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  1. Optimal cytoreduction to no residual disease (R0) correlates with improved disease outcome for high-grade serous ovarian cancer (HGSOC) patients. Treatment of HGSOC patients with neoadjuvant chemotherapy, howe...

    Authors: Emily R. Penick, Nicholas W. Bateman, Christine Rojas, Cuauhtemoc Magana, Kelly Conrads, Ming Zhou, Brian L. Hood, Guisong Wang, Niyati Parikh, Ying Huang, Kathleen M. Darcy, Yovanni Casablanca, Paulette Mhawech-Fauceglia, Thomas P. Conrads and G. Larry Maxwell
    Citation: Clinical Proteomics 2022 19:35
    Content type: Research Published on:

  2. Severe COVID-19 leads to important changes in circulating immune-related proteins. To date it has been difficult to understand their temporal relationship and identify cytokines that are drivers of severe COVI...

    Authors: Guillaume Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Sirui Zhou, Tomoko Nakanishi, Elsa Brunet-Ratnasingham, David Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi…
    Citation: Clinical Proteomics 2022 19:34
    Content type: Research Published on:

  3. Crotonaldehyde (CRA)—one of the major environmental pollutants from tobacco smoke and industrial pollution—is associated with vascular injury (VI). We used proteomics to systematically characterize the present...

    Authors: Ming-Zhang Xie, Jun-Li Liu, Qing-Zu Gao, De-Ying Bo, Lei Wang, Xiao-Chun Zhou, Meng-Meng Zhao, Yu-Chao Zhang, Yu-Jing Zhang, Guo-An Zhao and Lu-Yang Jiao
    Citation: Clinical Proteomics 2022 19:33
    Content type: Research Published on:

  4. Dabie bandavirus, also termed as severe fever with thrombocytopenia syndrome virus (SFTSV), was first isolated in China in 2010. At this time, the virus was found to have spread to South Korea, Japan, and othe...

    Authors: Sang-Yeop Lee, Sung Ho Yun, Hayoung Lee, Yun Gyeong Lee, Giwan Seo, Nam Hoon Kim, Edmond Changkyun Park, Chang-Seop Lee and Seung Il Kim
    Citation: Clinical Proteomics 2022 19:32
    Content type: Research Published on:

  5. Classification of disease severity is crucial for the management of COVID-19. Several studies have shown that individual proteins can be used to classify the severity of COVID-19. Here, we aimed to investigate...

    Authors: Jinlong Gao, Jiale He, Fangfei Zhang, Qi Xiao, Xue Cai, Xiao Yi, Siqi Zheng, Ying Zhang, Donglian Wang, Guangjun Zhu, Jing Wang, Bo Shen, Markus Ralser, Tiannan Guo and Yi Zhu
    Citation: Clinical Proteomics 2022 19:31
    Content type: Research Published on:

  6. Acute Myeloid Leukemia (AML) affects 20,000 patients in the US annually with a five-year survival rate of approximately 25%. One reason for the low survival rate is the high prevalence of clonal evolution that...

    Authors: Sara J. C. Gosline, Cristina Tognon, Michael Nestor, Sunil Joshi, Rucha Modak, Alisa Damnernsawad, Camilo Posso, Jamie Moon, Joshua R. Hansen, Chelsea Hutchinson-Bunch, James C. Pino, Marina A. Gritsenko, Karl K. Weitz, Elie Traer, Jeffrey Tyner, Brian Druker…
    Citation: Clinical Proteomics 2022 19:30
    Content type: Research Published on:

  8. Severe fever with thrombocytopenia syndrome (SFTS) virus is an emerging infectious virus which causes severe hemorrhage, thrombocytopenia, and leukopenia, with a high fatality rate. Since there is no approved ...

