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  1. Chronic kidney disease (CKD) has few objective symptoms, and it is difficult to make an early diagnosis by using existing methods. Therefore, new biomarkers enabling diagnosis of renal dysfunction at an early ...

    Authors: Kazuma Higashisaka, Sonoko Takeya, Haruhiko Kamada, Masanori Obana, Makiko Maeda, Mai Kabayama, Koichi Yamamoto, Nanan Ishida, Ryo Isaka, Hirofumi Tsujino, Kazuya Nagano, Noriyuki Tomiyama, Hiromi Rakugi, Yasushi Fujio, Kei Kamide and Yasuo Tsutsumi

    Citation: Clinical Proteomics 2022 19:3

    Content type: Research

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  2. Early detection of small cell lung cancer (SCLC) crucially demands highly reliable markers. Growing evidence suggests that extracellular vesicles carry tumor cell-specific cargo suitable as protein markers in ...

    Authors: Shona Pedersen, Katrine Papendick Jensen, Bent Honoré, Søren Risom Kristensen, Camilla Holm Pedersen, Weronika Maria Szejniuk, Raluca Georgiana Maltesen and Ursula Falkmer

    Citation: Clinical Proteomics 2022 19:2

    Content type: Research

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  3. Thrombocytopenia is frequent in Plasmodium vivax malaria but the role of platelets in pathogenesis is unknown. Our study explores the platelet (PLT) proteome from uncomplicated P. vivax patients, to fingerprint m...

    Authors: Diana Fernández, Cesar Segura, Mònica Arman, Suzanne McGill, Richard Burchmore and Tatiana Lopera-Mesa

    Citation: Clinical Proteomics 2022 19:1

    Content type: Research

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  4. Type 2 diabetic kidney disease is the most common cause of chronic kidney diseases (CKD) and end-stage renal diseases (ESRD). Although kidney biopsy is considered as the ‘gold standard’ for diabetic kidney dis...

    Authors: Guanjie Fan, Tongqing Gong, Yuping Lin, Jianping Wang, Lu Sun, Hua Wei, Xing Yang, Zhenjie Liu, Xinliang Li, Ling Zhao, Lan Song, Jiali He, Haibo Liu, Xiuming Li, Lifeng Liu, Anxiang Li…

    Citation: Clinical Proteomics 2021 18:32

    Content type: Research

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  5. Communicating hydrocephalus (CH) is a common neurological disorder caused by a blockage of cerebrospinal fluid. In this study, we aimed to explore the potential molecular mechanism underlying CH development.

    Authors: Lei Yuan, Dongdong Zou, Xia Yang, Xin Chen, Youming Lu, Aijun Zhang, Pengqi Zhang and Fance Wei

    Citation: Clinical Proteomics 2021 18:30

    Content type: Research

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  6. The rapid advancements of high throughput “omics” technologies have brought a massive amount of data to process during and after experiments. Multi-omic analysis facilitates a deeper interrogation of a dataset...

    Authors: Hui Zhang, Minghui Ao, Arianna Boja, Michael Schnaubelt and Yingwei Hu

    Citation: Clinical Proteomics 2021 18:29

    Content type: Research

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  7. Vitreous is an accessible, information-rich biofluid that has recently been studied as a source of retinal disease-related proteins and pathways. However, the number of samples required to confidently identify...

    Authors: Sarah R. Weber, Yuanjun Zhao, Jingqun Ma, Christopher Gates, Felipe da Veiga Leprevost, Venkatesha Basrur, Alexey I. Nesvizhskii, Thomas W. Gardner and Jeffrey M. Sundstrom

    Citation: Clinical Proteomics 2021 18:28

    Content type: Research

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  8. Liver transplantation (LT) can be offered to patients with Hepatocellular carcinoma (HCC) beyond Milan criteria. However, there are currently limited molecular markers on HCC explant histology to predict recur...

    Authors: Mamatha Bhat, Sergi Clotet-Freixas, Cristina Baciu, Elisa Pasini, Ahmed Hammad, Tommy Ivanics, Shelby Reid, Amirhossein Azhie, Marc Angeli, Anand Ghanekar, Sandra Fischer, Gonzalo Sapisochin and Ana Konvalinka

    Citation: Clinical Proteomics 2021 18:27

    Content type: Research

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  9. The KidneyIntelX™ test applies a machine learning algorithm that incorporates plasma biomarkers and clinical variables to produce a composite risk score to predict a progressive decline in kidney function in p...

