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  1. High red cell distribution width (RDW) has been increasingly recognized as a risk factor for cardiovascular diseases (CVDs), but the underlying mechanisms remain unknown. Our aim was to explore the association...

    Authors: Jingxue Pan, Yan Borné, Marju Orho-Melander, Jan Nilsson, Olle Melander and Gunnar Engström

    Citation: Clinical Proteomics 2021 18:12

    Content type: Research

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  2. Protein profiles that can predict allergy development in children are lacking and the ideal sampling age is unknown. By applying an exploratory proteomics approach in the prospective FARMFLORA birth cohort, we...

    Authors: Marit Stockfelt, Mun-Gwan Hong, Bill Hesselmar, Ingegerd Adlerberth, Agnes E. Wold, Jochen M. Schwenk, Anna-Carin Lundell and Anna Rudin

    Citation: Clinical Proteomics 2021 18:11

    Content type: Research

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  3. The pipeline of biomarker translation from bench to bedside is challenging and limited biomarkers have been adopted to routine clinical care. Ideally, biomarker research and development should be driven by unm...

    Authors: T. T. van Duijl, D. Soonawala, J. W. de Fijter, L. R. Ruhaak and C. M. Cobbaert

    Citation: Clinical Proteomics 2021 18:10

    Content type: Review

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  4. Pregnancy is a complicated physiological process. The multifaceted regulation of maternal–fetal interface is of great importance for maintaining normal pregnancy and avoiding fetal rejection and secondary abor...

    Authors: Xiang-Jie Yin, Wei Hong, Fu-Ju Tian and Xiao-Cui Li

    Citation: Clinical Proteomics 2021 18:9

    Content type: Research

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  5. Based on their potential to analyze aberrant cellular signaling in relation to biological function, kinase activity profiling in tumor biopsies by peptide microarrays and mass spectrometry-based phosphoproteom...

    Authors: Tineke E. Buffart, Rosanne A. H. M. van den Oord, Adriënne van den Berg, Riet Hilhorst, Niek Bastiaensen, Hans F. M. Pruijt, Adriaan van den Brule, Peet Nooijen, Mariette Labots, Richard R. de Goeij-de Haas, Henk Dekker, Sander R. Piersma, Thang V. Pham, Theo van der Leij, Rik de Wijn, Rob Ruijtenbeek…

    Citation: Clinical Proteomics 2021 18:8

    Content type: Research

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  6. Protein posttranslational modification is an indispensable regulatory element that can fine-tune protein functions and regulate diverse cellular processes. Lysine 2-hydroxyisobutyrylation (Khib) is a protein p...

    Authors: Shaoying Huang, Fengping Zheng, Hua Lin, Xianqing Zhou, Huixuan Xu, Cantong Zhang, Weier Dai, Berthold Hocher, Xinzhou Zhang, Donge Tang and Yong Dai

    Citation: Clinical Proteomics 2021 18:7

    Content type: Research

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  7. Quantitative proteomics is an invaluable tool in biomedicine for the massive comparative analysis of protein component of complex biological samples. In the last two decades, this technique has been used to de...

    Authors: Rosana Navajas, Fernando Corrales and Alberto Paradela

    Citation: Clinical Proteomics 2021 18:6

    Content type: Review

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  8. Plasma is a potentially rich source of protein biomarkers for disease progression and drug response. Large multi-center studies are often carried out to increase the number of samples analyzed in a given study...

    Authors: Patrick Halvey, Victor Farutin, Laura Koppes, Nur Sibel Gunay, Dimitrios A. Pappas, Anthony M. Manning and Ishan Capila

    Citation: Clinical Proteomics 2021 18:5

    Content type: Research

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  9. The purpose of this study was to determine whether the residual fixative from a liquid-based Pap test or a swab of the cervix contained proteins that were also found in the primary tumor of a woman with high g...

    Authors: Kristin L. M. Boylan, Somaieh Afiuni-Zadeh, Melissa A. Geller, Peter A. Argenta, Timothy J. Griffin and Amy P. N. Skubitz

    Citation: Clinical Proteomics 2021 18:4

    Content type: Research

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  10. To investigate the complexity of proteomics in cervical cancer tissues, we used isobaric tags for relative and absolute quantitation (iTRAQ)-based mass spectrometry analysis on a panel of normal cervical tissu...

