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  1. Research

    A multiplex platform for the identification of ovarian cancer biomarkers

    Currently, there are no FDA approved screening tools for detecting early stage ovarian cancer in the general population. Development of a biomarker-based assay for early detection would significantly improve t...

    Kristin L. M. Boylan, Kate Geschwind, Joseph S. Koopmeiners, Melissa A. Geller, Timothy K. Starr and Amy P. N. Skubitz

    Clinical Proteomics 2017 14:34

    Published on: 10 October 2017

  2. Research

    Serum protein pattern associated with organ damage and lupus nephritis in systemic lupus erythematosus revealed by PEA immunoassay

    Systemic lupus erythematosus (SLE) is a remarkably heterogeneous autoimmune disease. Despite tremendous efforts, our knowledge of serum protein patterns in severe SLE phenotypes is still limited. We investigat...

    Anna Petrackova, Andrea Smrzova, Petr Gajdos, Marketa Schubertova, Petra Schneiderova, Pavel Kromer, Vaclav Snasel, Martina Skacelova, Frantisek Mrazek, Josef Zadrazil, Pavel Horak and Eva Kriegova

    Clinical Proteomics 2017 14:32

    Published on: 3 October 2017

  3. Research

    Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy

    The clinical course of IgA nephropathy (IgAN) is variable and complement activation may predict prognosis. The present study investigated whether glomerular abundance of complement proteins associates with pro...

    Teodora Ioana Flavia Paunas, Kenneth Finne, Sabine Leh, Hans-Peter Marti, Tom Eirik Mollnes, Frode Berven and Bjørn Egil Vikse

    Clinical Proteomics 2017 14:30

    Published on: 14 August 2017

  4. Research

    Down-regulation of metabolic proteins in hepatocellular carcinoma with portal vein thrombosis

    Hepatocellular carcinoma is an aggressive malignancy with poor prognosis and easy to recur even the tumor is totally removed by surgery. Portal vascular invasion is one of the major factors contributing to tum...

    Wei-Chen Lee, Hong-Shiue Chou, Ting-Jung Wu, Chen-Fang Lee, Pao-Yueh Hsu, Hsiu-Ying Hsu, Tsung-Han Wu and Kun-Ming Chan

    Clinical Proteomics 2017 14:29

    Published on: 2 August 2017

  5. Research

    Discovery and validation of a colorectal cancer classifier in a new blood test with improved performance for high-risk subjects

    The aim was to improve upon an existing blood-based colorectal cancer (CRC) test directed to high-risk symptomatic patients, by developing a new CRC classifier to be used with a new test embodiment. The new te...

    Lisa J. Croner, Roslyn Dillon, Athit Kao, Stefanie N. Kairs, Ryan Benz, Ib J. Christensen, Hans J. Nielsen, John E. Blume and Bruce Wilcox

    Clinical Proteomics 2017 14:28

    Published on: 25 July 2017

  6. Research

    Proteomic discovery and verification of serum amyloid A as a predictor marker of patients at risk of post-stroke infection: a pilot study

    Post-stroke infections occur in 20–36% of stroke patients and are associated with high morbidity and mortality rates. Early identification of patients at risk of developing an infection could improve care via ...

    L. Azurmendi, V. Lapierre-Fetaud, J. Schneider, J. Montaner, M. Katan and Jean-Charles Sanchez

    Clinical Proteomics 2017 14:27

    Published on: 12 July 2017

  7. Research

    Clinical validation of a blood-based classifier for diagnostic evaluation of asymptomatic individuals with pulmonary nodules

    The number of pulmonary nodules detected in the US is expected to increase substantially following recent recommendations for nationwide CT-based lung cancer screening. Given the low specificity of CT screenin...

    Charles E. Birse, Jennifer L. Tomic, Harvey I. Pass, William N. Rom and Robert J. Lagier

    Clinical Proteomics 2017 14:25

    Published on: 5 July 2017

  8. Research

    Distinct proteome pathology of circulating microparticles in systemic lupus erythematosus

    The pathogenesis of systemic lupus erythematosus (SLE) is poorly understood but has been linked to defective clearance of subcellular particulate material from the circulation. This study investigates the orig...

    Ole Østergaard, Christoffer Tandrup Nielsen, Julia T. Tanassi, Line V. Iversen, Søren Jacobsen and Niels H. H. Heegaard

    Clinical Proteomics 2017 14:23

    Published on: 21 June 2017

  9. Research

    A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption

    Atherosclerotic plaque rupture is the culprit event which underpins most acute vascular syndromes such as acute myocardial infarction. Novel biomarkers of plaque rupture could improve biological understanding...

    Regent Lee, Roman Fischer, Philip D. Charles, David Adlam, Alessandro Valli, Katalin Di Gleria, Rajesh K. Kharbanda, Robin P. Choudhury, Charalambos Antoniades, Benedikt M. Kessler and Keith M. Channon

    Clinical Proteomics 2017 14:22

    Published on: 19 June 2017

  10. Research

    Lectin array and glycogene expression analyses of ovarian cancer cell line A2780 and its cisplatin-resistant derivate cell line A2780-cp

    Ovarian cancer is one of the most lethal gynecological malignancies, in which platinum resistance is a common cause of its relapse and death. Glycosylation has been reported to be involved in drug resistance, ...

    Ran Zhao, Wenjun Qin, Ruihuan Qin, Jing Han, Can Li, Yisheng Wang and Congjian Xu

    Clinical Proteomics 2017 14:20

    Published on: 23 May 2017

  11. Research

    The serum protein responses to treatment with Xiaoke Pill and Glibenclamide in type 2 diabetes patients

    The Xiaoke Pill containing Chinese herb extracts and Glibenclamide, is used in therapy for type 2 diabetes mellitus (T2DM), and is effective in reducing the risk of hypoglycemia and improving diabetes symptoms...

