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  1. Content type: Research

    Chinese Bama Yao Autonomous County is a well-known longevity region in the world. In the past 30 years, population and genome studies were undertaken to investigate the secret of longevity and showed that long...

    Authors: Shengliang Ye, Li Ma, Rong Zhang, Fengjuan Liu, Peng Jiang, Jun Xu, Haijun Cao, Xi Du, Fangzhao Lin, Lu Cheng, Xuefeng Zhou, Zhihui Shi, Yeheng Liu, Yaojin Huang, Zongkui Wang and Changqing Li

    Citation: Clinical Proteomics 2019 16:22

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  2. Content type: Research

    Cadmium is a toxic metal with multiple adverse health effects, including risk of cardiovascular disease (CVD). The mechanistic link between cadmium and CVD is unclear. Our aim was to examine the associations b...

    Authors: Yan Borné, Björn Fagerberg, Gerd Sallsten, Bo Hedblad, Margaretha Persson, Olle Melander, Jan Nilsson, Marju Orho-Melander, Lars Barregard and Gunnar Engström

    Citation: Clinical Proteomics 2019 16:21

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  3. Content type: Research

    Lung cancer is the leading cause of cancer death in China and around the world. Early detection is key to improving the survival rate of non-small cell lung cancer (NSCLC). Alteration in glycosylation has been...

    Authors: Yiqian Liang, Peng Han, Ting Wang, Hui Ren, Lei Gao, Puyu Shi, Shuo Zhang, Aimin Yang, Zheng Li and Mingwei Chen

    Citation: Clinical Proteomics 2019 16:20

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  4. Content type: Research

    Multiple sclerosis (MS) is an autoimmune, neuroinflammatory disease, with an unclear etiology. However, T cells play a central role in the pathogenesis by crossing the blood–brain-barrier, leading to inflammat...

    Authors: Tone Berge, Anna Eriksson, Ina Skaara Brorson, Einar August Høgestøl, Pål Berg-Hansen, Anne Døskeland, Olav Mjaavatten, Steffan Daniel Bos, Hanne F. Harbo and Frode Berven

    Citation: Clinical Proteomics 2019 16:19

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  5. Content type: Research

    Certain tumors such as pancreatic ductal adenocarcinoma (PDAC) are known to contain a variety of hydrolytic enzymes including RNases and proteases that may lead to degradation of RNA and proteins during sample...

    Authors: Jingi Bae, Su-Jin Kim, Seung-Eun Lee, Wooil Kwon, Hongbeom Kim, Youngmin Han, Jin-Young Jang, Min-Sik Kim and Sang-Won Lee

    Citation: Clinical Proteomics 2019 16:18

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  6. Content type: Research

    The bone marrow microenvironment provides an optimal substrate for multiple myeloma (MM) initiation and progression. The soluble component of MM niche is dynamic with the disease states of MM. We formerly emp...

    Authors: Ju Bai, Yun Yang, Jianli Wang, Lei Zhang, Fangxia Wang and Aili He

    Citation: Clinical Proteomics 2019 16:17

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  7. Content type: Research

    Blood-based protein measurement is a routine practice for detecting biomarkers in human disease. Comprehensive profiling of blood/plasma/serum proteome is a challenge due to an extremely large dynamic range, a...

    Authors: Kaushik Kumar Dey, Hong Wang, Mingming Niu, Bing Bai, Xusheng Wang, Yuxin Li, Ji-Hoon Cho, Haiyan Tan, Ashutosh Mishra, Anthony A. High, Ping-Chung Chen, Zhiping Wu, Thomas G. Beach and Junmin Peng

    Citation: Clinical Proteomics 2019 16:16

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  8. Content type: Research

    Prostate cancer (PCa) is the most frequently diagnosed non-skin cancer and a leading cause of mortality among males in developed countries. However, our understanding of the global changes of protein complexes...

    Authors: Bo Zhou, Yiwu Yan, Yang Wang, Sungyong You, Michael R. Freeman and Wei Yang

    Citation: Clinical Proteomics 2019 16:15

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  9. Content type: Research

    Endometriosis is a common gynaecological disorder affecting 5–10% of women of reproductive age who often experience chronic pelvic pain and infertility. Definitive diagnosis is through laparoscopy, exposing pa...