    Authors: Xiao Han, Siyi Zhong, Pengnan Zhang, Yanmei Liu, Sangsang Shi, Congquan Wu and Shujun Gao

    Citation: Clinical Proteomics 2021 18:2

    Content type: Research

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  11. Atrial fibrillation (AF) is the most common cardiac heterogeneous rhythm disorder. It represents a major cause of mortality and morbidity, mainly related to embolic events and heart failure. Mechanisms of AF a...

    Authors: Hanwen Ni, Wenqi Pan, Qi Jin, Yucai Xie, Ning Zhang, Kang Chen, Tianyou Lin, Changjian Lin, Yun Xie, Jiemin Wu, Peihua Ni and Liqun Wu

    Citation: Clinical Proteomics 2021 18:1

    Content type: Research

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  12. Diseases of the anterior segment of the eye may present different mechanisms, intensity of symptoms, and impact on the patients’ quality of life and vision. The tear film is in direct contact with the ocular s...

    Authors: Daniel de Almeida Borges, Marcos Rodrigo Alborghetti, Adriana Franco Paes Leme, Romenia Ramos Domingues, Bruna Duarte, Melina Veiga, Marilia Trindade Ferrer, Ana Claudia Viana Wanzeler, Carlos Eduardo Leite Arieta and Monica Alves

    Citation: Clinical Proteomics 2020 17:42

    Content type: Research

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  13. Following the introduction of routine Prostate Specific Antigen (PSA) screening in the early 1990′s, Prostate Cancer (PCa) is often detected at an early stage. There are also a growing number of treatment opti...

    Authors: Claire Tonry, Stephen Finn, John Armstrong and Stephen R. Pennington

    Citation: Clinical Proteomics 2020 17:41

    Content type: Review

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  14. Proteomic studies are typically conducted using flash-frozen (FF) samples utilizing tandem mass spectrometry (MS). However, FF specimens are comprised of multiple cell types, making it difficult to ascertain t...

    Authors: Lori A. Sturtz, Guisong Wang, Punit Shah, Richard Searfoss, Praveen-Kumar Raj-Kumar, Jeffrey A. Hooke, J. Leigh Fantacone-Campbell, Brenda Deyarmin, Mary Lou Cutler, Rangaprasad Sarangarajan, Niven R. Narain, Hai Hu, Michael A. Kiebish, Albert J. Kovatich and Craig D. Shriver

    Citation: Clinical Proteomics 2020 17:40

    Content type: Research

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  15. Remote ischaemic conditioning (RIC) is currently being explored as a non-invasive method to attenuate ischaemia/reperfusion injuries in organs. A randomised clinical study (CONTEXT) evaluated the effects of RI...

    Authors: Adam M. Thorne, Honglei Huang, Darragh P. O‘Brien, Marco Eijken, Nicoline Valentina Krogstrup, Rikke Norregaard, Bjarne Møller, Rutger J. Ploeg, Bente Jespersen and Benedikt M. Kessler

    Citation: Clinical Proteomics 2020 17:39

    Content type: Research

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  16. Weight gain is a common consequence of treatment with antipsychotic drugs in early psychosis, leading to further morbidity and poor treatment adherence. Identifying tools that can predict weight change in earl...

    Authors: Adrian Heald, Narges Azadbakht, Bethany Geary, Silke Conen, Helene Fachim, Dave Chi Hoo Lee, Nophar Geifman, Sanam Farman, Oliver Howes, Anthony Whetton and Bill Deakin

    Citation: Clinical Proteomics 2020 17:38

    Content type: Letter to the editor

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  17. PromarkerD is a novel proteomics derived blood test for predicting diabetic kidney disease (DKD). The test is based on an algorithm that combines the measurement of three plasma protein biomarkers (CD5L, APOA4...

    Authors: Scott Bringans, Jason Ito, Tammy Casey, Sarah Thomas, Kirsten Peters, Ben Crossett, Orla Coleman, Holger A. Ebhardt, Stephen R. Pennington and Richard Lipscombe

    Citation: Clinical Proteomics 2020 17:37

    Content type: Research

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  18. Femtosecond laser-assisted in situ keratomileusis (LASIK) has proven to be an efficacious, predictable, and safe procedure for the correction of refractive errors. We examined the early tear protein changes of...

