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  1. ALK tyrosine kinase inhibition has become a mainstay in the clinical management of ALK fusion positive NSCLC patients. Although ALK mutations can reliably predict the likelihood of response to ALK tyrosine kin...

    Authors: Mathilde Couëtoux du Tertre, Maud Marques, Suzan McNamara, Karen Gambaro, Cyrla Hoffert, Lise Tremblay, Nicole Bouchard, Razvan Diaconescu, Normand Blais, Christian Couture, Vincent Pelsser, Hangjun Wang, Laura McIntosh, Valérie Hindie, Stephane Parent, Laetitia Cortes…

    Citation: Clinical Proteomics 2020 17:5

    Content type: Research

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  2. Neoadjuvant chemotherapy (NACT) could improve prognosis and survival quality of patients with local advanced gastric cancer (LAGC) by providing an opportunity of radical operation for them. However, no effecti...

    Authors: Ruihuan Qin, Yupeng Yang, Hao Chen, Wenjun Qin, Jing Han, Yong Gu, Yiqing Pan, Xi Cheng, Junjie Zhao, Xuefei Wang, Shifang Ren, Yihong Sun and Jianxin Gu

    Citation: Clinical Proteomics 2020 17:4

    Content type: Research

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  3. Cancer stem cells (CSCs) are reported to be responsible for tumor initiation, progression, metastasis, and therapy resistance where P-glycoprotein (P-gp) as well as other glycoproteins are involved. Identifica...

    Authors: Feifei Xu, Yue Wang, Kaijie Xiao, Yechen Hu, Zhixin Tian and Yun Chen

    Citation: Clinical Proteomics 2020 17:3

    Content type: Research

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  4. Ubiquitination is a post-translational modification where ubiquitin is covalently attached to lysine residues on substrate proteins to signal their degradation by the 26S proteasome or initiate other non-degra...

    Authors: Ventzislava Hristova, Shisheng Sun, Hui Zhang and Daniel W. Chan

    Citation: Clinical Proteomics 2020 17:2

    Content type: Research

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  5. The “omics revolution: beyond genomics” satellite meeting, run under the auspices of the Australian Peptide Association, The Human Proteome Organisation (HUPO) and the HUPO Australia/New Zealand Chromosome 7 i...

    Authors: E. C. Nice

    Citation: Clinical Proteomics 2020 17:1

    Content type: Meeting report

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  6. The aim of this pilot study was to identify proteins associated with advancement of colon cancer (CC).

    Authors: Saira Saleem, Sahrish Tariq, Iffat Aleem, Sadr-ul Shaheed, Muhammad Tahseen, Aribah Atiq, Sadia Hassan, Muhammad Abu Bakar, Shahid Khattak, Aamir Ali Syed, Asad Hayat Ahmad, Mudassar Hussain, Muhammed Aasim Yusuf and Chris Sutton

    Citation: Clinical Proteomics 2019 16:44

    Content type: Research

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  7. There is a need to demonstrate a proof of principle that proteomics has the capacity to analyze plasma from breast cancer versus other diseases and controls in a multisite clinical trial design. The peptides o...

    Authors: Jaimie Dufresne, Pete Bowden, Thanusi Thavarajah, Angelique Florentinus-Mefailoski, Zhuo Zhen Chen, Monika Tucholska, Tenzin Norzin, Margaret Truc Ho, Morla Phan, Nargiz Mohamed, Amir Ravandi, Eric Stanton, Arthur S. Slutsky, Claudia C. dos Santos, Alexander Romaschin, John C. Marshall…

    Citation: Clinical Proteomics 2019 16:43

    Content type: Research

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  8. Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin with growing incidence. To better understand the biology of this malignant disease, immortalized cell lines are used in research f...

    Authors: Ulana Kotowski, Boban M. Erović, Julia Schnöll, Victoria Stanek, Stefan Janik, Martin Steurer and Goran Mitulović

    Citation: Clinical Proteomics 2019 16:42

    Content type: Research

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  9. Biological diagnosis of hemoglobin disorders is a complex process relying on the combination of several analytical techniques to identify Hb variants in a particular sample. Currently, hematology laboratories ...

