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Table 3 Differentially expressed proteins between AD and NDC using two-way ANOVA (p < 0.05)

From: Proteomic Profiling of Cerebrospinal Fluid by 8-Plex iTRAQ Reveals Potential Biomarker Candidates of Alzheimer’s Disease

Accession #

Description

p value

Fold changea

Modulation

F

M

CH3L1_HUMAN (P36222)

Chitinase-3-like protein 1

0.0006

1.3

1.4

Up

GUAD_HUMAN (Q9Y2T3)

Guanine deaminase

0.0025

1.8

1.2

Up

IGX1_HUMAN (Q8TAG5)

Semaphorin7A

0.0058

1.2

1.2

Up

CO1A1_HUMAN (P02452)

Collagen alpha 1(I) chain

0.0064

1.3

1.1

Up

SPTA2_HUMAN (Q13813)

Spectrin alpha chain, brain

0.0102

1.5

1.6

Down

PROS_HUMAN (P07225)

Vitamin K-dependent protein S

0.0134

1.1

1.2

Down

GGH_HUMAN (Q92820)

Gamma-glutamyl hydrolase precursor

0.0148

1.2

1.2

Up

BASP_HUMAN (P80723)

BASP1 protein (NAP-22)

0.0157

1.6

1.3

Up

CO1A2_HUMAN (P08123)

Collagen alpha 2(I) chain

0.0167

1.2

1.2

Up

SPB6_HUMAN (P35237)

Placental thrombin inhibitor (cytoplasmic antiproteinase)

0.0179

1.3

1.2

Down

NCA11_HUMAN (P13591)

N-CAM 140

0.0190

1.3

1.1

Up

LRP1_HUMAN (Q07954)

Low-density LRP1

0.0209

1.1

1.2

Down

TPIS_HUMAN (P60174)

Triosephosphate isomerase

0.0216

1.6

1.2

Up

CSTN1_HUMAN (O94985)

Calsyntenin-1

0.0271

1.2

1.1

Up

SODC_HUMAN (P00441)

Superoxide dismutase

0.0339

1.4

1.1

Up

MOG_HUMAN (Q16653)

Myelin–oligodendrocyte glycoprotein

0.0342

1.2

1.3

Up

CAH11_HUMAN (O75493)

CARP-2

0.0347

1.3

2.0

Up

PGRP2_HUMAN (Q96PD5)

N-Acetylmuramoyl-l-alanine amidase precursor

0.0350

1.3

1.1

Down

1433Z_HUMAN (P63104)

14-3-3 protein zeta/delta (protein KCIP-1)

0.0390

1.3

1.3

Up

OSTP_HUMAN (P10451)

Osteopontin

0.0395

1.2

1.2

Up

NXPH1_HUMAN (P58417)

Neurexophilin-1

0.0409

1.1

1.3

Down

TETN_HUMAN (P05452)

TN precursor (plasminogen-kringle 4 binding protein)

0.0448

1.1

1.1

Up

ASPG_HUMAN (P20933)

N(4)-(beta-N-acetylglucosaminyl)-l-asparaginase precursor (glycosylasparaginase)

0.0488

1.2

1.2

Up

MDHC_HUMAN (P40925)

Malate dehydrogenase, cytoplasmic

0.0494

1.2

1.1

Up

  1. BASP1 brain acid soluble protein 1, NAP-22 neuronal axonal membrane protein 22, LRP1 lipoprotein receptor-related protein 1, CARP-2 carbonic anhydrase-related protein 2, KCIP-1 protein kinase C inhibitor protein 1, TN tetranectin precursor, N-CAM 140 neural cell adhesion molecule 1, 140 kDa isoform precursor
  2. aThe magnitude of change in linear space; the greater of ratio or 1/ratio of change
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Clinical Proteomics

ISSN: 1559-0275