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Featured article: The plasma peptides of Alzheimer’s disease

Featured ArticleAlzheimer’s Disease (AD) is a neurodegenerative disorder affecting millions of elderly worldwide, and for which there is no cure yet. Biomarkers in body fluids such as the cerebrospinal fluid are supportive of the biological diagnosis of AD, but blood based biomarkers would have the preference, being obtained by low-invasive procedures. We here set out to identify AD specific peptides and proteins in plasma using analytical separation combined with in-depth mass spectrometry methods. We compared the profiles in AD patients compared to those obtained in healthy controls and patients with various diseases, in order to reveal disease specific patterns using elaborated statistical methods. The clinical groups thus included were: normals, multiple sclerosis, ovarian cancer, breast cancer, female normal, sepsis, ICU Control, heart attack, along with their institution-matched controls. The study revealed a multitude of differentially regulated proteins in plasma of AD patients, including brain specific and neuronal specific proteins. The study shows the feasibility of the approach, and indicates that there are several plasma proteins that merit to be studied in the course of this disease as potential biomarkers.


Archival content

In 2011, Clinical Proteomics converted from a subscription publication to a fully open access journal. The journal's back content can be viewed on SpringerLink.

Aims and scope

Clinical Proteomics encompasses all aspects of translational proteomics. Special emphasis will be placed on the application of proteomic technology to all aspects of clinical research and molecular medicine. The journal is committed to rapid scientific review and timely publication of submitted manuscripts.

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Editor's profile

Dr Daniel W Chan  is currently Professor of Pathology, Oncology, Urology, and Radiology at Johns Hopkins Medical Institutions, and Director of the Clinical Chemistry Division, Co-Director at the Pathology Core Laboratory, and Director at the Center for Biomarker Discovery and Translation at the Johns Hopkins University School of Medicine. He has worked extensively on the development and application of proteomic and immunologic techniques in the understanding of cancer. As the author of five books and over 300 articles, Dr Chan has become established as a leading expert in clinical proteomics and cancer research. Dr Chan is an active member of US Human Proteome Organization (USHUPO), American Association for Cancer Research (AACR) and American Association for Clinical Chemistry (AACC).

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