    Authors: Olivier Lassout, Ralf Hartmer, Wolfgang Jabs, Lorella Clerici, Yury O. Tsybin, Kaveh Samii, Nicolas Vuilleumier, Denis Hochstrasser, Alexander Scherl, Pierre Lescuyer and Didia Coelho Graça

    Citation: Clinical Proteomics 2019 16:41

    Content type: Research

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  10. Though subjective, poor self-rated health (SRH) has consistently been shown to predict cardiovascular disease (CVD). The underlying mechanism is unclear. This study evaluates the associations of SRH with bioma...

    Authors: Xue Bao, Yan Borné, Songjiang Yin, Kaijun Niu, Marju Orho-Melander, Jan Nilsson, Olle Melander and Gunnar Engström

    Citation: Clinical Proteomics 2019 16:40

    Content type: Research

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  11. Mycobacterium avium subsp. hominissuis (MAH) belongs to the clinically important non-tuberculous mycobacterial group that infects immunocompromised patients and individuals with underling lung conditions. The nee...

    Authors: Rajoana Rojony, Matthew Martin, Anaamika Campeau, Jacob M. Wozniak, David J. Gonzalez, Pankaj Jaiswal, L. Danelishvili and Luiz E. Bermudez

    Citation: Clinical Proteomics 2019 16:39

    Content type: Research

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  12. Neuroticism is a core personality trait and a major risk factor for several mental and physical diseases, particularly in females, who score higher on neuroticism than men, on average. However, a better unders...

    Authors: Lei Tian, Hong-Zhao You, Hao Wu, Yu Wei, Min Zheng, Lei He, Jin-Ying Liu, Shu-Zhen Guo, Yan Zhao, Ren-Lai Zhou and Xingang Hu

    Citation: Clinical Proteomics 2019 16:38

    Content type: Research

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  13. Intrahepatic cholangiocarcinoma (iCCA) is a malignancy that arises from the intrahepatic biliary tree, showing high mortality rates due to its late clinical presentation and limited treatment options. iCCA is ...

    Authors: Guido Carpino, Diletta Overi, Fabio Melandro, Alessio Grimaldi, Vincenzo Cardinale, Sabina Di Matteo, Gianluca Mennini, Massimo Rossi, Domenico Alvaro, Vincenzo Barnaba, Eugenio Gaudio and Carmine Mancone

    Citation: Clinical Proteomics 2019 16:37

    Content type: Research

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  15. N-linked glycoprotein is a highly interesting class of proteins for clinical and biological research. The large-scale characterization of N-linked glycoproteins accomplished by mass spectrometry-based glycopro...

    Authors: Shisheng Sun, Yingwei Hu, Minghui Ao, Punit Shah, Jing Chen, Weiming Yang, Xingwang Jia, Yuan Tian, Stefani Thomas and Hui Zhang

    Citation: Clinical Proteomics 2019 16:35

    Content type: Research

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  16. One of the most significant challenges in colorectal cancer (CRC) management is the use of compliant early stage population-based diagnostic tests as adjuncts to confirmatory colonoscopy. Despite the near cura...

    Authors: Seong Beom Ahn, Samridhi Sharma, Abidali Mohamedali, Sadia Mahboob, William J. Redmond, Dana Pascovici, Jemma X. Wu, Thiri Zaw, Subash Adhikari, Vineet Vaibhav, Edouard C. Nice and Mark S. Baker

    Citation: Clinical Proteomics 2019 16:34

    Content type: Research

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  18. Bone marrow stromal cells protect hematopoietic cells and provide drug resistance by delivering bunch of variable proteins. Thus, alterations of protein expression are typically associated with cell–cell signa...

    Authors: Rui Liu, Yi Wang, Bingxin Li, Hui Wang, Feng Guan, Zengqi Tan and Xiang Li

    Citation: Clinical Proteomics 2019 16:32

    Content type: Research

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  19. Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer that is characterized by its poor prognosis, rapid progression and development of drug resistance. Chemotherapy is a vital treatment option for most o...