    Authors: Patricia Connolly, Sharon Stapleton, Gohar Mosoyan, Ilya Fligelman, Ya-Chen Tonar, Fergus Fleming and Michael J. Donovan

    Citation: Clinical Proteomics 2021 18:26

    Content type: Research

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  10. SARS-CoV-2, a novel human coronavirus, has created a global disease burden infecting > 100 million humans in just over a year. RT-PCR is currently the predominant method of diagnosing this viral infection alth...

    Authors: Kiran K. Mangalaparthi, Sandip Chavan, Anil K. Madugundu, Santosh Renuse, Patrick M. Vanderboom, Anthony D. Maus, Jennifer Kemp, Benjamin R. Kipp, Stefan K. Grebe, Ravinder J. Singh and Akhilesh Pandey

    Citation: Clinical Proteomics 2021 18:25

    Content type: Letter to the editor

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  11. Osteoporosis (OP) is a systemic bone disease characterized by decreased bone mass, destruction of the bone tissue microstructure, increased bone brittleness and an increased risk of fracture. OP has a high inc...

    Authors: Ruikun Zhang, Kun Yan, Yulun Wu, Xinmiao Yao, Guijin Li, Linpu Ge and Zhineng Chen

    Citation: Clinical Proteomics 2021 18:24

    Content type: Research

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  12. Cardiovascular disease (CVD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and reduced lung function is an important risk factor for CVD and CVD-related death. However, the mechanisms...

    Authors: K. Egervall, A. Rosso and S. Elmståhl

    Citation: Clinical Proteomics 2021 18:23

    Content type: Research

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  13. Preeclampsia and gestational hypertension can cause vascular function impairment in offspring. In our previous work, we described the protein expression profiles of umbilical artery tissues from patients with ...

    Authors: Bin Yu, Hong-Dan Zhu, Xiao-Liang Shi, Pan-Pan Chen, Xiang-Mei Sun, Gui-Yu Xia, Min Fang, Yong-Xing Zhong, Xiao-Li Tang, Tao Zhang and Hai-Tao Pan

    Citation: Clinical Proteomics 2021 18:22

    Content type: Research

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  14. A hepatocellular carcinoma (HCC) prediction model (ASAP), including age, sex, and the biomarkers alpha-fetoprotein and prothrombin induced by vitamin K absence-II, showed potential clinical value in the early ...

    Authors: Bo Li, Youyun Zhao, Wangxi Cai, Anping Ming and Hanmin Li

    Citation: Clinical Proteomics 2021 18:21

    Content type: Research

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  15. It is not enough to optimize proteomics assays. It is critical those assays are robust to operating conditions. Without robust assays, proteomic biomarkers are unlikely to translate readily into the clinic. Th...

    Authors: Edith Serrano-Blesa, Andrew Porter, Dennis W. Lendrem, Costantino Pitzalis, Anne Barton, Achim Treumann and John D. Isaacs

    Citation: Clinical Proteomics 2021 18:20

    Content type: Research

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  16. Molecular diagnostics of the coronavirus disease of 2019 (COVID-19) now mainly relies on the measurements of viral RNA by RT-PCR, or detection of anti-viral antibodies by immunoassays. In this review, we discu...

    Authors: Yasmine Rais, Zhiqiang Fu and Andrei P. Drabovich

    Citation: Clinical Proteomics 2021 18:19

    Content type: Review

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  17. Placenta is a complex organ that plays a significant role in the maintenance of pregnancy health. It is a dynamic organ that undergoes dramatic changes in growth and development at different stages of gestatio...

    Authors: Sara Khorami Sarvestani, Sorour Shojaeian, Negar Vanaki, Behrouz Ghresi-Fard, Mehdi Amini, Kambiz Gilany, Hale Soltanghoraee, Soheila Arefi, Mahmood Jeddi-Tehrani and Amir-Hassan Zarnani

    Citation: Clinical Proteomics 2021 18:18

    Content type: Research

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  18. A practical strategy to discover proteins specific to Alzheimer’s dementia (AD) may be to compare the plasma peptides and proteins from patients with dementia to normal controls and patients with neurological ...

    Authors: Angelique Florentinus-Mefailoski, Peter Bowden, Philip Scheltens, Joep Killestein, Charlotte Teunissen and John G. Marshall

    Citation: Clinical Proteomics 2021 18:17

    Content type: Research

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  19. Gastrointestinal stromal tumor (GIST) is a common digestive tract tumor with high rate of metastasis and recurrence. Currently, we understand the genome, transcriptome and proteome in GIST. However, posttransc...

