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  1. We aimed to compare absolute plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) and growth differentiation factor 15 (GDF-15) obtained by a conventional immunoassay with the correspo...

    Authors: Emma Skau, Philippe Wagner, Jerzy Leppert, Johan Ärnlöv and Pär Hedberg
    Citation: Clinical Proteomics 2023 20:5
    Content type: Research Published on:

  2. Continuous renal replacement therapy (CRRT) has been considered as an adjuvant therapy for sepsis. However, the novel biomarker to evaluate the benefits of CRRT is limited. The aim of this study was to explore...

    Authors: Yun Cui, Shuyun Feng, Huijie Miao, Tiantian Liu, Jingyi Shi, Jiaying Dou, Chunxia Wang and Yucai Zhang
    Citation: Clinical Proteomics 2023 20:4
    Content type: Research Published on:

  3. Non-invasive detection of blood-based markers is a critical clinical need. Plasma has become the main sample type for clinical proteomics research because it is easy to obtain and contains measurable protein b...

    Authors: Xueting Ye, Xiaozhen Cui, Luobin Zhang, Qiong Wu, Xintong Sui, An He, Xinyou Zhang, Ruilian Xu and Ruijun Tian
    Citation: Clinical Proteomics 2023 20:3
    Content type: Research Published on:

  4. Spermatozoa have the task of delivering an intact paternal genome to the oocyte and supporting successful embryo development. The detection of sperm DNA fragmentation (SDF) has been emerging as a complementary...

    Authors: Chun-Hui Zhu, Ye Wei, Fang Chen, Feng Li, Sheng-Min Zhang, Nai-Jun Dong, Tong-Min Xue, Kai-Feng Liu, Heng-Mi Cui and Jin-Chun Lu
    Citation: Clinical Proteomics 2023 20:2
    Content type: Research Published on:

  5. The placenta remains one of the least studied organs within the human body. Yet, placental dysfunction has been associated with various pregnancy complications leading to both maternal and fetal death and long...

    Authors: Samprikta Manna, Julia Scheel, Aisling Noone, Colm J. McElwain, Caitriona Scaife, Shailendra Gupta, Jane English, Cathal McCarthy and Fergus P. McCarthy
    Citation: Clinical Proteomics 2023 20:1
    Content type: Review Published on:

  6. Immunoglobulin A nephropathy (IgAN), a globally common primary chronic glomerulopathy, is one of the leading causes of end-stage renal disease. However, the underlying mechanisms of IgAN have yet to be demonst...

    Authors: Di Zhang, Yaohan Li, Mingzhu Liang, Yan Liang, Jingkui Tian, Qiang He, Bingxian Yang, Juan Jin and Wei Zhu
    Citation: Clinical Proteomics 2022 19:51
    Content type: Research Published on:

  7. Despite the high morbidity and mortality associated with sepsis, the relationship between the plasma proteome and clinical outcome is poorly understood. In this study, we used targeted plasma proteomics to ide...

    Authors: Logan R. Van Nynatten, Marat Slessarev, Claudio M. Martin, Aleks Leligdowicz, Michael R. Miller, Maitray A. Patel, Mark Daley, Eric K. Patterson, Gediminas Cepinskas and Douglas D. Fraser
    Citation: Clinical Proteomics 2022 19:50
    Content type: Research Published on:

  8. The progression of chronic pancreatitis (CP), an inflammatory disease of the pancreas, causes pancreatic stones to form within the pancreatic ductal lumen/parenchyma, which occurs via protein plug formation. P...

    Authors: Renuka Goudshelwar, Bala Manikanta Adimoolam, Sundeep Lakhtakia, Jagadeshwar Reddy Thota, Prabhakar Sripadi, Karuna Rupula, D Nageshwar Reddy and Mitnala Sasikala
    Citation: Clinical Proteomics 2022 19:49
    Content type: Research Published on:

  9. Global high-throughput phosphoproteomic profiling is increasingly being applied to cancer specimens to identify the oncogenic signaling cascades responsible for promoting disease initiation and disease progres...