    Authors: Hong Peng, Ru Chen, Teresa A. Brentnall, Jimmy K. Eng, Vincent J. Picozzi and Sheng Pan

    Citation: Clinical Proteomics 2019 16:31

    Content type: Research

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  20. In the original version of the article [1], an error was noticed under the heading “Immunoprecipitation on protein G magnetic beads” in “Methods” section.

    Authors: Milena Music, Antoninus Soosaipillai, Ihor Batruch, Ioannis Prassas, Dimitrios P. Bogdanos and Eleftherios P. Diamandis

    Citation: Clinical Proteomics 2019 16:30

    Content type: Correction

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    The original article was published in Clinical Proteomics 2019 16:25

  21. Sepsis is a dysregulated host response to infection and a major cause of death worldwide. Respiratory tract infections account for most sepsis cases and depending on the place of acquisition, i.e., community o...

    Authors: Narendra Kumar Sharma, Bianca Lima Ferreira, Alexandre Keiji Tashima, Milena Karina Colo Brunialti, Ricardo Jose Soares Torquato, Antonio Bafi, Murillo Assuncao, Luciano Cesar Pontes Azevedo and Reinaldo Salomao

    Citation: Clinical Proteomics 2019 16:29

    Content type: Research

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  22. Chronic pelvic pain is often overlooked during primary examinations because of the numerous causes of such “vague” symptoms. However, this pain can often mask endometriosis, a smoldering disease that is not ea...

    Authors: Bao Weisheng, Ceana H. Nezhat, Gordon F. Huang, Ying-Qing Mao, Neil Sidell and Ruo-Pan Huang

    Citation: Clinical Proteomics 2019 16:28

    Content type: Research

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  23. In the version of this article that was originally published [1], some information in the “Acknowledgements” section was omitted.

    Authors: Jingi Bae, Su-Jin Kim, Seung-Eun Lee, Wooil Kwon, Hongbeom Kim, Youngmin Han, Jin-Young Jang, Min-Sik Kim and Sang-Won Lee

    Citation: Clinical Proteomics 2019 16:27

    Content type: Correction

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    The original article was published in Clinical Proteomics 2019 16:18

  24. This proof of concept study was aimed at characterizing novel salivary biomarkers specific for different subsets in primary Sjögren’s syndrome (pSS) in order to improve patients’ profiling.

    Authors: Antonella Cecchettini, Francesco Finamore, Nadia Ucciferri, Valentina Donati, Letizia Mattii, Enza Polizzi, Francesco Ferro, Francesca Sernissi, Marta Mosca, Stefano Bombardieri, Silvia Rocchiccioli and Chiara Baldini

    Citation: Clinical Proteomics 2019 16:26

    Content type: Research

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  25. Autoantibodies are produced when tolerance to self-antigens is broken and they can be mediators of tissue injury and systemic inflammation. They are excellent biomarkers because they are minimally invasive to ...

    Authors: Milena Music, Antoninus Soosaipillai, Ihor Batruch, Ioannis Prassas, Dimitrios P. Bogdanos and Eleftherios P. Diamandis

    Citation: Clinical Proteomics 2019 16:25

    Content type: Research

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    The Correction to this article has been published in Clinical Proteomics 2019 16:30

  26. Although sperm cryopreservation has been widely used in human reproductive medicine as an integral infertility management in infertility clinics and for banking sperm in sperm banks, the freezing/thawing proto...

    Authors: Shanshan Li, Lei Ao, Yaping Yan, Jiang Jiang, Bingbing Chen, Yanchao Duan, Fei Shen, Jinbao Chen, Briauna Inglis, Renmin Ni, Weizhi Ji and Wei Si

    Citation: Clinical Proteomics 2019 16:24

    Content type: Research

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  27. Inflammatory arthritis (IA) is an immunological disorder in which loss of immune tolerance to endogenous self-antigens perpetuates synovitis and eventual destruction of the underlying cartilage and bone. Patho...