    Authors: Bo Wang, Long Zhao, Zhidong Gao, Jianyuan Luo, Haoran Zhang, Lin Gan, Kewei Jiang, Shan Wang, Yingjiang Ye and Zhanlong Shen

    Citation: Clinical Proteomics 2021 18:16

    Content type: Research

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  20. The Coronavirus Disease 2019 (COVID-19) global pandemic has had a profound, lasting impact on the world's population. A key aspect to providing care for those with COVID-19 and checking its further spread is e...

    Authors: Andrew T. Rajczewski, Subina Mehta, Dinh Duy An Nguyen, Björn Grüning, James E. Johnson, Thomas McGowan, Timothy J. Griffin and Pratik D. Jagtap

    Citation: Clinical Proteomics 2021 18:15

    Content type: Research

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  21. Glioblastoma (GBM) is a grade IV glioma highly aggressive and refractory to the therapeutic approaches currently in use. O-GlcNAcylation plays a key role for tumor aggressiveness and progression in different t...

    Authors: Maria Cecilia Oliveira-Nunes, Glaucia Julião, Aline Menezes, Fernanda Mariath, John A. Hanover, Joseph Albert Medeiros Evaristo, Fábio César Sousa Nogueira, Wagner Barbosa Dias, Denise de Abreu Pereira and Katia Carneiro

    Citation: Clinical Proteomics 2021 18:14

    Content type: Research

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  22. Over the last decade, the use of proteomics in the setting of prematurity has increased and has enabled researchers to successfully identify biomarkers for an array of associated morbidities. The objective of ...

    Authors: Natasha Letunica, Tengyi Cai, Jeanie L. Y. Cheong, Lex W. Doyle, Paul Monagle and Vera Ignjatovic

    Citation: Clinical Proteomics 2021 18:13

    Content type: Review

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  23. High red cell distribution width (RDW) has been increasingly recognized as a risk factor for cardiovascular diseases (CVDs), but the underlying mechanisms remain unknown. Our aim was to explore the association...

    Authors: Jingxue Pan, Yan Borné, Marju Orho-Melander, Jan Nilsson, Olle Melander and Gunnar Engström

    Citation: Clinical Proteomics 2021 18:12

    Content type: Research

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  24. Protein profiles that can predict allergy development in children are lacking and the ideal sampling age is unknown. By applying an exploratory proteomics approach in the prospective FARMFLORA birth cohort, we...

    Authors: Marit Stockfelt, Mun-Gwan Hong, Bill Hesselmar, Ingegerd Adlerberth, Agnes E. Wold, Jochen M. Schwenk, Anna-Carin Lundell and Anna Rudin

    Citation: Clinical Proteomics 2021 18:11

    Content type: Research

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  25. The pipeline of biomarker translation from bench to bedside is challenging and limited biomarkers have been adopted to routine clinical care. Ideally, biomarker research and development should be driven by unm...

    Authors: T. T. van Duijl, D. Soonawala, J. W. de Fijter, L. R. Ruhaak and C. M. Cobbaert

    Citation: Clinical Proteomics 2021 18:10

    Content type: Review

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  26. Pregnancy is a complicated physiological process. The multifaceted regulation of maternal–fetal interface is of great importance for maintaining normal pregnancy and avoiding fetal rejection and secondary abor...

    Authors: Xiang-Jie Yin, Wei Hong, Fu-Ju Tian and Xiao-Cui Li

    Citation: Clinical Proteomics 2021 18:9

    Content type: Research

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  27. Based on their potential to analyze aberrant cellular signaling in relation to biological function, kinase activity profiling in tumor biopsies by peptide microarrays and mass spectrometry-based phosphoproteom...

    Authors: Tineke E. Buffart, Rosanne A. H. M. van den Oord, Adriënne van den Berg, Riet Hilhorst, Niek Bastiaensen, Hans F. M. Pruijt, Adriaan van den Brule, Peet Nooijen, Mariette Labots, Richard R. de Goeij-de Haas, Henk Dekker, Sander R. Piersma, Thang V. Pham, Theo van der Leij, Rik de Wijn, Rob Ruijtenbeek…

    Citation: Clinical Proteomics 2021 18:8

    Content type: Research

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  28. Protein posttranslational modification is an indispensable regulatory element that can fine-tune protein functions and regulate diverse cellular processes. Lysine 2-hydroxyisobutyrylation (Khib) is a protein p...