    Authors: Stella Irungu, Dimitrios Mavrelos, Jenny Worthington, Oleg Blyuss, Ertan Saridogan and John F. Timms

    Citation: Clinical Proteomics 2019 16:14

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  10. Content type: Research

    Prostate-specific antigen (PSA) is commonly used as a serum biomarker for the detection of prostate cancer. However, levels of PSA in serum do not reliably distinguish aggressive prostate cancer from non-aggre...

    Authors: Ce Wang, Naseruddin Höti, Tung-Shing Mamie Lih, Lori J. Sokoll, Rui Zhang, Zhen Zhang, Hui Zhang and Daniel W. Chan

    Citation: Clinical Proteomics 2019 16:13

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  11. Content type: Research

    Esophageal cancer (EC) is one of the malignant tumors with a poor prognosis. The early stage of EC is asymptomatic, so identification of cancer biomarkers is important for early detection and clinical practice.

    Authors: Yanping Zhu, Xiaoying Qi, Cuicui Yu, Shoujun Yu, Chao Zhang, Yuan Zhang, Xiuxiu Liu, Yuxue Xu, Chunhua Yang, Wenguo Jiang, Geng Tian, Xuri Li, Jonas Bergquist, Jiandi Zhang, Lei Wang and Jia Mi

    Citation: Clinical Proteomics 2019 16:12

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  12. Content type: Research

    Prevalence of many eye and ocular surface diseases increases with age. While the clinical characteristics and pathophysiologic mechanisms of these conditions are often either known or extensively studied, the ...

    Authors: Janika Nättinen, Antti Jylhä, Ulla Aapola, Petri Mäkinen, Roger Beuerman, Juhani Pietilä, Anu Vaajanen and Hannu Uusitalo

    Citation: Clinical Proteomics 2019 16:11

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  13. Content type: Research

    Cerebrospinal fluid (CSF) is in direct contact with the central nervous system. This makes human CSF an attractive source of potential biomarkers for neurologic diseases. Similarly to blood plasma, proteomic a...

    Authors: Eliska Jankovska, Marek Svitek, Karel Holada and Jiri Petrak

    Citation: Clinical Proteomics 2019 16:9

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  14. Content type: Research

    Colistin (polymyxin E) and polymixin B are important bactericidal antibiotics used in the treatment of serious infections caused by multi-drug resistant Gram-negative organisms. Transferrable plasmid-mediated ...

    Authors: Honghui Wang, Yong Chen, Jeffrey R. Strich, Steven K. Drake, Jung-Ho Youn, Avi Z. Rosenberg, Marjan Gucek, Patrick T. McGann, Anthony F. Suffredini and John P. Dekker

    Citation: Clinical Proteomics 2019 16:8

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  15. Content type: Research

    In-depth examination of the plasma proteomic response to infection with a wide variety of pathogens can assist in the development of new diagnostic paradigms, while providing insight into the interdependent pa...

    Authors: Michael D. Ward, Ernst E. Brueggemann, Tara Kenny, Raven E. Reitstetter, Christopher R. Mahone, Sylvia Trevino, Kelly Wetzel, Ginger C. Donnelly, Cary Retterer, Robert B. Norgren Jr., Rekha G. Panchal, Travis K. Warren, Sina Bavari and Lisa H. Cazares

    Citation: Clinical Proteomics 2019 16:7

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  16. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a progressive, eventually fatal disease. IPF is characterized by excessive accumulation of the extracellular matrix (ECM) in the alveolar parenchyma and progressive lung ...

    Authors: Yaqiong Tian, Hui Li, Yujuan Gao, Chuanmei Liu, Ting Qiu, Hongyan Wu, Mengshu Cao, Yingwei Zhang, Hui Ding, Jingyu Chen and Hourong Cai

    Citation: Clinical Proteomics 2019 16:6

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  17. Content type: Research

    It is difficult to distinguish benign pulmonary nodules (PNs) from malignant PNs by conventional examination. Therefore, novel biomarkers that can identify the nature of PNs are needed. Exosomes have recently ...