    Authors: Dilana E. Staudt, Heather C. Murray, David A. Skerrett-Byrne, Nathan D. Smith, M. Fairuz B. Jamaluddin, Richard G. S. Kahl, Ryan J. Duchatel, Zacary P. Germon, Tabitha McLachlan, Evangeline R. Jackson, Izac J. Findlay, Padraic S. Kearney, Abdul Mannan, Holly P. McEwen, Alicia M. Douglas, Brett Nixon…
    Citation: Clinical Proteomics 2022 19:48
    Content type: Research Published on:

  10. Recurrent spontaneous abortion (RSA) is a common and complicated pregnancy-related disease that lacks a suitable biomarker to predict its recrudescence.

    Authors: Xiaohe Sun, Jiamin Jin, Yin-Li Zhang, Yerong Ma, Songying Zhang and Xiaomei Tong
    Citation: Clinical Proteomics 2022 19:47
    Content type: Research Published on:

  11. The outbreak of a novel coronavirus (SARS-CoV-2) in 2019 led to a worldwide pandemic, which remains an integral part of our lives to this day. Coronavirus disease (COVID-19) is a flu like condition, often acco...

    Authors: Juergen Gindlhuber, Tamara Tomin, Florian Wiesenhofer, Martin Zacharias, Laura Liesinger, Vadim Demichev, Klaus Kratochwill, Gregor Gorkiewicz, Matthias Schittmayer and Ruth Birner-Gruenberger
    Citation: Clinical Proteomics 2022 19:46
    Content type: Research Published on:

  12. High blood glucose level is one of the main characteristics of diabetes mellitus. Based on previous studies, it is speculated longevity families may have certain advantages in blood glucose regulation. However...

    Authors: Rong Zhang, Fengjuan Liu, Shengliang Ye, Xi Du, Li Ma, Haijun Cao, Zongkui Wang and Changqing Li
    Citation: Clinical Proteomics 2022 19:45
    Content type: Research Published on:

  13. Lung cancer (LC) is a common malignant tumor with a high incidence and poor prognosis. Early LC could be cured, but the 5-year-survival rate for patients advanced is extremely low. Early screening of tumor bio...

    Authors: Hongyu Chen, Xiaoqin Lai, Yihan Zhu, Hong Huang, Lingyan Zeng and Li Zhang
    Citation: Clinical Proteomics 2022 19:44
    Content type: Research Published on:

  14. Circulating biomarkers play important roles in diagnosis of malignant tumors. N-glycosylation is an important post-translation patter and obviously affect biological behaviors of malignant tumor cells. However...

    Authors: Kai Fang, Qin Long, Zhonghua Liao, Chaoyu Zhang and Zhiqiang Jiang
    Citation: Clinical Proteomics 2022 19:43
    Content type: Correspondence Published on:

  15. Apolipoprotein E (ApoE) genotyping has been shown to have diagnostic value in the evaluation of cardiovascular diseases and neurodegenerative disorders such as Alzheimer’s disease. Although genetic testing is ...

    Authors: Anthony Maus, Dan Figdore, Dragana Milosevic, Alicia Algeciras-Schimnich and Joshua Bornhorst
    Citation: Clinical Proteomics 2022 19:42
    Content type: Research Published on:

  16. Regulatory degradation of intracellular proteins plays an essential role in most biological processes, particularly in the control of cell proliferation and differentiation.

    Authors: Hassan Filali, Ouadie Mohamed El Yaagoubi, Ayoub Lahmadi, Asmaa Quessar, Said El Antri, Hamid Samaki and Souad Aboudkhil
    Citation: Clinical Proteomics 2022 19:41
    Content type: Research Published on:

  17. Authors: Guillaume Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Sirui Zhou, Tomoko Nakanishi, Elsa Brunet-Ratnasingham, David Morrison, Laetitia Laurent, Jonathan Aflalo, Marc Aflalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi…
    Citation: Clinical Proteomics 2022 19:40
    Content type: Correction Published on:

    The original article was published in Clinical Proteomics 2022 19:34

  18. Proximity extension assay (PEA) is a novel antibody-based proteomic technology. Sparse data have been published concerning the matrix effect of serum vs. ethylenediamine tetraacetic acid (EDTA) plasma and the ...

