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  1. Roxadustat is a new oral anti-renal anemia medication that works by stabilizing hypoxia-inducible factor (HIF) which can activate the expression of more than 100 genes in addition to genes related to anemia. H...

    Authors: Xiaoe You, Baochun Guo, Zhen Wang, Hualin Ma and Xinzhou Zhang
    Citation: Clinical Proteomics 2022 19:21
  2. There is a lack of early and precise biomarkers for personalized respiratory medicine. Breath contains an aerosol of droplet particles, which are formed from the epithelial lining fluid when the small airways ...

    Authors: Jörgen Östling, Marleen Van Geest, Henric K. Olsson, Sven-Erik Dahlen, Emilia Viklund, Per M. Gustafsson, Ekaterina Mirgorodskaya and Anna-Carin Olin
    Citation: Clinical Proteomics 2022 19:20
  3. Embryo implantation is a complex developmental process that requires coordinated interactions among the embryo, endometrium, and the microenvironment of endometrium factors. Even though the impaired endometria...

    Authors: Jun Li, Xiaohua Jiang, Caihua Li, Huihui Che, Lin Ling and Zhaolian Wei
    Citation: Clinical Proteomics 2022 19:19
  4. Esophageal squamous cell carcinoma (ESCC) is a common digestive tract malignant tumor with high incidence and dismal prognosis worldwide. However, the reliable biomarkers for clinical diagnosis and the underly...

    Authors: Wenhu Liu, Qiang Wang, Jinxia Chang, Anup Bhetuwal, Nisha Bhattarai, Fan Zhang and Jiancai Tang
    Citation: Clinical Proteomics 2022 19:18
  5. Despite advances in diagnosis of congenital heart defects, there is no non-invasive biomarker clinically available for the early detection of fetal ventricular septal defects (VSD).

    Authors: Jing He, Liang Xie, Li Yu, Lijun Liu, Hong Xu, Tao Wang, Yuyang Gao, Xuedong Wang, You Duan, Hanmin Liu and Li Dai
    Citation: Clinical Proteomics 2022 19:17
  6. Glucagon serves as an important regulatory hormone for regulating blood glucose concentration with tight feedback control exerted by insulin and glucose. There are critical gaps in our understanding of glucago...

    Authors: Santosh Renuse, Linda M. Benson, Patrick M. Vanderboom, F. N. U. Ruchi, Yogesh R. Yadav, Kenneth L. Johnson, Benjamin C. Brown, Jane A. Peterson, Rita Basu, Daniel J. McCormick, Akhilesh Pandey and Ananda Basu
    Citation: Clinical Proteomics 2022 19:16
  7. Airway remodeling in patients with asthma, which leads to a decline in pulmonary function, is likely the result of repeated exacerbations often provoked by aeroallergen exposures. Aeroallegen exposure triggers...

    Authors: Yanlong Zhu, Stephane Esnault, Ying Ge, Nizar N. Jarjour and Allan R. Brasier
    Citation: Clinical Proteomics 2022 19:15
  8. Accumulating evidence suggests that the androgen receptor (AR) and its endogenous ligands influence disease progression in breast cancer (BCa). However, AR-mediated changes in BCa differ among the various BCa ...

    Authors: Stella K. Vasiliou, Panagiota S. Filippou, Sergi Clotet-Freixas, Antoninus Soosaipillai, Ihor Batruch, Foivos Viktor Tsianos, Ana Konvalinka and Eleftherios P. Diamandis
    Citation: Clinical Proteomics 2022 19:14
  9. Cerebrospinal fluid (CSF) is an important biofluid for biomarkers of neurodegenerative diseases such as Alzheimer’s disease (AD). By employing tandem mass tag (TMT) proteomics, thousands of proteins can be qua...

    Authors: Sophia Weiner, Mathias Sauer, Pieter Jelle Visser, Betty M. Tijms, Egor Vorontsov, Kaj Blennow, Henrik Zetterberg and Johan Gobom
    Citation: Clinical Proteomics 2022 19:13
  10. Treatment for glaucoma has traditionally been limited to reducing intraocular pressure (IOP). Inhibiting oxidative stress in the trabecular meshwork (TM) is regarded as a new treatment for glaucoma; however, t...

