Fig. 6
From: Proteomics of AML1/ETO Target Proteins: AML1–ETO Targets a C/EBP–NM23 Pathway
Model: AML1–ETO might block myeloid differentiation by blocking the ability of C/EBP proteins to downregulate the NM23 promoter. Our data suggest that C/EBP proteins downregulate NM23, which might be a prerequisite for normal cell growth and differentiation. AML1–ETO blocks this downregulation, thereby increasing the protein level of NM23, which might lead to a block in differentiation and increase in cell proliferation as seen in AML