    Authors: Shaoying Huang, Fengping Zheng, Hua Lin, Xianqing Zhou, Huixuan Xu, Cantong Zhang, Weier Dai, Berthold Hocher, Xinzhou Zhang, Donge Tang and Yong Dai

    Citation: Clinical Proteomics 2021 18:7

    Content type: Research

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  29. Quantitative proteomics is an invaluable tool in biomedicine for the massive comparative analysis of protein component of complex biological samples. In the last two decades, this technique has been used to de...

    Authors: Rosana Navajas, Fernando Corrales and Alberto Paradela

    Citation: Clinical Proteomics 2021 18:6

    Content type: Review

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  30. Plasma is a potentially rich source of protein biomarkers for disease progression and drug response. Large multi-center studies are often carried out to increase the number of samples analyzed in a given study...

    Authors: Patrick Halvey, Victor Farutin, Laura Koppes, Nur Sibel Gunay, Dimitrios A. Pappas, Anthony M. Manning and Ishan Capila

    Citation: Clinical Proteomics 2021 18:5

    Content type: Research

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  31. The purpose of this study was to determine whether the residual fixative from a liquid-based Pap test or a swab of the cervix contained proteins that were also found in the primary tumor of a woman with high g...

    Authors: Kristin L. M. Boylan, Somaieh Afiuni-Zadeh, Melissa A. Geller, Peter A. Argenta, Timothy J. Griffin and Amy P. N. Skubitz

    Citation: Clinical Proteomics 2021 18:4

    Content type: Research

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  32. To investigate the complexity of proteomics in cervical cancer tissues, we used isobaric tags for relative and absolute quantitation (iTRAQ)-based mass spectrometry analysis on a panel of normal cervical tissu...

    Authors: Xiao Han, Siyi Zhong, Pengnan Zhang, Yanmei Liu, Sangsang Shi, Congquan Wu and Shujun Gao

    Citation: Clinical Proteomics 2021 18:2

    Content type: Research

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  33. Atrial fibrillation (AF) is the most common cardiac heterogeneous rhythm disorder. It represents a major cause of mortality and morbidity, mainly related to embolic events and heart failure. Mechanisms of AF a...

    Authors: Hanwen Ni, Wenqi Pan, Qi Jin, Yucai Xie, Ning Zhang, Kang Chen, Tianyou Lin, Changjian Lin, Yun Xie, Jiemin Wu, Peihua Ni and Liqun Wu

    Citation: Clinical Proteomics 2021 18:1

    Content type: Research

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  34. Diseases of the anterior segment of the eye may present different mechanisms, intensity of symptoms, and impact on the patients’ quality of life and vision. The tear film is in direct contact with the ocular s...

    Authors: Daniel de Almeida Borges, Marcos Rodrigo Alborghetti, Adriana Franco Paes Leme, Romenia Ramos Domingues, Bruna Duarte, Melina Veiga, Marilia Trindade Ferrer, Ana Claudia Viana Wanzeler, Carlos Eduardo Leite Arieta and Monica Alves

    Citation: Clinical Proteomics 2020 17:42

    Content type: Research

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  35. Following the introduction of routine Prostate Specific Antigen (PSA) screening in the early 1990′s, Prostate Cancer (PCa) is often detected at an early stage. There are also a growing number of treatment opti...

    Authors: Claire Tonry, Stephen Finn, John Armstrong and Stephen R. Pennington

    Citation: Clinical Proteomics 2020 17:41

    Content type: Review

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  36. Proteomic studies are typically conducted using flash-frozen (FF) samples utilizing tandem mass spectrometry (MS). However, FF specimens are comprised of multiple cell types, making it difficult to ascertain t...

    Authors: Lori A. Sturtz, Guisong Wang, Punit Shah, Richard Searfoss, Praveen-Kumar Raj-Kumar, Jeffrey A. Hooke, J. Leigh Fantacone-Campbell, Brenda Deyarmin, Mary Lou Cutler, Rangaprasad Sarangarajan, Niven R. Narain, Hai Hu, Michael A. Kiebish, Albert J. Kovatich and Craig D. Shriver

    Citation: Clinical Proteomics 2020 17:40

    Content type: Research

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  37. Remote ischaemic conditioning (RIC) is currently being explored as a non-invasive method to attenuate ischaemia/reperfusion injuries in organs. A randomised clinical study (CONTEXT) evaluated the effects of RI...