    Authors: Qian Li, Liyu Zhang and Yuxin Xu
    Citation: Clinical Proteomics 2022 19:12
  11. Formalin-fixed paraffin-embedded (FFPE) tissue is the standard material for diagnostic pathology but poses relevant hurdles to accurate protein extraction due to cross-linking and chemical alterations. While n...

    Authors: Franz F. Dressler, Jana Schoenfeld, Olga Revyakina, Daniel Vogele, Selina Kiefer, Jutta Kirfel, Timo Gemoll and Sven Perner
    Citation: Clinical Proteomics 2022 19:10
  12. Non-invasive liquid biopsies could complement current pathological nomograms for risk stratification of prostate cancer patients. Development and testing of potential liquid biopsy markers is time, resource, a...

    Authors: Sandra Goetze, Peter Schüffler, Alcibiade Athanasiou, Anika Koetemann, Cedric Poyet, Christian Daniel Fankhauser, Peter J. Wild, Ralph Schiess and Bernd Wollscheid
    Citation: Clinical Proteomics 2022 19:9
  13. Mass spectrometry imaging (MSI) derives spatial molecular distribution maps directly from clinical tissue specimens and thus bears great potential for assisting pathologists with diagnostic decisions or person...

    Authors: Melanie Christine Föll, Veronika Volkmann, Kathrin Enderle-Ammour, Sylvia Timme, Konrad Wilhelm, Dan Guo, Olga Vitek, Peter Bronsert and Oliver Schilling
    Citation: Clinical Proteomics 2022 19:8
  14. Rheumatic heart disease (RHD) remains a major source of morbidity and mortality in developing countries. A deeper insight into the pathogenetic mechanisms underlying RHD could provide opportunities for drug re...

    Authors: M. Taariq Salie, Jing Yang, Carlos R. Ramírez Medina, Liesl J. Zühlke, Chishala Chishala, Mpiko Ntsekhe, Bernard Gitura, Stephen Ogendo, Emmy Okello, Peter Lwabi, John Musuku, Agnes Mtaja, Christopher Hugo-Hamman, Ahmed El-Sayed, Albertino Damasceno, Ana Mocumbi…
    Citation: Clinical Proteomics 2022 19:7
  15. Remote Ischemic Conditioning (RIC) has been proposed as a therapeutic intervention to circumvent the ischemia/reperfusion injury (IRI) that is inherent to organ transplantation. Using a porcine kidney transpla...

    Authors: Darragh P. O’Brien, Adam M. Thorne, Honglei Huang, Elisa Pappalardo, Xuan Yao, Peter Søndergaard Thyrrestrup, Kristian Ravlo, Niels Secher, Rikke Norregaard, Rutger J. Ploeg, Bente Jespersen and Benedikt M. Kessler
    Citation: Clinical Proteomics 2022 19:6
  16. The high incidence of pre-eclampsia, which affects 2–7% of all pregnancies, remains a major health concern. Detection of pre-eclampsia before the appearance of clinical symptoms is essential to allow early int...

    Authors: Rosana Navajas, Antonio Ramos-Fernandez, Ignacio Herraiz, Alberto Galindo, José Luis Bartha, Fernando Corrales and Alberto Paradela
    Citation: Clinical Proteomics 2022 19:5
  17. Oral squamous cell carcinoma (OSCC) is a main cause of oral cancer mortality and morbidity in central south Asia. To improve the clinical outcome of OSCC patients, detection markers are needed, which are prefe...

    Authors: Madiha Mumtaz, Irene V. Bijnsdorp, Franziska Böttger, Sander R. Piersma, Thang V. Pham, Samiullah Mumtaz, Ruud H. Brakenhoff, M. Waheed Akhtar and Connie R. Jimenez
    Citation: Clinical Proteomics 2022 19:4
  18. Chronic kidney disease (CKD) has few objective symptoms, and it is difficult to make an early diagnosis by using existing methods. Therefore, new biomarkers enabling diagnosis of renal dysfunction at an early ...

    Authors: Kazuma Higashisaka, Sonoko Takeya, Haruhiko Kamada, Masanori Obana, Makiko Maeda, Mai Kabayama, Koichi Yamamoto, Nanan Ishida, Ryo Isaka, Hirofumi Tsujino, Kazuya Nagano, Noriyuki Tomiyama, Hiromi Rakugi, Yasushi Fujio, Kei Kamide and Yasuo Tsutsumi
    Citation: Clinical Proteomics 2022 19:3
  19. Early detection of small cell lung cancer (SCLC) crucially demands highly reliable markers. Growing evidence suggests that extracellular vesicles carry tumor cell-specific cargo suitable as protein markers in ...