    Authors: Shalini M. Mahendran, Edward C. Keystone, Roman J. Krawetz, Kun Liang, Eleftherios P. Diamandis and Vinod Chandran

    Citation: Clinical Proteomics 2019 16:23

    Content type: Research

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  28. Chinese Bama Yao Autonomous County is a well-known longevity region in the world. In the past 30 years, population and genome studies were undertaken to investigate the secret of longevity and showed that long...

    Authors: Shengliang Ye, Li Ma, Rong Zhang, Fengjuan Liu, Peng Jiang, Jun Xu, Haijun Cao, Xi Du, Fangzhao Lin, Lu Cheng, Xuefeng Zhou, Zhihui Shi, Yeheng Liu, Yaojin Huang, Zongkui Wang and Changqing Li

    Citation: Clinical Proteomics 2019 16:22

    Content type: Research

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  29. Cadmium is a toxic metal with multiple adverse health effects, including risk of cardiovascular disease (CVD). The mechanistic link between cadmium and CVD is unclear. Our aim was to examine the associations b...

    Authors: Yan Borné, Björn Fagerberg, Gerd Sallsten, Bo Hedblad, Margaretha Persson, Olle Melander, Jan Nilsson, Marju Orho-Melander, Lars Barregard and Gunnar Engström

    Citation: Clinical Proteomics 2019 16:21

    Content type: Research

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  30. Lung cancer is the leading cause of cancer death in China and around the world. Early detection is key to improving the survival rate of non-small cell lung cancer (NSCLC). Alteration in glycosylation has been...

    Authors: Yiqian Liang, Peng Han, Ting Wang, Hui Ren, Lei Gao, Puyu Shi, Shuo Zhang, Aimin Yang, Zheng Li and Mingwei Chen

    Citation: Clinical Proteomics 2019 16:20

    Content type: Research

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  31. Multiple sclerosis (MS) is an autoimmune, neuroinflammatory disease, with an unclear etiology. However, T cells play a central role in the pathogenesis by crossing the blood–brain-barrier, leading to inflammat...

    Authors: Tone Berge, Anna Eriksson, Ina Skaara Brorson, Einar August Høgestøl, Pål Berg-Hansen, Anne Døskeland, Olav Mjaavatten, Steffan Daniel Bos, Hanne F. Harbo and Frode Berven

    Citation: Clinical Proteomics 2019 16:19

    Content type: Research

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  32. Certain tumors such as pancreatic ductal adenocarcinoma (PDAC) are known to contain a variety of hydrolytic enzymes including RNases and proteases that may lead to degradation of RNA and proteins during sample...

    Authors: Jingi Bae, Su-Jin Kim, Seung-Eun Lee, Wooil Kwon, Hongbeom Kim, Youngmin Han, Jin-Young Jang, Min-Sik Kim and Sang-Won Lee

    Citation: Clinical Proteomics 2019 16:18

    Content type: Research

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    The Correction to this article has been published in Clinical Proteomics 2019 16:27

  33. The bone marrow microenvironment provides an optimal substrate for multiple myeloma (MM) initiation and progression. The soluble component of MM niche is dynamic with the disease states of MM. We formerly emp...

    Authors: Ju Bai, Yun Yang, Jianli Wang, Lei Zhang, Fangxia Wang and Aili He

    Citation: Clinical Proteomics 2019 16:17

    Content type: Research

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  34. Blood-based protein measurement is a routine practice for detecting biomarkers in human disease. Comprehensive profiling of blood/plasma/serum proteome is a challenge due to an extremely large dynamic range, a...

    Authors: Kaushik Kumar Dey, Hong Wang, Mingming Niu, Bing Bai, Xusheng Wang, Yuxin Li, Ji-Hoon Cho, Haiyan Tan, Ashutosh Mishra, Anthony A. High, Ping-Chung Chen, Zhiping Wu, Thomas G. Beach and Junmin Peng

    Citation: Clinical Proteomics 2019 16:16

    Content type: Research

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  35. Prostate cancer (PCa) is the most frequently diagnosed non-skin cancer and a leading cause of mortality among males in developed countries. However, our understanding of the global changes of protein complexes...