    Authors: Muyu Kuang, Xiaoting Tao, Yizhou Peng, Wenjing Zhang, Yafang Pan, Lei Cheng, Chongze Yuan, Yue Zhao, Hengyu Mao, Lingdun Zhuge, Zhenhua Zhou, Haiquan Chen and Yihua Sun

    Citation: Clinical Proteomics 2019 16:5

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  18. Content type: Research

    Ulcerative colitis (UC) is one major form of inflammatory bowel disease. The cause and the pathophysiology of the disease are not fully understood and we therefor aim in this study to identify important pathop...

    Authors: Armin Schniers, Rasmus Goll, Yvonne Pasing, Sveinung Wergeland Sørbye, Jon Florholmen and Terkel Hansen

    Citation: Clinical Proteomics 2019 16:4

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  19. Content type: Research

    Biomarkers are urgently required to support current histological staging to provide additional accuracy in stratifying colorectal cancer (CRC) patients according to risk of spread to properly assign adjuvant c...

    Authors: Chandra Kirana, Lifeng Peng, Rose Miller, John P. Keating, Corinne Glenn, Hongjun Shi, T. William Jordan, Guy J. Maddern and Richard S. Stubbs

    Citation: Clinical Proteomics 2019 16:3

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  20. Content type: Research

    The biomarkers alpha-fetoprotein (AFP) and protein induced by vitamin K absence/antagonist-II (PIVKA-II) may be useful for detecting early-stage hepatocellular carcinoma (HCC). We evaluated the performance of ...

    Authors: Philip M. Hemken, Lori J. Sokoll, Xiaoqing Yang, Jianliang Dai, Debra Elliott, Susan H. Gawel, Michael Lucht, Ziding Feng, Jorge A. Marrero, Sudhir Srivastava, Daniel W. Chan and Gerard J. Davis

    Citation: Clinical Proteomics 2019 16:2

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  21. Content type: Research

    Misdiagnosis of autoimmune pancreatitis (AIP) as pancreatic cancer (PDAC) or vice versa can cause dismal patents’ outcomes. Changes in IgG glycosylation are associated with cancers and autoimmune diseases. Thi...

    Authors: Hsi-Chang Shih, Ming-Chu Chang, Chein-Hung Chen, I-Lin Tsai, San-Yuan Wang, Ya-Po Kuo, Chung-Hsuan Chen and Yu-Ting Chang

    Citation: Clinical Proteomics 2019 16:1

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  22. Content type: Research

    Cytauxzoonosis is a disease of felids in North America caused by the tick-transmitted apicomplexan parasite Cytauxzoon felis. Cytauxzoonosis is particularly virulent for domestic cats, but no vaccine currently ex...

    Authors: Megan E. Schreeg, Henry S. Marr, Jaime L. Tarigo, Meredith K. Sherrill, Hilton K. Outi, Elizabeth H. Scholl, David M. Bird, Adam Vigil, Chris Hung, Rie Nakajima, Li Liang, Angela Trieu, Denise L. Doolan, Jennifer E. Thomas, Michael G. Levy, Mason V. Reichard…

    Citation: Clinical Proteomics 2018 15:44

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  23. Content type: Research

    Rapid identification of novel targets and advancement of a vascular targeting strategy requires a comprehensive assessment of AVM endothelial membrane protein changes in response to irradiation. The aim of thi...

    Authors: Margaret Simonian, Dyna Shirasaki, Vivienne S. Lee, David Bervini, Michael Grace, Rachel R. Ogorzalek Loo, Joseph A. Loo, Mark P. Molloy and Marcus A. Stoodley

    Citation: Clinical Proteomics 2018 15:43

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  24. Content type: Research

    It may be possible to discover new diagnostic or therapeutic peptides or proteins from blood plasma by using liquid chromatography and tandem mass spectrometry to identify, quantify and compare the peptides cl...