    Authors: Janika Nättinen, Petri Mäkinen, Ulla Aapola, Lasse Orsila, Juhani Pietilä and Hannu Uusitalo

    Citation: Clinical Proteomics 2020 17:36

    Content type: Research

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  19. Autoantibodies are a hallmark of autoimmune diseases. Autoantibody screening by indirect immunofluorescence staining of HEp-2 cells with patient sera is a current standard in clinical practice. Differential di...

    Authors: Julia Y. Wang, Wei Zhang, Jung-hyun Rho, Michael W. Roehrl and Michael H. Roehrl

    Citation: Clinical Proteomics 2020 17:35

    Content type: Research

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  20. Peritoneal metastasis (PM) in gastric cancer (GC) remains an untreatable disease, and is difficult to diagnose preoperatively. Here, we aim to establish a novel prediction model.

    Authors: Junjie Zhao, Ruihuan Qin, Hao Chen, Yupeng Yang, Wenjun Qin, Jing Han, Xuefei Wang, Shifang Ren, Yihong Sun and Jianxin Gu

    Citation: Clinical Proteomics 2020 17:34

    Content type: Research

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  21. Verification of cerebrospinal fluid (CSF) biomarkers for multiple sclerosis and other neurological diseases is a major challenge due to a large number of candidates, limited sample material availability, disea...

    Authors: Astrid Guldbrandsen, Ragnhild Reehorst Lereim, Mari Jacobsen, Hilde Garberg, Ann Cathrine Kroksveen, Harald Barsnes and Frode S. Berven

    Citation: Clinical Proteomics 2020 17:33

    Content type: Research

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  22. Ginkgolide B (GB), the extract of G. biloba leaves, has been shown to be protective against many neurological disorders, including Parkinson’s disease (PD). Efforts have been made to synthesized ginkgolides analo...

    Authors: Zili Feng, Zhibin Zhu, Wang Chen, Yu Bai, Daihua Hu and Jia Cheng

    Citation: Clinical Proteomics 2020 17:32

    Content type: Research

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  23. Extracellular vesicles (EVs) released by neurons and glia reach the cerebrospinal fluid (CSF). Studying the proteome of CSF-derived EVs offers a novel perspective on the key intracellular processes associated ...

    Authors: Alexander G. Thompson, Elizabeth Gray, Imre Mäger, Marie-Laëtitia Thézénas, Philip D. Charles, Kevin Talbot, Roman Fischer, Benedikt M. Kessler, Mathew Wood and Martin R. Turner

    Citation: Clinical Proteomics 2020 17:31

    Content type: Research

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  24. The aetiologies and pathogeneses of the joint diseases rheumatoid arthritis (RA) and spondyloarthritis (SpA) are still not fully elucidated. To increase our understanding of the molecular pathogenesis, we anal...

    Authors: Svend Birkelund, Tue Bjerg Bennike, Kenneth Kastaniegaard, Mads Lausen, Thomas Bouet Guldbæk Poulsen, Tue Wenzel Kragstrup, Bent Winding Deleuran, Gunna Christiansen and Allan Stensballe

    Citation: Clinical Proteomics 2020 17:29

    Content type: Research

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  25. A practical strategy to discover sepsis specific proteins may be to compare the plasma peptides and proteins from patients in the intensive care unit with and without sepsis. The aim was to discover proteins a...

    Authors: Thanusi Thavarajah, Claudia C. dos Santos, Arthur S. Slutsky, John C. Marshall, Pete Bowden, Alexander Romaschin and John G. Marshall

    Citation: Clinical Proteomics 2020 17:26

    Content type: Research

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  26. Reliable high-throughput microbial pathogen identification in human urine samples is crucial for patients with cystitis symptoms. Currently employed methods are time-consuming and could lead to unnecessary or ...

    Authors: Damir Oros, Marina Ceprnja, Jurica Zucko, Mario Cindric, Amela Hozic, Jasenka Skrlin, Karmela Barisic, Ena Melvan, Ksenija Uroic, Blazenka Kos and Antonio Starcevic

    Citation: Clinical Proteomics 2020 17:25

    Content type: Research

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  27. Haematoxylin and eosin (H&E)—which respectively stain nuclei blue and other cellular and stromal material pink—are routinely used for clinical diagnosis based on the identification of morphological features. A...

