Table 1 The most promising proteomic biomarkers of glomerular renal diseases described in this review
From: The Quest for Renal Disease Proteomic Signatures: Where Should We Look?
Biomarker | Disease | Technique used | Reference |
|---|---|---|---|
Blood | |||
IgG4 Ab to M-phospholipase A2 receptor | IMN | HPLC-MS/MS | [22] |
Albumin sulfonation on Cys34 residue | FSGS | LC-ESI-MS/MS | [21] |
Kininogen-1-light chain; C3f fragment | IgA nephropathy | Magnetic bead peptide capture; MALDI-TOF; ESI-IT-MS/MS | [17] |
Urine | |||
Collagen I fragments | Diabetic nephropathy | CE-MS | [29] |
E-cadherin | Diabetics with proteinuria | 2D-DIGE; MALDI-TOF | [31] |
Hepcidin-20 | Lupus nephritis | Columns ≤30 kDa; SELDI-TOF | [33] |
Renal tissue | |||
Apolipoprotein E | MPGN-II? | Laser microdissection; LTQ-Orbitrap | [36] |
C7, C8 fragments | MPGN-II vs IC-MPGN | Â | [36] |