    Authors: Bo Zhou, Yiwu Yan, Yang Wang, Sungyong You, Michael R. Freeman and Wei Yang

    Citation: Clinical Proteomics 2019 16:15

    Content type: Research

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  36. Endometriosis is a common gynaecological disorder affecting 5–10% of women of reproductive age who often experience chronic pelvic pain and infertility. Definitive diagnosis is through laparoscopy, exposing pa...

    Authors: Stella Irungu, Dimitrios Mavrelos, Jenny Worthington, Oleg Blyuss, Ertan Saridogan and John F. Timms

    Citation: Clinical Proteomics 2019 16:14

    Content type: Research

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  37. Prostate-specific antigen (PSA) is commonly used as a serum biomarker for the detection of prostate cancer. However, levels of PSA in serum do not reliably distinguish aggressive prostate cancer from non-aggre...

    Authors: Ce Wang, Naseruddin Höti, Tung-Shing Mamie Lih, Lori J. Sokoll, Rui Zhang, Zhen Zhang, Hui Zhang and Daniel W. Chan

    Citation: Clinical Proteomics 2019 16:13

    Content type: Research

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  38. Esophageal cancer (EC) is one of the malignant tumors with a poor prognosis. The early stage of EC is asymptomatic, so identification of cancer biomarkers is important for early detection and clinical practice.

    Authors: Yanping Zhu, Xiaoying Qi, Cuicui Yu, Shoujun Yu, Chao Zhang, Yuan Zhang, Xiuxiu Liu, Yuxue Xu, Chunhua Yang, Wenguo Jiang, Geng Tian, Xuri Li, Jonas Bergquist, Jiandi Zhang, Lei Wang and Jia Mi

    Citation: Clinical Proteomics 2019 16:12

    Content type: Research

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  39. Prevalence of many eye and ocular surface diseases increases with age. While the clinical characteristics and pathophysiologic mechanisms of these conditions are often either known or extensively studied, the ...

    Authors: Janika Nättinen, Antti Jylhä, Ulla Aapola, Petri Mäkinen, Roger Beuerman, Juhani Pietilä, Anu Vaajanen and Hannu Uusitalo

    Citation: Clinical Proteomics 2019 16:11

    Content type: Research

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  41. Cerebrospinal fluid (CSF) is in direct contact with the central nervous system. This makes human CSF an attractive source of potential biomarkers for neurologic diseases. Similarly to blood plasma, proteomic a...

    Authors: Eliska Jankovska, Marek Svitek, Karel Holada and Jiri Petrak

    Citation: Clinical Proteomics 2019 16:9

    Content type: Research

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  42. Colistin (polymyxin E) and polymixin B are important bactericidal antibiotics used in the treatment of serious infections caused by multi-drug resistant Gram-negative organisms. Transferrable plasmid-mediated ...

    Authors: Honghui Wang, Yong Chen, Jeffrey R. Strich, Steven K. Drake, Jung-Ho Youn, Avi Z. Rosenberg, Marjan Gucek, Patrick T. McGann, Anthony F. Suffredini and John P. Dekker

    Citation: Clinical Proteomics 2019 16:8

    Content type: Research

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  43. In-depth examination of the plasma proteomic response to infection with a wide variety of pathogens can assist in the development of new diagnostic paradigms, while providing insight into the interdependent pa...

    Authors: Michael D. Ward, Ernst E. Brueggemann, Tara Kenny, Raven E. Reitstetter, Christopher R. Mahone, Sylvia Trevino, Kelly Wetzel, Ginger C. Donnelly, Cary Retterer, Robert B. Norgren Jr., Rekha G. Panchal, Travis K. Warren, Sina Bavari and Lisa H. Cazares

    Citation: Clinical Proteomics 2019 16:7

    Content type: Research

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  44. Idiopathic pulmonary fibrosis (IPF) is a progressive, eventually fatal disease. IPF is characterized by excessive accumulation of the extracellular matrix (ECM) in the alveolar parenchyma and progressive lung ...

