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Table 2 Partial list of proteins overexpressed in HCC

From: 18O Labeling for a Quantitative Proteomic Analysis of Glycoproteins in Hepatocellular Carcinoma

RefSeq accession number Gene symbol Protein name Lectin affinity (HCC:normal) Whole tissue analysis (HCC:normal)
NP_005498.1 CFL1 Cofilin 1 (non-muscle) 13* 3.2
NP_000604.1 HPX Hemopexin 12* 3.7
NP_066953.1 PPIA Cyclophilin A 12 1.4
NP_003509.1 HIST1H2BG H2B histone family, member A 9.3* 0.9
NP_006477.2 FBLN1 Fibulin 1 isoform D 7.8* NF
NP_000349.1 TGFBI Transforming growth factor, beta-induced, 68 kDa 7.5* 5.1
NP_000030.1 APOA1 Apolipoprotein A-I 7.1 3.8
NP_003093.1 SOD3 Superoxide dismutase 3, extracellular 6.6 NF
NP_000005.2 A2M Alpha-2-macroglobulin 6.5 2.7
NP_006861.1 DSTN Destrin isoform A 6.5* NF
NP_003177.2 TAGLN Transgelin 6.0* 4
NP_008949.4 CEP110 Centrosomal protein 110 kDa 6.0 NF
NP_001076.2 SERPINA3 Serpin peptidase inhibitor, clade A, 5.6* 5.1
NP_003364.1 VCL Vinculin 5.6* 2.8
NP_001054.1 TF Transferrin 5.6 3.5
NP_001002029.1 C4B Complement component 4B 5.6 2.5
NP_005727.1 ACTR1A ARP1 actin-related protein 1 homolog A, centractin 5.6 NF
NP_006491.2 MCAM Melanoma cell adhesion 5.3 NF
NP_997639.1 FN1 Fibronectin 1 isoform 6 5.2 5.8
NP_976084.1 CLU Clusterin isoform 2 5.1 NF
NP_001701.2 CFB Complement factor B 5.0 NF
NP_001613.1 AHSG Fetuin 5.0* NF
NP_443204.1 LRG1 Leucine-rich alpha-2-glycoprotein 1 4.7* NF
NP_001176.1 AZGP1 Alpha-2-glycoprotein 1, zinc 4.6* NF
NP_000497.1 F2 Coagulation factor II 4.5 NF
NP_005520.3 HSPG2 Heparan sulfate proteoglycan 2 4.3* NF
NP_001653.1 ARF5 ADP-ribosylation factor 5 4.3 0.8
NP_001744.2 CAV1 Caveolin 1 4.2 6.7
NP_005338.1 HSPA5 Heat shock 70 kDa protein 5 4.0 1.5
NP_001210.1 CALU Calumenin 3.8 NF
NP_001649.1 ARF1 ADP-ribosylation factor 1 3.8 0.7
NP_937895.1 GSN Gelsolin isoform b 3.5 4.4
NP_031381.2 HSP90AB1 Heat shock 90 kDa protein 1, beta 3.3 2.2
NP_001124.1 AFM Afamin 3.2* NF
NP_002281.1 LAMA4 Laminin, alpha 4 3.2 6.9
NP_000087.1 CP Ceruloplasmin 3.2 NF
NP_570602.2 A1BG Alpha 1B-glycoprotein 3.1 4.9
NP_002209.2 ITIH4 Inter-alpha (globulin) inhibitor H4 3.0 NF
NP_001035166.1 IGHG1 Anti-RhD monoclonal T125 gamma1 heavy chain 2.9 1.7
NP_002296.1 LGALS1 Beta-galactoside-binding lectin (Galectin 1) 2.8 NF
NP_008977.1 EMILIN1 Elastin microfibril interfacer 1 2.7 NF
NP_004069.1 CSRP1 Cysteine-rich protein 1 1.1* 2.9
  1. Fold change in the proteins detected in lectin enrichment method is compared with total protein level wherever available. Novel HCC-associated proteins detected in this study are highlighted with an asterisk.
  2. NF Not found