    Authors: Shona Pedersen, Katrine Papendick Jensen, Bent Honoré, Søren Risom Kristensen, Camilla Holm Pedersen, Weronika Maria Szejniuk, Raluca Georgiana Maltesen and Ursula Falkmer
    Citation: Clinical Proteomics 2022 19:2
  20. Thrombocytopenia is frequent in Plasmodium vivax malaria but the role of platelets in pathogenesis is unknown. Our study explores the platelet (PLT) proteome from uncomplicated P. vivax patients, to fingerprint m...

    Authors: Diana Fernández, Cesar Segura, Mònica Arman, Suzanne McGill, Richard Burchmore and Tatiana Lopera-Mesa
    Citation: Clinical Proteomics 2022 19:1
  21. Type 2 diabetic kidney disease is the most common cause of chronic kidney diseases (CKD) and end-stage renal diseases (ESRD). Although kidney biopsy is considered as the ‘gold standard’ for diabetic kidney dis...

    Authors: Guanjie Fan, Tongqing Gong, Yuping Lin, Jianping Wang, Lu Sun, Hua Wei, Xing Yang, Zhenjie Liu, Xinliang Li, Ling Zhao, Lan Song, Jiali He, Haibo Liu, Xiuming Li, Lifeng Liu, Anxiang Li…
    Citation: Clinical Proteomics 2021 18:32
  22. Communicating hydrocephalus (CH) is a common neurological disorder caused by a blockage of cerebrospinal fluid. In this study, we aimed to explore the potential molecular mechanism underlying CH development.

    Authors: Lei Yuan, Dongdong Zou, Xia Yang, Xin Chen, Youming Lu, Aijun Zhang, Pengqi Zhang and Fance Wei
    Citation: Clinical Proteomics 2021 18:30
  23. The rapid advancements of high throughput “omics” technologies have brought a massive amount of data to process during and after experiments. Multi-omic analysis facilitates a deeper interrogation of a dataset...

    Authors: Hui Zhang, Minghui Ao, Arianna Boja, Michael Schnaubelt and Yingwei Hu
    Citation: Clinical Proteomics 2021 18:29
  24. Vitreous is an accessible, information-rich biofluid that has recently been studied as a source of retinal disease-related proteins and pathways. However, the number of samples required to confidently identify...

    Authors: Sarah R. Weber, Yuanjun Zhao, Jingqun Ma, Christopher Gates, Felipe da Veiga Leprevost, Venkatesha Basrur, Alexey I. Nesvizhskii, Thomas W. Gardner and Jeffrey M. Sundstrom
    Citation: Clinical Proteomics 2021 18:28
  25. Liver transplantation (LT) can be offered to patients with Hepatocellular carcinoma (HCC) beyond Milan criteria. However, there are currently limited molecular markers on HCC explant histology to predict recur...

    Authors: Mamatha Bhat, Sergi Clotet-Freixas, Cristina Baciu, Elisa Pasini, Ahmed Hammad, Tommy Ivanics, Shelby Reid, Amirhossein Azhie, Marc Angeli, Anand Ghanekar, Sandra Fischer, Gonzalo Sapisochin and Ana Konvalinka
    Citation: Clinical Proteomics 2021 18:27
  26. The KidneyIntelX™ test applies a machine learning algorithm that incorporates plasma biomarkers and clinical variables to produce a composite risk score to predict a progressive decline in kidney function in p...

    Authors: Patricia Connolly, Sharon Stapleton, Gohar Mosoyan, Ilya Fligelman, Ya-Chen Tonar, Fergus Fleming and Michael J. Donovan
    Citation: Clinical Proteomics 2021 18:26
  27. SARS-CoV-2, a novel human coronavirus, has created a global disease burden infecting > 100 million humans in just over a year. RT-PCR is currently the predominant method of diagnosing this viral infection alth...

    Authors: Kiran K. Mangalaparthi, Sandip Chavan, Anil K. Madugundu, Santosh Renuse, Patrick M. Vanderboom, Anthony D. Maus, Jennifer Kemp, Benjamin R. Kipp, Stefan K. Grebe, Ravinder J. Singh and Akhilesh Pandey
    Citation: Clinical Proteomics 2021 18:25

    The Correction to this article has been published in Clinical Proteomics 2022 19:11

  28. Osteoporosis (OP) is a systemic bone disease characterized by decreased bone mass, destruction of the bone tissue microstructure, increased bone brittleness and an increased risk of fracture. OP has a high inc...

