In 2011, Clinical Proteomics converted from a subscription publication to a fully open access journal. The journal's back content can be viewed on SpringerLink.
Featured article: Neoplastic cell enrichment of tumor tissues using coring and laser microdissection for proteomic and genomic analyses of pancreatic ductal adenocarcinoma
One of the challenges in the proteogenomic analysis of cancer tissues, especially in pancreatic ductal adenocarcinoma (PDAC), is the low and heterogeneous composition of neoplastic cellularity in bulk tumors. In this study, we enriched neoplastic cells from bulk tumor tissues using coring and laser microdissection (LMD) sampling techniques. We assessed the protein and KRAS mutation changes associated with specimens obtained by these sampling techniques and evaluated the fraction of neoplastic cells in PDAC for proteomic and genomic analyses. We showed that both bulk and coring sampling techniques gave similar proteogenomic signatures, while the greatest enrichment of neoplastic cellularity could be obtained with the LMD technique.
Articles
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Discovery of novel glioma serum biomarkers by proximity extension assay
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Proteomic analysis of sialoliths from calcified, lipid and mixed groups as a source of potential biomarkers of deposit formation in the salivary glands
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Quantitative proteomics identifies and validates urinary biomarkers of rhabdomyosarcoma in children
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Potential biomarker proteins for aspiration pneumonia detected by shotgun proteomics using buccal mucosa samples: a cross-sectional case–control study
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Translation of proteomic biomarkers into FDA approved cancer diagnostics: issues and challenges
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Nanotechnologies in Glycoproteomics
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Basics and recent advances of two dimensional- polyacrylamide gel electrophoresis
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Recent advances in mass spectrometry based clinical proteomics: applications to cancer research
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Aberrant glycosylation associated with enzymes as cancer biomarkers
Archival content
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Aims and scope
Clinical Proteomics encompasses all aspects of translational proteomics. Special emphasis will be placed on the application of proteomic technology to all aspects of clinical research and molecular medicine. The journal is committed to rapid scientific review and timely publication of submitted manuscripts.
Editor's profile
Dr Daniel W Chan is currently Professor of Pathology, Oncology, Urology, and Radiology at Johns Hopkins Medical Institutions, and Director of the Clinical Chemistry Division, Co-Director at the Pathology Core Laboratory, and Director at the Center for Biomarker Discovery and Translation at the Johns Hopkins University School of Medicine. He has worked extensively on the development and application of proteomic and immunologic techniques in the understanding of cancer. As the author of five books and over 300 articles, Dr Chan has become established as a leading expert in clinical proteomics and cancer research. Dr Chan is an active member of US Human Proteome Organization (USHUPO), American Association for Cancer Research (AACR) and American Association for Clinical Chemistry (AACC).
Featured collections
Bioinformatic approaches for clinical proteomics: too many choices and no standardization
Guest edited by Ventzislava Hristova, Thang Pham, Bing Zhang
Spatial proteomics
Guest edited by Hui Zhang and Yuanwei Xu
Clinical translation of targeted proteomics
Guest edited by Tiannan Guo, Ed Nice, Stephen Pennington, Henry Rodriguez
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Affiliated with
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Clinical Proteomics is affiliated with the Human Proteome Organization (HUPO). HUPO is an international scientific organization representing and promoting proteomics through international cooperation and collaborations by fostering the development of new technologies, techniques and training.
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Annual Journal Metrics
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Citation Impact
5.000 - 2-year Impact Factor (2021)
4.323 - 5-year Impact Factor (2021)
0.932 - Source Normalized Impact per Paper (SNIP)
1.089 - SCImago Journal Rank (SJR)Speed
38 days to first decision for all manuscripts (Median)
50 days to first decision for reviewed manuscripts only (Median)Usage
258,084 Downloads (2021)
133 Altmetric mentions (2021)