    Authors: Troels D. Christensen, Emil Maag, Kasper Madsen, Sidsel Christy Lindgaard, Dorte L. Nielsen and Julia S. Johansen
    Citation: Clinical Proteomics 2022 19:39
    Content type: Research Published on:

  19. Most patients infected with SARS-CoV-2 display mild symptoms with good prognosis, while 20% of patients suffer from severe viral pneumonia and up to 5% may require intensive care unit (ICU) admission due to se...

    Authors: Fabiola Ciccosanti, Manuela Antonioli, Alessandra Sacchi, Stefania Notari, Anna Farina, Alessia Beccacece, Marisa Fusto, Alessandra Vergori, Gianpiero D’Offizi, Fabrizio Taglietti, Andrea Antinori, Emanuele Nicastri, Luisa Marchioni, Fabrizio Palmieri, Giuseppe Ippolito, Mauro Piacentini…
    Citation: Clinical Proteomics 2022 19:38
    Content type: Research Published on:

  20. BTBD7_hsa_circ_0000563 is a novel circRNA and contains conserved binding sites with RNA-binding proteins. However, BTBD7_hsa_circ_0000563 has not been fully studied in coronary artery disease (CAD). We aimed t...

    Authors: Hanxiao Zhou, Xiongkang Gan, Shu He, Yanjun Wang, Sheng Zhang, Jiaxin Chen, Yaqing Zhou, Can Hou, Lei Hua, Qian Zhang and Enzhi Jia
    Citation: Clinical Proteomics 2022 19:37
    Content type: Research Published on:

  21. The identification of differentially expressed tumor-associated proteins and genomic alterations driving neoplasia is critical in the development of clinical assays to detect cancers and forms the foundation f...

    Authors: Qing Kay Li, Yingwei Hu, Lijun Chen, Michael Schnaubelt, Daniel Cui Zhou, Yize Li, Rita Jui-Hsien Lu, Mathangi Thiagarajan, Galen Hostetter, Chelsea J. Newton, Scott D. Jewell, Gil Omenn, Ana I. Robles, Mehdi Mesri, Oliver F. Bathe, Bing Zhang…
    Citation: Clinical Proteomics 2022 19:36
    Content type: Research Published on:

  22. Optimal cytoreduction to no residual disease (R0) correlates with improved disease outcome for high-grade serous ovarian cancer (HGSOC) patients. Treatment of HGSOC patients with neoadjuvant chemotherapy, howe...

    Authors: Emily R. Penick, Nicholas W. Bateman, Christine Rojas, Cuauhtemoc Magana, Kelly Conrads, Ming Zhou, Brian L. Hood, Guisong Wang, Niyati Parikh, Ying Huang, Kathleen M. Darcy, Yovanni Casablanca, Paulette Mhawech-Fauceglia, Thomas P. Conrads and G. Larry Maxwell
    Citation: Clinical Proteomics 2022 19:35
    Content type: Research Published on:

  23. Severe COVID-19 leads to important changes in circulating immune-related proteins. To date it has been difficult to understand their temporal relationship and identify cytokines that are drivers of severe COVI...

    Authors: Guillaume Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Sirui Zhou, Tomoko Nakanishi, Elsa Brunet-Ratnasingham, David Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi…
    Citation: Clinical Proteomics 2022 19:34
    Content type: Research Published on:

    The Correction to this article has been published in Clinical Proteomics 2022 19:40

  24. Crotonaldehyde (CRA)—one of the major environmental pollutants from tobacco smoke and industrial pollution—is associated with vascular injury (VI). We used proteomics to systematically characterize the present...