    Authors: Sang-Yeop Lee, Hayoung Lee, Sung Ho Yun, Edmond Changkyun Park, Giwan Seo, Hye-Yeon Kim, Sangmi Jun, Nam Hoon Kim, Dongseob Tark, Ju Yeon Lee, Chang-Seop Lee and Seung Il Kim
    Citation: Clinical Proteomics 2022 19:28
    Content type: Letter to the editor Published on:

  9. Colon cancer is the third most common cancer and second highest cause of cancer deaths worldwide. The aim of the study was to find new biomarkers for diagnosis, prognosis and therapeutic drug targets for this ...

    Authors: Matthew J. Munro, Susrutha K. Wickremesekera, Swee T. Tan and Lifeng Peng
    Citation: Clinical Proteomics 2022 19:27
    Content type: Research Published on:

  10. Anti-phospholipase A2 receptor autoantibody (PLA2R Ab)-associated membranous nephropathy (MN) is the most common form of primary MN (pMN). On the other hand, bucillamine (BCL), an antirheumatic drug developed ...

    Authors: Hajime Kaga, Hirotoshi Matsumura, Takehiro Suzuki, Naoshi Dohmae, Masafumi Odaka, Atsushi Komatsuda, Naoto Takahashi and Hideki Wakui
    Citation: Clinical Proteomics 2022 19:26
    Content type: Research Published on:

  11. Breast cancer (BC) is the most common cancer and among the leading causes of cancer death in women. It is a heterogeneous group of tumours with numerous morphological and molecular subtypes, making predictions...

    Authors: Hugo Veyssière, Yannick Bidet, Frederique Penault-Llorca, Nina Radosevic-Robin and Xavier Durando
    Citation: Clinical Proteomics 2022 19:25
    Content type: Review Published on:

  12. Single-cell proteomic analysis provides valuable insights into cellular heterogeneity allowing the characterization of the cellular microenvironment which is difficult to accomplish in bulk proteomic analysis....

    Authors: Yuefan Wang, Tung-Shing Mamie Lih, Lijun Chen, Yuanwei Xu, Morgan D. Kuczler, Liwei Cao, Kenneth J. Pienta, Sarah R. Amend and Hui Zhang
    Citation: Clinical Proteomics 2022 19:24
    Content type: Research Published on:

  13. Multiple sclerosis (MS) is an autoimmune, neurodegenerative disorder with a strong genetic component that acts in a complex interaction with environmental factors for disease development. CD4+ T cells are pivotal...

    Authors: Chiara Cappelletti, Anna Eriksson, Ina Skaara Brorson, Ingvild S. Leikfoss, Oda Kråbøl, Einar August Høgestøl, Valeria Vitelli, Olav Mjaavatten, Hanne F. Harbo, Frode Berven, Steffan D. Bos and Tone Berge
    Citation: Clinical Proteomics 2022 19:23
    Content type: Research Published on:

  15. Roxadustat is a new oral anti-renal anemia medication that works by stabilizing hypoxia-inducible factor (HIF) which can activate the expression of more than 100 genes in addition to genes related to anemia. H...

    Authors: Xiaoe You, Baochun Guo, Zhen Wang, Hualin Ma and Xinzhou Zhang
    Citation: Clinical Proteomics 2022 19:21
    Content type: Research Published on:

  16. There is a lack of early and precise biomarkers for personalized respiratory medicine. Breath contains an aerosol of droplet particles, which are formed from the epithelial lining fluid when the small airways ...

    Authors: Jörgen Östling, Marleen Van Geest, Henric K. Olsson, Sven-Erik Dahlen, Emilia Viklund, Per M. Gustafsson, Ekaterina Mirgorodskaya and Anna-Carin Olin
    Citation: Clinical Proteomics 2022 19:20
    Content type: Research Published on:

    The Correction to this article has been published in Clinical Proteomics 2022 19:29

  17. Embryo implantation is a complex developmental process that requires coordinated interactions among the embryo, endometrium, and the microenvironment of endometrium factors. Even though the impaired endometria...

