Critical Evaluation of Product Ion Selection and Spectral Correlation Analysis for Biomarker Screening Using Targeted Peptide Multiple Reaction Monitoring

Table 4 Statistics comparison for T_corr/S_corr over the DIMS and MALDI spectra

	Spectra pairs of same peptides			Spectra pairs of different peptides
	Mean	SD	α for t test	Mean	SD	α for t test
DIMS spectra
S _corr	0.394	0.285	<0.001	0.241	0.099	<0.001
T _corr	0.517	0.308		0.364	0.182
MALDI spectra
S _corr	0.442	0.100	<0.001	0.392	0.074	<0.001
T _corr	0.759	0.115		0.645	0.149

For each dataset, the statistics were derived from scores over spectra pairs of same and different peptides. The α (columns 4 and 7) is the significance level of t test on T_corr and S_corr; and T_corr values are significantly higher than S_corrs

ISSN: 1559-0275