    Authors: Ming-Zhang Xie, Jun-Li Liu, Qing-Zu Gao, De-Ying Bo, Lei Wang, Xiao-Chun Zhou, Meng-Meng Zhao, Yu-Chao Zhang, Yu-Jing Zhang, Guo-An Zhao and Lu-Yang Jiao
    Citation: Clinical Proteomics 2022 19:33
    Content type: Research Published on:

  25. Dabie bandavirus, also termed as severe fever with thrombocytopenia syndrome virus (SFTSV), was first isolated in China in 2010. At this time, the virus was found to have spread to South Korea, Japan, and othe...

    Authors: Sang-Yeop Lee, Sung Ho Yun, Hayoung Lee, Yun Gyeong Lee, Giwan Seo, Nam Hoon Kim, Edmond Changkyun Park, Chang-Seop Lee and Seung Il Kim
    Citation: Clinical Proteomics 2022 19:32
    Content type: Research Published on:

  26. Classification of disease severity is crucial for the management of COVID-19. Several studies have shown that individual proteins can be used to classify the severity of COVID-19. Here, we aimed to investigate...

    Authors: Jinlong Gao, Jiale He, Fangfei Zhang, Qi Xiao, Xue Cai, Xiao Yi, Siqi Zheng, Ying Zhang, Donglian Wang, Guangjun Zhu, Jing Wang, Bo Shen, Markus Ralser, Tiannan Guo and Yi Zhu
    Citation: Clinical Proteomics 2022 19:31
    Content type: Research Published on:

  27. Acute Myeloid Leukemia (AML) affects 20,000 patients in the US annually with a five-year survival rate of approximately 25%. One reason for the low survival rate is the high prevalence of clonal evolution that...

    Authors: Sara J. C. Gosline, Cristina Tognon, Michael Nestor, Sunil Joshi, Rucha Modak, Alisa Damnernsawad, Camilo Posso, Jamie Moon, Joshua R. Hansen, Chelsea Hutchinson-Bunch, James C. Pino, Marina A. Gritsenko, Karl K. Weitz, Elie Traer, Jeffrey Tyner, Brian Druker…
    Citation: Clinical Proteomics 2022 19:30
    Content type: Research Published on:

  29. Severe fever with thrombocytopenia syndrome (SFTS) virus is an emerging infectious virus which causes severe hemorrhage, thrombocytopenia, and leukopenia, with a high fatality rate. Since there is no approved ...

    Authors: Sang-Yeop Lee, Hayoung Lee, Sung Ho Yun, Edmond Changkyun Park, Giwan Seo, Hye-Yeon Kim, Sangmi Jun, Nam Hoon Kim, Dongseob Tark, Ju Yeon Lee, Chang-Seop Lee and Seung Il Kim
    Citation: Clinical Proteomics 2022 19:28
    Content type: Letter to the editor Published on:

  30. Colon cancer is the third most common cancer and second highest cause of cancer deaths worldwide. The aim of the study was to find new biomarkers for diagnosis, prognosis and therapeutic drug targets for this ...

    Authors: Matthew J. Munro, Susrutha K. Wickremesekera, Swee T. Tan and Lifeng Peng
    Citation: Clinical Proteomics 2022 19:27
    Content type: Research Published on:

  31. Anti-phospholipase A2 receptor autoantibody (PLA2R Ab)-associated membranous nephropathy (MN) is the most common form of primary MN (pMN). On the other hand, bucillamine (BCL), an antirheumatic drug developed ...

    Authors: Hajime Kaga, Hirotoshi Matsumura, Takehiro Suzuki, Naoshi Dohmae, Masafumi Odaka, Atsushi Komatsuda, Naoto Takahashi and Hideki Wakui
    Citation: Clinical Proteomics 2022 19:26
    Content type: Research Published on:

  32. Breast cancer (BC) is the most common cancer and among the leading causes of cancer death in women. It is a heterogeneous group of tumours with numerous morphological and molecular subtypes, making predictions...

    Authors: Hugo Veyssière, Yannick Bidet, Frederique Penault-Llorca, Nina Radosevic-Robin and Xavier Durando
    Citation: Clinical Proteomics 2022 19:25
    Content type: Review Published on:

  33. Single-cell proteomic analysis provides valuable insights into cellular heterogeneity allowing the characterization of the cellular microenvironment which is difficult to accomplish in bulk proteomic analysis....