    Authors: Jeremy A. Herrera, Venkatesh Mallikarjun, Silvia Rosini, Maria Angeles Montero, Craig Lawless, Stacey Warwood, Ronan O’Cualain, David Knight, Martin A. Schwartz and Joe Swift

    Citation: Clinical Proteomics 2020 17:24

    Content type: Research

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  28. The pathophysiology of subclinical versus clinical rejection remains incompletely understood given their equivalent histological severity but discordant graft function. The goal was to evaluate serine hydrolas...

    Authors: Mario Navarrete, Brice Korkmaz, Carla Guarino, Adam Lesner, Ying Lao, Julie Ho, Peter Nickerson and John A. Wilkins

    Citation: Clinical Proteomics 2020 17:23

    Content type: Research

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  29. Human follicular fluid (HFF), which is composed by essential proteins required for the follicle development, provides an important microenvironment for oocyte maturation. Recently, overweight status has been c...

    Authors: Xin Liu, Yanhua Wang, Peng Zhu, Jiahui Wang, Juan Liu, Ning Li, Wenting Wang, Wendi Zhang, Chengli Zhang, Yanwei Wang, Xiaofang Shen and Fujun Liu

    Citation: Clinical Proteomics 2020 17:22

    Content type: Research

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  30. During the last two decades, over 100 proteomics studies have identified a variety of potential biomarkers in CSF of Alzheimer’s (AD) patients. Although several reviews have proposed specific biomarkers, to da...

    Authors: Cristina M. Pedrero-Prieto, Sonia García-Carpintero, Javier Frontiñán-Rubio, Emilio Llanos-González, Cristina Aguilera García, Francisco J. Alcaín, Iris Lindberg, Mario Durán-Prado, Juan R. Peinado and Yoana Rabanal-Ruiz

    Citation: Clinical Proteomics 2020 17:21

    Content type: Review

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  31. Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease affecting the axial skeleton and peripheral joints. The etiology of this disease remains poorly understood, but interactions between gene...

    Authors: Ji-Hyun Lee, Jae Hun Jung, Jeesoo Kim, Won-Ki Baek, Jinseol Rhee, Tae-Hwan Kim, Sang-Hyon Kim, Kwang Pyo Kim, Chang-Nam Son and Jong-Seo Kim

    Citation: Clinical Proteomics 2020 17:20

    Content type: Research

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  32. Alzheimer’s disease (AD) is the most common cause of dementia, characterized by progressive cognitive decline. Protein biomarkers of AD brain pathology, including β-amyloid and Tau, are reflected in cerebrospi...

    Authors: Maotian Zhou, Rafi U. Haque, Eric B. Dammer, Duc M. Duong, Lingyan Ping, Erik C. B. Johnson, James J. Lah, Allan I. Levey and Nicholas T. Seyfried

    Citation: Clinical Proteomics 2020 17:19

    Content type: Research

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  33. Glucocorticosteroid is used for patients with primary nephrotic syndrome. This study aims to identify and validate that biomarkers can be used to predict steroid resistance.

    Authors: Qinjie Weng, Qiongxiu Zhou, Jun Tong, Yuanmeng Jin, Yunzi Liu, Xialian Yu, Xiaoxia Pan, Hong Ren, Weiming Wang, Jingyuan Xie and Nan Chen

    Citation: Clinical Proteomics 2020 17:18

    Content type: Research

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  34. Metastasis of breast cancer to distal organs is fatal. However, few studies have identified biomarkers that are associated with distant metastatic breast cancer. Furthermore, the inability of current biomarker...

    Authors: Dongyoon Shin, Joonho Park, Dohyun Han, Ji Hye Moon, Han Suk Ryu and Youngsoo Kim

    Citation: Clinical Proteomics 2020 17:16

    Content type: Research

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  35. Human umbilical cord-derived MSCs (hUC-MSCs) have been identified as promising seeding cells in tissue engineering and clinical applications of regenerative medicine due to their advantages of simple acquisiti...

    Authors: Xufeng Fu, Bo Xu, Jiang Jiang, Xing Du, Xiaoli Yu, Yaping Yan, Shanshan Li, Briauna Marie Inglis, Huiming Ma, Hongyan Wang, Xiuying Pei and Wei Si

    Citation: Clinical Proteomics 2020 17:15

    Content type: Research

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  36. Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder. Biomarkers that can help monitor the progression of PD or response to disease-modifying agents will be invaluable in making app...