    Authors: Adam M. Thorne, Honglei Huang, Darragh P. O‘Brien, Marco Eijken, Nicoline Valentina Krogstrup, Rikke Norregaard, Bjarne Møller, Rutger J. Ploeg, Bente Jespersen and Benedikt M. Kessler

    Citation: Clinical Proteomics 2020 17:39

    Content type: Research

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  38. Weight gain is a common consequence of treatment with antipsychotic drugs in early psychosis, leading to further morbidity and poor treatment adherence. Identifying tools that can predict weight change in earl...

    Authors: Adrian Heald, Narges Azadbakht, Bethany Geary, Silke Conen, Helene Fachim, Dave Chi Hoo Lee, Nophar Geifman, Sanam Farman, Oliver Howes, Anthony Whetton and Bill Deakin

    Citation: Clinical Proteomics 2020 17:38

    Content type: Letter to the editor

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  39. PromarkerD is a novel proteomics derived blood test for predicting diabetic kidney disease (DKD). The test is based on an algorithm that combines the measurement of three plasma protein biomarkers (CD5L, APOA4...

    Authors: Scott Bringans, Jason Ito, Tammy Casey, Sarah Thomas, Kirsten Peters, Ben Crossett, Orla Coleman, Holger A. Ebhardt, Stephen R. Pennington and Richard Lipscombe

    Citation: Clinical Proteomics 2020 17:37

    Content type: Research

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  40. Femtosecond laser-assisted in situ keratomileusis (LASIK) has proven to be an efficacious, predictable, and safe procedure for the correction of refractive errors. We examined the early tear protein changes of...

    Authors: Janika Nättinen, Petri Mäkinen, Ulla Aapola, Lasse Orsila, Juhani Pietilä and Hannu Uusitalo

    Citation: Clinical Proteomics 2020 17:36

    Content type: Research

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  41. Autoantibodies are a hallmark of autoimmune diseases. Autoantibody screening by indirect immunofluorescence staining of HEp-2 cells with patient sera is a current standard in clinical practice. Differential di...

    Authors: Julia Y. Wang, Wei Zhang, Jung-hyun Rho, Michael W. Roehrl and Michael H. Roehrl

    Citation: Clinical Proteomics 2020 17:35

    Content type: Research

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  42. Peritoneal metastasis (PM) in gastric cancer (GC) remains an untreatable disease, and is difficult to diagnose preoperatively. Here, we aim to establish a novel prediction model.

    Authors: Junjie Zhao, Ruihuan Qin, Hao Chen, Yupeng Yang, Wenjun Qin, Jing Han, Xuefei Wang, Shifang Ren, Yihong Sun and Jianxin Gu

    Citation: Clinical Proteomics 2020 17:34

    Content type: Research

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  43. Verification of cerebrospinal fluid (CSF) biomarkers for multiple sclerosis and other neurological diseases is a major challenge due to a large number of candidates, limited sample material availability, disea...

    Authors: Astrid Guldbrandsen, Ragnhild Reehorst Lereim, Mari Jacobsen, Hilde Garberg, Ann Cathrine Kroksveen, Harald Barsnes and Frode S. Berven

    Citation: Clinical Proteomics 2020 17:33

    Content type: Research

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  44. Ginkgolide B (GB), the extract of G. biloba leaves, has been shown to be protective against many neurological disorders, including Parkinson’s disease (PD). Efforts have been made to synthesized ginkgolides analo...

    Authors: Zili Feng, Zhibin Zhu, Wang Chen, Yu Bai, Daihua Hu and Jia Cheng

    Citation: Clinical Proteomics 2020 17:32

    Content type: Research

    Published on:

  45. Extracellular vesicles (EVs) released by neurons and glia reach the cerebrospinal fluid (CSF). Studying the proteome of CSF-derived EVs offers a novel perspective on the key intracellular processes associated ...

    Authors: Alexander G. Thompson, Elizabeth Gray, Imre Mäger, Marie-Laëtitia Thézénas, Philip D. Charles, Kevin Talbot, Roman Fischer, Benedikt M. Kessler, Mathew Wood and Martin R. Turner

    Citation: Clinical Proteomics 2020 17:31

    Content type: Research

    Published on:

  46. The aetiologies and pathogeneses of the joint diseases rheumatoid arthritis (RA) and spondyloarthritis (SpA) are still not fully elucidated. To increase our understanding of the molecular pathogenesis, we anal...

    Authors: Svend Birkelund, Tue Bjerg Bennike, Kenneth Kastaniegaard, Mads Lausen, Thomas Bouet Guldbæk Poulsen, Tue Wenzel Kragstrup, Bent Winding Deleuran, Gunna Christiansen and Allan Stensballe

    Citation: Clinical Proteomics 2020 17:29

    Content type: Research

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