    Authors: Yuefan Wang, Tung-Shing Mamie Lih, Lijun Chen, Yuanwei Xu, Morgan D. Kuczler, Liwei Cao, Kenneth J. Pienta, Sarah R. Amend and Hui Zhang
    Citation: Clinical Proteomics 2022 19:24
    Content type: Research Published on:

  34. Multiple sclerosis (MS) is an autoimmune, neurodegenerative disorder with a strong genetic component that acts in a complex interaction with environmental factors for disease development. CD4+ T cells are pivotal...

    Authors: Chiara Cappelletti, Anna Eriksson, Ina Skaara Brorson, Ingvild S. Leikfoss, Oda Kråbøl, Einar August Høgestøl, Valeria Vitelli, Olav Mjaavatten, Hanne F. Harbo, Frode Berven, Steffan D. Bos and Tone Berge
    Citation: Clinical Proteomics 2022 19:23
    Content type: Research Published on:

  36. Roxadustat is a new oral anti-renal anemia medication that works by stabilizing hypoxia-inducible factor (HIF) which can activate the expression of more than 100 genes in addition to genes related to anemia. H...

    Authors: Xiaoe You, Baochun Guo, Zhen Wang, Hualin Ma and Xinzhou Zhang
    Citation: Clinical Proteomics 2022 19:21
    Content type: Research Published on:

  37. There is a lack of early and precise biomarkers for personalized respiratory medicine. Breath contains an aerosol of droplet particles, which are formed from the epithelial lining fluid when the small airways ...

    Authors: Jörgen Östling, Marleen Van Geest, Henric K. Olsson, Sven-Erik Dahlen, Emilia Viklund, Per M. Gustafsson, Ekaterina Mirgorodskaya and Anna-Carin Olin
    Citation: Clinical Proteomics 2022 19:20
    Content type: Research Published on:

    The Correction to this article has been published in Clinical Proteomics 2022 19:29

  38. Embryo implantation is a complex developmental process that requires coordinated interactions among the embryo, endometrium, and the microenvironment of endometrium factors. Even though the impaired endometria...

    Authors: Jun Li, Xiaohua Jiang, Caihua Li, Huihui Che, Lin Ling and Zhaolian Wei
    Citation: Clinical Proteomics 2022 19:19
    Content type: Research Published on:

  39. Esophageal squamous cell carcinoma (ESCC) is a common digestive tract malignant tumor with high incidence and dismal prognosis worldwide. However, the reliable biomarkers for clinical diagnosis and the underly...

    Authors: Wenhu Liu, Qiang Wang, Jinxia Chang, Anup Bhetuwal, Nisha Bhattarai, Fan Zhang and Jiancai Tang
    Citation: Clinical Proteomics 2022 19:18
    Content type: Research Published on:

  40. Despite advances in diagnosis of congenital heart defects, there is no non-invasive biomarker clinically available for the early detection of fetal ventricular septal defects (VSD).

    Authors: Jing He, Liang Xie, Li Yu, Lijun Liu, Hong Xu, Tao Wang, Yuyang Gao, Xuedong Wang, You Duan, Hanmin Liu and Li Dai
    Citation: Clinical Proteomics 2022 19:17
    Content type: Research Published on:

  41. Glucagon serves as an important regulatory hormone for regulating blood glucose concentration with tight feedback control exerted by insulin and glucose. There are critical gaps in our understanding of glucago...

    Authors: Santosh Renuse, Linda M. Benson, Patrick M. Vanderboom, F. N. U. Ruchi, Yogesh R. Yadav, Kenneth L. Johnson, Benjamin C. Brown, Jane A. Peterson, Rita Basu, Daniel J. McCormick, Akhilesh Pandey and Ananda Basu
    Citation: Clinical Proteomics 2022 19:16
    Content type: Research Published on:

  42. Airway remodeling in patients with asthma, which leads to a decline in pulmonary function, is likely the result of repeated exacerbations often provoked by aeroallergen exposures. Aeroallegen exposure triggers...