    Authors: Jaimie Dufresne, Pete Bowden, Thanusi Thavarajah, Angelique Florentinus-Mefailoski, Zhuo Zhen Chen, Monika Tucholska, Tenzin Norzin, Margaret Truc Ho, Morla Phan, Nargiz Mohamed, Amir Ravandi, Eric Stanton, Arthur S. Slutsky, Claudia C. dos Santos, Alexander Romaschin, John C. Marshall…

    Citation: Clinical Proteomics 2018 15:41

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  25. Content type: Research

    Talaromyces marneffei (TM) is an emerging pathogenic fungus that can cause a fatal systemic mycosis in patients infected with human immunodeficiency virus (HIV). Although global awareness regarding HIV/TM coinfec...

    Authors: Yahong Chen, Aiqiong Huang, Wen Ao, Zhengwu Wang, Jinjin Yuan, Qing Song, Dahai Wei and Hanhui Ye

    Citation: Clinical Proteomics 2018 15:40

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  26. Content type: Research

    It may be possible to discover new diagnostic or therapeutic peptides or proteins from blood plasma using LC–ESI–MS/MS to identify, quantify and compare the statistical distributions of peptides cleaved ex viv...

    Authors: Jaimie Dufresne, Pete Bowden, Thanusi Thavarajah, Angelique Florentinus-Mefailoski, Zhuo Zhen Chen, Monika Tucholska, Tenzin Norzin, Margaret Truc Ho, Morla Phan, Nargiz Mohamed, Amir Ravandi, Eric Stanton, Arthur S. Slutsky, Claudia C. dos Santos, Alexander Romaschin, John C. Marshall…

    Citation: Clinical Proteomics 2018 15:39

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  27. Content type: Research

    Over 500,000 women worldwide are diagnosed with ovarian or endometrial cancer each year. We have used a two-step strategy to identify plasma proteins that could be used to improve the diagnosis of women with a...

    Authors: Stefan Enroth, Malin Berggrund, Maria Lycke, Martin Lundberg, Erika Assarsson, Matts Olovsson, Karin Stålberg, Karin Sundfeldt and Ulf Gyllensten

    Citation: Clinical Proteomics 2018 15:38

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  28. Content type: Correction

    Unfortunately, after publication of this article [1], errors were noticed in Figs. 3 and 4.

    Authors: Xinyan Wu, Muhammad Saddiq Zahari, Santosh Renuse, Nandini A. Sahasrabuddhe, Raghothama Chaerkady, Mi-Sik Kim, Mary Jo Fackler, Martha Stampfer, Edward Gabrielson, Saraswati Sukumar and Akhilesh Pandey

    Citation: Clinical Proteomics 2018 15:37

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    The original article was published in Clinical Proteomics 2018 15:21

  29. Content type: Research

    Natural menopause is always accompanied by specific signs and symptoms, suggesting physiological changes in this peoriod. However, no systematic study has assessed the changes at molecular level in the ovaries...

    Authors: Jinling Yi, Huatianshu Hu, Peipei Shi, Song Shi, Junda Zhao, Linna Xu, Weining Yang, Bin Li, Jin Zhu and Shien Zou

    Citation: Clinical Proteomics 2018 15:36

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  30. Content type: Research

    Current risk prediction models in heart failure (HF) including clinical characteristics and biomarkers only have moderate predictive value. The aim of this study was to use matrix assisted laser desorption ion...

    Authors: Thong Huy Cao, Donald J. L. Jones, Paulene A. Quinn, Daniel Chu Siong Chan, Narayan Hafid, Helen M. Parry, Mohapradeep Mohan, Jatinderpal K. Sandhu, Stefan D. Anker, John G. Cleland, Kenneth Dickstein, Gerasimos Filippatos, Hans L. Hillege, Marco Metra, Piotr Ponikowski, Nilesh J. Samani…

    Citation: Clinical Proteomics 2018 15:35

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  31. Content type: Research

    Duchenne muscular dystrophy is a highly complex multi-system disease caused by primary abnormalities in the membrane cytoskeletal protein dystrophin. Besides progressive skeletal muscle degeneration, this neur...