    Authors: Yaqiong Tian, Hui Li, Yujuan Gao, Chuanmei Liu, Ting Qiu, Hongyan Wu, Mengshu Cao, Yingwei Zhang, Hui Ding, Jingyu Chen and Hourong Cai

    Citation: Clinical Proteomics 2019 16:6

    Content type: Research

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  45. It is difficult to distinguish benign pulmonary nodules (PNs) from malignant PNs by conventional examination. Therefore, novel biomarkers that can identify the nature of PNs are needed. Exosomes have recently ...

    Authors: Muyu Kuang, Xiaoting Tao, Yizhou Peng, Wenjing Zhang, Yafang Pan, Lei Cheng, Chongze Yuan, Yue Zhao, Hengyu Mao, Lingdun Zhuge, Zhenhua Zhou, Haiquan Chen and Yihua Sun

    Citation: Clinical Proteomics 2019 16:5

    Content type: Research

    Published on:

  46. Ulcerative colitis (UC) is one major form of inflammatory bowel disease. The cause and the pathophysiology of the disease are not fully understood and we therefor aim in this study to identify important pathop...

    Authors: Armin Schniers, Rasmus Goll, Yvonne Pasing, Sveinung Wergeland Sørbye, Jon Florholmen and Terkel Hansen

    Citation: Clinical Proteomics 2019 16:4

    Content type: Research

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  47. Biomarkers are urgently required to support current histological staging to provide additional accuracy in stratifying colorectal cancer (CRC) patients according to risk of spread to properly assign adjuvant c...

    Authors: Chandra Kirana, Lifeng Peng, Rose Miller, John P. Keating, Corinne Glenn, Hongjun Shi, T. William Jordan, Guy J. Maddern and Richard S. Stubbs

    Citation: Clinical Proteomics 2019 16:3

    Content type: Research

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  48. The biomarkers alpha-fetoprotein (AFP) and protein induced by vitamin K absence/antagonist-II (PIVKA-II) may be useful for detecting early-stage hepatocellular carcinoma (HCC). We evaluated the performance of ...

    Authors: Philip M. Hemken, Lori J. Sokoll, Xiaoqing Yang, Jianliang Dai, Debra Elliott, Susan H. Gawel, Michael Lucht, Ziding Feng, Jorge A. Marrero, Sudhir Srivastava, Daniel W. Chan and Gerard J. Davis

    Citation: Clinical Proteomics 2019 16:2

    Content type: Research

    Published on:

  49. Misdiagnosis of autoimmune pancreatitis (AIP) as pancreatic cancer (PDAC) or vice versa can cause dismal patents’ outcomes. Changes in IgG glycosylation are associated with cancers and autoimmune diseases. Thi...

    Authors: Hsi-Chang Shih, Ming-Chu Chang, Chein-Hung Chen, I-Lin Tsai, San-Yuan Wang, Ya-Po Kuo, Chung-Hsuan Chen and Yu-Ting Chang

    Citation: Clinical Proteomics 2019 16:1

    Content type: Research

    Published on:

  50. Cytauxzoonosis is a disease of felids in North America caused by the tick-transmitted apicomplexan parasite Cytauxzoon felis. Cytauxzoonosis is particularly virulent for domestic cats, but no vaccine currently ex...

    Authors: Megan E. Schreeg, Henry S. Marr, Jaime L. Tarigo, Meredith K. Sherrill, Hilton K. Outi, Elizabeth H. Scholl, David M. Bird, Adam Vigil, Chris Hung, Rie Nakajima, Li Liang, Angela Trieu, Denise L. Doolan, Jennifer E. Thomas, Michael G. Levy, Mason V. Reichard…

    Citation: Clinical Proteomics 2018 15:44

    Content type: Research

    Published on:

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Clinical Proteomics

ISSN: 1559-0275