    Authors: Jun Li, Xiaohua Jiang, Caihua Li, Huihui Che, Lin Ling and Zhaolian Wei
    Citation: Clinical Proteomics 2022 19:19
    Content type: Research Published on:

  18. Esophageal squamous cell carcinoma (ESCC) is a common digestive tract malignant tumor with high incidence and dismal prognosis worldwide. However, the reliable biomarkers for clinical diagnosis and the underly...

    Authors: Wenhu Liu, Qiang Wang, Jinxia Chang, Anup Bhetuwal, Nisha Bhattarai, Fan Zhang and Jiancai Tang
    Citation: Clinical Proteomics 2022 19:18
    Content type: Research Published on:

  19. Despite advances in diagnosis of congenital heart defects, there is no non-invasive biomarker clinically available for the early detection of fetal ventricular septal defects (VSD).

    Authors: Jing He, Liang Xie, Li Yu, Lijun Liu, Hong Xu, Tao Wang, Yuyang Gao, Xuedong Wang, You Duan, Hanmin Liu and Li Dai
    Citation: Clinical Proteomics 2022 19:17
    Content type: Research Published on:

  20. Glucagon serves as an important regulatory hormone for regulating blood glucose concentration with tight feedback control exerted by insulin and glucose. There are critical gaps in our understanding of glucago...

    Authors: Santosh Renuse, Linda M. Benson, Patrick M. Vanderboom, F. N. U. Ruchi, Yogesh R. Yadav, Kenneth L. Johnson, Benjamin C. Brown, Jane A. Peterson, Rita Basu, Daniel J. McCormick, Akhilesh Pandey and Ananda Basu
    Citation: Clinical Proteomics 2022 19:16
    Content type: Research Published on:

  21. Airway remodeling in patients with asthma, which leads to a decline in pulmonary function, is likely the result of repeated exacerbations often provoked by aeroallergen exposures. Aeroallegen exposure triggers...

    Authors: Yanlong Zhu, Stephane Esnault, Ying Ge, Nizar N. Jarjour and Allan R. Brasier
    Citation: Clinical Proteomics 2022 19:15
    Content type: Research Published on:

  22. Accumulating evidence suggests that the androgen receptor (AR) and its endogenous ligands influence disease progression in breast cancer (BCa). However, AR-mediated changes in BCa differ among the various BCa ...

    Authors: Stella K. Vasiliou, Panagiota S. Filippou, Sergi Clotet-Freixas, Antoninus Soosaipillai, Ihor Batruch, Foivos Viktor Tsianos, Ana Konvalinka and Eleftherios P. Diamandis
    Citation: Clinical Proteomics 2022 19:14
    Content type: Research Published on:

  23. Cerebrospinal fluid (CSF) is an important biofluid for biomarkers of neurodegenerative diseases such as Alzheimer’s disease (AD). By employing tandem mass tag (TMT) proteomics, thousands of proteins can be qua...

    Authors: Sophia Weiner, Mathias Sauer, Pieter Jelle Visser, Betty M. Tijms, Egor Vorontsov, Kaj Blennow, Henrik Zetterberg and Johan Gobom
    Citation: Clinical Proteomics 2022 19:13
    Content type: Research Published on:

  24. Treatment for glaucoma has traditionally been limited to reducing intraocular pressure (IOP). Inhibiting oxidative stress in the trabecular meshwork (TM) is regarded as a new treatment for glaucoma; however, t...

    Authors: Qian Li, Liyu Zhang and Yuxin Xu
    Citation: Clinical Proteomics 2022 19:12
    Content type: Research Published on:

  26. Formalin-fixed paraffin-embedded (FFPE) tissue is the standard material for diagnostic pathology but poses relevant hurdles to accurate protein extraction due to cross-linking and chemical alterations. While n...

    Authors: Franz F. Dressler, Jana Schoenfeld, Olga Revyakina, Daniel Vogele, Selina Kiefer, Jutta Kirfel, Timo Gemoll and Sven Perner
    Citation: Clinical Proteomics 2022 19:10
    Content type: Research Published on:

  27. Non-invasive liquid biopsies could complement current pathological nomograms for risk stratification of prostate cancer patients. Development and testing of potential liquid biopsy markers is time, resource, a...