    Xiuying Zhang, Haidan Sun, Sanjoy K. Paul, Quanhui Wang, Xiaomin Lou, Guixue Hou, Bo Wen, Linong Ji and Siqi Liu

    Clinical Proteomics 2017 14:19

    Published on: 17 May 2017

  12. Research

    Identification of protein targets in cerebral endothelial cells for brain arteriovenous malformation (AVMs) molecular therapies

    To develop a new molecular targeted treatment for brain (AVMs), identification of membrane proteins that are localised on the AVM endothelium is crucial. Current treatment methods are surgery and radiosurgery....

    Margaret Simonian, Rachel R. Ogorzalek Loo, Nalaka Rannulu, Joseph A. Loo, Mark P. Molloy and Marcus A. Stoodley

    Clinical Proteomics 2017 14:17

    Published on: 16 May 2017

  13. Research

    Potential urine proteomics biomarkers for primary nephrotic syndrome

    Nephrotic syndrome (NS) is a nonspecific kidney disorder, commonly caused by minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN). Here we analyzed urinary p...

    Young Wook Choi, Yang Gyun Kim, Min-Young Song, Ju-Young Moon, Kyung-Hwan Jeong, Tae-Won Lee, Chun-Gyoo Ihm, Kang-Sik Park and Sang-Ho Lee

    Clinical Proteomics 2017 14:18

    Published on: 16 May 2017

  14. Research

    An integrated proteomic and glycoproteomic approach uncovers differences in glycosylation occupancy from benign and malignant epithelial ovarian tumors

    Epithelial ovarian carcinomas encompass a heterogeneous group of diseases with a poor 5-year survival rate. Serous carcinoma is the most common type. Most FDA-approved serum tumor markers are glycoproteins. Th...

    Qing Kay Li, Punit Shah, Yuan Tian, Yingwei Hu, Richard B. S. Roden, Hui Zhang and Daniel W. Chan

    Clinical Proteomics 2017 14:16

    Published on: 10 May 2017

  15. Research

    Downregulation of ATP1A1 promotes cancer development in renal cell carcinoma

    Aberrant expression of Na+/K+-ATPase α1 subunit (ATP1A1) is widely observed in multiple types of tumors, and its tissue-specific expression relates to cancer development. However, the functions and molecular mech...

    Dan Zhang, Peng Zhang, Pengbo Yang, Yu He, Xixi Wang, Yanfang Yang, Hongxia Zhu, Ningzhi Xu and Shufang Liang

    Clinical Proteomics 2017 14:15

    Published on: 4 May 2017

  16. Research

    Identification of novel biomarker and therapeutic target candidates for acute intracerebral hemorrhage by quantitative plasma proteomics

    The systematic mechanisms of acute intracerebral hemorrhage are still unknown and unverified, although many recent researches have indicated the secondary insults. This study was aimed to disclose the patholog...

    Guo-chun Li, Lina Zhang, Ming Yu, Haiyu Jia, Ting Tian, Junqin Wang, Fuqiang Wang and Ling Zhou

    Clinical Proteomics 2017 14:14

    Published on: 26 April 2017

  17. Research

    Proteomic profiling of human intraschisis cavity fluid

    X-linked retinoschisis (XLRS) is a vitreoretinal degenerative disorder causing vision deterioration, due to structural defects in retina. The hallmark of this disease includes radial streaks arising from the f...

    Dhandayuthapani Sudha, Mahdokht Kohansal-Nodehi, Purnima Kovuri, Srikanth Srinivas Manda, Srividya Neriyanuri, Lingam Gopal, Pramod Bhende, Subbulakshmi Chidambaram and Jayamuruga Pandian Arunachalam

    Clinical Proteomics 2017 14:13

    Published on: 24 April 2017

  18. Research

    A clinical perspective on the utility of alpha 1 antichymotrypsin for the early diagnosis of calcific aortic stenosis

    Calcific aortic stenosis (CAS) is the most common heart valve disease in the elderly, representing an important economic and social burden in developed countries. Currently, there is no way to predict either t...

    Tatiana Martin-Rojas, Laura Mourino-Alvarez, Felix Gil-Dones, Fernando de la Cuesta, Esther Rosello-Lleti, Carlos M. Laborde, Miguel Rivera, Luis Fernando Lopez-Almodovar, Juan Antonio Lopez, Finn Akerstrom, Luis R. Padial and Maria G. Barderas

    Clinical Proteomics 2017 14:12

    Published on: 21 April 2017

  19. Review

    A review of studies of the proteomes of circulating microparticles: key roles for galectin-3-binding protein-expressing microparticles in vascular diseases and systemic lupus erythematosus

    Subcellular microvesicles (MVs) have attracted increasing interest during the past decades. While initially considered as inert cellular debris, several important roles for MVs in physiological homeostasis, ca...

    Christoffer T. Nielsen, Ole Østergaard, Niclas S. Rasmussen, Søren Jacobsen and Niels H. H. Heegaard

    Clinical Proteomics 2017 14:11

    Published on: 8 April 2017

  20. Research

    Glycated lysine-141 in haptoglobin improves the diagnostic accuracy for type 2 diabetes mellitus in combination with glycated hemoglobin HbA1c and fasting plasma glucose

    Recent epidemiological studies indicate that only 30–50% of undiagnosed type 2 diabetes mellitus (T2DM) patients are identified using glycated hemoglobin (HbA1c) and elevated fasting plasma glucose (FPG) levels. ...

    Sandro Spiller, Yichao Li, Matthias Blüher, Lonnie Welch and Ralf Hoffmann

    Clinical Proteomics 2017 14:10

    Published on: 28 March 2017

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