    Authors: Sandra Murphy, Margit Zweyer, Michael Henry, Paula Meleady, Rustam R. Mundegar, Dieter Swandulla and Kay Ohlendieck

    Citation: Clinical Proteomics 2018 15:34

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  32. Content type: Research

    Although total plasma lipoproteome consists of proteins that have shown promises as biomarkers that can identify Alzheimer’s disease (AD), effect sizes are modest. The objective of this study is to provide ini...

    Authors: Danni Li, Fangying Huang, Yingchun Zhao, Peter W. Villata, Timothy J. Griffin, Lin Zhang, Ling Li and Fang Yu

    Citation: Clinical Proteomics 2018 15:31

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  33. Content type: Letter to the Editor

    In recent years, there has been an emphasis on personalizing breast cancer treatment in order to avoid the debilitating side effects caused by broad-spectrum chemotherapeutic drug treatment. Development of per...

    Authors: Yvonne S. Ziegler, James J. Moresco, Patricia G. Tu, John R. Yates III and Ann M. Nardulli

    Citation: Clinical Proteomics 2018 15:30

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  34. Content type: Research

    Cerebrospinal fluid (CSF) is an important source of potential biomarkers that affect the brain. Biomarkers for neurodegenerative disorders are needed to assist in diagnosis, monitoring disease progression and ...

    Authors: Gajanan Sathe, Chan Hyun Na, Santosh Renuse, Anil Madugundu, Marilyn Albert, Abhay Moghekar and Akhilesh Pandey

    Citation: Clinical Proteomics 2018 15:29

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  35. Content type: Research

    Outer membrane vesicles (OMVs) of Acinetobacter baumannii are cytotoxic and elicit a potent innate immune response. OMVs were first identified in A. baumannii DU202, an extensively drug-resistant clinical strain....

    Authors: Sung Ho Yun, Edmond Changkyun Park, Sang-Yeop Lee, Hayoung Lee, Chi-Won Choi, Yoon-Sun Yi, Hyun-Joo Ro, Je Chul Lee, Sangmi Jun, Hye-Yeon Kim, Gun-Hwa Kim and Seung Il Kim

    Citation: Clinical Proteomics 2018 15:28

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  36. Content type: Research

    In the assisted reproduction, the infertile molecules of spermatozoa from normozoospermic men who underwent the unexplained failure of in vitro fertilization (IVF) due to the lack of sperm binding to the norma...

    Authors: Xin Liu, Gensheng Liu, Juan Liu, Peng Zhu, Jiahui Wang, Yanwei Wang, Wenting Wang, Ning Li, Xuebo Wang, Chenglin Zhang, Xiaofang Shen and Fujun Liu

    Citation: Clinical Proteomics 2018 15:27

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  37. Content type: Research

    Mass spectrometry-based proteomics has become a powerful tool for the identification and quantification of proteins from a wide variety of biological specimens. To date, the majority of studies utilizing tissu...

    Authors: Paul D. Piehowski, Vladislav A. Petyuk, Ryan L. Sontag, Marina A. Gritsenko, Karl K. Weitz, Thomas L. Fillmore, Jamie Moon, Hala Makhlouf, Rodrigo F. Chuaqui, Emily S. Boja, Henry Rodriguez, Jerry S. H. Lee, Richard D. Smith, Danielle M. Carrick, Tao Liu and Karin D. Rodland

    Citation: Clinical Proteomics 2018 15:26

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  38. Content type: Research

    Renal oncocytomas (ROs) are benign epithelial tumors of the kidney whereas chromophobe renal cell carcinoma (chRCCs) are malignant renal tumors. The latter constitute 5–7% of renal neoplasias. ROs and chRCCs s...

    Authors: Vanessa Drendel, Bianca Heckelmann, Christoph Schell, Lucas Kook, Martin L. Biniossek, Martin Werner, Cordula A. Jilg and Oliver Schilling

    Citation: Clinical Proteomics 2018 15:25

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  39. Content type: Research

    Advances in mass spectrometry have accelerated biomarker discovery in many areas of medicine. The purpose of this study was to compare two mass spectrometry (MS) methods, isobaric tags for relative and absolut...