    Authors: Sandra Goetze, Peter Schüffler, Alcibiade Athanasiou, Anika Koetemann, Cedric Poyet, Christian Daniel Fankhauser, Peter J. Wild, Ralph Schiess and Bernd Wollscheid
    Citation: Clinical Proteomics 2022 19:9
    Content type: Research Published on:

  28. Mass spectrometry imaging (MSI) derives spatial molecular distribution maps directly from clinical tissue specimens and thus bears great potential for assisting pathologists with diagnostic decisions or person...

    Authors: Melanie Christine Föll, Veronika Volkmann, Kathrin Enderle-Ammour, Sylvia Timme, Konrad Wilhelm, Dan Guo, Olga Vitek, Peter Bronsert and Oliver Schilling
    Citation: Clinical Proteomics 2022 19:8
    Content type: Research Published on:

  29. Rheumatic heart disease (RHD) remains a major source of morbidity and mortality in developing countries. A deeper insight into the pathogenetic mechanisms underlying RHD could provide opportunities for drug re...

    Authors: M. Taariq Salie, Jing Yang, Carlos R. Ramírez Medina, Liesl J. Zühlke, Chishala Chishala, Mpiko Ntsekhe, Bernard Gitura, Stephen Ogendo, Emmy Okello, Peter Lwabi, John Musuku, Agnes Mtaja, Christopher Hugo-Hamman, Ahmed El-Sayed, Albertino Damasceno, Ana Mocumbi…
    Citation: Clinical Proteomics 2022 19:7
    Content type: Research Published on:

  30. Remote Ischemic Conditioning (RIC) has been proposed as a therapeutic intervention to circumvent the ischemia/reperfusion injury (IRI) that is inherent to organ transplantation. Using a porcine kidney transpla...

    Authors: Darragh P. O’Brien, Adam M. Thorne, Honglei Huang, Elisa Pappalardo, Xuan Yao, Peter Søndergaard Thyrrestrup, Kristian Ravlo, Niels Secher, Rikke Norregaard, Rutger J. Ploeg, Bente Jespersen and Benedikt M. Kessler
    Citation: Clinical Proteomics 2022 19:6
    Content type: Research Published on:

  31. The high incidence of pre-eclampsia, which affects 2–7% of all pregnancies, remains a major health concern. Detection of pre-eclampsia before the appearance of clinical symptoms is essential to allow early int...

    Authors: Rosana Navajas, Antonio Ramos-Fernandez, Ignacio Herraiz, Alberto Galindo, José Luis Bartha, Fernando Corrales and Alberto Paradela
    Citation: Clinical Proteomics 2022 19:5
    Content type: Research Published on:

  32. Oral squamous cell carcinoma (OSCC) is a main cause of oral cancer mortality and morbidity in central south Asia. To improve the clinical outcome of OSCC patients, detection markers are needed, which are prefe...

    Authors: Madiha Mumtaz, Irene V. Bijnsdorp, Franziska Böttger, Sander R. Piersma, Thang V. Pham, Samiullah Mumtaz, Ruud H. Brakenhoff, M. Waheed Akhtar and Connie R. Jimenez
    Citation: Clinical Proteomics 2022 19:4
    Content type: Research Published on:

  33. Chronic kidney disease (CKD) has few objective symptoms, and it is difficult to make an early diagnosis by using existing methods. Therefore, new biomarkers enabling diagnosis of renal dysfunction at an early ...

    Authors: Kazuma Higashisaka, Sonoko Takeya, Haruhiko Kamada, Masanori Obana, Makiko Maeda, Mai Kabayama, Koichi Yamamoto, Nanan Ishida, Ryo Isaka, Hirofumi Tsujino, Kazuya Nagano, Noriyuki Tomiyama, Hiromi Rakugi, Yasushi Fujio, Kei Kamide and Yasuo Tsutsumi
    Citation: Clinical Proteomics 2022 19:3
    Content type: Research Published on:

  34. Early detection of small cell lung cancer (SCLC) crucially demands highly reliable markers. Growing evidence suggests that extracellular vesicles carry tumor cell-specific cargo suitable as protein markers in ...