    Authors: Ruikun Zhang, Kun Yan, Yulun Wu, Xinmiao Yao, Guijin Li, Linpu Ge and Zhineng Chen
    Citation: Clinical Proteomics 2021 18:24
  29. Cardiovascular disease (CVD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and reduced lung function is an important risk factor for CVD and CVD-related death. However, the mechanisms...

    Authors: K. Egervall, A. Rosso and S. Elmståhl
    Citation: Clinical Proteomics 2021 18:23
  30. Preeclampsia and gestational hypertension can cause vascular function impairment in offspring. In our previous work, we described the protein expression profiles of umbilical artery tissues from patients with ...

    Authors: Bin Yu, Hong-Dan Zhu, Xiao-Liang Shi, Pan-Pan Chen, Xiang-Mei Sun, Gui-Yu Xia, Min Fang, Yong-Xing Zhong, Xiao-Li Tang, Tao Zhang and Hai-Tao Pan
    Citation: Clinical Proteomics 2021 18:22
  31. A hepatocellular carcinoma (HCC) prediction model (ASAP), including age, sex, and the biomarkers alpha-fetoprotein and prothrombin induced by vitamin K absence-II, showed potential clinical value in the early ...

    Authors: Bo Li, Youyun Zhao, Wangxi Cai, Anping Ming and Hanmin Li
    Citation: Clinical Proteomics 2021 18:21
  32. It is not enough to optimize proteomics assays. It is critical those assays are robust to operating conditions. Without robust assays, proteomic biomarkers are unlikely to translate readily into the clinic. Th...

    Authors: Edith Serrano-Blesa, Andrew Porter, Dennis W. Lendrem, Costantino Pitzalis, Anne Barton, Achim Treumann and John D. Isaacs
    Citation: Clinical Proteomics 2021 18:20
  33. Molecular diagnostics of the coronavirus disease of 2019 (COVID-19) now mainly relies on the measurements of viral RNA by RT-PCR, or detection of anti-viral antibodies by immunoassays. In this review, we discu...

    Authors: Yasmine Rais, Zhiqiang Fu and Andrei P. Drabovich
    Citation: Clinical Proteomics 2021 18:19
  34. Placenta is a complex organ that plays a significant role in the maintenance of pregnancy health. It is a dynamic organ that undergoes dramatic changes in growth and development at different stages of gestatio...

    Authors: Sara Khorami Sarvestani, Sorour Shojaeian, Negar Vanaki, Behrouz Ghresi-Fard, Mehdi Amini, Kambiz Gilany, Hale Soltanghoraee, Soheila Arefi, Mahmood Jeddi-Tehrani and Amir-Hassan Zarnani
    Citation: Clinical Proteomics 2021 18:18
  35. A practical strategy to discover proteins specific to Alzheimer’s dementia (AD) may be to compare the plasma peptides and proteins from patients with dementia to normal controls and patients with neurological ...

    Authors: Angelique Florentinus-Mefailoski, Peter Bowden, Philip Scheltens, Joep Killestein, Charlotte Teunissen and John G. Marshall
    Citation: Clinical Proteomics 2021 18:17
  36. Gastrointestinal stromal tumor (GIST) is a common digestive tract tumor with high rate of metastasis and recurrence. Currently, we understand the genome, transcriptome and proteome in GIST. However, posttransc...

    Authors: Bo Wang, Long Zhao, Zhidong Gao, Jianyuan Luo, Haoran Zhang, Lin Gan, Kewei Jiang, Shan Wang, Yingjiang Ye and Zhanlong Shen
    Citation: Clinical Proteomics 2021 18:16
  37. The Coronavirus Disease 2019 (COVID-19) global pandemic has had a profound, lasting impact on the world's population. A key aspect to providing care for those with COVID-19 and checking its further spread is e...

    Authors: Andrew T. Rajczewski, Subina Mehta, Dinh Duy An Nguyen, Björn Grüning, James E. Johnson, Thomas McGowan, Timothy J. Griffin and Pratik D. Jagtap
    Citation: Clinical Proteomics 2021 18:15
  38. Glioblastoma (GBM) is a grade IV glioma highly aggressive and refractory to the therapeutic approaches currently in use. O-GlcNAcylation plays a key role for tumor aggressiveness and progression in different t...

