 |
NP_066953.1 | PPIA | Cyclophilin A | 12 | 1.4 |
NP_003509.1 | HIST1H2BG | H2B histone family, member A | 9.3* | 0.9 |
NP_006477.2 | FBLN1 | Fibulin 1 isoform D | 7.8* | NF |
NP_000349.1 | TGFBI | Transforming growth factor, beta-induced, 68Â kDa | 7.5* | 5.1 |
NP_000030.1 | APOA1 | Apolipoprotein A-I | 7.1 | 3.8 |
NP_003093.1 | SOD3 | Superoxide dismutase 3, extracellular | 6.6 | NF |
NP_000005.2 | A2M | Alpha-2-macroglobulin | 6.5 | 2.7 |
NP_006861.1 | DSTN | Destrin isoform A | 6.5* | NF |
NP_003177.2 | TAGLN | Transgelin | 6.0* | 4 |
NP_008949.4 | CEP110 | Centrosomal protein 110Â kDa | 6.0 | NF |
NP_001076.2 | SERPINA3 | Serpin peptidase inhibitor, clade A, | 5.6* | 5.1 |
NP_003364.1 | VCL | Vinculin | 5.6* | 2.8 |
NP_001054.1 | TF | Transferrin | 5.6 | 3.5 |
NP_001002029.1 | C4B | Complement component 4B | 5.6 | 2.5 |
NP_005727.1 | ACTR1A | ARP1 actin-related protein 1 homolog A, centractin | 5.6 | NF |
NP_006491.2 | MCAM | Melanoma cell adhesion | 5.3 | NF |
NP_997639.1 | FN1 | Fibronectin 1 isoform 6 | 5.2 | 5.8 |
NP_976084.1 | CLU | Clusterin isoform 2 | 5.1 | NF |
NP_001701.2 | CFB | Complement factor B | 5.0 | NF |
NP_001613.1 | AHSG | Fetuin | 5.0* | NF |
NP_443204.1 | LRG1 | Leucine-rich alpha-2-glycoprotein 1 | 4.7* | NF |
NP_001176.1 | AZGP1 | Alpha-2-glycoprotein 1, zinc | 4.6* | NF |
NP_000497.1 | F2 | Coagulation factor II | 4.5 | NF |
NP_005520.3 | HSPG2 | Heparan sulfate proteoglycan 2 | 4.3* | NF |
NP_001653.1 | ARF5 | ADP-ribosylation factor 5 | 4.3 | 0.8 |
NP_001744.2 | CAV1 | Caveolin 1 | 4.2 | 6.7 |
NP_005338.1 | HSPA5 | Heat shock 70Â kDa protein 5 | 4.0 | 1.5 |
NP_001210.1 | CALU | Calumenin | 3.8 | NF |
NP_001649.1 | ARF1 | ADP-ribosylation factor 1 | 3.8 | 0.7 |
NP_937895.1 | GSN | Gelsolin isoform b | 3.5 | 4.4 |
NP_031381.2 | HSP90AB1 | Heat shock 90Â kDa protein 1, beta | 3.3 | 2.2 |
NP_001124.1 | AFM | Afamin | 3.2* | NF |
NP_002281.1 | LAMA4 | Laminin, alpha 4 | 3.2 | 6.9 |
NP_000087.1 | CP | Ceruloplasmin | 3.2 | NF |
NP_570602.2 | A1BG | Alpha 1B-glycoprotein | 3.1 | 4.9 |
NP_002209.2 | ITIH4 | Inter-alpha (globulin) inhibitor H4 | 3.0 | NF |
NP_001035166.1 | IGHG1 | Anti-RhD monoclonal T125 gamma1 heavy chain | 2.9 | 1.7 |
NP_002296.1 | LGALS1 | Beta-galactoside-binding lectin (Galectin 1) | 2.8 | NF |
NP_008977.1 | EMILIN1 | Elastin microfibril interfacer 1 | 2.7 | NF |
NP_004069.1 | CSRP1 | Cysteine-rich protein 1 | 1.1* | 2.9 |