    Authors: Shona Pedersen, Katrine Papendick Jensen, Bent Honoré, Søren Risom Kristensen, Camilla Holm Pedersen, Weronika Maria Szejniuk, Raluca Georgiana Maltesen and Ursula Falkmer
    Citation: Clinical Proteomics 2022 19:2
    Content type: Research Published on:

  35. Thrombocytopenia is frequent in Plasmodium vivax malaria but the role of platelets in pathogenesis is unknown. Our study explores the platelet (PLT) proteome from uncomplicated P. vivax patients, to fingerprint m...

    Authors: Diana Fernández, Cesar Segura, Mònica Arman, Suzanne McGill, Richard Burchmore and Tatiana Lopera-Mesa
    Citation: Clinical Proteomics 2022 19:1
    Content type: Research Published on:

  36. Type 2 diabetic kidney disease is the most common cause of chronic kidney diseases (CKD) and end-stage renal diseases (ESRD). Although kidney biopsy is considered as the ‘gold standard’ for diabetic kidney dis...

    Authors: Guanjie Fan, Tongqing Gong, Yuping Lin, Jianping Wang, Lu Sun, Hua Wei, Xing Yang, Zhenjie Liu, Xinliang Li, Ling Zhao, Lan Song, Jiali He, Haibo Liu, Xiuming Li, Lifeng Liu, Anxiang Li…
    Citation: Clinical Proteomics 2021 18:32
    Content type: Research Published on:

  38. Communicating hydrocephalus (CH) is a common neurological disorder caused by a blockage of cerebrospinal fluid. In this study, we aimed to explore the potential molecular mechanism underlying CH development.

    Authors: Lei Yuan, Dongdong Zou, Xia Yang, Xin Chen, Youming Lu, Aijun Zhang, Pengqi Zhang and Fance Wei
    Citation: Clinical Proteomics 2021 18:30
    Content type: Research Published on:

  39. The rapid advancements of high throughput “omics” technologies have brought a massive amount of data to process during and after experiments. Multi-omic analysis facilitates a deeper interrogation of a dataset...

    Authors: Hui Zhang, Minghui Ao, Arianna Boja, Michael Schnaubelt and Yingwei Hu
    Citation: Clinical Proteomics 2021 18:29
    Content type: Research Published on:

  40. Vitreous is an accessible, information-rich biofluid that has recently been studied as a source of retinal disease-related proteins and pathways. However, the number of samples required to confidently identify...

    Authors: Sarah R. Weber, Yuanjun Zhao, Jingqun Ma, Christopher Gates, Felipe da Veiga Leprevost, Venkatesha Basrur, Alexey I. Nesvizhskii, Thomas W. Gardner and Jeffrey M. Sundstrom
    Citation: Clinical Proteomics 2021 18:28
    Content type: Research Published on:

  41. Liver transplantation (LT) can be offered to patients with Hepatocellular carcinoma (HCC) beyond Milan criteria. However, there are currently limited molecular markers on HCC explant histology to predict recur...

    Authors: Mamatha Bhat, Sergi Clotet-Freixas, Cristina Baciu, Elisa Pasini, Ahmed Hammad, Tommy Ivanics, Shelby Reid, Amirhossein Azhie, Marc Angeli, Anand Ghanekar, Sandra Fischer, Gonzalo Sapisochin and Ana Konvalinka
    Citation: Clinical Proteomics 2021 18:27
    Content type: Research Published on:

  42. The KidneyIntelX™ test applies a machine learning algorithm that incorporates plasma biomarkers and clinical variables to produce a composite risk score to predict a progressive decline in kidney function in p...