    Authors: Maria Cecilia Oliveira-Nunes, Glaucia Julião, Aline Menezes, Fernanda Mariath, John A. Hanover, Joseph Albert Medeiros Evaristo, Fábio César Sousa Nogueira, Wagner Barbosa Dias, Denise de Abreu Pereira and Katia Carneiro
    Citation: Clinical Proteomics 2021 18:14
  39. Over the last decade, the use of proteomics in the setting of prematurity has increased and has enabled researchers to successfully identify biomarkers for an array of associated morbidities. The objective of ...

    Authors: Natasha Letunica, Tengyi Cai, Jeanie L. Y. Cheong, Lex W. Doyle, Paul Monagle and Vera Ignjatovic
    Citation: Clinical Proteomics 2021 18:13
  40. High red cell distribution width (RDW) has been increasingly recognized as a risk factor for cardiovascular diseases (CVDs), but the underlying mechanisms remain unknown. Our aim was to explore the association...

    Authors: Jingxue Pan, Yan Borné, Marju Orho-Melander, Jan Nilsson, Olle Melander and Gunnar Engström
    Citation: Clinical Proteomics 2021 18:12
  41. Protein profiles that can predict allergy development in children are lacking and the ideal sampling age is unknown. By applying an exploratory proteomics approach in the prospective FARMFLORA birth cohort, we...

    Authors: Marit Stockfelt, Mun-Gwan Hong, Bill Hesselmar, Ingegerd Adlerberth, Agnes E. Wold, Jochen M. Schwenk, Anna-Carin Lundell and Anna Rudin
    Citation: Clinical Proteomics 2021 18:11
  42. The pipeline of biomarker translation from bench to bedside is challenging and limited biomarkers have been adopted to routine clinical care. Ideally, biomarker research and development should be driven by unm...

    Authors: T. T. van Duijl, D. Soonawala, J. W. de Fijter, L. R. Ruhaak and C. M. Cobbaert
    Citation: Clinical Proteomics 2021 18:10
  43. Pregnancy is a complicated physiological process. The multifaceted regulation of maternal–fetal interface is of great importance for maintaining normal pregnancy and avoiding fetal rejection and secondary abor...

    Authors: Xiang-Jie Yin, Wei Hong, Fu-Ju Tian and Xiao-Cui Li
    Citation: Clinical Proteomics 2021 18:9
  44. Based on their potential to analyze aberrant cellular signaling in relation to biological function, kinase activity profiling in tumor biopsies by peptide microarrays and mass spectrometry-based phosphoproteom...

    Authors: Tineke E. Buffart, Rosanne A. H. M. van den Oord, Adriënne van den Berg, Riet Hilhorst, Niek Bastiaensen, Hans F. M. Pruijt, Adriaan van den Brule, Peet Nooijen, Mariette Labots, Richard R. de Goeij-de Haas, Henk Dekker, Sander R. Piersma, Thang V. Pham, Theo van der Leij, Rik de Wijn, Rob Ruijtenbeek…
    Citation: Clinical Proteomics 2021 18:8
  45. Protein posttranslational modification is an indispensable regulatory element that can fine-tune protein functions and regulate diverse cellular processes. Lysine 2-hydroxyisobutyrylation (Khib) is a protein p...

    Authors: Shaoying Huang, Fengping Zheng, Hua Lin, Xianqing Zhou, Huixuan Xu, Cantong Zhang, Weier Dai, Berthold Hocher, Xinzhou Zhang, Donge Tang and Yong Dai
    Citation: Clinical Proteomics 2021 18:7
  46. Quantitative proteomics is an invaluable tool in biomedicine for the massive comparative analysis of protein component of complex biological samples. In the last two decades, this technique has been used to de...

    Authors: Rosana Navajas, Fernando Corrales and Alberto Paradela
    Citation: Clinical Proteomics 2021 18:6
  47. Plasma is a potentially rich source of protein biomarkers for disease progression and drug response. Large multi-center studies are often carried out to increase the number of samples analyzed in a given study...

    Authors: Patrick Halvey, Victor Farutin, Laura Koppes, Nur Sibel Gunay, Dimitrios A. Pappas, Anthony M. Manning and Ishan Capila
    Citation: Clinical Proteomics 2021 18:5

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