    Authors: Yanlong Zhu, Stephane Esnault, Ying Ge, Nizar N. Jarjour and Allan R. Brasier
    Citation: Clinical Proteomics 2022 19:15
    Content type: Research Published on:

  43. Accumulating evidence suggests that the androgen receptor (AR) and its endogenous ligands influence disease progression in breast cancer (BCa). However, AR-mediated changes in BCa differ among the various BCa ...

    Authors: Stella K. Vasiliou, Panagiota S. Filippou, Sergi Clotet-Freixas, Antoninus Soosaipillai, Ihor Batruch, Foivos Viktor Tsianos, Ana Konvalinka and Eleftherios P. Diamandis
    Citation: Clinical Proteomics 2022 19:14
    Content type: Research Published on:

  44. Cerebrospinal fluid (CSF) is an important biofluid for biomarkers of neurodegenerative diseases such as Alzheimer’s disease (AD). By employing tandem mass tag (TMT) proteomics, thousands of proteins can be qua...

    Authors: Sophia Weiner, Mathias Sauer, Pieter Jelle Visser, Betty M. Tijms, Egor Vorontsov, Kaj Blennow, Henrik Zetterberg and Johan Gobom
    Citation: Clinical Proteomics 2022 19:13
    Content type: Research Published on:

  45. Treatment for glaucoma has traditionally been limited to reducing intraocular pressure (IOP). Inhibiting oxidative stress in the trabecular meshwork (TM) is regarded as a new treatment for glaucoma; however, t...

    Authors: Qian Li, Liyu Zhang and Yuxin Xu
    Citation: Clinical Proteomics 2022 19:12
    Content type: Research Published on:

  47. Formalin-fixed paraffin-embedded (FFPE) tissue is the standard material for diagnostic pathology but poses relevant hurdles to accurate protein extraction due to cross-linking and chemical alterations. While n...

    Authors: Franz F. Dressler, Jana Schoenfeld, Olga Revyakina, Daniel Vogele, Selina Kiefer, Jutta Kirfel, Timo Gemoll and Sven Perner
    Citation: Clinical Proteomics 2022 19:10
    Content type: Research Published on:

  48. Non-invasive liquid biopsies could complement current pathological nomograms for risk stratification of prostate cancer patients. Development and testing of potential liquid biopsy markers is time, resource, a...

    Authors: Sandra Goetze, Peter Schüffler, Alcibiade Athanasiou, Anika Koetemann, Cedric Poyet, Christian Daniel Fankhauser, Peter J. Wild, Ralph Schiess and Bernd Wollscheid
    Citation: Clinical Proteomics 2022 19:9
    Content type: Research Published on:

  49. Mass spectrometry imaging (MSI) derives spatial molecular distribution maps directly from clinical tissue specimens and thus bears great potential for assisting pathologists with diagnostic decisions or person...

    Authors: Melanie Christine Föll, Veronika Volkmann, Kathrin Enderle-Ammour, Sylvia Timme, Konrad Wilhelm, Dan Guo, Olga Vitek, Peter Bronsert and Oliver Schilling
    Citation: Clinical Proteomics 2022 19:8
    Content type: Research Published on:

  50. Rheumatic heart disease (RHD) remains a major source of morbidity and mortality in developing countries. A deeper insight into the pathogenetic mechanisms underlying RHD could provide opportunities for drug re...

    Authors: M. Taariq Salie, Jing Yang, Carlos R. Ramírez Medina, Liesl J. Zühlke, Chishala Chishala, Mpiko Ntsekhe, Bernard Gitura, Stephen Ogendo, Emmy Okello, Peter Lwabi, John Musuku, Agnes Mtaja, Christopher Hugo-Hamman, Ahmed El-Sayed, Albertino Damasceno, Ana Mocumbi…
    Citation: Clinical Proteomics 2022 19:7
    Content type: Research Published on:
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ISSN: 1559-0275