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Featured article: Proteomic and phosphoproteomic measurements enhance ability to predict ex vivo drug response in AML

Protein measurements, alongside genetic mutations and gene expression assays, have long been used to study the heterogeneity of cancer data, specifically in Acute Myeloid Leukemia, which is not just one disease but a collection of molecularly distinct diseases. In this work we find that global proteomics can be even more useful that subtyping and can accurately predict drug response using our ex vivo drug assay across a small cohort of AML patients.  We believe this type of analysis will help bring proteomics more closely aligned with the clinic as we can identify proteins that predict drug response in patient samples.

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Archival content

In 2011, Clinical Proteomics converted from a subscription publication to a fully open access journal. The journal's back content can be viewed on SpringerLink.

Aims and scope

Clinical Proteomics encompasses all aspects of translational proteomics. Special emphasis will be placed on the application of proteomic technology to all aspects of clinical research and molecular medicine. The journal is committed to rapid scientific review and timely publication of submitted manuscripts.

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Editor's profile


Dr Daniel W Chan  is currently Professor of Pathology, Oncology, Urology, and Radiology at Johns Hopkins Medical Institutions, and Director of the Clinical Chemistry Division, Co-Director at the Pathology Core Laboratory, and Director at the Center for Biomarker Discovery and Translation at the Johns Hopkins University School of Medicine. He has worked extensively on the development and application of proteomic and immunologic techniques in the understanding of cancer. As the author of five books and over 300 articles, Dr Chan has become established as a leading expert in clinical proteomics and cancer research. Dr Chan is an active member of US Human Proteome Organization (USHUPO), American Association for Cancer Research (AACR) and American Association for Clinical Chemistry (AACC).

Featured collections

PediOme

Guest edited by Vera Ignjavtovic, Allen Everett and Hanno Steen

The Paediatric Proteomics (PediOme) is an initiative of HUPO that aims to advance the use of proteomic techniques to solve major issues in Paediatric medicine.

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Proteomics in India

Guest edited by Harsha Gowda and Akhilesh Pandey

This collections features the latest advances in Proteomics research from India.

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Glycoproteomics and glycomics

Guest edited by Punit Shah and Hui Zhang

This thematic series publishes both solicited and unsolicited content on the topic of protein glycosylation; one of the most common protein modifications in both normal biological processes and diseases. This series focuses on glycoproteomic or glycomic methods and their clinical applications.

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