    Authors: Antti Jylhä, Janika Nättinen, Ulla Aapola, Alexandra Mikhailova, Matti Nykter, Lei Zhou, Roger Beuerman and Hannu Uusitalo

    Citation: Clinical Proteomics 2018 15:24

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  40. Content type: Research

    Lower urinary tract symptoms (LUTS) and prostate specific antigen-based parameters seem to have only a limited utility for the differential diagnosis of prostate cancer (PCa). MALDI-TOF/MS peptidomic profiling...

    Authors: Andrea Padoan, Daniela Basso, Carlo-Federico Zambon, Tommaso Prayer-Galetti, Giorgio Arrigoni, Dania Bozzato, Stefania Moz, Filiberto Zattoni, Rino Bellocco and Mario Plebani

    Citation: Clinical Proteomics 2018 15:23

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  41. Content type: Letter to the Editor

    CD44 is a heavily glycosylated membrane receptor playing a key role in cell adhesion, signal transduction and cytoskeleton remodelling. It is also one of the most studied glycoproteins in cancer, frequently ex...

    Authors: Rita Azevedo, Cristiana Gaiteiro, Andreia Peixoto, Marta Relvas-Santos, Luís Lima, Lúcio Lara Santos and José Alexandre Ferreira

    Citation: Clinical Proteomics 2018 15:22

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  42. Content type: Research

    Cancer-associated fibroblasts (CAFs) are one of the most important components of tumor stroma and play a key role in modulating tumor growth. However, a mechanistic understanding of how CAFs communicate with t...

    Authors: Xinyan Wu, Muhammad Saddiq Zahari, Santosh Renuse, Nandini A. Sahasrabuddhe, Raghothama Chaerkady, Min-Sik Kim, Mary Jo Fackler, Martha Stampfer, Edward Gabrielson, Saraswati Sukumar and Akhilesh Pandey

    Citation: Clinical Proteomics 2018 15:21

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    The Correction to this article has been published in Clinical Proteomics 2018 15:37

  43. Content type: Research

    Epidemiological studies have shown that many welders experience respiratory symptoms. During the welding process a large number of airborne nanosized particles are generated, which might be inhaled and deposi...

    Authors: Neserin Ali, Stefan Ljunggren, Helen M. Karlsson, Aneta Wierzbicka, Joakim Pagels, Christina Isaxon, Anders Gudmundsson, Jenny Rissler, Jörn Nielsen, Christian H. Lindh and Monica Kåredal

    Citation: Clinical Proteomics 2018 15:20

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  44. Content type: Research

    Semen cryopreservation has been widely applied in assisted reproductive technologies and sperm bank, but it causes considerable impairments on sperm quality. It is necessary to find an evaluation indicator for...

    Authors: Ai-jie Xin, Yan-cheng Wu, Hui Lu, Li Cheng, Yi-hua Gu, Hua Diao, Guo-wu Chen, Bin Wu, Zheng Li, Sheng-ce Tao, Xiao-xi Sun and Hui-juan Shi

    Citation: Clinical Proteomics 2018 15:19

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  45. Content type: Research

    The development of clinically accessible biomarkers is critical for the early diagnosis of gastric cancer (GC) in patients. High-throughput proteomics techniques could not only effectively generate a serum pep...

    Authors: Feiyu Shi, Hong Wu, Kai Qu, Qi Sun, Fanni Li, Chengxin Shi, Yaguang Li, Xiaofan Xiong, Qian Qin, Tianyu Yu, Xin Jin, Liang Cheng, Qingxia Wei, Yingchao Li and Junjun She

    Citation: Clinical Proteomics 2018 15:18

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  46. Content type: Research

    The application of advanced imaging technologies for identifying pancreatic cysts has become widespread. However, accurately differentiating between low-grade dysplasia (LGD), high-grade dysplasia (HGD), and ...

    Authors: Misol Do, Dohyun Han, Joseph Injae Wang, Hyunsoo Kim, Wooil Kwon, Youngmin Han, Jin-Young Jang and Youngsoo Kim

    Citation: Clinical Proteomics 2018 15:17

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