    Authors: Patricia Connolly, Sharon Stapleton, Gohar Mosoyan, Ilya Fligelman, Ya-Chen Tonar, Fergus Fleming and Michael J. Donovan
    Citation: Clinical Proteomics 2021 18:26
    Content type: Research Published on:

  43. SARS-CoV-2, a novel human coronavirus, has created a global disease burden infecting > 100 million humans in just over a year. RT-PCR is currently the predominant method of diagnosing this viral infection alth...

    Authors: Kiran K. Mangalaparthi, Sandip Chavan, Anil K. Madugundu, Santosh Renuse, Patrick M. Vanderboom, Anthony D. Maus, Jennifer Kemp, Benjamin R. Kipp, Stefan K. Grebe, Ravinder J. Singh and Akhilesh Pandey
    Citation: Clinical Proteomics 2021 18:25
    Content type: Letter to the editor Published on:

    The Correction to this article has been published in Clinical Proteomics 2022 19:11

  44. Osteoporosis (OP) is a systemic bone disease characterized by decreased bone mass, destruction of the bone tissue microstructure, increased bone brittleness and an increased risk of fracture. OP has a high inc...

    Authors: Ruikun Zhang, Kun Yan, Yulun Wu, Xinmiao Yao, Guijin Li, Linpu Ge and Zhineng Chen
    Citation: Clinical Proteomics 2021 18:24
    Content type: Research Published on:

  45. Cardiovascular disease (CVD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and reduced lung function is an important risk factor for CVD and CVD-related death. However, the mechanisms...

    Authors: K. Egervall, A. Rosso and S. Elmståhl
    Citation: Clinical Proteomics 2021 18:23
    Content type: Research Published on:

  46. Preeclampsia and gestational hypertension can cause vascular function impairment in offspring. In our previous work, we described the protein expression profiles of umbilical artery tissues from patients with ...

    Authors: Bin Yu, Hong-Dan Zhu, Xiao-Liang Shi, Pan-Pan Chen, Xiang-Mei Sun, Gui-Yu Xia, Min Fang, Yong-Xing Zhong, Xiao-Li Tang, Tao Zhang and Hai-Tao Pan
    Citation: Clinical Proteomics 2021 18:22
    Content type: Research Published on:

  47. A hepatocellular carcinoma (HCC) prediction model (ASAP), including age, sex, and the biomarkers alpha-fetoprotein and prothrombin induced by vitamin K absence-II, showed potential clinical value in the early ...

    Authors: Bo Li, Youyun Zhao, Wangxi Cai, Anping Ming and Hanmin Li
    Citation: Clinical Proteomics 2021 18:21
    Content type: Research Published on:

  48. It is not enough to optimize proteomics assays. It is critical those assays are robust to operating conditions. Without robust assays, proteomic biomarkers are unlikely to translate readily into the clinic. Th...

    Authors: Edith Serrano-Blesa, Andrew Porter, Dennis W. Lendrem, Costantino Pitzalis, Anne Barton, Achim Treumann and John D. Isaacs
    Citation: Clinical Proteomics 2021 18:20
    Content type: Research Published on:

  49. Molecular diagnostics of the coronavirus disease of 2019 (COVID-19) now mainly relies on the measurements of viral RNA by RT-PCR, or detection of anti-viral antibodies by immunoassays. In this review, we discu...

    Authors: Yasmine Rais, Zhiqiang Fu and Andrei P. Drabovich
    Citation: Clinical Proteomics 2021 18:19
    Content type: Review Published on:

  50. Placenta is a complex organ that plays a significant role in the maintenance of pregnancy health. It is a dynamic organ that undergoes dramatic changes in growth and development at different stages of gestatio...

    Authors: Sara Khorami Sarvestani, Sorour Shojaeian, Negar Vanaki, Behrouz Ghresi-Fard, Mehdi Amini, Kambiz Gilany, Hale Soltanghoraee, Soheila Arefi, Mahmood Jeddi-Tehrani and Amir-Hassan Zarnani
    Citation: Clinical Proteomics 2021 18:18
    Content type: Research Published on:
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Clinical Proteomics

ISSN: 1559-0275