In 2011, Clinical Proteomics converted from a subscription publication to a fully open access journal. The journal's back content can be viewed on SpringerLink.
Alzheimer’s Disease (AD) is a neurodegenerative disorder affecting millions of elderly worldwide, and for which there is no cure yet. Biomarkers in body fluids such as the cerebrospinal fluid are supportive of the biological diagnosis of AD, but blood based biomarkers would have the preference, being obtained by low-invasive procedures. We here set out to identify AD specific peptides and proteins in plasma using analytical separation combined with in-depth mass spectrometry methods. We compared the profiles in AD patients compared to those obtained in healthy controls and patients with various diseases, in order to reveal disease specific patterns using elaborated statistical methods. The clinical groups thus included were: normals, multiple sclerosis, ovarian cancer, breast cancer, female normal, sepsis, ICU Control, heart attack, along with their institution-matched controls. The study revealed a multitude of differentially regulated proteins in plasma of AD patients, including brain specific and neuronal specific proteins. The study shows the feasibility of the approach, and indicates that there are several plasma proteins that merit to be studied in the course of this disease as potential biomarkers.
Make a suggestion here
Aims and scope
Clinical Proteomics encompasses all aspects of translational proteomics. Special emphasis will be placed on the application of proteomic technology to all aspects of clinical research and molecular medicine. The journal is committed to rapid scientific review and timely publication of submitted manuscripts.
Dr Daniel W Chan is currently Professor of Pathology, Oncology, Urology, and Radiology at Johns Hopkins Medical Institutions, and Director of the Clinical Chemistry Division, Co-Director at the Pathology Core Laboratory, and Director at the Center for Biomarker Discovery and Translation at the Johns Hopkins University School of Medicine. He has worked extensively on the development and application of proteomic and immunologic techniques in the understanding of cancer. As the author of five books and over 300 articles, Dr Chan has become established as a leading expert in clinical proteomics and cancer research. Dr Chan is an active member of US Human Proteome Organization (USHUPO), American Association for Cancer Research (AACR) and American Association for Clinical Chemistry (AACC).
Guest edited by Vera Ignjavtovic, Allen Everett and Hanno Steen
The Paediatric Proteomics (PediOme) is an initiative of HUPO that aims to advance the use of proteomic techniques to solve major issues in Paediatric medicine.
Proteomics in India
Guest edited by Harsha Gowda and Akhilesh Pandey
This collections features the latest advances in Proteomics research from India.
Glycoproteomics and glycomics
Guest edited by Punit Shah and Hui Zhang
This thematic series publishes both solicited and unsolicited content on the topic of protein glycosylation; one of the most common protein modifications in both normal biological processes and diseases. This series focuses on glycoproteomic or glycomic methods and their clinical applications.
Clinical Proteomics is affiliated with the Human Proteome Organization (HUPO). HUPO is an international scientific organization representing and promoting proteomics through international cooperation and collaborations by fostering the development of new technologies, techniques and training.
- Editorial Board
- Instructions for Editors
- Sign up for article alerts and news from this journal
Annual Journal Metrics
102 days to first decision for reviewed manuscripts only
92 days to first decision for all manuscripts
192 days from submission to acceptance
16 days from acceptance to publication
99 Altmetric Mentions