    Authors: Chan Hyun Na, Gajanan Sathe, Liana S. Rosenthal, Abhay R. Moghekar, Valina L. Dawson, Ted M. Dawson and Akhilesh Pandey

    Citation: Clinical Proteomics 2020 17:13

    Content type: Research

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  37. Sialolithiasis or salivary gland stones are associated with high clinical morbidity. The advances in the treatment of sialolithiasis has been limited, however, by our understanding of their composition. More s...

    Authors: Carlos S. Busso, Jessie J. Guidry, Jhanis J. Gonzalez, Vassilia Zorba, Leslie S. Son, Peter J. Winsauer and Rohan R. Walvekar

    Citation: Clinical Proteomics 2020 17:12

    Content type: Research

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  38. Detection of viral ribo-nucleic acid (RNA) via real-time polymerase chain reaction (RT-PCR) is the gold standard for the detection of Ebola virus (EBOV) during acute infection. However, the earliest window for...

    Authors: Michael D. Ward, Tara Kenny, Ernie Bruggeman, Christopher D. Kane, Courtney L. Morrell, Molly M. Kane, Sandra Bixler, Sarah L. Grady, Rachel S. Quizon, Mekbib Astatke and Lisa H. Cazares

    Citation: Clinical Proteomics 2020 17:11

    Content type: Research

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  39. Henoch-Schönlein purpura nephritis (HSPN) is the principal cause of morbidity and mortality in children with Henoch-Schönlein purpura (HSP). However, the criteria for risk assessment currently used is not sati...

    Authors: Xiang Fang, Heyan Wu, Mei Lu, Yan Cao, Ren Wang, Meiqiu Wang, Chunlin Gao and Zhengkun Xia

    Citation: Clinical Proteomics 2020 17:10

    Content type: Research

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  40. Reversible protein phosphorylation represents a key mechanism by which signals are transduced in eukaryotic cells. Dysregulated phosphorylation is also a hallmark of carcinogenesis and represents key drug targ...

    Authors: Allison L. Hunt, Mariaelena Pierobon, Elisa Baldelli, Julie Oliver, Dave Mitchell, Glenn Gist, Nicholas W. Bateman, G. Larry Maxwell, Emanuel F. Petricoin and Thomas P. Conrads

    Citation: Clinical Proteomics 2020 17:9

    Content type: Research

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  41. The various pathogenesis between Clear cell renal carcinoma (CCRCC) and Chromophobe renal carcinoma (CHRCC) contributes to the different tumor growth rate and metastasis. In this study, we explored the distinc...

    Authors: Yang Lu, Guangda Luo, Songbiao Zhu, Xu Wang, Yuling Chen, ZhouHuan Dong, Shiyu Wang, Jie Ma, Haiteng Deng, Di Wu and Jun Dong

    Citation: Clinical Proteomics 2020 17:7

    Content type: Research

    Published on:

  42. In the original publication of the article, Figure 2d was published incorrectly. The corrected Fig. 2 was given in this Correction article [1]. The original article has been corrected.

    Authors: Ventzislava Hristova, Shisheng Sun, Hui Zhang and Daniel W. Chan

    Citation: Clinical Proteomics 2020 17:6

    Content type: Correction

    Published on:

    The original article was published in Clinical Proteomics 2020 17:2

  43. ALK tyrosine kinase inhibition has become a mainstay in the clinical management of ALK fusion positive NSCLC patients. Although ALK mutations can reliably predict the likelihood of response to ALK tyrosine kin...

    Authors: Mathilde Couëtoux du Tertre, Maud Marques, Suzan McNamara, Karen Gambaro, Cyrla Hoffert, Lise Tremblay, Nicole Bouchard, Razvan Diaconescu, Normand Blais, Christian Couture, Vincent Pelsser, Hangjun Wang, Laura McIntosh, Valérie Hindie, Stephane Parent, Laetitia Cortes…

    Citation: Clinical Proteomics 2020 17:5

    Content type: Research

    Published on:

  44. Neoadjuvant chemotherapy (NACT) could improve prognosis and survival quality of patients with local advanced gastric cancer (LAGC) by providing an opportunity of radical operation for them. However, no effecti...

    Authors: Ruihuan Qin, Yupeng Yang, Hao Chen, Wenjun Qin, Jing Han, Yong Gu, Yiqing Pan, Xi Cheng, Junjie Zhao, Xuefei Wang, Shifang Ren, Yihong Sun and Jianxin Gu

    Citation: Clinical Proteomics 2020 17:4

    Content type: Research

    Published on:

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